http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 주제어 : mitochondria-selective (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
A viscosity sensitive fluorescent dye for real-time monitoring of mitochondria transport in neurons
Baek, Yeonju,Park, Sang Jun,Zhou, Xin,Kim, Gyungmi,Kim, Hwan Myung,Yoon, Juyoung Elsevier 2016 Biosensors & Bioelectronics Vol.86 No.-
<P><B>Abstract</B></P> <P>We present here a viscosity sensitive fluorescent dye, namely thiophene dihemicyanine (TDHC), that enables the specific staining of mitochondria. In comparison to the common mitochondria tracker (Mitotracker Deep Red, MTDR), this dye demonstrated its unique ability for robust staining of mitochondria with high photostability and ultrahigh signal-to-noise ratio (SNR). Moreover, TDHC also showed high sensitivity towards mitochondria membrane potential (ΔΨ<SUB>m</SUB>) and intramitochondria viscosity change. Consequently, this dye was utilized in real-time monitoring of mitochondria transport in primary cortical neurons. Finally, the Two-Photon Microscopy (TPM) imaging ability of TDHC was also demonstrated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We presented here a viscosity sensitive dye that can remarkably improve signal-to-noise ratio for mitochondria specific staining. </LI> <LI> This dye showed high photostability, and high sensitivity to mitochondria membrane potential alteration. </LI> <LI> The dye was utilized in real-time monitoring mitochondria transport in primary cortical neurons. </LI> <LI> TPM imaging ability of the dye was also demonstrated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>The viscosity sensitive fluorescent dye, which enable to specifically stain mitochondria with ultrahigh signal-to-noise ratio, was utilized in real-time monitoring mitochondria transport in primary cortical neurons.</P> <P>[DISPLAY OMISSION]</P>
-
Mitochondria-Selective Photodynamic Tumor Therapy Using Globular PEG Nanoparticles
구은비,오경택,윤유석,이은성 한국고분자학회 2016 Macromolecular Research Vol.24 No.7
In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery.
-
A Molecular Approach to Mitophagy and Mitochondrial Dynamics
Yoo, Seung-Min,Jung, Yong-Keun Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.1
Mitochondrial quality control systems are essential for the maintenance of functional mitochondria. At the organelle level, they include mitochondrial biogenesis, fusion and fission, to compensate for mitochondrial function, and mitophagy, for degrading damaged mitochondria. Specifically, in mitophagy, the target mitochondria are recognized by the autophagosomes and delivered to the lysosome for degradation. In this review, we describe the mechanisms of mitophagy and the factors that play an important role in this process. In particular, we focus on the roles of mitophagy adapters and receptors in the recognition of damaged mitochondria by autophagosomes. In addition, we also address a functional association of mitophagy with mitochondrial dynamics through the interaction of mitophagy adaptor and receptor proteins with mitochondrial fusion and fission proteins.
-
A Molecular Approach to Mitophagy and Mitochondrial Dynamics
유승민,정용근 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.1
Mitochondrial quality control systems are essential for the maintenance of functional mitochondria. At the organelle level, they include mitochondrial biogenesis, fusion and fission, to compensate for mitochondrial function, and mitophagy, for degrading damaged mitochondria. Specifically, in mitoph-agy, the target mitochondria are recognized by the autophagosomes and delivered to the lysosome for degradation. In this review, we describe the mechanisms of mitophagy and the factors that play an important role in this process. In particular, we focus on the roles of mitophagy adapters and receptors in the recognition of damaged mitochondria by au-tophagosomes. In addition, we also address a functional association of mitophagy with mitochondrial dynamics through the interaction of mitophagy adaptor and receptor proteins with mitochondrial fusion and fission proteins.
-
Mitochondrial Effects on the Physiological Characteristics of Lentinula edodes
Minseek Kim,Seong-Hyeok Yang,Hui-Gang Han,Eunbi Kim,Sinil Kim,Youn-Lee Oh,Hyeon-Su Ro 한국균학회 2022 Mycobiology Vol.50 No.5
In the mating of filamentous basidiomycetes, dikaryotic mycelia are generated through the reciprocal movement of nuclei to a monokaryotic cytoplasm where a nucleus of compatible mating type resides, resulting in the establishment of two different dikaryotic strains having the same nuclei but different mitochondria. To better understand the role of mitochondria in mushrooms, we created four sets of dikaryotic strains of Lentinula edodes, including B2 E13 (B2 side) and B2 E13 (E13 side), B5 E13 (B5 side) and B5 E13 (E13 side), E8 H3 (E8 side) and E8 H3 (H3 side), and K3 H3 (K3 side) and K3 H3 (H3 side). The karyotypes and mitochondrial types of the dikaryotic strains were successfully identified by the A mating type markers and the mitochondrial variable length tandem repeat markers, respectively. Comparative analyses of the dikaryotic strains on the mycelial growth, substrate browning, fruiting characteristics, and mitochondrial gene expression revealed that certain mitochondria are more effective in the mycelial growth and the production of fruiting body, possibly through the activated energy metabolism. Our findings indicate that mitochondria affect the physiology of dikaryotic strains having the same nuclear information and therefore a selection strategy aimed at mitochondrial function is needed in the development of new mushroom strain.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
