Incidence, prevalence, and mortality of Behcet’s disease in Korea: a nationwide, population-based study (2006-2015)

( Young Bok Lee ),( Soo Young Lee ),( Jin Young Choi ),( Ji Hyun Lee ),( Jin-wou Kim ),( Dong Soo Yu ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: The epidemiology of Behcet’s disease varies among ethnic populations worldwide. Trends in the incidence of Behcet’s disease have not been investigated based on the Korean National Health Insurance database. Objectives: This study investigated the incidence and mortality of Behcet’s disease by age using nationwide population data in Korea. Methods: A nationwide population-based cohort study was performed using the Korean National Health Insurance Claims Database from 2006 to 2015. Results: The annual incidence of Behcet’s disease per 100,000 person-years was 3.976 (2.587 for males and 5.373 for females) from 2006 to 2015. The incidence of Behcet’s disease peaked among people in their 40s (6.561 per 100,000 person-years). Incidence was significantly higher in subjects with comorbid metabolic conditions, such as diabetes mellitus, hypertension, and dyslipidemia. The mortality rate per 1,000 person-years increased with age in Behcet’s disease patients. Conclusion: This study showed the incidence, prevalence, and mortality of Behcet’s disease. Metabolic conditions increased the risk of Behcet’s disease among Koreans.

Interstitial Lung Disease and Lung Cancer Development: A 5-Year Nationwide Population-Based Study

최원일,박순효,박병주,이충원 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2

Purpose In this nationwide 5-year longitudinal population-based study, we aimed at investigating the incidence of lung cancer among patients with interstitial lung disease. Materials and Methods Data was collected from the Korean National Health Insurance Research Database from 49,773,195 Korean residents in 2009. Thirteen thousand six hundred and sixty-six patients with interstitial lung disease diagnosed January-December 2009. The end of follow-up was June 30, 2014. Up to four matching chronic obstructive pulmonary disease controls were selected to compare the lung cancer high-risk group based on age, sex, diagnosis date (within 30 days), and hospital size. The number of patients with newly developed lung cancer was determined. Results The incidences of lung cancer were 126.98, 156.62, and 370.38 cases per 10,000 person- years (2,732, 809, and 967 cases of cancer, respectively) in the chronic obstructive pulmonary disease, interstitial lung disease, and chronic obstructive pulmonary disease with interstitial lung disease groups, respectively. Of the 879 patients with idiopathic pulmonary fibrosis, 112 developed lung cancer (incidence, 381.00 cases per 10,000 personyears). Conclusion Incidence of lung cancer among patients with interstitial lung disease was high. Interstitial lung diseases have a high potential for developing into lung cancer, even when concurrent with chronic obstructive pulmonary disease.

고추 흰가루병균(Leveillula taurica)의 발아특성 및 접종법

김대현,박종한,이중섭,한경숙,한유경,황정환 한국식물병리학회 2009 식물병연구 Vol.15 No.3

Pepper powdery mildew, Leveillula taurica is one of the most important pathogens of pepper in the greenhouses and fields in Korea and is becoming a worldwide disease. These experiments were carried out to investigate the optimal germination, disease development conditions, disease incidence and effective inoculation methods of pepper powdery mildew. The incidence of powdery mildew was investigated throughout the country based on the major pepper growing areas in 2009. The average rate of infected leaves ranged from 15.3% to 81.8% in greenhouses and fields. Powdery mildew incidences were more severe in greenhouses than those of fields. The optimal temperature for conidial germination was 25oC and showed the highest germination at 6 hs after treatment. The range of temperature for germination was 10oC to 35oC. Temperature of greater than 30oC and below 20oC affected the abnormal germination and germ tube elongation. The optimal relative humidity for germination and germ tube elongation was 85% and germination increased as relative humidity increased. Disease development started 8 days after inoculation and showed the highest disease severity at 15 days in greenhouse and field regardless of varieties. Among three different inoculation methods tested the spore dropping method was better than touching with infected leaves and spraying with spore suspension. However, the method has limitation in mass inoculation due to the amount of time consumed. Pepper powdery mildew, Leveillula taurica is one of the most important pathogens of pepper in the greenhouses and fields in Korea and is becoming a worldwide disease. These experiments were carried out to investigate the optimal germination, disease development conditions, disease incidence and effective inoculation methods of pepper powdery mildew. The incidence of powdery mildew was investigated throughout the country based on the major pepper growing areas in 2009. The average rate of infected leaves ranged from 15.3% to 81.8% in greenhouses and fields. Powdery mildew incidences were more severe in greenhouses than those of fields. The optimal temperature for conidial germination was 25oC and showed the highest germination at 6 hs after treatment. The range of temperature for germination was 10oC to 35oC. Temperature of greater than 30oC and below 20oC affected the abnormal germination and germ tube elongation. The optimal relative humidity for germination and germ tube elongation was 85% and germination increased as relative humidity increased. Disease development started 8 days after inoculation and showed the highest disease severity at 15 days in greenhouse and field regardless of varieties. Among three different inoculation methods tested the spore dropping method was better than touching with infected leaves and spraying with spore suspension. However, the method has limitation in mass inoculation due to the amount of time consumed.

청해부대 파병 기간동안 호발하는 질환과 그 발생에 영향을 미치는 요인 분석

이성 ( Lee Sung ),임승혁 ( Yim Seung Hyuk ),박상헌 ( Park Sang Hun ) 국군의무사령부 2020 대한군진의학학술지 Vol.51 No.1

Objectives; the purpose of this research is to obtain a high prevalence disease list during the deployment period of the cheong-hae unit and do an analysis of factors affecting incidence rate. Methods; 301 Navy Crews were deployed for 201 days, total medical records were retrospectively utilized, and we compared the disease’s incidence rates with that of the general population. Independent variables are age, department, exercise time, smoking, bed place, duty schedule, and clinic visit period. To Compare the variables, we used х² test and Logistic Regression Test. Results; Most high prevalence disease was upper respiratory disease, which was linked to the clinic visit period. and sleep problem was revealed to be the most high risk ratio compared to the general population. Trauma and musculoskeletal diseases show no difference among clinic visit period but we observed very high incidence rate in ‘Cooking Department’. Duty schedule has a correlation to Gastro-intestinal Disease. smoking is revealed risk factor of dental problem and head & neck musculoskeletal disease. Conclusions; There are many factors affecting a disease’s incidence rate. This findings offer basic reference for preparing Cheong-hae unit deployment and enhancing the Navy Crew’s health by preventing the high prevalence disease.

한국 성인 순환기질환의 빈도 및 변동추이

손장원(Jang Won Sohn),이재웅(Jae Ung Lee),윤석남(Seok Nam Yoon),이상(Sahng Lee),김경수(Kyung Soo Kim),김정현(Jeong Hyun Kim),임헌길(Heon Kil Lim),이방헌(Bang Hun Lee),이정균(Chung Kyun Lee) 대한내과학회 1995 대한내과학회지 Vol.49 No.6

Objectives: By rapid socioeconomic progress, recent change in disease pattern was marked in Korea. Herein, we reviewed statistical data to evaluate the changes in incidence and trend of each cardiovascular disease. Methods: Statistical observation was made on the adult patients with cardiovascular diseases who were admitted in the Han Yang University Hospital for 12 years(1982-1993). These results were compared with previous report in same hospital(1972-1981). Results: 1) The increments of frequency of each cardiovascular disease were observed in consecutive years, especially in hypertension, ischemic heart disease, valvular heart disease, arrhythmia and pericarditis(p<0.01). 2) Hypertension was the most common form of cardiovascular problem, accounting for 44.8 per 1000 inpatients. Incidense of hypertension was high in the fifth and sixth decade. The male to female ratio was I:1.07 3) Ischemic heart disease made incidence of 15.3 per 1000 inpatients. The male to female ratio was I:0.9. The increment of incidence of ischemic heart disease was marked in male patients, Female patients were older than male in general. 4) Incidence of valvuler heart disease was 8.5 per 1000 inpatients. The male to female ratio was 1:1.5. 5) Incidences of the remaining forms of cardiovascular diseases per 1000 inpatients were arrhythmia in 23.4, congenital heart disease in 2.7, heart failure in 4.2, endocarditis in 0.3, pericarditis in 2.3, and cor pulmonale in 0.8. Conclusion: Incidences of majorcardiovascular diseases increased significantly in Han Yang University Hospital. We advocate establishing preventive measures and performing continuous epidemiologic study.

Risk for Parkinson’s disease in patients with Behcet’s Disease: A nationwide population-based dynamic cohort study in Korea

( Min Ji Kang ),( Ji Min Seo ),( Joo Hee Lee ),( Dong Soo Yu ),( Young Bok Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Although several studies have reported a correlation between Behcet’s disease and Parkinson’s disease, this association has not yet been clarified. Objectives: The aim of this study is to determine the risk of Parkinson’s disease in patients with Behcet’s disease. Methods: Behcet’s disease patients (n = 17,179; mean age, 51.12±8.09 years; male, 34.95%) without known previous diagnosis of Parkinson’s disease were selected from the Korean National Health Insurance Database between 2010 and 2013. An age and gender-matched control population of individuals without Behcet’s disease was randomly sampled at a ratio of 3:1 (n = 34,575). Both cohorts were followed for development of Parkinson’s disease until 2015. Results: Among a total of 11,525 Behcet’s disease patients, 50 (0.43%) developed Parkinson’s disease, whereas only 51 among the 34,575 individuals in the non- Behcet’s disease group developed Parkinson’s (0.15%, P < 0.0001). The incidence of Parkinson’s disease was significantly higher in Behcet’s disease patients than in controls. In addition, during the follow-up period, patients with Behcet’s disease were more likely to be diagnosed with Parkinson’s disease than those in the non- Behcet’s disease group. Conclusion: Behcet’s disease patients had a higher risk of Parkinson’s disease compared to non- Behcet’s disease controls. Physicians should carefully monitor patients with Behcet’s disease for potential development of Parkinson’s disease.

Increased cardiovascular risk and all-cause death in patients with Behcet’s disease: a nationwide population-based dynamic cohort study

( Soo Young Lee ),( Min Ji Kang ),( Joo Hee Lee ),( Young Bok Lee ),( Dong Soo Yu ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Behcet’s disease is a inflammatory multiorgan disease. An increased risk of cardiovascular disease and heightened death rate with Behcet’s disease have been suggested, but, to our knowledge, a nationwide large-scale study has not been conducted to date. Objectives: This study aimed to determine the overall cardiovascular risk and death rate in Behcet’s disease patients versus controls using the Korean National Health Insurance Service claim database. Methods: Patients with Behcet’s disease (n = 5,576) with no previous history of cardiovascular disease were selected from 2010 to 2014. An age- and sex-matched control population of individuals without Behcet’s disease (n = 27,880) was randomly sampled at a ratio of 5:1. Both cohorts were followed for incident cardiovascular disease or all-cause death until 2015. Results: The risks of myocardial infarction [hazard ratio (HR): 1.72, 95% CI: 1.01-2.73] and stroke [HR: 1.65, 95% CI: 1.09-2.50] were significantly higher in Behcet’s disease patients than in control patients. Behcet’s disease patients also had a significantly higher risk of all cause death [HR: 1.82, 95% CI: 1.40-2.37] compared to controls. Conclusion: Korean Behcet’s disease patients had a higher overall risk of cardiovascular disease than did those without Behcet’s disease. Therefore, patients with Behcet’s disease must be carefully monitored for the potential development of cardiovascular disease to ensure that appropriate early treatments are delivered.

Association between smoking and Behcet’s disease: A nationwide population-based study in Korea

( Ji Min Seo ),( Soo Young Lee ),( Joo Hee Lee ),( Dong Soo Yu ),( Young Bok Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: There have been conflicting results about the asssociation between Behcet’s disease and smoking. Smoking has been reported to be a protective factor for Behcet’s disease, but smoking may have a role in triggering Behcet’s disease. Objectives: This study aimed to investigate the incidence of Behcet’s disease in Korea according to smoking status using nationwide population data. Methods: We analysed clinical data from individuals 20 years of age and older who received a health examination arranged by the Korean national insurance programme between 2009 and 2012. The incidence of Behcet’s disease was analysed according to smoking status reported by individuals during their health examination. Newly diagnosed cases of Behcet’s disease were identified using claims data from baseline to the date of diagnosis or until 31 December 2016. Results: The risk of Behcet’s disease was lower in current smokers compared with never-smokers regardless of the amount and duration of smoking. The decreased risk of Behcet’s disease in current smoker persisted after adjusting for age, sex, regular exercise, drinking status, BMI, diabetes mellitus, hypertension, and dyslipidemia, history of stroke and/or history of ischemic heart diseases. Conclusion: This study found a decreased incidence of Behcet’s disease in current smokers compared with never smokers. Further investigation of the pathophysiology responsible for the negative association between smoking and Behcet’s disease is needed.

Effect of Phytoecdysteroid on Disease Incidence, Melting and Economic Characters of the Mulberry Silkworm

Mithilesh Kar,P. Sudhakara Rao,S. Kishore,T. Selva Kumar,Nisha Gopal,A. R. Narasimha Nayaka,K. Chandrasekaran 한국잠사학회 2009 International Journal of Industrial Entomology Vol.18 No.1

A study has been made to know the effect of a phytoecdysteroid `Sampoorna` on uniform maturation of silkworms during spinning and its effect on diseased silkworms infected by major silkworm disease viruses, Bombyx mori nuclear polyhedrosis virus (BmNPV) and Bombyx mori infectious flacherie virus (BmIFV). In the present investigation, the effect of the phytoecdysteroid "Sampoorna" on Grasserie disease caused by BmNPV have shown an average cocoon melting of 11.91% with a disease incidence of 5.83%. The values of `t` test for different treatments of BmNPV indicated low survival rate and cocoon traits were drastically reduced. Another major disease Flacherie caused by BmIFV has shown considerable levels of larval disease incidence (22-32%) and cocoon melting (3-7.67%) with an average melting of 12.95% and 20.24% disease incidence. There is a drastic reduction in survival rate, cocoon yield and other economic traits. The control batches were indicated negligible values for disease incidence and cocoon melting with Sapoorna application and without the inoculation of the two disease-causing viruses. The application of Sampoorna on already infected batches with major pathogens triggered high mortality and disease incidence and melting percentage was also significantly increased with reduced economic traits. Hence, it is suggested that application of Sampoorna in infected batches should be done only in the extreme conditions of rearing. Application of Sampoorna on healthy batches led to uniform maturation and improvement in productivity.

Effect of Phytoecdysteroid on Disease Incidence, Melting and Economic Characters of the Mulberry Silkworm

Kar, Mithilesh,Rao, P. Sudhakara,Kishore, S.,Kumar, T. Selva,Gopal, Nisha,Nayaka, A.R. Narasimha,Chandrasekaran, K. Korean Society of Sericultural Science 2009 International Journal of Industrial Entomology Vol.18 No.1

A study has been made to know the effect of a phytoecdysteroid 'Sampoorna' on uniform maturation of silkworms during spinning and its effect on diseased silkworms infected by major silkworm disease viruses, Bombyx mori nuclear polyhedrosis virus (BmNPV) and Bombyx mori infectious flacherie virus (BmIFV). In the present investigation, the effect of the phytoecdysteroid "Sampoorna" on Grasserie disease caused by BmNPV have shown an average cocoon melting of 11.91% with a disease incidence of 5.83%. The values of 't' test for different treatments of BmNPV indicated low survival rate and cocoon traits were drastically reduced. Another major disease Flacherie caused by BmIFV has shown considerable levels of larval disease incidence (22-32%) and cocoon melting (3-7.67%) with an average melting of 12.95% and 20.24% disease incidence. There is a drastic reduction in survival rate, cocoon yield and other economic traits. The control batches were indicated negligible values for disease incidence and cocoon melting with Sapoorna application and without the inoculation of the two disease-causing viruses. The application of Sampoorna on already infected batches with major pathogens triggered high mortality and disease incidence and melting percentage was also significantly increased with reduced economic traits. Hence, it is suggested that application of Sampoorna in infected batches should be done only in the extreme conditions of rearing. Application of Sampoorna on healthy batches led to uniform maturation and improvement in productivity with the added advantage of better quality cocoons and labour saving.