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      • KCI등재

        근골격계 질환의 증식치료(prolotherapy)에 대한 체계적 문헌 고찰

        고광표(Kwang-Pyo Ko),박영환(Young Hwan Park),안태근(Tae-Keun Ahn) 대한정형외과학회 2024 대한정형외과학회지 Vol.59 No.4

        증식치료란 새롭게 조직이 재생되도록 유도하는 치료를 의미하며, 전통적으로 여러 자극제들이 증식제로 사용되어 왔으나 현재는 안정성과 효과에서 상대적으로 우수한 고농도 덱스트로스(Dextrose) 용액이 주로 사용되고 있다. 증식치료는 약화되어 있는 인대나 건 부착부에 약제를 주입하여 염증을 유발시키고, 염증이 유발된 조직의 증식 및 재형성 과정을 이용하는 치료 방법이다. 이러한 증식치료는 만성 근골격계 질환에 사용될 수 있는 비수술적 치료 방법 중 하나이다. 현재까지 많은 문헌들이 다양한 근골격계질환에 대한 증식치료의 효과에 대해 보고하였으나, 용법과 시술 횟수, 주기 등이 표준화되어 있지 않아 저자들마다 다양한 프로토콜을 보고하였다. 따라서 본 연구에서 저자들은 증식치료에 대한 체계적 문헌 고찰을 시행하여 증식치료의 프로토콜과 임상효과를 분석하고, 해당 문헌들을 종합하여 증식치료의 대상 질환 및 질환별 치료 방법에 대한 현재까지의 지견을 제시하고자 한다. Prolotherapy is a treatment that induces tissue regeneration. Traditionally, various stimulants have been used as proliferative agents, but currently, high-concentration dextrose solutions, which have relatively excellent safety and effectiveness, are mainly used. Prolotherapy induces inflammation by injecting a proliferant into a weakened ligament or tendon enthesis and uses the process of proliferation and remodeling of the damaged tissue. The effectiveness of prolotherapy for different musculoskeletal diseases has been reported, but each author reported a different protocol because the method, number of procedures, and cycle have not been standardized. Therefore, the authors conducted a systematic literature review on prolotherapy to analyze the protocols and clinical outcomes of prolotherapy. This paper presents the current knowledge on the diseases targeted by prolotherapy and the treatment methods for each disease.

      • KCI등재

        턱관절 장애 환자에서 턱관절 증식치료(Prolotherapy)의 효과 : 문헌고찰

        권정욱(Jung-Wook Kwon),현승철(Seung-Chul Hyun),김동혁(Dong-Hyuck Kim),이의석(Eui-Seok Lee),임호경(Ho-Kyung Lim) 대한치과의사협회 2023 대한치과의사협회지 Vol.61 No.13

        This paper reviewed prolotherapy as an approach to treating temporomandibular joint disorders (TMD), focusing on temporomandibular joint subluxation and hypermobility. Prolotherapy, commonly used in orthopedics, involves injecting substances like dextrose or lidocaine to promote healing in musculoskeletal conditions. Clinical studies in which this prolo- therapy was used for TMD were reviewed. Total 13 papers involving 372 patients (Male 90, Female 282) were examined, considering factors such as dextrose concentration (10%~50%), injection frequency (one to four times), injection period (one to four weeks) and injection sites. The assessment primarily focused on pain reduction and changes in maximum mouth opening after prolotherapy. In all papers, a consistent trend of pain reduction after prolotherapy was observed. Regarding maximum mouth opening, there were 6 cases of decreased range and 7 cases of increased range. With prolotherapys rec- ognition as a new medical technology for TMD, it emerges as a potential alternative treatment, highlighting its significance in the field.

      • SCOPUSKCI등재
      • SCOPUSKCI등재
      • KCI등재

        Evaluation of the effects of prolotherapy on condyles in temporomandibular joint hypermobility using fractal dimension analysis

        Sadi Memiş 대한구강악안면외과학회 2022 대한구강악안면외과학회지 Vol.48 No.1

        Objectives: Prolotherapy is a method that has gained popularity in recent years and has been reported to have positive short-term and long-term clini-cal results in maxillofacial surgery, especially temporomandibular joint (TMJ) hypermobility. This study aimed to evaluate the changes in the trabecu-lar structure of mandibular condyles in patients who underwent prolotherapy due to TMJ hypermobility using the fractal analysis method. Materials and Methods: Forty-five patients who received dextrose prolotherapy at a concentration of 20% and fifteen control patients were included in the study. All patients had panoramic radiographs just before (T0) and six months after treatment (T1). The patients who received treatment were di-vided into three groups according to the number of prolotherapy injections. The regions of interest were selected from bone areas close to the articular surfaces of the condyles. The fractal dimension (FD) values were calculated. Results: The main effect of time on the FD value was significant [F (1, 56)=86.176, P<0.001]. This effect was qualified by a significant time×group interaction effect [F (3, 56)=9.023, P<0.001]. The decreases in FD values in all treatment groups between T0 and T1 times were significant (P=0.004). However, changes in FD values were not significant in the control group (P=0.728). Conclusion: Dextrose prolotherapy without the effect of the number of injections caused a decrease in FD values in the mandibular condyles over time.

      • KCI등재

        Regenerative Injection Therapy on Tendon Healing: Dextrose Prolotherapy versus Platelet-Rich Plasma

        Jungmin Lim,Won-Jae Lee,Min-Soo Seo,Seong Mok Jeong,Sae-Kwang Ku,Youngsam Kwon,Sungho Yun 한국임상수의학회 2023 한국임상수의학회지 Vol.40 No.2

        The tendon is a dense connective tissue that connects muscle to bone and plays an essential role in joint motion. The injured tendon heals slowly owing to its low cellularity and vascularity. This study aimed to evaluate and compare the effects of regenerative injection therapy (RIT), 20 % dextrose prolotherapy (DP), and platelet-rich plasma (PRP) injections that can promote tendon healing. Twenty-one New Zealand white rabbits were divided into the control, DP, and PRP treatment groups. The superficial digital flexor tendon (SDFT) of the right hindlimb of each rabbit was used. A round defect of 2 mm was induced. Approximately 0.2 mL of 20% dextrose and autologous PRP were injected into the proximal and distal ends of the SDFT mass. Radiographic and ultrasonographic examination and cross-sectional area (CSA) calculations were performed pre-operatively and at 2, 4, and 8 weeks. The SDFT of both limbs was transected for biomechanical and histomorphometric evaluations. The SDFT of the left limb was transected for intact control. Semi-quantitative analysis was performed to evaluate the histomorphometric properties. Additional analysis was performed using H&E, Masson’s trichrome, and immunohistochemical staining. The biomechanical evaluation showed that the treatment groups had higher tensile strength compared to the defect control group, while the PRP group had higher tensile strength than the DP group. On histological examination, the treatment groups appeared to be relatively closer to the remodeling phase of the healing process than the defect control group; the characteristics of the PRP group were closer to the remodeling phase than those of the DP group. The ultrasonographic examination showed different tendencies. Increased values in the CSA were observed during the early period in the treatment groups. This study suggests that PRP and DP can promote the healing of tendon injury, and these effects were superior with PRP than that with DP.

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