반코마이신 내성 장내구균 분리 환자에서 황색포도알균의 내성

김동욱,신선혜,김혜진,류선,이선희,장철훈,김영대,곽임수 대한감염학회 2004 감염과 화학요법 Vol.36 No.1

목적 : Vancomycin-resistant enterococci (VRE)로부터 S. aureus로의 vacomycin 내성 유전자의 전파는 오래전부터 예견되어져 왔으며 큰 걱정거리로 남아있다. 최근에 vanA 유전자를 가지고 있는 vancomycin-resistant S. aureus 2주가 미국에서 분리되었다. 이 연구의 목적은 VRE를 보균하고 있는 환자들에서 S. aureus 보균양상과 항균제 내성을 알아보는데 그 목적이 있다. 재료 및 방법 : 2001년 1월부터 2001년 12월까지 부산대학교병원에 입원하였던 환자들 중 임상검체에서 VRE가 분리된 환자 7명과 2001년 9월부터 12월까지 외과 중 환자실에 입원하였던 환자들 중 VRE 감시배양을 시행하였던 20명의 환자들을 대상으로 하였다. 환자들은 전비공, 액와부, 회음부, 직장에서 매주 면봉으로 검체를 채취하였다. 선별배지에서 검체를 배양하여 S. aureus를 분리하였고 원판 확산법을 이용하여 methicillin 감수성을 측정하였다. Broth microdilution 법으로 vancomycin MIC를 측정하였다. 결과 : 총 27명에서 73회의 방문과 292회의 배양이 시행되었으며 총 67주의 S. aureus가 분리되었다. 이중 64주(95.5%)가 methicillin 내성이었다. 전비공 MRSA 보균율은 VRE를 보균하고 있었던 환자는 19명 중 11명(58%)에서, VRE를 보균하지 않았던 환자는 8명 중 3명(37.5%)으로 VRE 보균자에서 보균율이 더 높았다. 총 64주의 MRSA의 vancomycin MIC의 분포는 0.5-2㎍/mL였으며 2㎍/mL를 초과하는 균주는 발견되지 않았다. 64주 중 vancomycin MIC가 1㎍/mL인 균주가 54주(84.4%)로 가장 많았으며 2㎍/mL 6주(9.4%), 0.5㎍/mL 4주(6.3%)의 순이었다. 결론 : VRE 환자에서 S. aureus의 보균율은 비보균자 보다 높았으며 분리된 균주들은 대부분 MRSA였다. VRSA 균주는 발견되지 않았다. Background : The transfer of vancomycin resistance from vancomycin-resistant enterococci (VRE) to Staphylococcus aureus has been predicted. The purpose of this study is to determine the prevalence and antibiotics resistance of S. aureus among patients colonized with VRE. Methods : Between January 2001 and December 2001, a prospective study was performed at Pusan National University Hospital on 27 patients. Surveillance swabs from nasal cavity, axilla, perineum, and rectum were obtained at weekly intervals. Methicillin susceptability of S. aureus was determined by oxacillin disk diffusion test and minimum inhibitory concentration (MIC) for vancomycin by microdilution broth test. Results : Total of 292 swab cultures were performed and 67 S. aureus isolates were collected. 64 isolates (95.5%) were resistant to methicillin. The prevalence of nasal MRSA carrier in 19 patients colonized with VRE was higher than that in 8 patients not colonized with VRE (58% vs. 37.5%). In 64 MRSA isolates, MIC (㎍/mL) for vancomycin ranged from 0.5 to 2. No isolates with MIC >2 ㎍/mL were observed. MIC of 1 ㎍/mL was shown (observed) in 54 isolates, 2 ㎍/mL in 6 isolates, and 0.5 ㎍/mL in 4 isolates. Conclusion : The prevalence of S. aureus with colonization of VRE is higher than that without colonization of VRE. Most of S. aureus isolates were resistant to methicillin. VRSA isolates were not observed.

Staphylococcus aureus와 Coagulase-Negative Staphylococcus Species에 대한 Arbekacin의 시험관내 항균력

위성헌,강진한,허동호,이동건,김상일,김양리,최정현,김종현,유진흥,허재균,신완식,강문원 대한감염학회 2001 감염 Vol.33 No.4

Background : Most strains of methicillin-resistant Staphylococcus aureus (MRSA) now exhibit high-level resistance to various antibiotics, such as β -lactam antibiotics, aminoglycosides, macrolides, tetracyclines and quinolones. Recent reports describing the therapeutic failure of vancomycin for MRSA infections have arisen considerable concerns regarding the emergence of MRSA strains, which will require new therapeutic agents. Arbekacin, an aminoglycoside antibiotic, has antibacterial activity against both gram-positive and gram-negative bacteria and is stable in the presence of aminoglycoside inactivating enzymes produced by S. aureus. In this study, we compared the antibacterial activity of arbekacin with those of vancomycin, gentamicin, and amikacin against Staphylococcus aureus (S. aureus) and coagulase-negative staphylococci (CNS). Methods : For a collection of 549 S. aureus and 251 CNS isolates from three Catholic University Hospitals in Korea, minimum inhibitory concentrations (MICs) of arbekacin, vancomycin, amikacin and gentamicin were determined by agar dilution method using Mueller-Hinton agar according to NCCLS (National Committee for Clinical Laboratory Standards, USA)criteria. Results : Among 549 S. aureus isolates, 278 isolates were MRSA and 271 isolates were methicil sensitive S. aureus (MSSA). MIC50 & MIC90 of arbekacin against 549 S. aureus were 0.5 & 1 ㎍/mL, and MIC50 & MIC90 of vancomycin were 1 & 1 ㎍/mL. MIC of arbekacin against 549 S. aureus isolates ranges from 0.03 to 4 ㎍/mL, and MIC of vancomycin against 549 S. aureus ranges from 0.25 to 2 ㎍/mL. MIC90 of amikacin against 549 S. aureus was 32㎍/mL, and that of gentamicin was 128 ㎍/mL. MICs of amikacin and gentamicin were variable, ranging from 0.125 to 256, and otherwise arbekacin and vancomycin revealed relatively narrow range of MICs. MIC90 of arbekacin against 278 MRSA isolates & 271 MSSA were 1 & 0.5 ㎍/mL, and those of vancomycin against MRSA & MSSA were 1 & 1 ㎍/mL. MIC90 of amikacin against 278 MRSA & 271 MSSA isolates were 32 & 4 ㎍/mL, and that of gentamicin against MRSA & MSSA isolates were 128 & 32 ㎍/mL respectively. Among 251 CNS isolates, 122 isolates were MRCNS and 129 were MSCNS. MICSO & MIC90 of arbekacin against 251 CNS isolates were 0.25 & 2 ㎍/mL, and those of vancomycin were 1 & 2 ㎍/mL. MIC of arbekacin against 251 CNS isolates ranges from 0.015 to 32 ㎍/mL, and that of vancomycin isolates ranges from 0.25 to 2 ㎍/mL, MIC90 of arbekacin against 122 MRCNS & 129 MSCNS isolates were 2&0.3 ㎍/ML, and those of vancomycin were 2&s ㎍/ML. MIC90 of amikacin against 251 CNS isolates was 32 ㎍/ML, and that of gentamicin was 128 ㎍/ML for CNS. MIC90 of amikacin against 122 MRCNS & 129 MSCNS isolates were 128 & 8㎍/mL, and those of gentamicin ere 256 & 32 ㎍/mL. Conclusion : Considering above results, arbekacin can be useful agent against most strains of MRSA and MRCMS, which exhibit high-level resistance to amikacin and gentamicin. (Korea J Infect Dis 33:254~260, 2001)

대학생들의 비강으로부터 분리된 메티실린 내성 황색포도알균의 분자유전학적 특성

이은광,오대환,박소현,정선진,최연임 한국의료정보교육협회 2021 보건의료생명과학논문지 Vol.9 No.2

Staphylococcus aureus and methicillin resistant S. aureus (MRSA) is a major cause of nosocomial infections and is one of the most commonly isolated bacterial species in the hospital and continues to be an important pathogens in both community and hospital-acquires infection. The purpose of this study is to investigate the carrier rate of S. aureus and MRSA in the community and molecular genetic characteristics of these organisms. The identification of S. aureus and MRSA were done by the procedures in Murray’s manual of Clinical Microbiology and antibiotic susceptibility patterns by the Clinical and Laboratory Standards Institute(CLSI). MRSA strains were confirms by oxacillin disk diffusion method. forty-six strains (71.9%) of S. aureus were isolated from the nasal specimens of 64 students in health science university. twenty-two strains (22%) of 46 S. aureus were resistant to penicillin and oxacillin. twenty-two strains of the 46 S. aureus isolates were methicillin-resistant Staphylococcus aureus (MRSA). The mecA genes in MRSA were detected by polymerase chain reaction (PCR). Community and nosocomial infections caused by methicillin-resistant Staphylococcus aureus are a significant problem worldwide. There continuous epidemiological study is to investigate the prevalence of MRSA in community acquired infections.

Methicillin 내성 Staphylococcus aureus의 검출을 위한 분자유전학적 기법에 관한 연구

조태흠,김민정,오양효 한국생명과학회 1999 생명과학회지 Vol.9 No.4

Thirty strains of methicillin resistant Staphylococcus aureus were obtained from the clinical isolates. In order to investigate the pursuit of the pathogens of nosocomial infection, these strains were studied for antibiotic sensitivity as well as its resistant pattern. Among the methods of hybridization which directly confirm the specific antibiotic resistant genes by means of the recently developed specific probe DNA, dot blot hybridization and southern blot hybridization were performed and these two methods were compared in their sensitivity and specificity. Strains that is sensitive to cephalothin to the subject of methicillin resistant Staphylococcus aureus were in 43%. Those that are sensitive to cefoperazone and cefuroxime were 26% and 23%, respectively. In case of MIC, MIC50 of cefoperazone was 8 $\mu\textrm{g}$/$m\ell$, and MIC90 was 128 $\mu\textrm{g}$/$m\ell$ to be the lowest. As the results of plasmid DNA electrophoresis, most of methicillin resistant Staphylococcus aureus strains had more than 4 plasmids. These plasmids digested by BamHI, methicillin resistant Staphylococcus aureus is distributed as 10 fragments with the size of 65 kb to 1.5 kb. Dot blot hybridization were performed to examine the existence of mecA gene to show the detection rate of 50%. Southern blot hybridization were done to see if DNA bands which amplify the activity of digoxigenium-labeled probe by PCR were actually PCR products of mecA gene and it showed the detection rate of 53%. It can be concluded that the southern blot hybridization seemed to be better in sensitivity and specificity when it is compared with the results of dot blot hybridization.

Methicillin - Resistant Staphylococcus aureus ( MRSA ) 의 Ciprofloxacin 에 대한 신속한 내성획득에 관한 고찰

최철원(Chul Weon Choi),정희진(Hee Jin Jung),우흥정(Heung Jung Woo),강세용(Sei Yong Kang),김우주(Woo Joo Kim),박승철(Seung Chul Park) 대한내과학회 1993 대한내과학회지 Vol.45 No.1

Objectives: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) strains are serious medical problems because only a few effective therapeutic agents are available. Some fluoroquinolones, such as ofloxacin, ciprolfloxacin and others, have been used for the treatment of MRSA infections. However, along with their wide use, the emergence of fluoroquinolone-resistant strains of Staphylococcus aureus has been recently reported. Methods: Authors studied the development of ciprofloxacin resistance in MRSA and prevalence of MRSA among staphylcocci isolates retrospectively in Guro hospital from June 1990 to June 1992. Total 929 isolates of S. aureus were tested for the resistance to ciprofloxacin by Kirby-Bauer disc diffusion method. Results: Among 929 isolates, 425 (45.7%) isolates were MRSA and 504 (54.3%) isolates were MSSA (methicillin-susceptible S. aureus). Among 660 isolates from in-patients, MRSA were 336 (50.9%) isolates and MSSA were 324 (49.1%) isolates. Among 269 isolates from out-patients, MRSA were 89 (33.1%) isolates and MSSA were180 (66.9%) isolates. 192 (45.2%) isolates of MRSA and 9 (1.6%) isolates of MSSA were tested for the resistance to ciprofloxacin by disc diffusion method. Prevalence of ciprofloxacin-resistant MRSA by month is 0% for the first 4 months, 6.7% on October 1990, 18.5% on November 1990, 53.3% on December 1990, 66.7% on June 1991, and 70% on June 1992. Among 171 patients with ciprofloxacin-resistant S. aureus isolates, 148 (86.5%) patients had nosocomial acquisition. And only 31 (18%) patients had a history of previous ciprofloxacin use. Ciprofloxacin-resistant MRSA isolates were most commonly recovered from sputum, wound, ear and eye discharge, urine, and closed pus specimens in order of incidence. Conclusion: Ciprofloxacin resistance of MRSA which was isolated from tertiary hospital was also rapidly developed in Korea. More judicious use of new antibiotics and further study for the mechanism of ciprofloxacin resistance are required.

Rates of Staphylococcus Aureus and Methicillin-resistant Staphylococcus Aureus Nasal Carriage Infections among Nursing Students

보안공학연구지원센터(IJBSBT) 보안공학연구지원센터 2015 International Journal of Bio-Science and Bio-Techn Vol.7 No.5

Staphylococcus aureus is considered one of the most frequently occurring community- and hospi-tal-associated pathogens. Infectious diseases caused by Staphylococcus aureus are in various forms, ranging from mild skin infection, endocarditis, to fulminant septicemia. The purpose of this study was to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage rates among nursing students. The relevant data were collected using a questionnaire, and microbial samples were collected from the nasal cavities of 215 nursing students. From the collected specimens, strains of Staphylococcus aureus were isolated and subjected to antibiotic susceptibility tests. Of 215 students, 62 (28.8%) were nasal carriers of Staphylococcus aureus, and three students (1.4%) were nasal carriers of MRSA. None of the three students with MRSA had any history of hospitalization over the past 12 months and had not provided nursing care for MRSA patients. However, two students among these three had received antibiotics. All MRSA isolated from these three students were mupirocin-sensitive. According to the results, the rates of MRSA nasal carriage among the nursing students were lower than those of patients or other healthcare workers. Thus, routine screening for nasal MRSA culturing is not recommended in students who practice in the clinic. However, students should be educated about infection control in order to prevent practice-related MRSA nasal.

Antibiotic Susceptibility of Staphylococcus aureus in Atopic Dermatitis: Current Prevalence of Methicillin-Resistant Staphylococcus aureus in Korea and Treatment Strategies

( Mi Young Jung ),( Jong Youn Chung ),( Hae Young Lee ),( Jiho Park ),( Dong Youn Lee ),( Jun Mo Yang ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.4

Background: Staphylococcus aureus is a well-known microbe that colonizes or infects the skin in atopic dermatitis (AD). The prevalence of methicillin-resistant S. aureus (MRSA) in AD has recently been increasing. Objective: This study aimed to determine the antimicrobial susceptibility patterns in AD skin lesions and evaluate the prevalence of MRSA in Korea. We also recommend proper first-line topical antibiotics for Korean patients with AD. Methods: We studied S. aureus-positive skin swabs (n=583) from the lesional skin of infants, children, and adults who presented to our outpatient clinic with AD from July 2009 to April 2012. Results: S. aureus exhibited high susceptibility against most antimicrobial agents. However, it exhibited less susceptibility to benzylpenicillin, erythromycin, clindamycin, and fusidic acid. The prevalence of MRSA was 12.9% among 583 S. aureus isolates, and the susceptibility to oxacillin was significantly lower in infants in both acute and chronic AD lesions. Conclusion: S. aureus from AD has a high prevalence of MRSA and multidrug resistance, especially in infants. In addition, the rate of fusidic acid resistance is high among all age groups, and mupirocin resistance increases with age group regardless of lesional status. This is the first study comparing the antimicrobial susceptibility rates of S. aureus isolates from AD cases with respect to age and lesion status in Korea. (Ann Dermatol 27(4) 398∼403, 2015)

Antibacterial Effect of Some Plant Extracts against Actinobacillus actinomycetemcomitans and Methicillin-resistant Staphylococcus aureus

Han, Seung-Ho,Hur, Jong-Moon,Yang, Chun-Ho,Lee, Sook-Hee,You, Yong-Ouk,Park, Jong-Cheol,Jeong, Seung-Il,Kook, Joong-Ki,Kim, Kang-Ju 대한구강생물학회 2003 International Journal of Oral Biology Vol.28 No.3

Antibiotic resistance is the one of important problems in dental and medical fields. Therefore, new agents are needed to treat Actinobacillus actinomycetemcomitans (A. actino-mycetemcomitans) and methicillin-resistant Staphylococcus aureus (MRSA) from oral infection. The methanol (MeOH) extract and 3 fractions [chloroform (CHCI_(3)), n-butanol (n-BuOH) and water (H_(2)0)] of Phellinus linteus (P. linteus), the xanthone from Hypericum ascyron (H. ascyron) L. and the bisdemethoxycurcumin and curcumin from Curcuma longa (C. longa) were investigated for antibacterial activity against A. actinomycetemcomitans and methicillin-resistant Staphylococcus aureus (S. aureus). The n-butanol fraction of P. linteus showed the potent antibacterial activity (MIC, 63-125㎎/㎖) against S. aureus, and the methanol extract showed the antibacterial activity (MIC, 500 ㎎/㎖) against all tested strains. The xanthone showed the antibacterial activity against all tested strains. The bisdemethoxycurcumin and curcumin showed the antibacterial activity against A. actinomycetemcomitans, one standard Methicillin-supceptible Staphylococcus aureus (MSSA) and three methicillin-resistant Staphylococcus aureus (MRSA). These results suggest that extracts of P. linteus, C. longa and H. ascyron might be useful in oral infection.

약용식물의 항생제 내성균주에 대한 항균활성

지영주,이지원,이인선,Ji, Young-Ju,Lee, Ji-Won,Lee, In-Seon 한국생명과학회 2007 생명과학회지 Vol.17 No.3

본 연구는 병원 내 감염의 주된 원인균으로 알려진 황색 포도상구균(Staphylococcus aureus : S. aureus)와 항생제 내성구균 (Methicillin-Resistant Staphylococcus aureus : MRSA)에 대해 항균활성이 우수한 천연 항균성 물질을 검색하기 위해 예로부터 민간과 한방에서 널리 이용되어 온 38종의 약용식물을 메탄올에 추출하여 항균활성을 조사해 보았다. MRSA에 대해 항균력 검색을 한 결과 세신, 황련, 호장근, 미역취씨 순으로 높은 항균활성이 나타났다. MRSA로 선별된 4종의 약용식물에 대해 농도와 배지를 다르게 하여 항균력을 측정한 결과 완전 배지인 TSA 배지에서 항균력을 측정한 결과 세신이 고농도인 5 mg/disc에서 S. aureus, MRSA 에 대해각각 21 mm, 19 mm로 우수한 항균력을 보였고, 미역취씨를제외한 3종의 약용식물은 S. aureus에서 MRSA보다 높은 항균력을 보였으며 미역취씨의 경우 두 균주 모두에서 효과가 나타나지 않았다. MSA 배지에서는 4종의 약용식물 모두 TSA 배지보다 높은 저해율을 보였고 특히 세신이 5 mg/disc 농도에서 S. aureus을 30 mm에 가까운 아주 우수한 항균력을 보였으며, 낮은 농도에서도 20 mm이상의 저해를 보였다. 미역취씨의 경우 TSA 배지에서는 항균력을 나타내지 않았으나 MSA배지의 경우 2.5 mg/disc의 낮은 농도에서도 두 균주 모두에서 10 mm이상을 저해하는 항균력을 보였다. 또한 4종의 약용식물을 서로 혼합하였을 경우 항균효과를 측정한 결과 TSA배지의 경우 두 균주 모두에서 세신과 황련을 혼합하였을 경우 세신, 황련의 각각 2.5 mg/disc의 항균력 보다 높게 나타났으며, MSA 배지의 경우 두 균주 모두에서 세신과 혼합한 3종의 약용식물에서 모두 항균력이 상승했고, 특히 호장근과 미역취씨는 20 mm의 높은 항균력을 보였다. In the present study, we investigated antimicrobial activity of the medicinal plants against various strains of methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus (S. aureus). Among the tested, the plants extracts of Asiasarum heterotropoides var. mandshuricum, Coptidis rhizoma, Reynoutria elliptica Migo., Solidago virga-aurea var. gigantea Miq.seed exhibited significant antimicrobial activities against MRSA KCCM 11812, 40510 and S. aureus ATCC 25923. The methanol extract of Asiasarum heterotropoides var. mandshuricum showed strong antimicrobial activity against MRSA KCCM 11812, 40510 and S. aureus ATCC 25923 at the 5 mg/disc. A synergistic effect was found in combined extracts of Asiasarum heterotropoides var. mandshuricum and Coptidis rhizoma as compared to each extracts alone. The result suggests that medicinal plant extracts can be used as an effective natural antimicrobial agent in food.

메티실린 저항성에 따른 황색포도알균 각막염에 대한 임상분석

안장환,이상범 대한안과학회 2017 대한안과학회지 Vol.58 No.8

Purpose: This study analyzed clinical characteristics of Staphylococcus aureus keratitis according to methicillin-resistance. Methods: The authors performed a retrospective chart review of 46 isolates in 46 eyes with Staphylococcus aureus keratitis that were followed up for more than 2 months between January 1998 and December 2014. Comparative analyses of the epidemiology, predisposing factors, initial clinical manifestations, antibiotics susceptibility and clinical outcome between methicillin-resistant Staphylococcus aureus (MRSA) keratitis and methicillin-sensitive Staphylococcus aureus (MSSA) keratitis were performed. Risk factors of poor visual outcome were analyzed using logistic regression analysis. Results: Among 46 eyes, MRSA was present in 15 eyes (33%) and MSSA in 31 eyes (67%). Male (61%) and older than 60 year-old group (48%) were common. Ocular surface disease/ocular surgery history and trauma were more common as a predisposing factor. Vancomycin was 100% sensitive to both the MRSA and MSSA groups. Antibiotics susceptibility to MRSA was significantly low in the oxacillin (0%), gentamicin (13.3%) and trimethoprim/sulfamethoxazole (53.3%) groups. Sensitivity to fluoroquinolone was 81.3% (MRSA 64.3% vs. MSSA 94.4%; p = 0.064). There were no differences in early corneal findings between the groups. The ratio of BCVA 0.5 or more was 24.4% initially and increased to 44.4% after treatment among all eyes (p = 0.046). Risk factors for poor visual outcomes included a BCVA less than 0.1 at initial evaluation (p = 0.033). Conclusions: Among eyes with Staphylococcus aureus keratitis, 33% were MRSA. The ratio of BCVA 0.5 or more increased after treatment among all eyes. There were no differences between MRSA and MSSA eyes in terms of epidemiology, predisposing factors, initial clinical manifestations or clinical outcome, except for antibiotic susceptibility. For positive patient outcomes, a treatment approach considering methicillin-resistance as well as various factors affecting clinical course is recommended. 목적: 황색포도알균 각막염에서 메티실린 저항성과 감수성 균주 간의 임상양상과 항생제감수성, 치료성적을 비교해보고자 하였다. 대상과 방법: 1998년부터 2014년까지 황색포도알균 각막염으로 진단받고 2개월 이상 추적 관찰했던 46명 환자의 의무기록을 후향적으로 분석하였다. Methicillin-resistant Staphylococcus aureus (MRSA)와 methicillin-sensitive Staphylococcus aureus (MSSA) 두 군으로 나누어 역학적 특성과 선행요인, 초기 임상양상, 항생제감수성, 치료성적을 비교 분석하였고 로지스틱 회귀분석을 통해 시력호전불량 위험인자를 확인하였다. 결과: 전체 46안 중 MRSA는 15안(33%), MSSA는 31안(67%)이었다. 남자(61%)와 60세 이상(48%)에서 흔했고, 선행요인으로 안구표면질환/안수술력과 외상이 많았다. MRSA 감수성은 vancomycin (100%)에서 높았고, oxacillin (0%)과 gentamicin (13.3%), trimethoprim/ sulfamethoxazole (53.3%)에서 낮았다. Fluoroquinolone은 81.3% (MRSA 64.3%, MSSA 94.4%; p=0.064)의 감수성을 보였다. 초기 임상소견은 두 군 간에 유의한 차이가 없었다. 교정시력 0.5 이상의 비율은 초진 시 24.4%에서 치료 후 44.4%로 유의하게 증가하였다(p=0.046). 시력과 합병증, 수술 여부를 종합한 치료성적은 두 군 간에 유의한 차이가 없었다. 시력호전불량 위험인자는 전체 군에서 초진 교정시력 0.1 미만(p=0.033)이 확인되었다. 결론: 황색포도알균 각막염 중 MRSA는 33%를 차지하였다. 치료 후 교정시력 0.5 이상의 비율은 전체 안에서 증가하였다. 두 군 간에 항생제감수성을 제외한 역학적 특성과 선행요인, 초기 임상양상, 치료성적 등은 유의한 차이가 없었다. 메티실린 저항성뿐만 아니라 임상 경과에 영향을 미치는 여러 요소를 종합적으로 고려한 치료 접근이 바람직할 것으로 생각된다.