2-Pyridone을 이용한 Nucleic Acid Bases간의 Multiple Hydrogen Bonding에 관한 연구

황정숙 대전대학교 기초과학연구소 2000 自然科學 Vol.11 No.2

핵산 염기간의 multiple hydrogen bonding model로서 2-pyridone의 N-methyl-2-pyrrolidone 에 대한 hydrogen bonding association을 25℃ 사염화 탄소 용액에서 측정하여 94 M^(?)의 값을 얻었다. Complexation constant 값을 고정한 후, pK_(a) of N-H acids와 bases의 log K 간의 Bronsted relationship을 이용하여, 2-Pyridone의 dimerization constant 값 k_(d)를 계산한 결과 1.2×10^(5) M^(-1)로 나왔다. 2-pyridone의 oxygen bases에 대한 hydrogen bonding equilbrium constant는 다른 N-H acid의 같은 bases에 대한 예상처보다 큰 것으로 보였다. Hydrogen bonding association of 2-pyridone to N-methyl-2-pyrrolidone in carbon tetrachloride at 25° was measured( 94N^(-l)). After fixing the complaxation constant, the dunerization constant of 2-pyridone was also calculated from the relationship between the pK_(a), of N-H acids and log K for bases and got the value of kd as 12x10^(5) with the standard deviation of 0.002. it seems that the hydrogen bonding equilibrium constant for 2-pyridone to the oxygen bases is larger than the expected from the other N-H acid to the same base.

3-메틸아미노프로필아민과 N-메틸-2-피롤리돈을 포함한 저수계 흡수제의 CO2 포집 특성

홍연기,왕슈아이,홍정현,유정균 한국화학공학회 2023 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.61 No.4

Conventional aqueous amine-based CO2 capture has a problem in that a large amount of renewable energy is required for CO2 stripping and solvent regeneration in its industrial applications. This work proposes a water-lean absorbent that can reduce regeneration energy by lowering the water content in the absorbent with high absorption capacity for CO2. To this purpose, this water-lean solvent introduced NMP (N-methyl-2-pyrrolidone), which has a higher physical solubility in CO2 and a low specific heat capacity comparing to water, along with 3-methylaminopropylamine (MAPA), a diamine, into the absorbent. The circulating absorption capacity and absorption rate for CO2 of this water-lean solvent were measured using a packed tower. When NMP was added to the absorbent, the absorption rate was improved. In the case of the absorbent containing 2.5M MAPA was used, the maximum circulating absorption capacity was obtained when 10 wt% of NMP was included in absorbent. The overall mass transfer coefficient increased as the concentration of NMP increased. However, at loading values higher than 0.5, the increment in mass transfer coefficient decreased as the concentration of NMP increased. When the lean loading value is low, the mass transfer resistance due to viscosity of the absorbent is low, so the overall mass transfer coefficient increases with the addition of NMP. However, as the lean loading value increases, the viscosity of the absorbent increases, and the diffusivity of CO2 and MAPA decreases, resulting in sharply decreasing of the overall mass transfer coefficient.

N-methyl-2-pyrrolidone 제제의 경피흡수촉진효과

이근수 ( Geun Soo Lee ),이동환 ( Dong Hwan Lee ),김경범 ( Kyoung Bum Kim ),고현주 ( Hyun Joo Ko ),표형배 ( Hyeong Bae Pyo ) 대한화장품학회 2010 대한화장품학회지 Vol.36 No.2

피부에서 표피를 통한 물질의 수송은 피부의 여러 가지 보호 작용으로 인해 경피 흡수가 쉽게 이루어지지 않아 결과적으로 생리 활성 성분이 그 효과를 발휘하는 진피층까지 도달하기 어렵다. 본 연구는 피부에서 매우 낮은 농도가 투과되는 친수도가 높은 약물(알부틴)의 경피흡수를 촉진하는 화학적 촉진제의 in vitro 흡수 양상에 대한 연구이다. 화학적 촉진제로 N-methyl-2-pyrrolidone (NMP)을, 경피흡수장치는 Franz diffusion cell을 사용하였다. NMP는 약물의 경피흡수에 상당히 영향을 준다는 것을 알 수 있었다. NMP는 피부 지질층의 유동성에 영향을 주지 않고 약물의 보조흡수제로 작용하여 알부틴의 경피흡수촉진비율을 약 1.3 ~ 1.5배 증가 시켰지만 지연 시간의 변화는 없었다. 따라서 NMP는 친수성 생리활성 물질의 효과적인 화학적 경피흡수 촉진제로 작용하였으며, 향후 화장품 제형 및 약물전달체계에 응용이 기대된다. The formidable barrier property of the stratum cornemum and the high hydrophilicity of active ingredient make it difficult to permeate through the skin and reach to its site of action. The aim of this study was to investigate the effect of chemical penetration enhancers on the skin permeation of a hydrophilic cosmetic active ingredient, such as arbutin. The enhancing effects of N-methyl-2-pyrrolidone (NMP) on the permeation of a hydrophilic cosmetic active ingredient were evaluated by using Franz diffusion cell. The study indicated that NMP has considerable influence on the skin permeability. NMP was not only the most effective enhancer but also increased the skin permeability of arbutin approximately 1.3 ~ 1.5 fold compared with control without penetration enhancer. The lag time did not change with NMP, which suggested no effect of NMP on skin lipid fluidity. This suggest that arbutin co-permeated with NMP. The results indicate NMP is effective enhancer of a hydrophilic cosmetic active ingredient in penetration, with potential applications for drug delivery system.

DME 생산공정에서 노말 메틸 피로리돈(N-Methyl-2-Pyrrolidone) 용매를 이용한 이산화탄소 제거공정 연구

정종태(Jongtae Jung),노재현(Jaehyun Roh),조정호(Jungho Cho) 한국청정기술학회 2012 청정기술 Vol.18 No.4

본 연구에서는 디메틸에테르(dimethyl ether, DME) 생산 공정에 포함되어 있는 이산화탄소 제거공정에서 이산화탄소 제거용 용매로써 노말 메틸 피로리돈(N-methyl-2-pyrrolidone, NMP)수용액을 사용하는 공정에 대한 전산모사를 수행하였다. 한편, 이산화탄소 제거공정을 모사하기 위해서 Invensys 사의 PRO/II with PROVISION 9.1을 사용하였으며, 열역학 모델식으로는 NRTL 액체활동도계수 모델식과 Soave-Redlich-Kwong 상태방정식을 사용하였다. 그리고 기체 성분들의 NMP 용매에 대한 용해도 추산을 위해서 헨리의 법칙을 추가적으로 사용하였다. NRTL 액체 활동도계수 모델식의 이성분계 상호작용 매개변수를 결정하기 위하여 상평형 실험 데이터의 회귀분석을 수행하였으며 결정한 매개변수의 정확성은 실험 데이타와의 비교를 통해 검증하였다. 또한 재비기의 열 소모량을 최소화시키기 위한 최적의 원료 주입단 위치를 결정하였다. In this study, simulation works have been performed for the CO2 removal process contained in the DME production process using NMP (N-methyl-2-pyrrolidone) as a solvent. PRO/II with PROVISION release 9.1 at Invensys was used as a chemical process simulator and NRTL activity coefficient model with Henry"s law option and Soave-Redlich-Kwong equation of state were used for thermodynamic models. For the determination of the binary interaction parameters in NRTL model, regression works have been performed to match the experimental thermodynamic data. Optimal feed tray location which minimizes the reboiler heat duty was determined.

Highly Convenient and Large Scale Synthesis of 5-chloroindole and its 3-substituted Analogues

Keetha, Laxminarayana,Palle, Sadanandam,Ramanatham, Vinodkumar,Khagga, Mukkanti,Chinnapillai, Rajendiran Korean Chemical Society 2011 대한화학회지 Vol.55 No.2

A large scale and commercially feasible synthesis of 5-chloroindole and its 3-substituted analogues has been described via a halogen - halogen exchange reaction from 5-bromoindole and its derivatives using cuprous chloride and dipolar aprotic solvent N-methyl-2-pyrrolidone in one pot with good yields. CuCl과 N-methyl-2-pyrrolidone을 이용하여 5-bromoindole을 halogen - halogen 교환반응을 통하여 5-chloroindole계 화합물을 합성하는 one-pot대량합성방법을 개발하였다.

비휘발성 용매(NMP)를 사용한 인산형 연료전지(PAFC)용 전해질 매트릭스 제조 및 특성

윤기현,양병덕 한국세라믹학회 2000 한국세라믹학회지 Vol.37 No.1

Preparation and characteristics of a matrix retaining electrolyte using SiC whisker, PES binder, and NMP(n-methyl-2-pyrrolidone) as a non-volatile solvent for a phosphoric acid fuel cell were investigated. The conditions of binder and plasticizer, and the effects of substituting a volatile solvent by a non-volatile solvent were also studied. The minimum amount of the binder was about 17 wt% for the proper bubble pressure and surrounding SiC whiskers. And the maximum amount of the plasticizer was about 10wt% to be fitted into the polymer chain of the binder. The matrix prepared by using a non-volatile solvent needed longer time to dry, and its pore size was smaller compared with that of the matrix prepared by using volatile solvent. The small pore size resulted in decrease of the overall pore volume. The ionic conductivity in the condition of the same thickness was decreased due to decrease of phosphoric acid absorbancy. As the internal resistance of the electrolyte increased, the fuel cell performance slightly decreased.

전극 합성 유기용매 최적화를 통한 고성능 고분자 전해질막 연료전지 개발

송자윤(Ja Yun Song),심정우(Jung Woo Shim),심준형(Joon Hyung Shim) 한국자동차공학회 2023 한국자동차공학회 부문종합 학술대회 Vol.2023 No.5

Autoxidation in amide-based electrolyte and its suppression for enhanced oxygen efficiency and cycle performance in non-aqueous lithium oxygen battery

Kim, Dong Wook,Lee, Dong Hun,Ahn, Su Mi,Kim, Do Youb,Suk, Jungdon,Choi, Dong Hoon,Kang, Yongku Elsevier 2017 Journal of Power Sources Vol.347 No.-

<P><B>Abstract</B></P> <P>In spite of several desirable properties such as high stability against superoxide anion and low vapor pressure, <I>N</I>-methyl-2-pyrrolidone (NMP) electrolyte is reported not suitable for use in lithium-oxygen (Li-O<SUB>2</SUB>) batteries because of severe degradation upon cycling and low oxygen efficiency. In this work, we find that NMP electrolyte is reactive with O<SUB>2</SUB> gas in the presence of lithium metal and such O<SUB>2</SUB>-consuming reaction (<I>i.e.,</I> autoxidation) is a possible cause for the poor performance in Li-O<SUB>2</SUB> batteries with NMP electrolyte. The autoxidation of NMP is verified by direct measurement of the depletion of O<SUB>2</SUB> gas in the hermetically sealed symmetric Li/Li cells via in-situ gas pressure analysis. In-situ differential electrochemical mass spectroscopy (DEMS) experiment reveals that the autoxidation resulted in significant O<SUB>2</SUB> consumption upon discharge, very low O<SUB>2</SUB> efficiency upon charge, and eventually fast capacity fading. Lithium nitrate (LiNO<SUB>3</SUB>), which provides a protective layer on the surface of lithium metal, is employed to suppress the autoxidation, leading to significantly enhanced oxygen efficiency and cycle life.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NMP electrolyte is reactive with O<SUB>2</SUB> gas in the presence of lithium metal. </LI> <LI> Autoxidation is verified by in-situ gas pressure analysis and DEMS. </LI> <LI> Autoxidation results in low O<SUB>2</SUB> efficiency and fast capacity fading. </LI> <LI> LiNO<SUB>3</SUB> is employed to suppress the autoxidation. </LI> <LI> LiNO<SUB>3</SUB> is efficient in enhancing oxygen efficiency and cycle life. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Isobaric vapor-liquid equilibria for the formic acid-N-methyl-2-pyrrolidone binary system at 50, 20, and 10 kPa andmodeling using the NRTL-HOC and PC-SAFT models

( Denis Usosky ),정광덕 한국공업화학회 2022 한국공업화학회 연구논문 초록집 Vol.2022 No.-

Engineered Self-Expander Hydrogel for Sustained Release of Drug Molecules

Ji-eun KIM,Dongmyong KIM,Hochang KANG,Jonghoon CHOI 한국생물공학회 2015 한국생물공학회 학술대회 Vol.2015 No.4