http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Cheoljin Kim,Jaeeun Kim,Hyung-Yeon Park,Hee-Jin Park,Chan Kyung Kim,윤제용,이준희 한국분자세포생물학회 2009 Molecules and cells Vol.28 No.5
The quorum sensing (QS) inhibitors that antagonize TraR, a receptor protein for N-3-oxo-octanoyl-L-homoserine lac-tones (3-oxo-C8-HSL), a QS signal of Agrobacterium tume-faciens were developed. The structural analogues of 3-oxo-C8-HSL were designed by in silico molecular modeling us-ing SYBYL packages, and synthesized by the solid phase organic synthesis (SPOS) method, where the carboxamide bond of 3-oxo-C8-HSL was replaced with a nicotinamide or a sulfonamide bond to make derivatives of N-nicotinyl-L-homoserine lactones or N-sulfonyl-L-homoserine lactones. The in vivo inhibitory activities of these compounds against QS signaling were assayed using reporter systems and compared with the estimated binding energies from the modeling study. This comparison showed fairly good corre-lation, suggesting that the in silico interpretation of ligand-receptor structures can be a valuable tool for the pre-design of better competitive inhibitors. In addition, these inhibitors also showed anti-biofilm activities against Pseudomonas aeruginosa.
은행나무 접목묘의 모수 지역별에 따른 엽 추출물의 flavonol glycosides 및 terpene lactones 함량 특성
황석인 ( Suk In Hwang ),이위영 ( Wi Young Lee ),이문호 ( Moon Ho Lee ),이병실 ( Byoung Sil Lee ),장용석 ( Yong Seok Jang ),이욱 ( Uk Lee ) 한국산림과학회 2004 한국산림과학회지 Vol.93 No.5
Ginkgo tree, Ginkgo biloba L. is a dioecious, coniferous species which is valuable for timber, nuts and high tolerance to air pollution. Also, this species is one of the tree species increasingly explored by medicinal chemists due to its pharmaceutically active leaf terpenes and flavonoids. To clarify the contents of flavonol glycosides and terpene lactones in the leaf, the clonal grafts having the large fruit and high productivity were planted in the same place, and compared with the sites effect of their mother trees. The flavonol glycosides contents showed significant difference among sites of their mother trees; The leaf extracts collected from Jeonnam and Chungnam had higher amounts of flavonol glycosides than those collected from Gyeonggi, China and Chungbuk. However, no significant difference was found in the amount of terpene lactones of extracts among sites of their mother tree. Superior seed bearing trees contented more terpene lactones with significant difference than those of the control trees,but the flavonol glycoside contents didn`t show significant difference between both of them. The contents of terpene lactones in Ginkgo tree leaf were less affected on sites effect than that of flavonol glycosides. In these result, we can suppose that selection of Ginkgo tree getting higher contents of terpene lactones is to get high extraction efficiency for useful substances from the leaf extract.
Synthesis of the Tetraketide Lactones from the Pikromycin Biosynthetic Pathway
Oh, Hong-Se,Yun, Ji-Suk,Nah, Ki-Hyun,Kang, Han-Young,Sherman, David H. WILEY-VCH Verlag 2007 European journal of organic chemistry Vol.2007 No.20
<P>Synthesis of tetraketide lactones 2 and 3, which are likely to be produced by a model pikromycin polyketide synthase (PKS), has been investigated. The tetraketide lactones with six-membered rings, 2a and 2b, were synthesized successfully by the asymmetric aldol reaction, allylation, and the Reformatsky reaction. The attempted synthesis of tetraketide lactones with eight-membered rings, 3a and 3b, led to the formation of the compounds 2a and 2b. The synthesis of another tetraketide lactone compounds 35 was attempted with the hope that introducing an additional methyl group would lead to a change in thermodynamic stability. However, it produced the corresponding tetraketide lactone 34 with a six-membered ring. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)</P> <B>Graphic Abstract</B> <P> <img src='wiley_img/1434193X-2007-2007-20-EJOC200700254-fig000.gif' alt='wiley_img/1434193X-2007-2007-20-EJOC200700254-fig000'> </P>
Cephalosporolides H and I, Two Novel Lactones from a Marine-Derived Fungus, Penicillium sp.
Xiang Li,Yanhua Yao,Yinan Zheng,Isabel Sattler,Wenhan Lin 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
Two novel lactones, Cephalosporolides H (1) and I (2), were isolated from the lyophilized culture broth of the marine-derived fungus, Penicillium sp. The structures were elucidated on the basis of extensive 1D- and 2D-NMR, as well as HRESI-MS spectroscopic analyses. The relative stereochemistries of the compounds were assessed by comparison of the NOESY analysis and spectral data with those in the literature.
Cephalosporolides H and I, Two Novel Lactones from a Marine-Derived Fungus, Penicillium sp.
Yao, Yanhua,Zheng, Yinan,Sattler, Isabel,Lin, Wenhan,Li, Xiang 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
Two novel lactones, Cephalosporolides H (1) and I (2), were isolated from the lyophilized culture broth of the marine-derived fungus, Penicillium sp. The structures were elucidated on the basis of extensive 1D- and 2D-NMR, as well as HRESI-MS spectroscopic analyses. The relative stereochemistries of the compounds were assessed by comparison of the NOESY analysis and spectral data with those in the literature.
SESQUITERPENE LACTONES FROM CARPESIUM DIV ARICATUM
KIM, DAE KEUN,LEE, KANG RO,ZEE, OK PYO 성균관대학교 약학연구소 1997 成均藥硏論文集 Vol.9 No.1
The aerial parts of Carpesium divaricatum afforded two known and two new germacranolides, 2β, 5-epoxy-5, 10-dihydroxy-6α-angeloyloxy-9β-isobutyloxy-germacran-8α, 12-olide and 2α, 5-epoxy-5, 10-dihydroxy-6α-angeloyloxy-9β-isobutyloxy-germacran-8β, 12-olide.
이재승,김윤곤,김성민,송원석,조성현,전효진 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
As the AHLs are used for antibacterial drug development and cell-to-cell communication, these are important secondary metabolites. Here, we proposed a highly sensitive and reliable MALDI-MS based 3-oxo AHL quantitation method, which ketone group of AHLs were derivatized with Girard’s reagent T to (GT) to produce a permanent cationic charge state [M]+. By the chemical derivatization of 3-oxo AHLs, its detection sensitivity was improved and the derivatization also allowed accurate quantitative analysis from the PAO1 culture supernatants. This method could be applied for developing high-throughput and sensitive detection methods of quorum sensing signal molecules.