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Leukocytes as a Prognostic Factor for Patients with Pulmonary Embolism
최원일,조준연,최원일,권용식,이진욱,전영준 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Background: Hemodynamic status and cardiac function are major pulmonary embolism (PE) prognostic factors. Although inflammation is considered a risk factor for deep vein thrombosis, the prognostic significance of the systemic inflammatory response syndrome (SIRS) and leukocytosis has not been well studied. Objective: This study evaluates PE prognostic factors, including SIRS and leukocytes. Patients/Methods: This retrospective cohort study included 667 PE patients. Risk evaluation included SIRS and leukocytosis. A prediction model was developed based on independent predictors of 30-day mortality. Results and Conclusions: Fifty-seven patients (8.5%) died within 30 days. Multivariate analysis showed that SIRS satisfying the WBC criteria (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.6-7.1), altered mental status (OR, 2.9; 95% CI, 1.2-7.4), and right-to-left ventricle diameter ratio (OR, 2.0; 95% CI, 1.1-3.7) were associated with 30-day mortality. SIRS criteria including body temperature (OR, 4.6; 95% CI, 1.4-14.8), heart rate (OR, 2.0; 95% CI, 1.1-3.6), respiratory rate (OR, 2.5; 95% CI, 1.4-4.6), and WBC count (OR, 1.9; 95% CI, 1.2-3.5) predicted short-term mortality in PE. The area under the receiver operating characteristic curve for the prognostic model`s prediction performance was 0.76 (95% CI, 0.66-0.85), and for pulmonary embolism severity index (PESI) and PESI + WBC count were 0.72 (95% CI, 0.68-0.75) and 0.76 (95% CI, 0.72-0.79, P<0.01 versus PESI), respectively. Leukocytoes and SIRS are important factors in determining short-term outcomes.
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최원일 대한의사협회 2020 대한의사협회지 Vol.63 No.1
Idiopathic pulmonary fibrosis (IPF) is a condition that has been described as alveolar collapse and thickening, which correlate with dysregulated surfactant production and injury to type 2 alveolar cells. As resolution of chest computed tomography has improved, especially with the development of high-resolution computed tomography (HRCT), the diagnostic measures adopted for pulmonary fibrosis has gradually shifted from biopsy to HRCT. This shift towards HRCT has aided in diagnostic evaluation and detection of the therapeutic and adverse effects of drugs for pulmonary fibrosis. Further, after the endpoint was changed to forced vital capacity, significant improvements are being observed in clinical trial outcomes. Currently active clinical trials are replacing lung biopsy with HRCT. In 2014, pirfenidone and nintedanib gained approval for tandem use in patients with IPF. These drugs were found to not only reduce the progression of pulmonary fibrosis, but also the acute exacerbation and mortality associated with the condition. These drugs showed consistent benefits regardless of the severity of patients’ symptoms. Additionally, both nintedanib and pirfenidone were found to be effective in patients with advanced pulmonary fibrosis that was not classified as IPF. Nintedanib has been shown to reduce forced vital capacity in interstitial lung diseases associated with systemic sclerosis. In the next three to five years, many changes in treatment are expected, not only for IPF, but also for the entire spectrum of pulmonary fibrotic diseases. Pirfenidone and nintedanib are now considered standard treatments for IPF and few other fibrotic lung diseases. Clinicians treating patients with pulmonary fibrosis should keep themselves updated with the results of clinical trials that are currently underway.
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최원일,Yoon Jae-Hyun,Choi Seo-Hyun,Jeon Bu-Nam,Kim Hail,Hur Man-Wook 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Zbtb7c is a proto-oncoprotein that controls the cell cycle and glucose, glutamate, and lipid metabolism. Zbtb7c expression is increased in the liver and white adipose tissues of aging or high-fat diet-fed mice. Knockout or knockdown of Zbtb7c gene expression inhibits the adipocyte differentiation of 3T3-L1 cells and decreases adipose tissue mass in aging mice. We found that Zbtb7c was a potent transcriptional repressor of SIRT1 and that SIRT1 was derepressed in various tissues of Zbtb7c -KO mice. Mechanistically, Zbtb7c interacted with p53 and bound to the proximal promoter p53RE1 and p53RE2 to repress the SIRT1 gene, in which p53RE2 was particularly critical. Zbtb7c induced p53 to interact with the corepressor mSin3A-HADC1 complex at p53RE. By repressing the SIRT1 gene, Zbtb7c increased the acetylation of Pgc-1α and Pparγ, which resulted in repression or activation of Pgc-1α or Pparγ target genes involved in lipid metabolism. Our study provides a molecular target that can overexpress SIRT1 protein in the liver, pancreas, and adipose tissues, which can be beneficial in the treatment of diabetes, obesity, longevity, etc.
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최원일,이차영 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.10
매미나방류는 국내에서는 돌발적으로 발생하는 산림해충으로 알려져 있으나 북미에서는 외국에서 유입된 중요 산림해충으로 간주되어 집중적으로 연구되고 있다. 국립산림과학원에서는 전국 산림병해충 발생 모니터링 연구를 수행하고 있으며 매미나방류도 돌발해충으로서 모니터링 되고 있다. 매미나방 발생 자료는 돌발 발생이 보고된 경우, 관광지, 유적지 등 특정 지역에 대한 주기적 모니터링, 유아등을 이용한 나방류 모니터링 결과를 활용하여 발생 이력을 조사하였다. 모니터링 결과 조사된 매미나방류는 모두 4종으로 매미나방, 붉은매미나방, 얼룩매미나방, 물결매미나방이 관찰되었다. 4종의 매미나방 모두 우화최성기가 7∼8월이었다. 돌발발생 기록과 유아등 조사에 의한 지역적 대발생은 해마다 변이가 있어 온도, 강우 등 환경요인에 의한 영향이 있는 것으로 추정된다.
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