정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

크롬(Ⅵ)의 체내 흡수와 소실속도에 관한 연구

김현영,이성배,임철홍,이권섭,정용현,이종성,한정희,전윤석,황호순,이용묵 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

The CrO3 mostly used in plating. metal surface disposal, leather, cosmetic manufacturing, as an experiment material by repeatedly inhaling and exposure the male S.D. rats at a 0.00, 0.2., 0.50, 1.25 mg/㎡ concentration(particle size: 0.5-0.5 aerosol)6hours a day, 5day a week in 13weeks comparing with 2weeks, 8weeks of recovery group about the noxiousness of the experiment animal and the reduce scale of the CrO3 in the internal organ especially in blook and respiratory organ with the period of convalescent and clearance. The experiment results which we received are as follows. 1. In blood the RBC, HGB and HCT experiment, rats with 0.20, 0.50 mg/㎡ concentration showed that there were some decreases but not dependent. The kidneys absolute weight compared with control group was reduced intentionally(p〈0.05) and the lungs absolute weight compared with control group showed intentional increase(p〉0.05). 2. After the exposure of the experiment material, the whole blook, l\blood plasma and red blood cell in blood by (x): the period of convalescent, per (y); the decreasing of Cr concentration, was y=66.51 e -0.057x, y=67.2 e-0.101x, y=70.01 e-0.030 in 0.50 mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life (day)was estimated 12.0, 6086, 23.0 each. 3, After the exposure of the experiment material, the experiment animals lung, liver and kidneys by(x); the period of convalescent, per (y); the decreasing of Cr conentration, was y=1808 e-0.00493x, y=12.02e-0.0297x, y=67.61 e-0.0292x in 0.50mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life(day)was estimated 140.6, 23.3, 23.7, each, and including lung, liver with all of the experiment internal organs, the Cr clearance decreased as the exposure concentration increased.

SD Rats를 이용 1-hexene의 흡입독성 연구

김현영,임철홍,정용현,이권섭,이성배,이준연,한정희,전윤석,이용묵 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.4

The purpose of this study was to investigate the acute (4 hours) and repeated-dose (6 hours a day, 5 days a week, 4 weeks) toxic effects of I -hexene on Sprague- Dawley (SD) rats which were treated by inhalation. The results were as follows; I. The median lethal concentration (LC_(50)) was estimated 52,694 ppm (confidence limit 95%; 49,494~55,447 ppm) in acute inhalation. Abnormal clinical signs related to the l-Hexene were not observed with the acute inhalation dose. Gross findings of necropsy revealed on evidence of specific toxicity related to the 1-hexene, II. By repeated inhalation exposure the body weight of male were more or less reduced by the dose of 2,500 ppm and 5,000 ppm compared with control group. However there were no significant variation hematology and blood biochemistry for the exposed rats compared with the control rats. Abnormal clinical signs and gross findings of necropsy related to the 1-hexene were not shown. In conclusion when we exposed I-hexene to SD rats for 4 weeks, 5 days per week, 6 hours per day, the Lowest observed effect level (LOEL) was over 2,500 ppm and Non observed effect level (NOEL) was below 500 ppm.

社會主義諸國의 經濟改革에 관한 硏究

李洪閏 효성여자대학교 산업경영연구소 1987 경영경제 Vol.4 No.-

The objective of this study is to survey the background of economic reforms in the sociolist countries and how to improve the method of planning. The Soviet union adopted the method of planning in resource allocation in 1930s. After the second World War, the countries of Eastern Europe and the communist China adopted, with few variations, the method of planning, Stalin's Model(the old centralized model). Under this system, prices have primarily an accounting functions, and firms are to follow detailed directives received from the central authorities. This centralization management system had a certain usefulness in the early post-war years when a limited number of economic objectives were pursued, because it permitted rapid shifts in sources which might have been more difficult to achieve by the use of the price mechanism. Howover, in the more developed of the socialist countries the disadvantages of the system soon assumed importance. With the multiplicity of objectives and the growing complexity of manufacturing industry, the task of centrally became increasingly difficult. After critique against Stalin, the economic reforms in the socialist countries have been continued. Communist China carreid out some more economic reforms in the latter half of 1970s. Its system was copied from the yugoslvia's type. Even North Korea which was closed shows signs of economic reform. For example, the law for introduction of foreign capital was established. This made foreign policy open, and then the method economic management could have to be reformed. No signs mean economic reform in North Korea. But to increace the efficiency of resource allocations, the method of planning is to be reformed. Because of political reason or idelogy, I think the economic reforms in the socialist countries will not produce rapid transformation.

편성조직과 게이지에 따른 면 위편성물의 구조적 특성변화

홍수숙;고순영;이연희;박명자 한양대학교 2005 韓國 生活 科學 硏究 Vol.25 No.2

The scoured and undyed 100% cotton yarn (2/30's) were weft-knitted from 13 different stitches with 7 and 12 machine gauge using a V-bed knitting machine. Structure of knit fabrics was characterized and analyzed: fabric length and width, fabric count, fabric weight per area, and fabric thickness were measured. The thickness of the full cardigan 2✕2 and 4✕4 rib presented the highest values due to usage of tuck stitch. The fabric width of 4✕4, 1✕1, and 2✕2 rib stitches were the narrowest group resulted in relaxation shrinkage after knitting. Also 4✕4rib stitch gave the highest value in fabric density and weight. Fabric stitch and structure were well co-related each other, which give the changes of fabric appearance and properties.

신경성 염증질환에서 지질 신호전달물질인 lactosylceramide의 역할

이윤선, 유재명, 최경미, 이용문, 홍진태, 윤여표, 유환수 충북대학교 약품자원개발연구소 2007 약학논문집 Vol.22 No.-

-본문참고-

漢陽 原形景觀의 二元的 重層性 考察

홍윤순,이규목 서울시립대학교 부설 서울학연구소 2002 서울학연구 Vol.- No.19

This study attempts to interpret the immanent dualism of the archetype landscape of Hanyang based on Yin-Yang's dualistic structure. The north eastern Asian dualism being different from western analytical dualism, it shows the following relational attitudes. First, others are recognized as essentially pre-requisite for its own existence not as antagonistic. Second, Yin-yang represents the complementarity. Third, Yin-yang is not independent but inter-related elements. Forth, Yin-yang shows not static but dynamic characteristics. Fifth, the concept of Yin-yang is considered as both extreme points of Taegeuk that has holistic characteristics. In this study, the compound dualistic relationships of the archetype landscape of Hanyang are analyzed according to the aspects of physical environment, activity, and meaning. The contents are as follows; mountain and city boundary represent the dualistic relationships of nature and city. In detail, dualism of settlement for living such as outside the fortress and inside the fortress is also found. The dualism showed through land use and arrangement of main facilities is that Jongmyo and Sajik were arranged along the dualistic characteristics since the establishment of Chosun Dynasty and type of settlement was divided into Northern-village and Southern-village. In addition, the meaning of north-south and east-west roads was dualized and main road and sub-road showed the complementary characteristics in the linear surroundings. In the aspects of facilities, dualistic relationships between palace, fortress and gate, Sadaebu house, Hangrang, and general buildings showed dualism of meaning, size, settlement and types. These dualistic characteristics projected from the aspects of physical environment, meaning and activity reflect the detailed characteristics of Yin-yang. It was found that the concept of Yin-yang is compound from architectural environment to urban unit scale. It is implied that the cities in Korea were formed on the basis of inter-relationships and ultimately represented the unification and reconciliation.

한국전통생활문화에 관한 고찰

이숙,홍윤호,신윤숙,신효식,한경미,최정미,김은정 全南大學校家政科學硏究所 2002 生活科學硏究 Vol.12 No.-

This study is objected on preliminary research for more scientific and wider studies on the Traditional Living Culture of Korea. For this purpose, studies about clothing, food, home management, Traditional Living Culture were reviewed and analysed. The results were as follows : First, Clothing culture studies concentrated on ritual clothings, Second, Food Culture studies included history of traditional food development and recipes. Third, in the field of home management value system, attitudes and parent-child relations were studied,

유고의 自主管理型 經濟體制

李洪閏 효성여자대학교 산업경영연구소 1990 경영경제 Vol.7 No.-

The objective of the study is to examine whether the self-managed economic system realize economic democracy or not. From the first beginning, the yugoslavia adopted the centrally planned economy of the Soviet type. But the yugo has introduced the new economic system. It was colled the self-managed economic system. This system has the following key features. First, Instead of state ownership and collective ownership, there are social ownership of the means of production. Social ownership as on economic category is not vested in any holder. Second, Instead of the distribution by wages types, the distribution by income pattern came into effect. Third, as a corollary of decentralized decision making there has to be a greater reliance on market as a guide to the allocation of resources. This means the reduction of centrallized planning and control. The plan for the economy as a whole is "only aimed at channelling and coordinating the trends of general development. Finally the yugoslavia expected attainment of economic democracy by implementing the transition to the new economic system with more independence for enterprises, broader rights or self-management and clear market elements. But the complete withering away of the state, the exploitaion of state by state, and inequitable distribution of income still persist in spite of improving the shortcomings of the centrally planned economy. The evolution of the new system designed to incorporate these basic principles has been characterized, first, by a pragamtic experimental and relatively mondogmatic approach. Second, at no stage during the development of the system the process of reform has been brought to a halt. Finally the above process had occurred in an envrionment of relatively free and open discussion at all levels and has been market by a deep involvement of all element in yugoslav society.

요추부 수술후 통증관리를 위하여 실시한 Morphine Sulfate를 이용한 Caudal Block의 효과

윤승환,박형천,김은영,전병윤,이홍식,이성근 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.6