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신영민,신흥수,박한수 한국고분자학회 2011 Macromolecular Research Vol.19 No.8
A variety of surface modification techniques have been proposed to improve the cell-biomaterial interactions. On the other hand, these processes may cleave long-chained polymers, and compromise their mechanical properties. In this study, dopamine was used as a bridge molecule to immobilize gelatin on the poly(L-lactide-co-ε-caprolactone) (PLCL) fibrous matrices, which may then be used as a cell delivery carrier. The PLCL fibrous matrices coated with polydopamine by dipping (D-PLCL) can subsequently immobilize gelatin (GD-PLCL). The D-PLCL matrices showed minimal changes in the mechanical properties with a tensile strain of 251.0±33.4% and 247.8±32.1% before and after the coating process, respectively. The cellular activities on the fibrous matrices increased in the order of PLCL<G-PLCL<D-PLCL<GD-PLCL; the H9c2 myoblasts on the GD-PLCL matrices showed approximately two-times higher adhesion and spreading than those on the PLCL matrices, and the proliferation was significantly greater on the GD-PLCL matrices than on the other matrices. Therefore, polydopamine can effectively immobilize the bioactive functional groups on the surface of electrospun fibrous matrices for the development of a tissue specific cell delivery carrier.
젊은 성인 남자에서 기관지 내 Epinephrine 도포 후 발생한 심실 세동 -증례 보고-
신영민,김종형,김형욱,최보식,정진규,황정원,서광원,안종준,나승원 대한중환자의학회 2011 Acute and Critical Care Vol.26 No.4
Ventricular fibrillation and cardiac arrest rarely occur after local application of epinephrine. Local and superficial application of epinephrine is a common hemostatic method during bronchoscopy, especially after biopsies. Although high plasma levels following endobronchial application of epinephrine have been observed in previous animal studies, there is no report of ventricular fibrillation after a usual dose of endobronchial application of epinephrine during bronchoscopy. We present a case of endobronchial epinephrine-induced ventricular fibrillation and cardiac arrest in a 31-year-old man with no previous history of cardiac disease.
신영민,이승기,장수환,박재형 한국물리학회 2014 Current Applied Physics Vol.14 No.5
In this study, wetting properties of a hierarchical structure using a silicon micro-tip array covered with ZnO nanowire are characterized, and compared with hierarchical structures composed of micro-pillars for micro-scale roughness. The superhydrophobicity of a surface can be efficiently enhanced by using a micro-tip array, compared with a micro-pillar structure, because a micro-tip structure with high aspect ratio and small apex radius can significantly reduce fractions of liquid droplet area in contact, maintaining the droplet in the regime of the Cassie state. The micro-tip array was simply fabricated by combining anisotropic and isotropic silicon etching processes with one-step photolithography and a single etch mask. The measured height and aspect ratio of the fabricated micro-tip was around 40 mm and 8, respectively, when the center-to-center distance between micro-tips was 30 mm. The maximum CA on the hierarchical surface using the micro-tip array was measured to be 165.0 2.3 with a period of 30 mm, while the hierarchical surface using the micro-pillar array showed the maximum CA of 158.6 1.1 with 20 mm-diameter and 70 mm-gap between micro-pillars. The smallest CAH on the hierarchical micro-tip array was measured to be 5.0 0.3 for the center-to-center distance between micro-tips of 30 mm.
폐암 말기 환자에서 발생한 Phialemonium dimorphosporum과 Myrothecium Species에 의한 심재성 피부 진균증 1예
신영민,박소현,신동훈,최종수,김기홍,배영경 대한의진균학회 2005 대한의진균학회지 Vol.10 No.4
Phialemonium and Myrothecium species are rare agents of human deep mycosis infection and those have been increasingly documented as emerging agents of opportunistic infection in immunocompromised patients. We discribed a 69-year-old Korean male, previously diagnosed as lung cancer, presented with 2×2 cm sized normal skin to erythematous nodules on the both lower legs for 10 years. Biopsy specimen showed brownish septated hyphae in the dermis and subcutaneous tissue from the left lower leg and colorless spores from the right leg (H&E). Each identifications were confirmed by polymerase chain reaction of ITS2 using universal fungal primers as Phialemonium dimorphosporum on the left lower leg and Myrothecium species on the right lower leg. The patient was treated with surgical excision and fluconazole.