뚜렛 증후군에서의 경두개 자기자극술

이문수,Lee, Moon-Soo 한국정신신체의학회 2010 정신신체의학 Vol.18 No.1

Gilles de la Tourette syndrome is a chronic motor and vocal tic disorder of childhood onset. Abnornmalities in basal ganglia-thalamo-cortical circuits may play an important role in the pathophysiology underlying the involuntary tics. It is often complicated by comorbid attention-deficit/hyperactivity disorder or obsessive-compulsive disorder. Transcranial magnetic stimulation(TMS) is a neurophysiologic technique with research ap-plication. As there is good evidence that this technique can modify cortical activity, repetitive TMS is also used for treatment to change the cortical excitability and therefore affect underlying interconnected cortical-sub-cortical loop. We reviewed the neurophysiologic parameters and the clinical applicability of TMS and rTMS.

항우울제의 복약 순응도

이문수,고영훈,조숙행,Lee, Moon-Soo,Ko, Young-Hoon,Joe, Sook-Haeng 대한생물정신의학회 2010 생물정신의학 Vol.17 No.1

Depressive disorder is a chronic disabling condition with recurrent episodes. Medication noncompliance is a significant problem for effective management of depressive disorder. However, compliance with antidepressant medication is poor. There are difficulties in assessing compliance accurately. Various methods for assessing compliance are in use. A patient's compliance with antidepressant may be affected by many factors including the clinical characteristics of depression, pharmacologic properties of antidepressants, patients' characteristics, accessibility treatment, and doctor-patient relationships. For enhancing the treatment compliance, psychotherapeutic considerations in patient-therapist relationship are needed.

팽윤습열연신에 의한 아크릴섬유의 고강도화에 관한 연구

이문수,송경헌,Song, Kyoung-Hun,Lee, Mun-Soo 배재대학교 자연과학연구소 1995 自然科學論文集 Vol.8 No.1

The stretching of synthetic fibers by hot dry process is very difficult, because these fibers have high glass transition temperature at above $150^{\circ}C$. But, we used a swell-wet stretching precess; the fibers are stretched in a swelling agent such as organic solvents at lower temperature. In this study, 100% acryl fibers were uniaxially stretched with free width at $70^{\circ}C$ by swell-wet process in organic solvents. The stretchability was estimated by stretching work. This work is concerned with stretching stress and strain, and initial modulus. We found that it is a good parameter for the estimatation of high strength to the acrylic fiber. The effects of stretching conditions on the molecular orientation for high strength and mechanical properties of PAN fibers were measured.

오존에 의한 반응성 염료의 탈색에 관한 연구

이문수,Lee, Mun-Soo 배재대학교 자연과학연구소 1997 自然科學論文集 Vol.9 No.1

We studied on the decoloring efficiency of a dying and finishing industrial wastewater containing reactive dyes in the ozone treatment system. The wastewater containing reactive dyes improved the decolorization by the ozone oxidation. In order to determine the optical conditions for ozonation, various operation factors such as initial wastewater concentrations, pH, temperature, and ozone dose were evaluated. Ozone utilization rate was improved in general with the increase of initial concentration of wastewater. And the decolorization speed or reactive dyes was more decreased in deep color of blue series than in light color such as yellow series. The colorization of wastewater containing reactive dyes was changed step through midle color depending upon increasing of ozone treated time. The efficiency of decolorization for wastewater was improved with the pH increased and the temperature of ozone treatment system decreased.

오존을 이용한 마직물의 표백성 향상에 관한 연구

이문수,송경헌,김경아,송봉근,이래연,Lee, Mun-Soo,Song, Kyong-Hun,Kim, Gyoung-A,Song, Bong-Keun,Lee, Rae-Yohn 배재대학교 자연과학연구소 1998 自然科學論文集 Vol.10 No.1

In order to study on the bleaching efficiency of flex fabrics, ozone which has been produced by an ozone generator, has been contacted with flex fabrics in water at various conditions. The equipments used for the ozone reatment of flex fabrics were the ozone generator and a liquor/ozone contactor. For the study of the bleaching efficiency on flex fabrics, the Hunter's whiteness, tensile strength, microscopic properties of the ozone treated flex fabrics were measured. The concentration of generated ozone was increased, as the voltage increase, flow ratio decrease and oxygen amount increase. The bleaching efficiency of ozone treated fabrics was increased with increasing the net concentration of ozone. The whiteness ozone of treated fabrics was found to be best when treated temperature was $0-15^{\circ}C$ and treated time was 20 min. The tensile strength of treated fabrics decreased as the treating time increased, and as the temperature raised.

Engineered AAV 벡터 개발 및 유전자치료제 핵심바이오원부자재 사업화

이문수,이균민,나상준 한국생물공학회 2024 한국생물공학회 학술대회 Vol.2024 No.9

현대 루마니아 어휘에 끼친 영어의 영향

이문수 한국외국어대학교 2001 한국외국어대학교 논문집 Vol.33 No.-

유기향균제를 이용한 타올의 향균가공에 관한 연구

이문수,송윤준,Lee, Mun-Soo,Song, Yoon-Jun 배재대학교 자연과학연구소 1999 自然科學論文集 Vol.11 No.1

The study was investigated to the effect of antimicrobial finishing of towel treated by organic antimicrobial agent. It was measured for the optimal condition such as treated time, treated concentration and temperature. After amtimicrobial treatment, mechanical and fastness properties, anti-laundering property were measured.The antimicrobial activity of samples was analyzed quantitatively by masureing the number of colonies of Staphylococcus aureus using the shake flask method. Towel samples treated with the optimal condition such as treated time of 10 minute, and treated temperature of $30^{\circ}C$, concentration of organic antimicrobial agent of 3.5% were shown a high reduction rate in the number of colonies grown and clear zones of inhibition.The effect of reduction rate for laundering until the number of 20 times was shown high reduction rate of over 80%. And the mechanical properties of samples treated with organic antimicrobial agent were not changed approximately.

우울증을 수반한 폐경후기 여성에서 세로토닌재흡수억제제와 단기순차병합 호르몬 대치요법 증강치료의 효과:예비 연구

이문수,양재원,고영훈,조숙행 대한정신약물학회 2008 대한정신약물학회지 Vol.19 No.4

Objectives:Estrogen may be useful to manage depression. Some studies have suggested that treatment using antidepressant medications augmented with estrogen can be more effective than using antidepressant medication alone. However, data about the estrogen augmentation of selective serotonin reuptake inhibitor (SSRI) medication is insufficient. We investigated the effect of hormonal replacement treatment (HRT) as an augmentation in postmenopausal women with depression who were already being treated with SSRIs. Methods:This was an 8- week prospective, open trial study. The subjects were 13 patients who met the DSM-IV criteria for major depressive disorder or dysthymia. The menses of all subjects had ceased for at least one year, and all subjects had serum levels of follicular stimulating hormone (FSH) greater than 40 mIU/mL. All subjects were already taking sertraline (50-150 mg) or paroxetine (20-30 mg);during the study they received sequential combined hormone replacement treatment (1.25 mg estrogen +5 mg medroxyprogesterone). Subjects continued their SSRI medication at their original dosages throughout the 8-week study. Mood and anxiety symptoms were measured with the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI). Menopause-related symptoms were assessed using the Women’s Health Questionnaire (WHQ). Overall clinical symptoms were also assessed using the Symptom Checklist 90-Revised (SCL-90-R). Serum levels of luteinizing hormone (LH), FSH, prolactin, estradiol, and progesterone were measured. Measurements were conducted at three times: baseline, four weeks, and endpoint. Results:The subjects’ mean age was 53.54±5.38 years and mean postmenopausal duration was 4.46±3.67 years. During the HRT, BDI and Trait Anxiety Inventory scores decreased significantly. On the WHQ subscales, scores for somatic symptoms, vasomotor symptoms, sexual behavior, and sleep problems were significantly improved. Hormonal levels of LH, FSH, and estradiol changed significantly. Menopausal duration was significantly correlated with changes in each assessment:somatic symptoms (r=-0.583, p=0.037), anxiety symptoms (r=-0.623, 0.023), WHQ depressive symptoms (r=-0.586, p=0.035), depression (r=-0.584, p= 0.036), global severity index (r=-0.642, p=0.018), and positive symptom distress index (r=-0.592, p=0.033) of SCL-90-R. Conclusion:The results suggest that HRT may augment the antidepressant response to SSRIs in postmenopausal women with depression. The treatment effect of augmentation by HRT seems to be influenced by menopausal duration. Therefore, further controlled studies should be conducted to test estrogen augmentation of antidepressants, dependent on the duration of menopause. 본 연구에서는 단기간의 전향적인 개방 표지 방식으 로 SSRI를 투여 받고 있는 폐경후기 우울증 여성 환자 들에서 호르몬 대체요법을 실시하여 호르몬 농도 변화 및 우울증상과 폐경기 관련 증상들의 변화, 폐경 이후 기간과의 상관성을 조사하였다. DSM-IV에 따라 주요 우울장애나 기분저하증으로 진단을 받았으며, 폐경기간 이 최소 1년 이상이면서 혈중 FSH농도가 40 IU/L를 초과한 13명의 여성이 연구에 등록되었다. 각 연구참가 자는 sertraline(50~150 mg)이나 paroxetine(20~30 mg)을 투여 받고 있었고, 연구기간 동안에는 항우울제 약물의 용량을 고정하여, 8주간 호르몬 대체요법 중 주 기적 estrogen과 progesterone 병합요법 방식을 사용 하였다. BDI, STAI, WHQ, SCL-90-R을 사용하였고, 각 평가는 연구 시작, 4주, 8주 종료 시점에서 이루어졌 다. 본 연구에서는 호르몬 대치요법에 의한 추가적인 항 우울효과가 있는 것으로 나타났다. 본 연구에서는 추가 적 항우울효과의 크기가 폐경기간과 관련성을 보였으며, 폐경기간과 일부 우울척도에서 유의한 부적 상관을 보 인 점으로 보아, 호르몬 대치요법의 효과는 폐경기간의 영향을 받는 것으로 생각된다.

COVID-19와 공동체

이문수 한국자치학회 2020 월간 공공정책 Vol.180 No.-