Functional Adhesives: from Medical to Eco-friendly Adhesives

Hyo Jeong KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10

Adhesive is any substance that is capable of holding two separate materials together in a functional manner by surface attachment. Since its early discovery by the Egyptians (3300 year ago), intensive research efforts have been made with the purpose of obtaining high performance or biocompatible adhesives. Natural materials such as tree pitches and beeswax were replaced by synthetic polymers that had a high degree of structural strength and resistance to severe environmental conditions; nowadays, the focus is being mostly on eco-friendly adhesives. Here, different types of adhesive are introduced from biomimetic adhesives for medical applications to ecofriendly adhesives. Depending on the types of adherend and the required mechanical behavior of the bonded structure, adhesive materials will be determined. The protein-based tissue adhesive derived from marine mussel is suitable for bonding wet tissues under highly dynamic environments of the human body because of its biocompatibility and water-immiscible property. On the other hand, pressure sensitive adhesive (PSA) film made of polyolefins with very low water permeability can be a good candidate for a sealing material protecting OLED from humidity. Lastly, a fully bio-derived adhesive is a greener alternative to the intensively used synthetic polymer-based adhesives which have concerning environmental issues related to the growing use of petroleum-based materials.

알데히드화 덱스트란과 폴리라이신으로 구성된 의료용 접착제의 창상 봉합 및 지혈 효능의 평가

이종호,정태곤,황대연,강현구,한동욱,현승휴 한국생체재료학회 2011 생체재료학회지 Vol.15 No.3

This study concentrates upon evaluating the wound closure and antihemorrhagic efficiency of a new biodegradable medical adhesive, Lydex, composed of aldehyded dextran and ε-poly(L-lysine). Each component of Lydex was mixed together and then immediately gelatinized to form an adhesive. Gel formation time of Lydex was approximately 20~30 sec at 25℃. The mechanism of Lydex gelation is based on Schiff base formation between aldehyded dextran and ε-poly(L-lysine). Lydex showed more excellent bonding strength and compressive stress than fibrin glue. The animal study in rat skin wounds (about 20 mm long) revealed that the wound closure efficiency of Lydex was superior to that of taping as (–) control after 10 d, but relatively inferior to that of Dermabond® as (+) control. The hemostatic effects of Lydex were evaluated on the rabbit liver with a surgical incision (critical-sized injury, about 20 mm long and about 5 mm deep). The hemorrhage quantity of Lydex-applied liver was significantly smaller than those of non-applied and fibrin glue-applied livers, showing that hemostasis was almost completed within 30 sec. Furthermore, when applied to surgically incised rabbit liver, Lydex bonded securely to the rabbit liver surface and tissue reaction of liver bonded to Lydex was mild without inflammation and abnormalities after 4 wk. The gel was decomposed with the progress in the time, and the complete degradation was done at 6 wk. These results suggest that a bioocompatible adhesive, Lydex could be effectively used as a medical adhesive with bleeding-stoppage function.

Antimicrobial Effect of Medical Adhesive Composed of Aldehyded Dextran and ε-Poly(L-Lysine)

( Jeong Hyun Lee ),( Hye Lee Kim ),( Mi Hee Lee ),( Hideaki Taguchi ),( Suong Hyu Hyon ),( Jong Chul Park ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.11

Infection of surgical wounds is a severe problem. Conventional tissue reattachment methods have limits of incomplete sealing and high susceptibility to infection. Medical adhesives have several advantages over traditional tissue reattachment techniques, but still have drawbacks, such as the probability of infection, low adhesive strength, and high cytotoxicity. Recently, a new medical adhesive (new-adhesive) with high adhesive strength and low cytotoxicity, composed of aldehyded dextran and ε-poly(Llysine), was developed. The antimicrobial activity of the new-adhesive was assayed using agar media and porcine skin. In the agar diffusion method, inoculated microorganisms that contacted the new-adhesive were inactivated, but this was not dependent on the amount of new-adhesive. Similar to the agar media results, the topical antimicrobial effect of new-adhesive was confirmed using a porcine skin antimicrobial assay, and the effect was not due to physical blocking based on comparison with the group whose wounds were wrapped.

TAPE: A medical adhesive inspired by a ubiquitous compound in plants

김금연,신미경,고미영,류지현,이문수,홍선기,이해신 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1

Adhesives play an important role in industrial fields such as electronics, architectures, energy plantation, and others. However, adhesives used for medical purpose are rather under-developed compared with those used in industry and consumer products. One key property required for medical adhesives is to maintain their adhesiveness in the presence of body fluid. Here, we report an entirely new class of medical adhesives called TAPE, which is produced by inter-molecular hydrogen bonding between a well-known polyphenol compound, tannic acid (TA), and poly(ethylene glycol) (PEG). The preparation method of TAPE is extremely easy, forming a few liters at once by just the simple mixing of the two compounds without any further chemical synthetic procedures. TAPE shows a 250% increase in adhesion strength compared with fibrin glue, and the adhesion is well maintained in aqueous environments. We have demonstrated that TAPE is an effective hemostatic material and a biodegradable patch for detecting gastroesophageal reflux disease in vivo. We anticipate the widespread use of TAPE in various medical and pharmaceutical applications such as muco-adhesives, drug depots, and others, because of its scalability, adhesion, and facile preparation.

의료용 접착제 및 유착방지막의 최신 연구개발 동향

이종호,김현용,정태곤,한인호,박종철,박기동,최재봉,현승휴,한동근,한동욱 한국생체재료학회 2010 생체재료학회지 Vol.14 No.2

In the case of surgical operation for the treatment of cancers, vascular diseases and diabetes mellitus, the use of medical (or biotissue) adhesives is gradually increasing instead of suturing. Together with this trend, the development of anti-adhesion membranes (or barriers) is rapidly increasing for preventing complications originated from post-operative tissue adhesions frequently occurring. In general, all medical devices should pass the testing for biological safety and effectiveness. Thus, newly developed medical adhesives and anti-adhesion membranes must be evaluated according to the well-regulated standard guidelines, such as ISO, OECD, ASTM, etc, under authorized institution, otherwise they cannot be commercialized. In this review, medical adhesives and anti-adhesion membranes were categorized and compared according to their use and materials followed by a brief description of the properties of products commercially available. Furthermore, this review dealt with the present state of commercialization, the size of market and the recent trends of research and development regarding medical adhesives and anti-adhesion membranes

Advances in medical adhesives inspired by aquatic organisms’ adhesion

박규하,성금용,양승윤,서성백 한국생체재료학회 2017 생체재료학회지 Vol.21 No.4

In biomedicine, adhesives for hard and soft tissues are crucial for various clinical purposes. However, compared with that under dry conditions, adhesion performance in the presence of water or moisture is dramatically reduced. In this review, representative types of medical adhesives and the challenging aspects of wet adhesion are introduced. The adhesion mechanisms of marine mussels, sandcastle worms, and endoparasitic worms are described, and stemming from the insights gained, designs based on the chemistry of molecules like catechol and on coacervation and mechanical interlocking platforms are introduced in the viewpoint of translating these natural adhesion mechanisms into synthetic approaches.

Medical adhesive related skin injury after dental surgery

Kim, Tae-Heung,Lee, Jun-Sang,Ahn, Ji-Hye,Kim, Cheul-Hong,Yoon, Ji-Uk,Kim, Eun-Jung The Korean Dental Society of Anesthsiology 2018 Journal of Dental Anesthesia and Pain Medicine Vol.18 No.5

An 87-year-old woman was referred for the extraction of residual teeth and removal of tori prior to prosthetic treatment. After surgery under general anesthesia, the surgical tape was removed to detach the bispectral index sensor and the hair cover. After the surgical tape was removed, skin injury occurred on the left side of her face. After epidermis repositioning and ointment application, a dressing was placed over the injury. Her wound was found to have healed completely on follow-up examination. Medical adhesive related skin injury (MARSI) is a complication that can occur after surgery and subjects at the extremes of age with fragile skin are at a higher risk for such injuries. Careful assessment of the risk factors associated with MARSI is an absolute necessity.

The Effect of Material Type of Medical Adhesive Tape on Skin Irritation

EunSook Lee,ChangHui Hong,Daseol Kim 한국간호과학회 2015 한국간호과학회 학술대회 Vol.2015 No.10

Synthesis and Characterization of Acrylic Pressure Sensitive Adhesives with Hydrophilicity Control for Application in Medical Patches

석웅철,이상국,송호준 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-

The hydrophilic acrylic PSAs were synthesized by controlling the contents of 2-ethylhexyl acrylate, isobornyl acrylate, and 2-hydroxyethyl acrylate. Surface contact angle of acrylic PSA film decreased from 77.87° to 70.23° in case of Acryl-2 to Acryl-8 (below HEA 10 wt%). However, the surface contact angle of Acryl-10 to Acryl-40 (HEA 10 wt% to 40 wt%) increased up to 92.29°, indicating hydrophobicity. According to X-ray diffraction measurement, hydrophilic acrylic PSAs exhibits amorphous property and it was confirmed that the morphology of acrylic PSA film was significantly affected by the flexibility of the polymer chain and the strength of hydrogen bonding. The affinity with hydrophilic materials for acrylic PSA films is determined by the hydrophilicity of the acrylic PSA film. Synthesized acrylic PSA film is non-toxic regardless of the hydrophilicity, any irritation was not observed in the skin where the acrylic PSA film was attached even after 72 hr.

생체모사 삼차원 미세구조 기반 점착소재 및 응용기술

방창현 한국진공학회 2018 한국진공학회 학술발표회초록집 Vol.2018 No.8