야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

Clinical Significance of Classification of Graves` Disease According to the Characteristics of TSH receptor Antibodies

(Won Bae Kim),(Hyun Kyung Chung),(Young Joo Park),(Do Joon Park),(Hong Kyu Lee),(Bo Youn Cho) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3

N/A Background:It has been widely accepted that the epitope (s) and/or functional characteristics of thyrotropin receptor antibodies (TSHRAb) from Graves` patients are heterogenous among patients. However, the clinical significance of such heterogeneity has not been systematically evaluatedyet. We were to elucidate and find the clinical significance of heterogeneity for TSH receptor antibodies in Graves` disease. Methods:We measured stimulating TSHRAb (TSAb) activities using CHO-hTSHR cells, FRTL-5 cells and chimeric receptor expressing cells (Mc1+2 and Mc2), specific blocking TSHRAb (TSBAb) activities using Mc2 cells and TBII activities using porcine thyroid membrane in 136 patients with untreated hyperthyroid Graves` disease. Results: Based on various TSHRAb activities from each patient, the patients could be categorized into 7 subgroups by cluster analysis; 1) Group 1 (n=41) was characterized by moderate TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, typical TSAb epitope, rare blocking antibodies and high TBII activities. 2) Group 2 (n=16) was characterized by the presence of blocking TSHRAb in most patients, albeit the other characteristics were the same as those in Group 1. 3) Group 3 (n=19) patients had low TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, seldom had blocking TSHRAb, but they had high TBII activities. 4) Group 4 (n=30) could be categorized as `mild disease` group, as they had low activities in all kinds of TSHRAb assay and had low antim icrosomal antibody activities. 5) Group 5 (n=14) was characterized by moderate TSAb activities with atypical epitope (s), rare blocking TSHRAb and moderate TBII activities. 6) Group 6 (n=10) patients had veryhigh TSAb activities with typical epitopes, seldom blocking TSHRAb and low TBII activities. 7) Group 7 (n=6) was characterized by very high TSAb activities with atypical epitopes and high TBII activities. Pretreatment serum thyroid hormone level was low only in group 4 patients compared to the other 6 groups (p<0.05). The size of goiter was significantly larger in those in group 1 and group 3 (p<0.05) compared to the other 5 groups. The prevalence of clinically significant ophthalmopathy was higher in group 2 patients than the other 6 groups (50%vs.27.5%,p=0.06). Among 6 kinds of TSHRAb activities, only the blocking TSHRAb activity was significantly associated with the presence of ophthalmopathy in multivariate analysis. Conclusion:These results suggest that the differences inepitopes for TSAb or the presence of blocking TSHRAb is not a major factor in determining the degree of thyrotoxicosis in Graves` disease. Although the pathogenic mechanism is not clearyet, we suggest that patients with ophthalmopathy have different TSHRAb repertoire from those without ophthalmopathy in Graves` disease.

Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome

( Yeo Kyung Lee ),( Jo Eun Kim ),( Hyun Ju Oh ),( Kyung Sun Park ),( Soo Kyung Kim ),( Seok Won Park ),( Moon Jong Kim ),( Yong Wook Cho1 ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4

Background/Aims: The proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (TSH) concentration are intensely debated. However, few reports have investigated TSH concentrations in Asian ethnic groups. Therefore, the present study was designed to define the TSH reference range in a Korean population and to investigate the metabolic significance of TSH concentration. Methods: We enrolled patients who underwent medical examination at the CHA Bundang Medical Center. Anthropometric data were evaluated, and serum TSH, free T4, and lipid profiles were assayed. Results: A total of 7,270 subjects were included. Mean TSH concentration of the study population was 1.82 ± 0.95 mU/L, and we observed a sex-related difference in TSH concentration (male, 1.67 ± 0.87 mU/L; female, 2.02 ± 1.01 mU/L; p < 0.01). When the 2.5 and 97.5 percentiles were calculated, 95% TSH reference limits were 0.52-4.29 mU/L. TSH concentration was higher in elderly subjects, during winter, in postmenopausal women, and in obese males. Moreover, TSH showed significantly positive correlations with serum total cholesterol, triglyceride, and low density lipoprotein cholesterol regardless of sex, age, season, obesity, or menopausal status (all p < 0.01). Finally, TSH concentration was positively related to the prevalence of metabolic syndrome. Conclusions: We demonstrated the association between TSH concentration within the normal reference range and serum lipid levels. TSH concentration varies according to sex, age, season, and body mass index (only in males). Moreover, high normal TSH levels were significantly associated with an increased prevalence of metabolic syndrome, which may be of importance when evaluating subjects with high normal TSH concentration.

일반논문(一般論文) : 『황제내경(黃帝內經)』에 나타난 부인과(婦人科)에 관(關)한 문헌고찰(文獻考察)

김혜원 ( Hye Won Kim ),조정훈 ( Jung Hoon Cho ),장준복 ( Jun Bock Jang ),이경섭 ( Kyung Sub Lee ) 대한한의학원전학회 ( 구 대한원전의사학회 ) 2005 대한한의학원전학회지 Vol.18 No.1

복합하중상태에 있는 복합재료 원통형 쉘의 거동

양원호,조명래,여경수 기계기술연구소 1999 성균관대학교 논문집 기계기술편 Vol.1 No.1

The advent of laminate composite materials opened the way for efficient shell structures. Cylindrical shells are already widely used in indstrial applications. And their buckling behaviour is a vital safety consideration. The objective of this paper is to analyse buckling behavior of laminated composite cylindrical shells subjected to combination of axial compression and torsion by finite element analysis. The influence of load type, fiber orientation angle, and stacking sequence on the buckling behaviour is discussed.

PWC170의 算出方法 評價에 關한 硏究

趙庚旭,金泰完,張鳳愚,張鍾仁 忠北大學校 平生體育硏究所 1985 平生體育硏究所 論文集 Vol.1 No.-

The purpose of this study is to estimate the maximal oxygen up-take and the physical work capacity by four experimental methods in PWC170. The subjects of this study start to pedal the bicycle ergometer at the three work loads; the first work rate with 450∼600kpm/min, the second work rate with 600∼750kpm/min, and the third work rate with 750∼900kpm/min. Each exercise bout is 6 minutes long. We used a pedal frequency of 50 revolutions per minute. The first method is the first and second work rates the second method the second and the third work rates the third method the first second and hird work rates and the fourth method an integration by the third work rate. We measured and recorded the heart rate during the last 30 seconds of every minute of exercise. Since the subjects worked in a steady state, it is not necessary that they should exercise exactly 6 minutes each time. If problems happened during the taking of heart rate or other data, we continued to exercise another 30 to 60 second. The estimation of maximal oxygen uptake and physical work capacity was conducted by work loads and heart rates during exercise. The results are as follows: 1. The estimation by four different, methods showed 2∼3 persentile difference in maximal oxygen uptake(1min, ml/kg/min) and PWC170(kpm/min, kpm/kg/min). 2. The estimation by four different methods did not show significant differene, therefore for the estimation we had better use simplified method for the first work rate and the second work rate.

Bisphenol A가 마우스의 장기무게 및 운동능력에 미치는 영향

조경혜,문세보,이정원 서울여자대학교 자연과학연구소 2002 자연과학연구논문집 Vol.14 No.-

Bisphenol A (BPA) is an environmental endocrine disrupting chemical that affects reproduction in wildlife and human beings and has been shown to mimic the actions of estrogens. BPA has been thought to be a harmful compound to human beings as well as wildlife. However, there have been few reports on the effect of BPA on movement capability or weights of several organs of animals. The purpose of the paper is to investigate the effect of BPA on weights of several organs and movement capability. BPA exposure was performed in ICR male mouse at dose levels of 0.015, 1.5 or 30 mg/ml in the drinking water for 8 weeks. To evaluate the effect on movement capability, 30 min swimming was applied to mouse administrated with various doses of BPA. After experimental treatment for 8 weeks, mice were sacrificed, and experiments were performed for serolog ical evaluation and comparison of organ weights. There were no differences in serological parameters such as blood cholesterol, blood glucose. total serum protein and serum LDH activity among all groups. There were no change in weights of body and several organs. except spleen between BPA-treated and nontreated mouse. The movement capabilities were decreased in the mice treated with BPA. Electron micrographs of cross sectioned skeletal muscle fibers showed that administration of BPA caused swelling of sarcoplasmic reticulum. These results suggested that BPA may cause the structural transformation of skeletal muscle fibers and then may induce the decrease of movement capability.

구개골내 정중치에서 발생한 함치성낭종 1례

조원표,김재영,서경식 건국대학교 의과학연구소 1995 건국의과학학술지 Vol.5 No.-

Dentigerous cyst may occur any place around jaw. Dentigerous cyst can develop from unerupted tooth, and cyst from supernumerary tooth is rare. Among dentigerous cyets, palatal dentigrous cyst from a mesiodens is a very rare case. So we report a large(2.5×2.5㎝) dentigerous cyst arising from a mesiodens which was found at left premaxillary area eroding palate, premaxilla, nasal floor and roots of left upper central and lateral incisors. En bloc enucleation of the cyst was performed and the large bony defect was filled with antibiotic and thrombin-impregnated Gelfoam. The incision site was closed with meticulous water-tight interrupted 5-0 nylon sutures. We report with follow up CT scans after 4 months. So far as we have followed up the patient, filling the bony defect with thrombin and ??, a absorbable gelatin sponge revealed a good tissue replacement material.

누설자속법을 이용한 저장탱크 바닥판재의 부식평가

원순호,조경식 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.1

본 연구에서는 누설자속법을 적용한 저장용 탱크 바닥판재의 부식측정 기술에 관한 연구를 수행하였다. 시험편은 두께 6mm 및 10mm 강판에 20%, 40%, 60%, 80%의 깊이를 갖는 홈을 가공한 대비시험편을 사용하였다. 영구자석을 이용하여 요크를 제작하고 홀센서를 이용하여 시험편에서 누설자속을 측정하였다. 실험결과는 인공홈에서 발생된 누설자속을 효과적으로 검출할 수 있다는 것을 보여주었다. 또한 transverse형 홀센서를 이용하여 시험편에 가공한 홈의 크기를 근사적으로 측정할 수 있다는 결과를 제시하였다. 홈의 위치에 따른 누설자속 진폭을 측정한 결과, 누설자속법으로는 판재 상, 하부의 홈 위치를 구별할 수 없다는 것이 밝혀졌고, lift-off 거리에 따라서 진폭이 현저하게 변하기 때문에 고정된 lift-off 거리를 유지하는 것이 중요하다는 사실을 보여주었다. In this research, MFL technique has been studied for the inspection of storage tank floor. The reference specimens having 20%, 40%, 60% and 80% slot's are fabricated using the carbon steel plates of a 6mm and 10mm thick. Powerful permanent magnets and Hall effect sensors are used to this application. It is shown that our system is able to detect metal loss like a slot. Also, it is possible that slot diameter is measured using transverse type of Hall generator. It is demonstrated that MFL can not differentiate between the response from top side and bottom side slot. Flux leakage response from a bottom side indication is significantly lower in amplitude than that from an equivalent top side slot. It is essential to know this sensor lift-off distance because the MFL signal also changes considerably with the sensor lift-off distance.

제 1형 신경섬유종증 환자에서 발생한 위장관 간질종양 1예

원경준,이준,변유미,조민근,한경택,김원,홍란,임성철,김경종,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Gastrointestinal stromal tumor (GIST) is the most common non-epithelial neoplasm arising in the gastrointestinal tract, but this tumor is rarely seen in association with type l neurofibromatosis (NFl) Generally, the majority of GISTs are isolated neoplasm and they are sporadically found in the stomach, but the GISTs in NFl patients are usually multiple and usually found in the small intestine. We report a case of multiple GISTs in the jejunum of a 63-year-old woman diagnosed as NFl accompanied by complication of gastrointestinal bleeding, In this case, Patient had multiple cafe-au lait spots and neurofibroma on skin and had freckling on axilla and groin, and then, we made a diagnosis of NFl. Gastrointestinal bleeding is controlled by resection of multiple GISTs. Generally, only 3-5% of all gastrointestinal bleeding comes from the small bowel. Causes of small intestinal bleeding are angiodysplasia, neoplasm, NSAIDs induced ulcer etc. but, If patients have NFl accompanied by complication of gastrointestinal bleeding, GISTs on small bowel must be considered.