소아 구내염의 한약치료에 대한 임상연구 동향: 중의학 무작위대조군 임상시험을 중심으로

허유진,이신희,조연수,Heo, Yu Jin,Lee, Shin Hee,Cho, Yun Soo 대한한방소아과학회 2021 대한한방소아과학회지 Vol.35 No.4

Objectives This study aims to find out the recent trend of the herbal medicine treatment in children's stomatitis in China, and propose better methods to treat children's stomatitis in Korea. Methods The randomized controlled trials (RCT) relevant to 'Herbal medicine treatment on children's stomatitis' were searched using China Academic Journal (CAJ). The search method we used included search formula, (SU = '口內炎' + '口腔炎' + 'stomatitis') and (SU = '儿童' + '小儿' + 'children' + 'child') from 2000 to September 2021. Results A total of 9 RCTs were selected and analyzed. All reports showed that oral administration of herbal medicine were effective and improved clinical symptoms. The most-used herbal medicine category was Heat-clearing medicine (淸熱藥). Conclusions The literatures from China have shown that herbal medicine improves children's stomatitis. These outcomes may be helpful for the treatment of children's stomatitis in Korea. However, further studies are needed to develop treatment guidelines for children's stomatitis.

재발성 아프타성 구내염 환자에 대한 가미육미지황탕의 효능

김주연,김진성,손지희,선종기,강경,장승원,손지영,류봉하,Kim, Ju-Yeon,Kim, Jin-Sung,Son, Ji-Hee,Seon, Jong-Ki,Kang, Kyung,Jang, Seung-Won,Son, Ji-Young,Ryu, Bong-Ha 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.2

Objectives : This study was designed to investigate the Efficacy of Gamiyukmijihwang-tang on Recurrent Aphthous Stomatitis. Methods : We surveyed 10 recurrent aphthous stomatitis patients visited the oral diseases clinic in the Kyung Hee University Oriental Medicine Hospital from September, 2011 to March, 2012. Before and 2 weeks after taking Gamiyukmijihwang-tang, the subjects were evaluated on clinical characteristics of recurrent aphthous stomatitis, severity of pain using visual analogue scale (VAS), quality of life about oral health (based on the 14-item Oral Health Impact Profile-14) and yin-deficiency condition (based on the 10-item Yin-deficiency Questionnaire). Then, 5 patients who had already finished treatment were assessed about recurrence of recurrent aphthous stomatitis by telephone survey 6 weeks later. Results : After 2 weeks taking Gamiyukmijihwang-tang, clinical characteristics of 10 patients of recurrent aphthous stomatitis improved; their severity of pain, quality of life about oral health and yin-deficiency condition improved significantly. After 6 weeks, 3 of 5 patients who had already finished treatment didn't experience recurrence of recurrent aphthous stomatitis. The other 2 patients experienced a recurrence, but their clinical characteristics of recurrent aphthous stomatitis improved significantly. Conclusions : Gamiyukmijihwang-tang is effective on recurrent aphthous stomatitis. Studies with a larger number of cases and longer follow-up will be needed in the future.

구내염의 한방 치료에 대한 문헌 고찰

임유라,정호준 대한한방안이비인후피부과학회 2023 한방안이비인후피부과학회지 Vol.36 No.1

Objectives : The purpose of this study is to investigate the treatments of Stomatitis in Korean medicine. Methods : We reviewed domestic journals through databases on RISS, KISS, OASIS, KISTI to search case reports and follow-up studies about ‘Stomatitis’ and ‘口瘡’ using the terms with ‘Korean medicine’ or ‘Korean medicine treatment’. Also, we used CNKI to find Randomized controlled trials(RCTs) from Chinese journals by using the term ‘口腔炎’. Results : A total of 16 articles were searched. Those of 7 are case report, 2 are follow-up study, 7 are RCTs. The way to treat stomatitis were through using herb medicine, acupuncture, electro-acupuncture, herbal acupuncture, external preparation, indirect moxibustion and so on. All papers reported that after Korean medicine treatment, symptoms of stomatitis are relieved. Conclusions : According to these journals, Korean medicine is helpful to treat Stomatitis. In the future, more clinical studies are needed to establish the foundation of Korean medicine to treat stomatitis.

재발성 아프타성 구내염에 대한 국소 스테로이드 요법의 효과

최종욱,정광윤,박정수,김영호,유홍균 대한기관식도과학회 1996 大韓氣管食道科學會誌 Vol.2 No.2

Recurrent aphthous stomatitis is one of the most common diseases of ulcerative oral mucosal lesions and its cause remains elusive. The purpose of this study is to evaluate the therapeutic effect of topical steroids for the treatment of recurrent aphthous stomatitis. We performed the study with 50 cases who had visited to our office for the treatment of recurrent aphthous stomatitis during the recent five years. We devided 50 cases into five groups. Group 1 is that triamcinolone of 0.1-0.2mg was injected into the submucosal lesions of ulcerations. Group 2 is that the gargling of 5ml with triamcinolone tablet of 2mg was used three times per day for seven days. Group 3 is that the gargling of 5ml with betamethasone tablet 0.5mg was used three times per day for seven days. Group 4 is that tetracycline gargling was used six times per day for seven days. Group 5 is that normal saline gargling was used six times per day for seven days. The retrospective analysis of results were as follows : Betamethasone gargling was effective in the treatment of minor aphthous stomatitis and the submucosal injection of triamcinolone was effective in the treatment of major aphthous stomatitis, but none of the different therapeutic methods was effective for herpetiform stomatitis. In the evaluation of mean recurrence periods, the triamcinolone gargling and betamethasone gargling showed longer asymptomatic periods than other methods. We concluded that some kinds of topical steroids can be used for the treatment of recurrent aphthous stomatitis but the proper selection of agents according to the type of the disease is important for the treatment.

급성백혈병 환자를 대상으로 구강함수제별 구내염 및 구강안위감에 대한 무작위대조시험연구

송지은(Song Chi Eun),소향숙(So Hyang Sook),주덕(Ju Deok),김은정(Kim Eun Jeong) 대한종양간호학회 2011 Asian Oncology Nursing Vol.11 No.1

Purpose: This study compared the effect of two oral care agents on preventing stomatitis and discomfort for acute leukemic patients. Methods: A total of forty patients was enrolled and randomly assigned to sodium bicarbonate or chlorhexidine group. WHO oral toxicity scale was used for measuring stomatitis and Beck’s subjective oral discomfort scale for evaluating oral comfort. Data was collected from August 2009 to February 2010. The data was analyzed using Chi-square test, Fisher’s exact test, and Mann-Whitney test. Results: Data analyzed was thirty five one. The incidence of stomatitis was 47.4%, 68.8% in sodium bicarbonate and chlohexidine group respectively. The onset of stomatitis was about the 10th and 9th day after chemotherapy initiation, and the duration was 8.0 and 8.67 day respectively. The severity of stomatitis was highest on the 21st day after chemotherapy initiation. There were no statistical differences in the status of stomatitis and the levels of oral comfort during treatment periods. Conclusion: Nurses should routinely assess oral cavity and encourage patients to do oral care actively from second to third week after chemotherapy initiation. Also sodium bicarbonate agent can be recommended to for preventing stomatitis.

항암화학요법 후 발생한 구내염에 대한 침 치료 치험 1례

조나경,이유리,최홍식,김경순,김승모,Cho, Na-kyung,Lee, Yu-Ri,Choi, Hong-sic,Kim, Kyung-soon,Kim, Seung-Mo 대한암한의학회 2017 大韓癌韓醫學會誌 Vol.22 No.2

Objectives: This case report presents improvement after receiving acupuncture treatment for a chemotherapy-induced stomatitis. Methods: The patient was treated for 6 times with acupuncture. And effects of treatments were measured with the World Health Organization (WHO) oral toxicity scale and Visual Analogue Scale (VAS). Results: The clinical symptoms of the stomatitis were improved that WHO oral toxicity scale decreased from grade 4 to grade 0 and Visual Analogue Scale decreased from 7 to 2 after treated with acupuncture. Conclusions: In this study, acupuncture might be effective way to cure the cancer patient suffering from chemotherapy-induced stomatitis.

아프타성 구내 염환자의 한방치료 증례보고

조현희 ( Hyun Hee Cho ),김연수 ( Yeon Soo Kim ),지선영,황보민 ( Min Hwangbo ) 대구한의대학교제한동의학술원 2022 東西醫學 Vol.47 No.1

Objectives : This study was carried out to investigate the effect of Korean traditional medicine on Aphthous stomatitis. Methods : We treated 1 aphthous stomatitis patient with oral pain. We used the Visual Analogue Scale(VAS), and recorded the condition of patient with Oral Health Impact Profile-14(OHIP-14) scale. Results : After the treatments, patient VAS and OHIP-14 score of oral pain were remarkably decreased and aphthous stomatitis had disappeared. Conclusions : This study suggests that Korean traditional medicine is effective on aphthous stomatitis with oral pain.

항암화학요법 유발 구내염에 대한 황련해독탕 함수의 효능

김해심,최정은,유화승,Kim, Hae-Sim,Choi, Jung-Eun,Yoo, Hwa-Seung 대한암한의학회 2011 大韓癌韓醫學會誌 Vol.16 No.1

Background and Objectives : This study is an observational study of nonequivalent control group based on time lag design in order to determine the effectiveness of gargling Hwangryunhaedok-tang (HRHDT) on stomatitis caused by chemotherapy. Methods : The study period is from July 1st, 2010 to September 30th, 2010. The subjects are 13 patients who fit the profile of the study and who are admitted in the tumor department of the regional cancer center of C University Hospital which is located in Chung-Joo City. When stomatitis occurs after chemotherapy, the level of stomatitis is assessed using oral assessment guide score and oral discomfort score. Then mix 5 g of powered HRHDT and 60 ml of distilled water, and 15 ml of the solution is given to patients 4 times per day to gargle for 1 minute. For the control group, 60 ml of Chlorohexidin gargling solution is used; everyday for one week, 4 times per day, 15 ml per gargle and gargled for 1 minute. Oral Assessment Guide score and Oral Discomfort Score are assessed at same hour everyday. Crosstabulation analysis $X^2$(${\rho}$) was used to examine the demographic characteristics and difference of the two groups by using SPSS/WIN 12.0. For mean and standard deviation, descriptive statistical analysis was used. T-test was used to determine the difference of the oral discomfort scores. Result : The study has shown that the Oral Assessment Guide score of the experimental group has decreased more with more regularity. On the third day, the score of the control group is 20.16 and the score of the experimental group was 18.75, which showed a statistically significant difference with the level of significance of p<0.05. Oral Discomfort Score of the control group's score was 13.60 on the first day and 6.80 on the seventh day and the experimental group's score was 13.00 on the first day and 2.25 on the seventh day. The experimental group's score 2.25 is statistically significantly lower than the control group's score of 6.80 with the level of significance of p<0.05. Conclusions : The HRHDT gargling solution showed more regular effectiveness compared to Chlorohexidin solution on chemotherapy-caused stomatitis. Therefore this study has shown that HRHDT gargling solution can be used as an alternative medicine.

베체트병과 재발성 아프타 구내염에서의 Pathergy 검사

이수근 ( Soo Keun Lee ),손숙자 ( Sook Ja Son ),김용재 ( Yong Jae Kim ),유희준 ( Hee Joon Yu ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4

Background : Pathergy, or skin hypersensitivity to needle puncture has been reported as a diagnostic test for Behcets ciisease. But the positivity of pathergy test in recurrent aphthous stomatitis which can be a comporent of Behcets disease is obscure. In recent years it has been noted that the positivity of the test has decreased. It is possible to say that the disposable needles used nowadays are less trauniatic to initiate the reaction than are the nondisposable ones used in the preAIDS ara by some uthors. Objective : It is the porpose of this study to clarify the value of pathergy test in differentiating Behcets disease from recurrent aphthous stomatitis and to evaluate the difference of positivity using various kinds of needles, and finally to suggest the most profitable one. Methods : 34 patients with Behcets disease according to the diagnostic criteria of Shimizu(revisecl) 25 ones in case of applying that of International study group for Behcets disease(ISG) and 21 ones with recurrent aphthous stomatitis, and 25 normal controls were selected. A pathergy test, i.e., intradermal injection of 0.1 ml physiological saline by using 26 gauge k 20 gauge disposable needles and l.6 gauge R 20 gauge nondisposable ones were given and the evaluation was made after 24 hours and 48 hours. Results : 1. The positive rates of pathergy test using all kinds of needles in Behcets disease were significantly higher than thoen recurrent aphthous stomatitis and normal controls(p=0.00000-0.03600). The sensitivity were 29.4% 64.7% (Shimizu) and 32.0% 76.0% (ISG), respectively, and the specificity were 91.3%-100.0% for all of them. 2. In Behcets disease, the positive rates of the pathergy test using 26 gauge disposable needles were not significantly different from that of using ZO gauge disposable needles in total and active patients after 24 and 4.3 hours and so were 26 gauge R 20 gauge nondisposable ones(p=0.40134 -0.80603(Shimizu), 0.37551-0.77078(ISG) ). 3. In Behcets disease, the positive rates of pathergy test using 26 gauge nondisposable needles were 59%-68%(Shimiu) and 64% 79% (ISG), which were significantly different, from the test using 20 gauge disposable needles, i.e. 29%-36%(Shimizu), 40%-46%(ISG) in total and active patients(p==0.00753-0.01512) after 24 and 48 hours except for those by the criteria of ISG after 24 hours(p=0.14573-0.15597). Conclusion : This study shows that the pathergy test is obviously useful in differentiating Behcets disease from ecurrent aphthous stomatitis and we recommend the intradermal injection of 0.1 ml physiological saline by using 26 gauge nondisposable needle and the evaluation after 48 hours as a standard mithod of pathergy test. (Kor J Dermatol 1995;33(4): 625-632)

항암화학요법을 받는 암환자의 구내염 관련 간호중재연구 고찰

배진현 한국디지털정책학회 2018 디지털융복합연구 Vol.16 No.1

The purpose of this study was to review the current domestic research trends for published Nursing Intervention Studies on Cancer Patients Receiving Chemotherapy with Stomatitis. As a result of searching for 'chemo chemotherapy', 'stomatitis' and 'oral cavity' Of 23 studies. 13(56.6%) studies used a most commonly study design were nonequivalent control group non-synchronized design. But randomized control group pre-post design was only 2(8.7%). The most commonly used tool for measuring stomatitis was Oral Assessment Guide, which was used in 11(47.9%) studies. 19(82.6%) studies used a single intervention such as gargling. 13(56.5%) studies had positive effects on stomatitis. Based on the results of this study, that can provide basic data for developmental direction of stomatitis related nursing research in cancer patients and this research can be applied to research in the same field. 본 연구는 국내 항암화학요법을 받는 암환자의 구내염과 관련된 간호중재연구를 바탕으로 연구동향을 살펴보고자 실시되었다. 2017년 10월까지 국내에서 발표된 논문을 대상으로 ‘항암화학요법’, ‘구내염’, ‘구강’을 주요어로 검색하고 선정기준과 제외기준을 근거로 검토하여 최종 23편의 논문이 분석에 포함되었다. 연구 분석 결과 1995년에 처음 구내염 중재연구가 시작되었고 연구설계의 분석 결과 비동등성 대조군 전후 설계 13편(56.5%), 순수실험설계인 무작위 대조군 전후 설계는 2편(13.1%)뿐이었다. 구내염 사정도구는 구강사정지침(OAG)이 11편(47.9%)으로 가장 많았고 단일 중재로 가장 많은 것은 가글링이 13편(5.5%)이었다. 종속변수인 구내염에 대한 효과를 분석한 결과 긍정적 효과는 13편(56.5%)이었고 효과가 없는 경우는 10편(10%)로 나타났다. 본 연구의 결과를 기초로 암환자의 구내염 관련 간호 연구 발전 방향을 위한 기초 자료를 마련하고 동일 분야 연구에 활용이 있을 것으로 사료된다.