최근 보건의료분야에서 활발하게 연구되고 있는 "Epigenetics"란 무엇인가? -기본개념 및 기전을 중심으로-

이선동,박성균,고성규,신헌태,김명동,Lee, Sun-Dong,Park, Sung-Kyun,Ko, Seong-Gyu,Shin, Heon-Tae,Kim, Myung-Dong 대한예방한의학회 2010 대한예방한의학회지 Vol.14 No.2

The individual differences in disease development and susceptibility have been researched primarily on the subject of genes, environment or the interaction between genes and the environment respectively. However, there have been limitations in explaining complex diseases, and the differences in health and diseases in monozygotic and dizygotic twins. Fortunately, thanks to active research on the relationship between genes and the environment, and epigenetics, there has been much progress in the understanding of body's reactions and changes. Epigenetics is referred to as a study of gene expression through the interactions of DNA methylation, chromatin's histone and the change of structure in tail, RNA editing without any change in DNA sequence. In this paper, we introduce the basic concepts and mechanisms of epigenetics. The result of the epigenetics is heritable ; can regulate gene expressions ; is reversible ; and has many variable forms depending on cell types. The influences of epigenetics occur throughout life, but it is mainly determined in utero during early pregnancies. Diseases occur or the risk rises if these influences continue after birth until adult life when problems occur in excess/lack of nutrition, environmental plasticity, or already inputted data. Therefore, there is a need for change and innovation, especially in interest and investment in health education for young women near pregnancies and correct treatment of epigenetic-related diseases.

천식과 후성유전학

배다정 ( Da Jeong Bae ),박춘식 ( Choon Sik Park ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.1

For the past two decades, a huge number of genetic studies have been conducted to identify the genetic variants responsible for asthma risk. Several types of genetic and genomic approaches, including linkage analysis, candidate gene single nucleotide polymorphism studies, and whole genome-wide association studies have been applied. However, the genetic impacts of these studies are minimal because asthma is a complex syndrome affected by interaction with many environmental factors mediated by epigenetics. Epigenetics is alteration of genetic expression without changes of DNA sequence. Three major forms of epigenetic is DNA methylation, histone modfications and specific microRNA expression that are known to have vast effects on gene expression. However, knowledge regarding the epigenetic effect on the development of asthma and its traits is limited up to date. Recently, new data on epigenetics have been brought up to explain the phenotypic alterations of asthma. In this review, we present general concept of epigenetics, environmental factors inducting epigenetic changes and the background mechanisms in epigenetics behind development asthma and epigenetic therapy. (Allergy Asthma Respir Dis 1(1):4-10, 2013)Allergy Asthma Respir Dis 1(1):4-10, 2013)

Epigenetics: general characteristics and implications for oral health

Seo, Ji-Yun,Park, Yoon-Jung,Yi, Young-Ah,Hwang, Ji-Yun,Lee, In-Bog,Cho, Byeong-Hoon,Son, Ho-Hyun,Seo, Deog-Gyu The Korean Academy of Conservative Dentistry 2015 Restorative Dentistry & Endodontics Vol.40 No.1

Genetic information such as DNA sequences has been limited to fully explain mechanisms of gene regulation and disease process. Epigenetic mechanisms, which include DNA methylation, histone modification and non-coding RNAs, can regulate gene expression and affect progression of disease. Although studies focused on epigenetics are being actively investigated in the field of medicine and biology, epigenetics in dental research is at the early stages. However, studies on epigenetics in dentistry deserve attention because epigenetic mechanisms play important roles in gene expression during tooth development and may affect oral diseases. In addition, understanding of epigenetic alteration is important for developing new therapeutic methods. This review article aims to outline the general features of epigenetic mechanisms and describe its future implications in the field of dentistry.

Epigenetics: Linking Nutrition to Molecular Mechanisms in Aging

Joo Hyun Park,Yeongran Yoo,Yoon Jung Park 한국식품영양과학회 2017 Preventive Nutrition and Food Science Vol.22 No.2

Healthy aging has become a major goal of public health. Many studies have provided evidence and theories to explain molecular mechanisms of the aging process. Recent studies suggest that epigenetic mechanisms are responsible for life span and the progression of aging. Epigenetics is a fascinating field of molecular biology, which studies heritable modifications of DNA and histones that regulate gene expression without altering the DNA sequence. DNA methylation is a major epigenetic mark that shows progressive changes during aging. Recent studies have investigated aging-related DNA methylation as a biomarker that predicts cellular age. Interestingly, growing evidence proposes that nutrients play a crucial role in the regulation of epigenetic modifiers. Because various nutrients and their metabolites function as substrates or cofactors for epigenetic modifiers, nutrition can modulate or reverse epigenetic marks in the genome as well as expression patterns. Here, we will review the results on aging-associated epigenetic modifications and the possible mechanisms by which nutrition, including nutrient availability and bioactive compounds, regulate epigenetic changes and affect aging physiology.

Epigenetics: general characteristics and implications for oral health

서지윤,박윤정,이영아,황지윤,이인복,조병훈,손호현,서덕규 대한치과보존학회 2015 Restorative Dentistry & Endodontics Vol.40 No.1

Genetic information such as DNA sequences has been limited to fully explain mechanisms of gene regulation and disease process. Epigenetic mechanisms, which include DNA methylation, histone modification and non-coding RNAs, can regulate gene expression and affect progression of disease. Although studies focused on epigenetics are being actively investigated in the field of medicine and biology, epigenetics in dental research is at the early stages. However, studies on epigenetics in dentistry deserve attention because epigenetic mechanisms play important roles in gene expression during tooth development and may affect oral diseases. In addition, understanding of epigenetic alteration is important for developing new therapeutic methods. This review article aims to outline the general features of epigenetic mechanisms and describe its future implications in the field of dentistry.

자유의지에 대한 과학적 증명, 그 의미와 한계 -후성유전학을 둘러싼 철학적 논의를 중심으로

손향구,조은희 대동철학회 2017 大同哲學 Vol.81 No.-

This thesis aims to examine critically philosophical debate that has been based on the findings of epigenetics. Epigenetics is characterized by the fact that expression itself and expression levels of genes are regulated through factors determined by the nutritional status and mental experience of individuals. This implies that people can control their gene expression by choosing their own environment and giving them the intended mental experience, which is presented as the main basis for establishing free will. The free will argument associated with epigenetics has been presented as a major basis for overcoming genetic determinism or materialistic mechanics in the fields of evolution, genetic engineering, and neuroscience, and furthermore, to treat various diseases caused by gene mutations. It implies the possibility of controlling each person's behavior as desired, so much attention has been focused on philosophical implication. However, the cases in which the epigenetic basis is revealed scientifically are only a few. This will not be easy to improve even if research continues to be done in the future. It is not easy to find a universal epigenetic rule that regulates DNA expression sites, as human organisms are complex organisms that are difficult to be reduced to basic structures, as has been fully demonstrated in the discussion of past genetic engineering stability issues. It is highly appreciated that epigenetics can explain both a mechanism beyond the controversy of past nature and nurturing, and provide grounds for overcoming genetic determinism. However, if the generic principle for controlling the gene expression site is difficult to establish, suggesting epigenetic genetics as a basis for establishing free will will not only be logically contradictory but may also lead to various social problems. Therefore we need to take a more cautious approach in this regard. 이 글은 후성유전학에 기초하여 전개되어온 철학적 논의를 비판적으로 검토하기 위해 쓰여졌다. 후성유전학은 개체의 영양 상태나 정신적 경험에 의해 결정되는 DNA메틸화, 히스톤변형, 비번역 RNA의 작용 등의 요인을 통해 유전자의 발현 여부와 발현정도가 조절되고 최종적으로 개체의 표현형질이 변한다는 사실을 밝혀냈다. 이러한 내용은 사람들이 스스로 환경을 선택하고 의도된 정신적 경험을 부여함으로써 유전자 발현을 조절할 수 있다는 내용을 함축하고 있어 자유의지 성립을 위한 주요한 근거로 제시되었다. 후성유전학과 연관된 자유의지 논증은 그동안 진화론, 유전공학, 신경과학 등의 분야에서 주장된 유전자결정론이나 유물론적 기계론을 극복하고 나아가 유전자 돌연변이로 인해 발생하는 다양한 질병을 치료하거나 원하는 대로 각자의 행동을 조절할 수 있는 가능성까지 함축하는 것이어서 사회적, 철학적 관심이 집중되기도 하였다. 하지만 후성유전학적 근거가 제대로 밝혀진 경우는 몇몇 사례에 불과하고 특히 분자적 수준에서의 인과성을 통해 전 과정을 체계적으로 설명한 경우는 극소수에 불과해 논의의 타당성에 의문이 제기될 수 있다. 이러한 문제는 앞으로 후성유전학 연구가 지속된다고 하더라도 쉽게 개선되기는 어려울 것이다. 과거 유전공학의 안정성 문제에 대한 논의에서 충분히 드러났듯이 인간은 기본적인 구조로 환원되기 어려운 유기체적 복잡성을 갖고 있기 때문에 DNA발현부위를 조절하는 보편적인 후성유전 법칙을 찾아내기란 쉬운 일이 아니기 때문이다. 후성유전학이 과거 본성과 양육의 대립논쟁을 뛰어넘어 이 둘을 하나의 메커니즘안에서 종합적으로 설명하고 유전자결정론을 극복할 수 있는 근거를 마련한 것은 높이 평가할 부분이다. 하지만 유전자발현부위 조절에 대한 일반적 원리가 정립되기 어려운 상황에서 후성유전학을 자유의지 성립 근거로 제시한다면 논리적으로 반박당할 가능성이 클 뿐만 아니라 사회적으로도 다양한 문제를 야기할 수도 있어 보다 신중한 태도로 접근할 필요가 있다.

Epigenetics: Linking Nutrition to Molecular Mechanisms in Aging

Park, Joo Hyun,Yoo, Yeongran,Park, Yoon Jung The Korean Society of Food Science and Nutrition 2017 Preventive Nutrition and Food Science Vol.22 No.2

Healthy aging has become a major goal of public health. Many studies have provided evidence and theories to explain molecular mechanisms of the aging process. Recent studies suggest that epigenetic mechanisms are responsible for life span and the progression of aging. Epigenetics is a fascinating field of molecular biology, which studies heritable modifications of DNA and histones that regulate gene expression without altering the DNA sequence. DNA methylation is a major epigenetic mark that shows progressive changes during aging. Recent studies have investigated aging-related DNA methylation as a biomarker that predicts cellular age. Interestingly, growing evidence proposes that nutrients play a crucial role in the regulation of epigenetic modifiers. Because various nutrients and their metabolites function as substrates or cofactors for epigenetic modifiers, nutrition can modulate or reverse epigenetic marks in the genome as well as expression patterns. Here, we will review the results on aging-associated epigenetic modifications and the possible mechanisms by which nutrition, including nutrient availability and bioactive compounds, regulate epigenetic changes and affect aging physiology.

Epigenetics: Linking Nutrition to Molecular Mechanisms in Aging

박주현,유영란,박윤정 한국식품영양과학회 2017 Preventive Nutrition and Food Science Vol.22 No.2

Healthy aging has become a major goal of public health. Many studies have provided evidence and theories to explain molecular mechanisms of the aging process. Recent studies suggest that epigenetic mechanisms are responsible for life span and the progression of aging. Epigenetics is a fascinating field of molecular biology, which studies heritable modifications of DNA and histones that regulate gene expression without altering the DNA sequence. DNA methylation is a major epigenetic mark that shows progressive changes during aging. Recent studies have investigated aging-related DNA methylation as a biomarker that predicts cellular age. Interestingly, growing evidence proposes that nutrients play a crucial role in the regulation of epigenetic modifiers. Because various nutrients and their metabolites function as substrates or cofactors for epigenetic modifiers, nutrition can modulate or reverse epigenetic marks in the genome as well as expression patterns. Here, we will review the results on aging-associated epigenetic modifications and the possible mechanisms by which nutrition, including nutrient availability and bioactive compounds, regulate epigenetic changes and affect aging physiology.

노화의 후생유전학적 기전에 대한 증거

이정윤 ( Jung Yun Lee ),김진주 ( Jin Ju Kim ),구승엽 ( Seung Yup Ku ) 서울대학교 인구의학연구소 2010 人口醫學硏究論集 Vol.23 No.-

Until recently, central dogma in generics has supported genetic determinism in mechanisms of aging. Since epigenetics is now regarded as another important factor for aging, aging mechanisms cannot be fully explained only by genetic factors. Epigenetics can be defined as phenotypic changes caused by mechanisms that are not related to changes in DNA sequence itself. Two major mechanisms include DNA methylation and histone modification. In addition, RNA interference, related to all steps of protein production, can also be considered part of epigenetics. Herein we review the genetic and epigenetic mechanisms of aging and focus on the role of epigenetics in aging. Increased understanding of aging process will enable us to prevent and treat age-related diseases.

제주 3대 大기근과 4.3사건의 後成遺傳(Epigenetic)현상 개연성

이문호,김정수 국제문화기술진흥원 2019 The Journal of the Convergence on Culture Technolo Vol.5 No.2

인간 유전자 게놈 프로젝트가 1990-2003년까지 30억 달러를 들여 인간유전자 99%를 해독했다. 그런데, 유전자에 대한 많은 연구가 진행됨에 따라 유전자에 구조적인 변질이 오지 않고도 질병이 발생하는 경우가 많다는 사실이밝혀지고 있다. 최신 학문인 후성유전자학이 이 문제에 대한 답을 내놓고 있다. 1670-1795년까지 제주를 덮친 흉년과제주도민이 외부로 출도금지령 200년간의 고통, 그리고 1948년 4.3사건으로 도민이 삼분에 일이 죽임을 당하는 수난이 후성유전현상으로 자손대에 비만과 질병으로 발현될 수 있음을 세계역사속의 과학으로 보였다. 5G 기반의 헬스케어 IoT 기술을 이용하면 이러한 현상에 대한 후성유전학적 분석이 가능해져 비만 치료에 이용될 수 있다. The human genome project decoded 99% of human genes for $ 3 billion by 1990-2003. However, as many studies on genes have progressed, it has become clear that there are many cases where diseases occur without structural alteration of genes. The latest study, Epigenetics, has come up with the answer to this problem. The famine that hit Jeju until 1670-1795, the ban on the exclusion of Jeju Island to the outside 200 years of suffering, and in 1948, one third of the citizens were killed by the 4.3 incident generate Epigenetic. It has been shown in the world history science that starving-stress can be manifested as obesity and disease in progeny due to hereditary phenomena. 5G-based healthcare IoT technology can be used for the treatment of obesity by enabling Epigenetic analysis of this phenomenon.