참치 뼈를 이용한 Hydroxyapatite 세라믹 복합체의 합성 및 생체 친화성(제3보) : 인공체액에서의 Hydroxyapatite 세라믹 복합체간의 결합의 전자현미경 관찰 SEM Photographs of Bonding Properties between Hydroxyapatite Ceramics Composites in the Simulated Body Fluid

김세권,최진삼,이창국,변희국,전유진,이응호,박인용 대전산업대학교 반도체기술연구소 1999 半導體技術硏究所報 Vol.1 No.-

참치 뼈에서 추출한 hydroxyapatite를 출발물질로 여러 가지 세라믹 복합체를 제조하여 인공체액에서의 hydroxyapatite 복합체간의 화학결합을 조사하였다. hydroxyapatite 복합체들은 인공체액에서 4주 후부터 화학 결합성질을 나타내었다. 결합강도는 bioglass가 가장 강하게 나타났으며, 조성에 따른 의존성은 관찰할 수 없었다. 인공체액에서 복합체들은 이들의 경계면에서 불균일 핵생성 및 성장에 의해 화학적 결합으로 이루어졌다. Chemical bonding was investigated in the simulated body fluid of several selected hydroxyapatite-containing composites. The hydroxyapatite-containing composites chemically bonded with each other in the simulated body fluid after 4 weeks. Bioglass was strongly bonded in the simulated body fluid, but bonding strength was not depended on composition. Their composite bodies were chemically bonded by heterogeneous nucleation and growth at the interfaces of the specimens in the simulated body fluid.

노인정신장애 평가척도(Psychogeriatric Assessment Scale)의 한국판 표준화 연구

조맹제,박임순,신영민,김무진,정희연,정은기,최용성,조성진,서국희,함봉진 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

연구목적 : 본 연구는 치매와 우울증을 다차원적으로 평가할 수 있는 도구인 Psychogeriatric Assessment Scale(PAS)의 한국판(PAS-K)을 개발하기 위한 것이다. 방 법 : 번역, 역번역, 그리고 세차례의 예비조사를 통하여 PAS-K를 제작하였다. 60세 이상의 노인 291명(임상환자군 : 58명, 지역사회노인군 : 168명, 수용시설 거주자 : 67명)과 그들의 정보제공자들을 대상으로 PAS-K, Geriatric Depression Scale(GDS), Korean version of Mini-Mental State Examination(MMSE-K), Hamilton Rating Scale for Depression(HRSD), 그리고 Hachinski Ischemic Score 를 적용하고, Diagnostic Interview chedule(DIS-Ⅲ-R)을 사용하여 치매와 우울증을 진단하였다. PAS-K의 신뢰도와 타당도를 평가하고, 예민도와 특이도, Kappa값, 그리고 ROC커브 분석법을 이용하여 PAS-K의 6개의 소척도들(피검자면접 : 인지기능 장애척도, 우울척도, 뇌졸중척도, 정보제공자면접 : 인지기능 저하척도, 행동변화척도, 뇌졸중척도)의 최적 절단점을 구하였다. 결 과 : PAS-K는 높은 내적 일관성을 보였고, 검사자간 신뢰도도 만족할 만한 수준이었다. PAS-K의 소척도들을 다른 표준화된 검사도구들과 비교하였을 때 인지기능 장애척도와 인지기능 저하척도는 MMSE-K와, 우울척도는 GDS 및 HRSD와 유의한 상관관계를 보였으며, 뇌졸중척도는 Hachinski Ischemic Score와 통계적으로 의미있는 상관관계를 보였다. 최적절단점은 인지기능 장애척도 10점, 인지기능 저하척도 3점, 우울척도 5점, 피검자면접과 정보제공자 뇌졸중척도 모두 1점, 그리고 행동변화척도 2점으로 추정하였다. 결 론 : 본 연구를 통해 PAS-K의 신뢰도와 타당도가 검증되었고, 노인정신의학 역학연구나 보건분야에서 치매와 우울증의 임상경과관찰 및 일차 선별도구로서 유용하게 사용될 수 있게 되었다. Objectives : This study was designed to develop the Korean version of the Psychogeriatric Assessment Scale(PAS-K), a multidimensional screening tool for the dementia and depression. Methods : Through three times preliminary trials, the authors translated PAS into Korean. The PAS-K, Geriatric Depression Scale, Hamilton Depression Rating Scale, Hachinski Ischemic Scale and Mini-Mental State Examination-Korean version were administered to 291 subjects over the age of 60 and the same number of their informants(67 subjects were institutionalized, 168 subjects were in community, 58 subjects were psychiatric hospital patients). And the Diagnostic Interview Schedule(DSM-Ⅲ-R) was independently administered to exactly diagnose dementia and depression. The reliability and validity test, optimal cut-off point estimation for six each scale and ROC curve analyses were done to investigate the diagnostic validity of PAS-K. Results : Internal consistency and interrater reliability of the PAS-K were high. Concurrent validity of each scales of PAS-K was good in being measured with other standardized scales. The optimal cut-off points of each scale of the PAS-K were estimated as follows : 1) Stroke Scale of subject interview : 1, 2) Cognitive Impairment Scale of subject interview: 10, 3) Depression Scale of subject interview : 5, 4) Stroke Scale of informant interview : 1, 5) Cognitive Decline Scale of informant interview : 3, and 6) Behavioral Change Scale of informant : 2. conclusions : The PAS-K was valid and reliable screening tools for detecting dementia and depression. Therefore the PAS-K could be widely and extensively used in psychogeriatric epidemiological research or clinical setting of primary screening for dementia and depression.

Reconstruction plates used in the surgery for mandibular discontinuity defect

Guk-Jin Seol,Eun-Gyu Jeon,Jong-Sung Lee,So-Young Choi,Jin-Wook Kim,Tae-Geon Kwon,Jun-Young Paeng 대한구강악안면외과학회 2014 대한구강악안면외과학회지 Vol.40 No.6

Objectives: The purpose of this study was to analyze the survival rate of reconstruction plates that were used to correct mandibular discontinuity defects. Materials and Methods: We analyzed clinical and radiological data of 36 patients. Only discontinuous mandibular defect cases were included in the study. Reconstruction plate survival rate was analyzed according to age, gender, location of defect, defect size, and whether the patient underwent a bone graft procedure, coronoidectomy, and/or postoperative radiation therapy (RT). Results: Plate-related complications developed in 8 patients, 7 of which underwent plate removal. No significant differences were found in plate sur- vival rate according to age, gender, location of defect, defect size, or whether a bone graft procedure was performed. However, there were differences in the plate survival rate that depended on whether the patient underwent coronoidectomy or postoperative RT. In the early stages (9.25±5.10 months), plate fracture was the most common complication, but in the later stages (35.75±17.00 months), screw loosening was the most common complication. Conclusion: It is important to establish the time-related risk of complications such as plate fracture or screw loosening. Coronoidectomy should be considered in most cases to prevent complications. Postoperative RT can affect the survival rate and hazard rate after a reconstruction plate is fitted.

Balloon-Occluded Retrograde Transvenous Obliteration for Gastric Variceal Bleeding : Its Feasibility Compared with Transjugular Intrahepatic Portosystemic Shunt

Choi, Young Ho,Yoon, Chang Jin,Park, Jae Hyung,Chung, Jin Wook,Kwon, Jong Won,Choi, Guk Myung Korean Radiological Society 2003 Korean Journal of Radiology Vol.4 No.2

Characterization of fatty acid biosynthetic gene cluster from Shewanella hanedai KMG427

Hye-Jin Choi,Soo-young Park,Jin-Hyung Lee,Soon-Ok Rim,Kwon-Ho Song,Jong-Guk Kim 한국생명과학회 2006 한국생명과학회 심포지움 Vol.46 No.-

Spin-orbit torque induced auto-oscillation in NiFe/heavy metal bilayers

Jong-Guk Choi,Jaehyeon Park,Kab-Jin Kim,Byong-Guk Park 한국자기학회 2019 한국자기학회 학술연구발표회 논문개요집 Vol.29 No.2

Comparative occurrence of ischemic stroke with the rhythm versus rate control strategy in a national prospective cohort of atrial fibrillation

( Jae Guk Kim ),( Young Soo Lee ),( Ki-woon Kang ),( Eue-keun Choi ),( Myung-jin Cha ),( Jung-myung Lee ),( Jin-bae Kim ),( Junbeom Park ),( Jin-kyu Park ),( Tae-hoon Kim ),( Jae-sun Uhm ),( Jaemin Sh 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1

Background/Aims: Comparative occurrence of ischemic stroke for rhythm versus rate control strategy in patients with non-valvular atrial fibrillation (NVAF) is still inconclusive. The purpose of this study was to investigate whether the rhythm control strategy is associated with a lower risk of ischemic stroke compared to the rate control strategy in NVAF patients. Methods: The CODE-AF registry prospectively enrolled 6,280 consecutive patients who were treated for NVAF at 10 tertiary referral centers in South Korea. Of these, 2,513 NVAF patients (age, 67 ± 10 years; male, 61.8%) were clinically followed up for over 1-year and divided into rate and rhythm control groups. Results: Those treated with the rhythm control strategy were younger and had less proportions of underlying disease compared to those treated with the rate control strategy. After the propensity matching analysis, those treated with the rhythm control strategy had similar baseline characteristics including the CHA₂DS₂-VASC score compared to those treated with the rate control strategy. The rate of oral anticoagulation, all bleeding, and hospitalization were also similarly between the two groups. The incidence rate of ischemic stroke in the rhythm control group was significantly lower than in the rate control group (0.7 vs. 6.9 per 1,000 person-years, p = 0.011). Conclusions: The rhythm control strategy demonstrated a beneficial effect to lower the risk of ischemic stroke during a 1-year follow-up compared to the rate control strategy.

High expression level of SOX2 is significantly associated with shorter survival in patients with thymic epithelial tumors

Lee, Guk Jin,Lee, Heejung,Woo, In Sook,Kim, Taejung,An, Ho Jung,Choi, Hyun Joo,Lee, Youn Soo,Lee, Kyo Young,Lee, Jieun,Kang, Jin-Hyoung Elsevier 2019 Lung cancer Vol.132 No.-

<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Thymic epithelial tumors (TET) are heterogenous tumors which are composed of thymoma (TM) and thymic carcinoma (TC). We attempted to determine differences in gene expression between TM and TC, and to determine the effect of such genes on the prognosis of patients with TET.</P> <P><B>Materials and methods</B></P> <P>Gene expression profiles of SOX2, OCT-4, IGF-1, IGF-1R and IR mRNA transcripts in tumor tissues of TM and TC were determined using real-time PCR (RT-PCR). We constructed tissue microarray with 140 paraffin-embedded tumor tissues and performed immunohistochemistry (IHC) for IGF-1R-related signaling molecules, including SOX2, IGF-1, IGF-1R and pAKT.</P> <P><B>Results</B></P> <P>SOX2 mRNA expression was notably higher (216-fold) in TCs than in TMs. However, there was no significant difference in expression of IGF-1, IGF-1R, OCT-4 or IR between the two tumor types. In IHC results, SOX2 (HR: 7.57, P = 0.001) and IGF-1 (HR: 9.43, P = 0.001) expression levels in TC were significantly higher than those in TM. There was a significant correlation in expression of SOX2 with IGF-1 (P = 0.021) and pAKT (P = 0.026). In univariate analysis, clinical TNM stage, WHO classification, serum LDH, expression of SOX2, IGF-1R, IGF-1 and pAKT, were significantly correlated with overall survival (OS). Multivariate analysis using a forward-selection procedure revealed that clinical N stage (HR: 4.08, P < 0.001), M stage (HR: 3.37, P = 0.001) and SOX2 expression (HR: 4.53, P = 0.010) were significantly associated with OS.</P> <P><B>Conclusions</B></P> <P>SOX2 is expressed significantly higher in TC than in TM. SOX2 expression is also closely related to IGF-1 and pAKT expression. The higher expression of SOX2 is significantly associated with shorter survival in patients with TET.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thymic epithelial tumors (TET) are divided into two broad categories, thymoma (TM) and thymic carcinoma (TC). </LI> <LI> Molecular biology of TETs are poorly understood. </LI> <LI> We suggest that SOX2 might be potential biomarker to predict biologic aggressiveness and poor prognosis in TETs. </LI> </UL> </P>

Spin Hall nano-oscillators for neuromorphic computing

Jong-Guk Choi,Jaehyeon Park,Min-Gu Kang,Doyoon Kim,Jae-Sung Rieh,Kyung-Jin Lee,Kab-Jin Kim,Byong-Guk Park 한국자기학회 2022 한국자기학회 학술연구발표회 논문개요집 Vol.32 No.2

국내 광역관광안내지도 그래픽심벌 디자인 사례 연구

최진국(Jin Guk Choi),송지성(Ji Sung Song) 한국디자인리서치학회 2023 한국디자인리서치 Vol.8 No.3

본 연구는 국가표준 KS S ISO 7001로 지정된 그래픽심벌 사용에 대한 광역관광안내지도 그래픽심벌 디자인 연구를 수행하였다. 문화체육관광부에서 발행한 관광안내지도 제작 가이드는 산업통상자원부 국가기술표준원의 공공안내 그림표지(KS)에 따른 표기를 원칙으로 제시하고 있다. 2023년에 발행된 17개 지역 광역관광안내지도를 취합하여 14개 관광안내지도지에서 사용된 그래픽심벌을 추출하여 분석 결과, 광역관광안내지도에 사용된 그래픽심벌은 표준형, 이전표준형, 유사형, 관습형의 4가지 종류로 분류되었다. 14개 지역 중 강원도관광안내지도는 표준화 그래픽심벌이 적용되었으며, 인천, 광주, 울산 3개 지역은 관습형, 그 외 지역은 4가지 종류의 혼합적용으로 그래픽심벌이 사용됨을 확인하였다. 광역지방자치단체와 디자이너는 공공 안내 그림표지(KS)적용을 준수하여 내·외국인 관광객에게 통일성과 일관적인 메세지를 전달해야한다. 본 연구는 공공 안내 그림표지(KS) 표기원칙에 따른 관광안내지도의 그래픽심벌 사용현황을 제시하며, 관광안내지도 디자인을 진행하는 디자이너를 위한 기초자료로 활용되길 기대한다. This study conducted a graphic symbol design study on the use of graphic symbols designated as the national standard KS S ISO 7001. The tourist information map production guide issued by the Ministry of Culture, Sports and Tourism suggests the notation according to the public guide picture cover (KS) of the National Agency for Technology and Standards of the Ministry of Trade, Industry and Energy as a rule. As a result of the analysis, graphic symbols used in 14 tourist guide maps were extracted by collecting 17 regional tourist guide maps issued in 2023. It was classified into four types of customary types. Among the 14 regions, it was confirmed that the Gangwon-do tourist information map applied standardized graphic symbols, Incheon, Gwangju, and Ulsan 3 regions used custom-type symbols, and other regions used 4 types of mixed-applied graphic symbols. Metropolitan municipalities and designers must comply with the application of the public guide picture sign (KS) to deliver uniformity and consistent messages to domestic and foreign tourists. This study presents the current status of using graphic symbols on tourist guide maps according to the KS marking principle, and expects them to be used as basic data for designers who design tour guide maps.