두경부 악성 림프종의 면역조직화학적 유형분석 및 Epstein-Barr virus의 검출

김성현,전세영,임동명 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

Background and Objectives : The Epstein-Barr virus(EBV) is a human herpes virus which causes infectious mononucleosis and is associated with such human cancers as Burkitt's lymphoma and nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head and neck tumors is not fully elucidated. Malignant lymphoma is a tumor of the immune system which is commonly known as a non-epithelioid tumor of the head and neck region. Recent studies have suggested a probable etiologic association between EBV and lymphomas. This study was performed to investigate the strength of the association of EBV with malignant lymphoma and to carry out an immunohistochemical classification. Materials and Methods : Twenty one cases of non-Hodgkin's lymphoma tissues in the head and neck were used. Immunohistochemical staining was carried out with EBV protein, CD20 and CD3. Results : Among the 21 cases of malignant lymphoma, 9(43%) of the cases were of B cell lineage, 10(48%) of the cases of T cell lineage and 2(10%) of the cases were of an unclassifiable type. The commonest histopathologic type were diffuse large cell types and diffuse mixed types in 8(38%) of the cases. All 6 cases(100%) of nasal/paranasal sinus lymphoma were T-cell lymphoma. The detection rate of EBV in malignant lymphoma tissue was 52%. EBV was detected in 5 cases(56%) of B-cell lineage and 6 cases(60%) of T-cell lineage. Among 6 cases of nasal/paranasal sinus T-cell lymphoma, 4(67%) were positive for anti-human EBV protein. In the positive cases, a large number of the neoplastic cells and infiltrated lymphocytes showed strong nuclear signals. Conclusion : These results suggest that most nasal/paranasal sinus lymphomas are T-cell type neoplasms and EBV probably plays an etiologic role in the pathogenesis of group nasal/paranasal sinus T-cell lymphomas.

Epidemiologic overview of malignant lymphoma

허주령 대한혈액학회 2012 Blood Research Vol.47 No.2

Malignant lymphoma encompasses a wide variety of distinct disease entities. It is generally more common in developed countries and less common in developing countries. The East Asia region has one of the lowest incidence rates of malignant lymphoma. The incidence of malignant lymphoma around the world has been increasing at a rate of 3-4% over the last 4 decades, while some stabilization has been observed in developed countries in recent years. The reasons behind this lymphoma epidemic are poorly understood, although improving diagnostic accuracy, the recent AIDS epidemic, an aging world population and the increasing adoption of cancer-causing behaviors are suggested as contributing factors. Etiologies of malignant lymphoma include infectious agents, immunodeficiency, autoimmune disease, exposure to certain organic chemicals, and pharmaceuticals. The distribution of many subtypes exhibit marked geographic variations. Compared to the West, T/natural killer (NK) cell lymphomas (T/NK-cell lymphoma) and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) are relatively more common, whereas other B-cell lymphomas, particularly follicular lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, are less common in Asia. Some subtypes of T/NK-cell lymphomas defined by Epstein-Barr virus association are predominantly Asian diseases, if not exclusively so. Both ethnic and environmental factors play roles in such diversity. In this review, we discuss the geographic distribution and etiology of malignant lymphoma, as well as the trend.

이하선 종괴로 발현된 악성 림프종

정웅윤(Woong Youn Chung),이효상(Hyo Sang Lee),서진학(Jin Hak Seo),양우익(Woo Ik Yang),박정수(Cheong Soo Park) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.1

Background: Primary malignant lymphoma of the parotid gland is a rare disease and defined as any malignant lymphoma that first manifests in the parotid gland, regardless of the subsequent stage of the diseases, whether it arises in the parenchyma or intraglandular lymph nodes. This study was performed to review the clinicopathological characteristics of primary parotid lymphoma and identify its optimal treatment modality. Materials and Methods: Six cases with parotid mass as first presentation of malignant lymphoma between 1988 and 2000, were studied on the basis of clinical features, diagnostic tools, treatment modality, treatment outcomes, and clinical stage by Ann Arbor Criteria. All were microscopically reevaluated and classified by NCI working formulation. Results: All patients were males and mean age was 36.7 years (2-66 years). Rapid growing non-tender mass was presented in all the cases and cervical lymphnodes were palpated in 4 cases. However, there was not any evidence of concurrent autoimmune disease such as Sjogren's syndrom or Rheumatoid arthritis. One case was confirmed by surgical specimen after superficial parotidectomy, 2 by excisional biopsy, and 3 by incisional biopsy. The stage of disease by NCI working formulation was IE in 1 patient, IIE in 4 and IV in 1. All were classified into non-Hodgkin' lymphoma, of which there were 5 cases of B-cell type and 1 case of T-cell type. There were 3 diffuse large cell lymphomas, 1 Burkitt lymphoma, 1 MALT lymphoma and 1 T-lymphoblastic lymphoma. Three cases were treated by chemotherapy only, 2 by radiotherapy only and 1 by chemo-radiotherapy. One case with Burkitt lymphoma was died from the disease and one case was lost to follow-up. The others are alive with no evidence of recurrence. Conclusions: Although primary parotid lymphoma is rare and difficult to diagnose preoperatively, most were detected in early stage and showed a relatively good response to the chemotherapy or radiotherapy like other types of extranodal malignant lymphoma.

경도 B세포 림프종 분류시 파라핀 포매 조직에서 시행한 면역조직화학기법의 유용성

황태숙,이승숙,김지은,한혜승,김철우 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.12

자궁경부의 원발성 악성 림프종 2예

임선옥 ( Sun Ok Lim ),기은영 ( Eun Young Key ),노덕영 ( Duck Yeong Ro ),박병준 ( Byung Joon Park ),김용욱 ( Yong Wook Kim ),김태응 ( Tae Eung Kim ),정재근 ( Jae Keun Jung ),한치화 ( Chi Wha Han ),이안희 ( An Hi Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.10

Primary malignant lymphoma of the uterine cervix is very rare. Lymphomas account for 3.5% of all malignant tumors in the females. Approximately, 25% of all malignant lymphomas arise from extranodal sites, most frequently from gastrointestinal tract and skin. Although the incidence of systemic non-Hodgkin`s lymphoma (NHL) and extranodal NHL has increased in recent decades, only 1 to 1.5% arises from female genital tract. Primary pelvic sites include ovary, which is the most common site, uterine corpus, cervix, vagina, and vulva. Primary cervical lymphomas account for 0.12~0.6% of all extranodal lymphomas. However, there is still no consensus on the management of cervical lymphomas due to low incidence of the disease and limited experience in the literature. We experienced two cases of primary malignant lymphoma of the uterine cervix. A 41-year-old woman, Ann Arbor stage IE, was treated with laparoscopically assisted vaginal hysterectomy and both salpingo-oophorectomy and 4 cycles chemotherapy. A second case was a 73-year-old postmenopausal woman, Ann Arbor stage III, received five courses chemotherapy without any surgery. In this article, two cases of uterine cervical lymphoma are presented with a review of the available literature.

악성 임파종의 골수 침범에 관한 임상적 연구

한지숙,박중원,민유홍,고윤웅,양우익,최인준 大韓血液學會 1990 大韓血液學會誌 Vol.25 No.2

이하선에 발생한 악성 임파종의 임상 증례 보고 1례

김창진,이영만,양순재,박성진,박종섭,박은수 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.1

Malignant lymphoma is a neoplastic proliferation of cells in the lymphoreticular system and divided largely as Hodgkin's disease and non-Hodgkin's lymphoma. Non-Hodgkin's lymphoma occurs primarily in lymph nodes and is rare found in extralymphatic organs. The most frequently affected extranodal sites area head and neck, gastrointestinal tract, followed by bladder, skin, brain, eye and bone. Primary lymphomas arising in salivary glands are very uncommon. Lymphomas in salivary glands represented 1.7∼5% of all reported salivary neoplasms. Recently authors experienced one case of primary malignant lymphoma in parotid gland and report that with a brief review of literature.

복합 항암 화학요법 후 HBsAg 양성 악성림프종환자의 임상경과

구본권(Bon Kwon Ku),한지숙(Jee Sook Hahn),한광협(Kwang Hyub Hahn),이승태(Seung Tae Lee),서형찬(Hyung Chan Suh),권건호(Kun Ho Kwon),이진헌(Jin Hun Lee),민유홍(Yoo Hong Min),고윤웅(Yun Woong Ko) 대한내과학회 1997 대한내과학회지 Vol.52 No.4

N/A Objectives: Infection and replication of the hepatitis B virus are closely related to the host imm- unity. Anticancer chemotherapy decreases the immune response of the host, Especially, glucocorticoid can activate the replication of hepatitis B virus directly. It is well known that hepatitis B virus infection and hepatic complications are more common in patients with hematologic malignancies like malignant lymphoma. We studied the incidence of hepatitis B virus infection and hepatic complications following anti- cancer chemotherapy in patients with malignant lymphoma. Methods: Among 224 cases diagnosed as malignant lymphoma from January 1989 to December 1993 at Yonsei University Medical Center, 77 cases tested for hepatitis B virus serology was studied. Results: 1) Eighteen cases (23%) was HBsAg positive. 2) The results of hepatitis C virus serology in six cases were all negative. 3) Eight (57%) of 14 follow-up cases had hepatic complications, Two patients had fulminant hepatitis, two nonicteric hepatitis and four icteric hepatitis. 4) Interferon-alpha was administered in three cases among the patients with hepatic complications. Loss of HBeAg was observed in one case and loss of HBsAg in another case. Conclusion: Serious hepatic complications can be occurred following anticancer chemotherapy in HBsAg-positive patients with malignant lymphoma. Therefore, we recommend that patients being considered as candidates for anticancer chemotherapy should routinely undergo serologic test for Hepatitis B virus. In addition HBsAg-positive patients with anticancer chemotherapy should be regularly monitored for hepatic injury. And with the careful use of steroid and interferon, prolongation of survival might be searched for these patients.

후두악성임파종

조정일(Jung Il Cho),김광문(Kwang Moon Kim),김영호(Young Ho Kim),최재진(Jae Jin Choi) 대한두경부종양학회 1995 대한두경부 종양학회지 Vol.11 No.2

후두에 생긴 원발성 임파종은 성문상부에 잘 생기며 일차치료로 방사친치료가 이용되나 후두외로 퍼진 경우는 항암화학치료와의 병용요법이 필요하다. 후두악성임파종의 전이나 재발여부에 대해 장기적 추적 관찰이 중요함을 문헌고찰과 함께 보고하는 바이다. Malignant lymphoma affecting the larynx is uncommon, probably accounts for less than 1 percent of malignant lesion of the larynx. Malignant lymphoma of the larynx is predominantly localized to supraglottis such as epiglottis, aryepiglottic fold. Laryngoscopy reveals a irregular submucosal mass with a smooth surface and no ulceration. Most of which belongs to non­Hodgkin's lymphoma. After it has been determined that the disease is localized, radiation therapy is the choice of the treatment. Chemotherapy with or without irradiation is reserved for more advanced tumor. Then life-long follow-up is essential. This paper deals with 5 cases malignant lymphoma of the larynx to review our clinical experience and to suggest the optimum treatment in the course of the disease.

소아의 악성 림프종 -그 조직학적 유형의 특징에 관하여-

박성혜,신성식,김철우,지제근 대한병리학회 1990 Journal of Pathology and Translational Medicine Vol.24 No.2