A case of extraskeletal osteochondroma on the first toe

( Jun-oh Shin ),( Kihyuk Shin ),( Woo-il Kim ),( Min-young Yang ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Won-ku Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Osteochondroma is the most common benign tumor occurring in the metaphyseal region of the long bones. Extraskeletal osteochondroma, however, is relatively rare benign soft tissue tumor, commonly arising within the soft tissue of the hands, feet and surrounding knee without any continuity adjacent bone or joint. Extraskeletal osteochondroma usually present as a well-circumscribed, calcified mass that slowly enlarging and rarely exceed 3 cm in its greatest dimension. Herein, we report a rare case of extraskeletal osteochondroma. A 28-year-old male presented with a skin-colored nodule on the left first toe that had been present for 11 years. In the first year, local excision of mass had been done, but soon recurred. Tumor gradually increased in size and caused discomfort. Physical examination showed a firm, fixed nodule measuring 2.0 X 1.3 cm in dimension. Under local anesthesia, a tumor had been reached and was totally removed. The tumor was located in tendon sheath, not attached to adjacent bone. Histopathologic finding reveals hyaline cartilage cap covered with fibrous capsule at the peripheral portion, and mature trabecular bone at the center. Based on the clinical and histological findings, the extraskeletal osteochondroma was diagnosed. No recurrence was observed during the 18 months since the excision. To our knowledge, this is the first case of extraskeletal osteochondroma in Korean dermatology journal.

Case Report : Primary extraskeletal mesenchymal chondrosarcoma of the vulva

( Eun Ae Jeh ),( Young Jin Lee ),( Heung Yeol Kim ),( Ari Kim ),( Jun Hee Lee ) 대한산부인과학회 2013 Obstetrics & Gynecology Science Vol.56 No.5

Extraskeletal chondrosarcoma is rare, making up only 1% of reported chondrosarcoma. We experienced 3 cases of extraskeletal chondrosarcoma, especially in vulva. They were suspected as lipoma of the vulva. The patients had noticed a small but growing mass on their vulva which had been palpated earlier. The masses were excised with a 2 cm resection margin. The final pathological reports confirmed extraskeletal mesenchymal chondrosarcoma (EMC) of the vulva revealing no microscopic lesions on the resection margins. After 24 months of following from the initial diagnosis, the patients remain without evidence of any recurrent. Management of EMC is not well studied due to the rare and variable nature of the disease. However, the surgery, such as we had, is the mainstay of local treatment with studies showing better survival in patients who undergo wide surgical resection. The establishment of adjuvant systemic pharmacotherapy could be expected in the future.

Extraskeletal Osteochondroma in an Unusual Location: A Case Report

( Jae Yeon Ryu ),( Ju Hee Han ),( Chul Hwan Bang ),( Young Min Park ),( Jun Young Lee ),( Ji Hyun Lee ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.4

Extraskeletal osteochondroma is a rare, benign, bone tumor of the soft tissue that generally affects the soft tissue of the hands and feet, followed by the trunk, and is rarely reported in the head and neck area. A 41-year-old female presented with an asymptomatic, skin-colored, palpable nodule on the neck that had been slowly growing over an unknown period of time. An ultrasound examination revealed a 0.9-cm-sized, dense, calcified lesion in the skin layer on the left side of the neck. Calcinosis cutis, pilomatricoma, and other benign tumors were clinically suspected, and a tumor excision was performed. The histological examination showed encapsulated round nodules composed of mature hyaline cartilage, which gradually changed into mature bone tissue. Extraskeletal osteochondroma was diagnosed by pathological examination. Here, we report an interesting case of extraskeletal osteochondroma in an unusual location. (Korean J Dermatol 2020;58(4):276∼278)

A case of subungual extraskeletal chondroma

( Hyun Seok Choi ),( Won Seon Koh ),( Jae Min Shin ),( Eun Jin Kim ),( Jeong Eun Kim ),( Joo Yeon Ko ),( Young Suck Ro ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Extraskeletal chondroma is a relatively uncommon, benign tumor that occurs in soft tissue, without adhesion to the underlying bone. It is usually solitary and may attach to tendon, tendon sheaths, or joint capsule. Although the most common site is hand, consisting of more than 60% of all extraskeletal chondromas, a few case of testis, liver and subungual area have been documented. A 59-year-old woman presented with solitary hyperkeratotic nodule on right first toe. Skin lesion had gradually developed over a period of 15 years. She complained of mild pain and tenderness on palpation. On physical examination, a 0.8 x 0.4 cm sized nodule was on the medial side of toenail with nail deformity. We planned to perform an incisional biopsy, but well-circumscribed mass was observed after partial nail extraction and we removed the mass completely. Histopathologically, epidermis showed hyperkeratosis, parakeratosis, and irregular acanthosis and there was a fibrous and hyalinized stroma composed of plump chondrocytes with distinctive reniform and elonaged nuclei and partially concomitant calcification. From these findings, she was diagnosed with subungual extraskeletal chondroma. The nail regenerated without deformity and there was no recurrence over 10 months. Herein, we report a case of subungual extraskeletal chondroma and clinicians should consider it as a differential diagnosis when a subungual nodular lesion occurs.

The Development of a Giant Extraskeletal Osteochondroma in the Masticatory Space of the Mandible

Lee, Jee-Ho,Han, Yoon-Sic,Cho, Young-Ah,Hong, Sam-Pyo,Kim, Myung-Jin Korean Association of Maxillofacial Plastic and Re 2011 Maxillofacial Plastic Reconstructive Surgery Vol.33 No.5

Extraskeletal osteochondroma is an uncommon benign tumor that arises in soft tissues lacking continuity with an adjacent bone and joint. Due to similar histopathological findings, extraskeletal osteochondroma is often misdiagnosed for a conventional osteochondroma, the most common benign tumor that arises from the epiphyseal plates of long bones. The pathogenesis of extraskeletal osteochondroma is unclear, but metaplasia of synovial mesenchymal tissue is the best supported etiology. The most common sites of extraskeletal osteochondroma are the hands and feet, and it is rarely found in the maxillofacial area. We present a case of a two-year-old boy with a giant extraskeletal osteochondroma that developed in the masticatory space of the mandible along with a review of the relevant literature.

우측 팔에 발생한 골격외 유잉육종 1례

김상일,송홍석,손승원 啓明大學校 醫科大學 1998 계명의대학술지 Vol.17 No.4

저자들은 53세 남자환자가 우측 팔의 무통성 종괴를 주소로 내원하여 조직검사상 골격외 유잉육종으로 판명되어 광범위절제술, 항암화학요법 및 방사선치료로 완치를 보인 1례를 경험하였기에 이에 문헌고찰과 함께 보고하는 바이다. Extraskeletal Ewing's sarcoma is a rare primary malignant soft tissue tumor that was first described by Angervall and Enzinger in 1975. These tumors tend to occur chiefly in young adults. Because of their undifferentiated histologic appearance, the differential diagnosis must exclude other small round cell neoplasm such as neuroblastoma, rhabdomyosarcoma, neuroepithelioma, and poorly differentiated malignant lymphoma. The extraskeletal Ewing's sarcoma are mainly involved the soft tissues of the trunk and lower extremity. We recently experienced a case of extraskeletal Ewing's sarcoma of the right arm in a 53 years old male. The patient underwent local wide excision and postoperative radiation of 6.480cGy and combination chemotherapy with VP-16, adriamycin, vincristine, prednisolone and cyclophosphamide. We presented a case of extraskeletal Ewing's sarcoma in the right arm with review of world literature.

골외골육종의 압착도말 소견 - 1예 보고 -

구미진,배영경,김미진,최준혁,최원희,Gu, Mi-Jin,Bae, Young-Kyung,Kim, Mi-Jin,Choi, Joon-Hyuk,Choi, Won-Hee 대한세포병리학회 2000 대한세포병리학회지 Vol.11 No.1

Extraskeletal osteosarcoma is an uncommon tumor originated from soft tissue without evidence of skeletal involvement. It usually affects adults and its common locations are extremity, buttock, and retroperitoneum. Although the histologic feature of this tumor is well known, there have been few reports on the fine needle aspiration cytologic findings. We report the imprint cytologic feature of extraskeletal osteosarcoma. The patient was a 49-year-old man with a mass of the left anterior chest for 2 years. On the Imprint preparation, the smears showed malignant round, polygonal or spindle cells with coarsely clumped chromatin and occasionally prominent nucleoli. The malignant cells occur singly, in clusters, or associated with amorphous eosinophilic osteoid. Mitotic figures are also seen.

[P310] Pancreatic extraskeletal osteosarcoma metastasizing to the scalp

( Hak Tae Kim ),( Young Jae Kim ),( Chong Hyun Won ),( Sung Eun Chang ),( Mi Woo Lee ),( Jee Ho Choi ),( Woo Jin Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Extraskeletal osteosarcoma (ESOS) is a rare mesenchymal soft tissue neoplasm which accounts for approximately 1% of all soft tissue sarcomas. More than 70% of this malignant tumor progresses local recurrence and metastasis. It is commonly metastasized to the lungs, lymph nodes, bone, and skin with poor survival outcome. Cutaneous metastasis is an exceedingly rare and known to be a flag sign of widespread metastases. We present a 57-year-old woman presented with a rapidly growing protruding mass on the scalp which is finally diagnosed with metastatic ESOS from primary pancreatic ESOS. To our knowledge, there has been no reported case of pancreatic extraskeletal osteosarcoma metastasizing to the scalp.

Extraskeletal Mesenchymal Chondrosarcoma of the Heart Responded to Systemic Chemotherapy: A Case Report

Chien Ter Hsing,Sung Yong Oh,Suee Lee,권혁찬,Sung-Hyun Kim,Tae-Ho Park,Jong Soo Woo,Seo Hee Na,김효진 대한암학회 2007 Cancer Research and Treatment Vol.39 No.3

Mesenchymal chondrosarcoma is a rare cartilaginous neoplasm of an extraskeletal origin, and this predominately occurs in the head and neck, and also in the lower extremities. Fewer than twenty cases of cardiac mesenchymal chondrosarcoma have so far been reported on. For the most part, the results of treatment for patients with this condition have been dismal. In this study, we describe a case of cardiac mesenchymal chondrosarcoma that responded to chemotherapy following surgical biopsy. A 46-year-old man was referred for evaluation of his pleural effusions in both lungs. Chest computed tomography revealed an ovoid-shaped mass in the posterior wall of the patient’s left atrium. The echocardiogram revealed a large ovoid-shaped immobile mass (11×6 cm2) in the pericardiac space, which was attached tothe posterior wall of the left atrium. Emergency pericardiostomy with closure thoracostomy was performed. Seven days later, a thoracotomy was performed for reduction and diagnosis of the cardiac mass. The pathological diagnosis was extraskeletal mesenchymal chondrosarcoma of the heart.. Postoperative chemotherapy was performed for the huge remaining mass with a combined regimen of etoposide, ifosfamide and cisplatin. After 6 cycles, the patient showed a partial response without symptoms. Although cardiac mesenchymal chondrosarcoma has been reported to be chemotherapy- resistant with a short survival duration, chemotherapy may prove to be an effective treatment modality. (Cancer Res Treat. 2007;39:131-133)

A case of primary cutaneous extraskeletal osteosarcoma on the back

( Kihyuk Shin ),( Sang Hyeon Won ),( Woo Il Kim ),( Min Young Yang ),( Won Ku Lee ),( Gun Wook Kim ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Extraskeletal osteosarcoma (ESOS) is a malignant mesenchymal neoplasm composed of tumor cells producing bone, osteoid, and/or chondroid material without attachment to skeletal structures. Despites most reports of ESOS were located in deep soft tissue, primary cutaneous SFT is extremely rare. A 77-year-old man presented with subcutaneous mass on the left lower back, which had been growing slowly for 1.5 years. The patient did not complain of lesionassociated pain and itching. A biopsy was performed, and the tumor was composed of proliferating atypical and pleomorphic spindle cells with focal osteoid formation. On immunohistochemical examination, the tumor cells were positive for vimentin, and negative for cytokeratin, CD68, CD31 and CD34. Beyond histopathological examination, computed tomography and positron emission tomography-computed tomography revealed no other skeletal involvement. These clinicopathologic findings were consistent with primary cutaneous ESOS. The tumor was excised, and the patient was transferred to the oncology department for the chemotherapy. To our knowledge, this is the second report of primary cutaneous ESOS in Korean dermatologic literature. Despite its rarity, ESOS should be considered in the differential diagnoses when osteoid is found on the skin.