대학생의 폐활량에 대한 기초체력과 신체활동량의 관계

배주용(Ju Yong Bae),박경진(Kyung Jin Park),김지영(Ji Young Kim),이율효(Yul-Hyo Lee),김지선(Ji-Sun Kim),하민성(Min-Seong Ha),노희태(Hee-Tae Roh) 한국응용과학기술학회 (구.한국유화학회) 2021 한국응용과학기술학회지 Vol.38 No.4

본 연구의 목적은 한국 대학생들의 기초체력과 신체활동량이 폐기능과 상관관계가 있는지를 분석하고, 성별에 따른 차이를 검증하는데 있다. 건강한 참여자 312명(남성 150명[평균연령: 19.29±1.72세], 여성 160명[평균연령: 19.05±1.17세])은 신체조성, 기초체력, 신체활동량 설문지, 그리고 노력성폐활량 (FVC)과 1초간 강제호기량(FEV1)의 폐기능 검사를 수행하였다. 연구결과, 남학생의 폐기능은 우악력과 좌악력, 그리고 배근력과 관련이 있었고, 여학생의 폐기능은 모든 기초체력 하위 요인과 관련이 있었다. 또한 여성의 폐기능은 중강도 신체활동량과 관련이 있는 반면 남성의 폐기능은 신체활동량의 모든 하위 요인과 관련이 있었다. 본 연구의 주요 발견은 폐기능을 개선하기 위해서 남학생은 신체활동량을 증가시키고, 여학생은 기초체력을 향상시킬 필요가 있음을 제안한다. 대학생들의 폐기능을 유지하고 개선시키기 위해서는 폐기능 관련 인자에 대한 성별의 차이를 이해하고, 성별에 맞는 교육적 노력이 필요할 것이다. The purpose of this study was to analyze the correlation between pulmonary function, basic physical fitness (PF), and physical activity (PA), and to compare the differences by gender in Korean college students. Measurements of body composition, basic PF, PA (questionnaire), and pulmonary function tests of forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) using a Quark pulmonary function test were carried out on 312 healthy participants (150 males [mean age: 19.29±1.72 years] and 162 females [mean age: 19.05±1.17 years]). The pulmonary function of male students was related to right-handedness, left-handedness, and back strength, and the pulmonary function of female students was related to all basic PF. The pulmonary function of male students was related to all PA variables, whereas the pulmonary function of female students was related to middle-intensity PA. The findings of this study suggest that male students need to increase PA, and female students need to improve basic PF to sustain a healthy pulmonary function. Understand gender differences for pulmonary function-related factors and the gender-specific educational efforts are needed to improve and maintain pulmonary capacity in college students.

The effects of pulmonary rehabilitation during chest radiotherapy in patients with malignancy

( Myeong Geun Choi ),( Jae Seung Lee ),( Yeon-mok Oh ),( Sang-do Lee ),( Sei Won Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Radiotherapy become a treatment of choice for lung cancer or esophageal cancer when surgery cannot be an option due to poor lung function. Radiotherapy can affect pulmonary function and induce pneumonitis or pneumonia, which can be fatal in patients with poor lung function. The purpose of this study is to ensure that the reduction of pulmonary function tests (PFT) after radiotherapy can be minimized through pulmonary rehabilitation (PR). Methods: The patients, who initiated pulmonary rehabilitation with radiotherapy for lung cancer from January 2018 to June 2019, were enrolled. The results of the pulmonary function test and 6 minute walk test (6MWT) conducted within six months prior and after radiotherapy were analyzed. Results: A total of 10 patients performed pulmonary rehabilitation at least once a week during chest radiotherapy, and conducted pulmonary function test prior and after radiotherapy. The mean age was 68 and they were all male. Nine patients had non-small cell lung cancer, one had esophageal cancer and seven had COPD. The FEV1 (%) and FEV/FVC (%) were significantly increased by 10.5% (p=0.004) and 6.2% (p=0.038), respectively, compared with baseline (55.6%, 51.6%). The 6MWT results were also significantly increased from 405.6m to 466.9m (p=0.009). Conclusions: Pulmonary rehabilitation during chest radiotherapy improved pulmonary function and exercise capacity in patients with lung or esophageal cancer. This can be an important basis for further studies to identify the effects of pulmonary rehabilitation during chest radiotherapy through large study with long-term follow up period.

지역사회 거주 여성 노인의 폐 기능과 근감소증과의 상관성 연구

김시현 대한심장호흡물리치료학회 2024 대한심장호흡물리치료학회지 Vol.12 No.1

Purpose: This study aimed to compare pulmonary function between functionally sarcopenic and non-sarcopenic older individuals and to demonstrate the association of sarcopenia with pulmonary function in community-dwelling older women. Methods: The SARC-F questionnaire, handgrip strength, and gait speed were examined to assess sarcopenia. To evaluate pulmonary function, forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow(PEF) were measured. Independent t-tests or Mann–Whitney U tests were used to compare variables of pulmonary function (FVC, FEV1, FEV1/FVC, and PEF), and logistic regression analysis was performed to demonstrate the association between functional sarcopenia and pulmonary function. Results: Functionally sarcopenic older women showed significantly lower values of FVC, FEV1, and PEF than non-sarcopenic older women(p<.05). In addition, older women with low FVC, FEV1, and PEF were less likely to have sarcopenia(p<.05). Conclusion: This study demonstrated differences in pulmonary function between functionally sarcopenic and non-sarcopenic older women. In addition, a reduction in pulmonary function (FVC, FEV1, and PEF) measured by spirometry was associated with the presence of functional sarcopenia in older women. Future longitudinal studies are needed to investigate the effects of improving pulmonary function on functional sarcopenia through the management and intervention of pulmonary function in older women with sarcopenia.

The Effect of Body Composition on Pulmonary Function

박정은,정진홍,이관호,신경철 대한결핵및호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.5

Background: The pulmonary function test is the most basic test method to diagnosis lung disease. The purpose of this study was to research the correlation of the body mass index (BMI), the fat percentage of the body mass (fat%), the muscle mass, the fat-free mass (FFM) and the fat-free mass index (FFMI), waist-hip ratio (WHR), on the forced expiratory volume curve. Methods: Between March and April 2009, a total of 291 subjects were enrolled. There were 152 men and 139female (mean age, 46.3±9.92 years), and they were measured for the following: forced vital capacity (FVC), forced expiratory volume at 1 second (FEV1), and forced expiratory flow during the middle half of the FVC (FEF25-75)from the forced expiratory volume curve by the spirometry, and the body composition by the bioelectrical impedance method. Correlation and a multiple linear regression, between the body composition and pulmonary function, were used. Results: BMI and fat% had no correlation with FVC, FEV1 in male, but FFMI showed a positive correlation. In contrast, BMI and fat% had correlation with FVC, FEV1 in female, but FFMI showed no correlation. Both male and female, FVC and FEV1 had a negative correlation with WHR (male, FVC r=−0.327, FEV1 r=−0.36; p<0.05;female, FVC r=−0.175, FEV1 r=−0.213; p<0.05). In a multiple linear regression of considering the body composition of the total group, FVC explained FFM, BMI, and FFMI in order (r2=0.579, 0.657, 0.663). FEV1 was explained only fat% (r2=0.011), and FEF25-75 was explained muscle mass, FFMI, FFM (r2=0.126, 0.138, 0.148). Conclusion: The BMI, fat%, muscle mass, FFM, FFMI, WHR have significant association with pulmonary function but r2 (adjusted coefficient of determination) were not high enough for explaining lung function. Background: The pulmonary function test is the most basic test method to diagnosis lung disease. The purpose of this study was to research the correlation of the body mass index (BMI), the fat percentage of the body mass (fat%), the muscle mass, the fat-free mass (FFM) and the fat-free mass index (FFMI), waist-hip ratio (WHR), on the forced expiratory volume curve. Methods: Between March and April 2009, a total of 291 subjects were enrolled. There were 152 men and 139female (mean age, 46.3±9.92 years), and they were measured for the following: forced vital capacity (FVC), forced expiratory volume at 1 second (FEV1), and forced expiratory flow during the middle half of the FVC (FEF25-75)from the forced expiratory volume curve by the spirometry, and the body composition by the bioelectrical impedance method. Correlation and a multiple linear regression, between the body composition and pulmonary function, were used. Results: BMI and fat% had no correlation with FVC, FEV1 in male, but FFMI showed a positive correlation. In contrast, BMI and fat% had correlation with FVC, FEV1 in female, but FFMI showed no correlation. Both male and female, FVC and FEV1 had a negative correlation with WHR (male, FVC r=−0.327, FEV1 r=−0.36; p<0.05;female, FVC r=−0.175, FEV1 r=−0.213; p<0.05). In a multiple linear regression of considering the body composition of the total group, FVC explained FFM, BMI, and FFMI in order (r2=0.579, 0.657, 0.663). FEV1 was explained only fat% (r2=0.011), and FEF25-75 was explained muscle mass, FFMI, FFM (r2=0.126, 0.138, 0.148). Conclusion: The BMI, fat%, muscle mass, FFM, FFMI, WHR have significant association with pulmonary function but r2 (adjusted coefficient of determination) were not high enough for explaining lung function.

교육과 풍선을 이용한 연습이 소아 폐기능 검사에 미치는 영향

홍용희,하선미,전유훈,양현종,편복양 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.5

Purpose:The results of pulmonary function test (PFT) in children are variable according to the patient's cooperation and comprehensiveness. This study has intended to figure out the effectiveness of pre-education and training with balloons on PFT in children. Methods:One hundred six children mean aged 9.35±2.92 years were tested. All participants performed PFT twice in 30 minutes intervals. First PFT were performed after usual instruction and second PFT were performed according to randomly classified grouping; Group 1 : repeat PFT after training with balloons, Group 2 : repeat PFT after training and education, both, Group 3 : repeat PFT after education about objects and necessities of pulmonary function test, Group 4 : repeat PFT without any education and training. Results:There were no difference statistically on the results of percent of predicted FEV1, FEV1/FVC, FEF25-75% and PEFR in Group 1, 2 and 4 patients. In some cases, the average is decreased with repeated PFT. At the case of repeated PFT after education, the average of percent of predicted FEV1, FEV1/FVC, FEF25-75% and PEFR is increased. There was statistically significant difference on the value of FEV1, FEF25-75% and PEFR between first and second PFT in Group 3. Conclusion:Training with balloons before PFT causes fatigueness and lowers concentration. Understanding of PFT makes results better than training. Therefore, enough explanation and education about PFT before examination is most effective for appropriate PFT in children. (Korean J Pediatr 2008;51:506-511) Purpose:The results of pulmonary function test (PFT) in children are variable according to the patient's cooperation and comprehensiveness. This study has intended to figure out the effectiveness of pre-education and training with balloons on PFT in children. Methods:One hundred six children mean aged 9.35±2.92 years were tested. All participants performed PFT twice in 30 minutes intervals. First PFT were performed after usual instruction and second PFT were performed according to randomly classified grouping; Group 1 : repeat PFT after training with balloons, Group 2 : repeat PFT after training and education, both, Group 3 : repeat PFT after education about objects and necessities of pulmonary function test, Group 4 : repeat PFT without any education and training. Results:There were no difference statistically on the results of percent of predicted FEV1, FEV1/FVC, FEF25-75% and PEFR in Group 1, 2 and 4 patients. In some cases, the average is decreased with repeated PFT. At the case of repeated PFT after education, the average of percent of predicted FEV1, FEV1/FVC, FEF25-75% and PEFR is increased. There was statistically significant difference on the value of FEV1, FEF25-75% and PEFR between first and second PFT in Group 3. Conclusion:Training with balloons before PFT causes fatigueness and lowers concentration. Understanding of PFT makes results better than training. Therefore, enough explanation and education about PFT before examination is most effective for appropriate PFT in children. (Korean J Pediatr 2008;51:506-511)

The Effects of Simultaneous Pulmonary Rehabilitation during Thoracic Radiotherapy in the Treatment of Malignant Diseases

( Myeong Geun Choi ),( Hyang Yi Lee ),( Si Yeol Song ),( Su Ssan Kim ),( Seung Hak Lee ),( Won Kim ),( Chang-min Choi ),( Sei Won Lee ) 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.2

Background: Radiotherapy is a common treatment option for lung or esophageal cancer, particularly when surgery is not feasible for patients with poor lung function. However, radiotherapy can affect pulmonary function and thereby induce pneumonitis or pneumonia, which can be fatal in patients with respiratory impairment. The purpose of this study is to evaluate if reductions in pulmonary function after radiotherapy can be minimized through simultaneous pulmonary rehabilitation (PR). Methods: In this matched case control study, we retrospectively analyzed patients who had undergone radiotherapy for thoracic malignant disease between January 2018 and June 2019. We analyzed results from pulmonary function tests and 6-minute walking tests (6MWT) conducted within the six months before and after radiotherapy treatment. Results: In total, results from 144 patients were analyzed, with 11 of the patients receiving PR and radiotherapy simultaneously. Of the 133 patients in the control group, 33 were matched with 11 patients in the PR group. Changes in forced expiratory volume in one second (FEV₁) and FEV₁/forced vital capacity were significantly different between the PR group and the matched control group (240 mL vs. -10 mL, p=0.017 and 5.5% vs. 1.0%, p=0.038, respectively). The median distance of 6MWT in the PR group also increased significantly, from 407.5 m to 493.0 m after radiotherapy (p=0.017). Conclusion: Simultaneous PR improved pulmonary function, particularly in measures of FEV₁, and exercise capacity for patients with lung or esophageal cancer even after radiotherapy treatment. These findings may provide an important base of knowledge for further large population studies with long-term follow-up analysis in the identification of the PR’s effects during thoracic radiotherapy.

Analysis of high predicted pulmonary function: possibility of overestimation in small elderly examinees

( Youjin Chang ),( Ho Cheol Kim ),( Kyung-wook Jo ),( Jae Seung Lee ),( Yeon-mok Oh ),( Sang Do Lee ),( Sei Won Lee ) 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.1

Background/Aims: Few studies have attempted to interpret unusually high predicted pulmonary function test results. This study aimed to investigate the demographic features of patients with an unusually high predicted pulmonary function. Methods: The demographic data of subjects who underwent pulmonary function testing at a tertiary referral hospital during between January 2011 and December 2011 were retrospectively reviewed. Results: Of the 68,693 included patients, 55 (0.08%) had a percent predicted forced expiratory volume in 1 second or forced vital capacity ≥ 140%. These patients had a relatively older median age (72 years vs. 54 years, p < 0.001), female predominance (65.5% vs. 42.5%, p = 0.001), lower body weight (52.5 kg vs. 64.5 kg, p < 0.001) and shorter height (148.4 cm vs. 164.2 cm, p < 0.001). Furthermore, 6.1% of women older than 80 years with weight < 50 kg and height < 150 cm had a high predicted pulmonary function. Conclusions: A high predicted pulmonary function is not rare among elderly subjects with a small body size. Physicians should consider the demographics of the examinees, especially those of minority populations, particularly as the test results might be determined using an incorrect reference equation.

고령의 호흡기 질환 환자에서 상부 위장관 내시경 검사시 폐기능 장애 정도에 따른 산소 포화도의 변화

정윤형(Yun Hung Jung),이진석(Jin Suk Lee),한종학(Jong Hak Han),김재홍(Jae Hong Kim),정동성(Dong Sung Jung),이귀래(Gwi Lae Lee),한창완(Chang Wan Han),박운식(Woon Sik Park),조영삼(Young Sam Cho),주홍돈(Hong Don Joo),두창준(Chang Joon D 대한내과학회 1995 대한내과학회지 Vol.49 No.2

Objectives : We performed following experiment in order to find the relationship between impairment of pulmonary function test (PFT) and oxygen desaturation during upper gastrointestinal endoscopy examination among the elderly patients. Methods : Pulmonary function test and ABGA (arterial blood gas analysis) were performed before endoscopy. Arterial oxygen saturation and pulse rate were monitored with pulse oximeter before endoscopy until 5minutes its completion. We classified the population by control group and patients group by pulmonary function test. we classified patients group by mild group, moderate group and severe group (Table 2). Results : 1) Oxygen saturation was decreased significantly among all of groups, the most decreased within 1 minutes after insertion endoscopy and recovered soon before endoscopic completion. 2) The duration of worst SaO2 did not correlated with the pulmonary function test impairment. 3) The time of endoscopy did not correlated with decrease in SaO2 during endoscopy 4) There is decreased oxygen saturation in mild group, but no significant change from control group. 6) Pulse rate did not correlated with pulonary function test impairment. Conclualon : Oxygen saturation was decreased all groups in elderly populaton during upper gastro-intestinal endoscopy especially moderate or severe groups, therefore, incidence of cardio-pulmonary disease is increased. To prevent cardio-pulmonary complication, we should detect oxygen desaturation early by using pulse oximeter during upper gastrointestinal endoscopic procedure in moderate or severe group. If needed, termination of the procedure, oxygen supplement or assisted ventilation minimize cardiopulmonary complication.

기관지폐이형성증 영아에서 폐기능 측정의 유용성

김경원 ( Kyung Won Kim ),최봉석 ( Bong Seok Choi ),이용주 ( Yong Ju Lee ),은호선 ( Ho Seon Eun ),손명현 ( Myung Hyun Sohn ),박국인 ( Kook In Park ),남궁란 ( Gung Ran Nam ),이철 ( Chul Lee ),김규언 ( Kyu Earn Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2010 소아알레르기 및 호흡기학회지 Vol.20 No.1

목적: 건강한 미숙아에서 기관지폐이형성증을 가진 미숙아에 이르기까지 미숙아의 폐기능은 다양한 정도로 감소되어 있다고 알려져 있다. 영아에서 폐기능을 평가하는 방법은 오랜 노력 끝에 표준화되기에 이르렀으나 국내에서 아직까지 연구된 바 없다. 본 연구에서는 만성 폐질환을 가진 미숙아에서 폐기능을 객관적인 평가방법을 통하여 측정하고 폐기능 감소에 영향을 미치는 위험 요인들을 분석하여 그 유용성을 알아보고자 하였다. 방법: 세브란스 어린이병원에서 출생한 54명을 대상으로 하였다. 전체 대상아 중 남자는 31명, 여자는 23명이었고, 평균연령은 5.6±3.7개월이었다. 대상자에서 영아폐기능 측정기구(Exhalyser; EcoMedics, Du rnten, Switzer-land)를 이용하여 일회호흡량(tidal volume, TV) 및 기능적잔기량(functional Residual Capacity, FRC)을 측정하였고, 기관지확장제 흡입 후 같은 방법으로 측정하여 변화를 관찰하였다. 전체 대상아에서 검사와 관련된 부작용은 없었다. 결과: 대상 환아 54명 중 22명은 재태주령 28주 미만 출생아, 25명은 28주 이상 33주 미만 출생아, 7명은 33주 이상 37주 미만의 출생아였다. 또한 초극소 저체중출생아 23명, 극소 저체중출생아 23명, 저체중출생아는 8명이었다. 기관지확장제 흡입 전후 기능적잔기량 변화(delta FRC, dFRC)는 재태주령이 어릴수록(P<0.05), 출생체중이 작을수록(P<0.05) 의미있게 증가하였다. 기능적잔기량 변화는 재태주령(r=-0.35; P=0.013), 출생체중(r=-0.32; P=0.026)과 유의한 음의 상관관계를, 기계호흡일수(r=0.42; P =0.0028), 산소치료일수(r=0.43; P =0.0024)와는 양의 상관관계를 보였다. 기관지확장제 흡입 전 기능적잔기량은 출생체중이 작을수록 유의하게 작았으며, (r=0.43;P=0.0013) 기관지확장제 흡입 전 일회호흡량은 기계호흡일수와 음의 상관관계를 나타내었다. (r=-0.39; P=0.0048) 결론: 미숙아에서 출생체중이 작을수록, 재태주령이 어릴수록, 기계호흡일수와 산소치료일수가 길수록 기관지확장제에 의한 기능적잔기량의 가역성이 증가하였다. 기능적잔기량 가역성은 만성 폐질환 미숙아에서 안전하게 측정할 수 있는 유용한 폐기능 지표로 생각된다. Purpose: Pulmonary function is decreased in varying degrees in healthy premature infants as well as those with bronchopulmonary dysplasia. The evaluation of pulmonary function in infants is finally standardized after strenuous efforts, but it has not yet been in Korea. In this study, we aimed at the evaluation of the utility of pulmonary function tests in premature infants with chronic lung disease by objectively measuring pulmonary function and by analyzing the risk factors that may decrease lung function. Methods: Fifty-four premature infants born in Severance Hospital were selected. Among the 54 infants, 31 were male and 23 were female, and their mean age was 5.6±3.7 years. Exhalyser was used to measure tidal volume and functional residual capacity, and then their change after the inhalation of bronchodilators was evaluated. There was no test related complication in all subjects. Results: Among the 54 subjects, 22 were at the gestational age of <28 weeks, 25 were at the gestational age between 28 and 33 weeks, and 7 were at the gestational age between 33 and 37 weeks. As for birth weight, 23 had extreme low birth weight, 23 had very low birth weight, and 8 had low birth weight. The delta functional residual capacities (FRCs) before and after the inhalation of bronchodilator were significantly increased in infants with younger gestational age (P<0.05) and lower birth weight (P<0.05). There was a significant negative correlation between gestational age and birth weight, and a significant positive correlation with the duration of ventilator care and that of oxygen therapy. The delta FRC before the inhalation of bronchodilator was significantly lower in infants with lower birth weight, and the tidal volume before the inhalation of bronchodilator correlated negatively with the duration of ventilator care. Conclusion: The reversibility of FRC is increased in premature infants with lower birth weight, younger gestational age, and longer duration of ventilator care and oxygen therapy. The reversibility of FRC may be a useful parameter of pulmonary function that can be safely measured in premature infants with chronic lung disease. [Pediatr Allergy Respir Dis(Korea) 2010;20:68-75]

기관지폐이형성증 영아에서 폐기능 측정의 유용성

김경원,최봉석,이용주,은호선,박국인,남궁란,이철,김규언,손명현 대한 소아알레르기 호흡기학회 2010 Allergy Asthma & Respiratory Disease Vol.20 No.1

목 적:건강한 미숙아에서 기관지폐이형성증을 가진 미숙아에 이르기까지 미숙아의 폐기능은 다양한 정도로 감소되어 있다고 알려져 있다. 영아에서 폐기능을 평가하는 방법은 오랜 노력 끝에 표준화되기에 이르렀으나 국내에서 아직까지 연구된 바 없다. 본 연구에서는 만성 폐질환을 가진 미숙아에서 폐기능을 객관적인 평가방법을 통하여 측정하고 폐기능 감소에 영향을 미치는 위험 요인들을 분석하여 그 유용성을 알아보고자 하였다. 방 법:세브란스 어린이병원에서 출생한 54명을 대상으로 하였다. 전체 대상아 중 남자는 31명, 여자는 23명이었고, 평균연령은 5.6±3.7개월이었다. 대상자에서 영아폐기능 측정기구(Exhalyser; EcoMedics, Dürnten, Switzerland)를 이용하여 일회호흡량(tidal volume, TV) 및 기능적잔기량(functional Residual Capacity, FRC)을 측정하였고, 기관지확장제 흡입 후 같은 방법으로 측정하여 변화를 관찰하였다. 전체 대상아에서 검사와 관련된 부작용은 없었다. 결 과:대상 환아 54명 중 22명은 재태주령 28주 미만 출생아, 25명은 28주 이상 33주 미만 출생아, 7명은 33주 이상 37주 미만의 출생아였다. 또한 초극소 저체중출생아 23명, 극소 저체중출생아 23명, 저체중출생아는 8명이었다. 기관지확장제 흡입 전후 기능적잔기량 변화(delta FRC, dFRC)는 재태주령이 어릴수록(P<0.05), 출생체중이 작을수록(P<0.05) 의미있게 증가하였다. 기능적잔기량 변화는 재태주령(r=-0.35; P=0.013), 출생체중(r=-0.32; P=0.026)과 유의한 음의 상관관계를, 기계호흡일수(r= 0.42; P=0.0028), 산소치료일수(r=0.43; P=0.0024)와는 양의 상관관계를 보였다. 기관지확장제 흡입 전 기능적잔기량은 출생체중이 작을수록 유의하게 작았으며,(r=0.43; P=0.0013) 기관지확장제 흡입 전 일회호흡량은 기계호흡일수와 음의 상관관계를 나타내었다.(r=-0.39; P= 0.0048)결 론:미숙아에서 출생체중이 작을수록, 재태주령이 어릴수록, 기계호흡일수와 산소치료일수가 길수록 기관지확장제에 의한 기능적잔기량의 가역성이 증가하였다. 기능적잔기량 가역성은 만성 폐질환 미숙아에서 안전하게 측정할 수 있는 유용한 폐기능 지표로 생각된다. Purpose:Pulmonary function is decreased in varying degrees in healthy premature infants as well as those with bronchopulmonary dysplasia. The evaluation of pulmonary function in infants is finally standardized after strenuous efforts, but it has not yet been in Korea. In this study, we aimed at the evaluation of the utility of pulmonary function tests in premature infants with chronic lung disease by objectively measuring pulmonary function and by analyzing the risk factors that may decrease lung function. Methods:Fifty-four premature infants born in Severance Hospital were selected. Among the 54 infants, 31 were male and 23 were female, and their mean age was 5.6±3.7 years. Exhalyser was used to measure tidal volume and functional residual capacity, and then their change after the inhalation of bronchodilators was evaluated. There was no test related complication in all subjects. Results:Among the 54 subjects, 22 were at the gestational age of <28 weeks, 25 were at the gestational age between 28 and 33 weeks, and 7 were at the gestational age between 33 and 37 weeks. As for birth weight, 23 had extreme low birth weight, 23 had very low birth weight, and 8 had low birth weight. The delta functional residual capacities (FRCs) before and after the inhalation of bronchodilator were significantly increased in infants with younger gestational age (P<0.05) and lower birth weight (P<0.05). There was a significant negative correlation between gestational age and birth weight, and a significant positive correlation with the duration of ventilator care and that of oxygen therapy. The delta FRC before the inhalation of bronchodilator was significantly lower in infants with lower birth weight, and the tidal volume before the inhalation of bronchodilator correlated negatively with the duration of ventilator care. Conclusion:The reversibility of FRC is increased in premature infants with lower birth weight, younger gestational age, and longer duration of ventilator care and oxygen therapy. The reversibility of FRC may be a useful parameter of pulmonary function that can be safely measured in premature infants with chronic lung disease.