중독(中毒)과 해독(解毒)에 관한 문헌적(文獻的) 고찰(考察) - (동의보감(東醫寶鑑)을 중심(中心)으로) -

이강녕,최창원,이영수,김희철,곽정진,Lee Gang-Nyoung,Choi Chang-Won,Lee Young-Soo,Kim Hee-Chul,Kwack Jeong-Jin 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.1

From the study of the definition of and intoxication, detoxication poisonous drug, the symptom and treatment of intoxication, andantidotes with DONG YUI BO GAM etc, it can be concluded as follows. 1. In ancint times, the poisonous drug was a drug which could treat diseases but after that it has been a drug which can injure one's health because it has severe property, poison or side effects 2. Intoxication means that poison goes and works in the body. Detoxication means treatment which clears the symptom of intoxication and removes the toxin in the body or on the body 3. At the intoxication's symptom, vomiting, madness, diarrhea, abdomianl pain, consumption are frequent in order 4. At the intoxication's treatment, vomiting method is used when poison is in the stomach, purgative method is used when poison is the intestine. 5. Mostly Hei-dou is used in drugs and Gan-kao. Qing-yan are used in order. 6. Mostly drugs of reliving fever are used in drugs. 7. Mostly cold drugs are used in drugs and warm, even, hot, cool drugs are used in order and mostly mild drugs are used in drugs and bitter, hot, salty, sore drugs are used in order.

횡문근융해증을 유발하는 음독 약물별 임상경과 분석

이미진,김형민,김영민,이원재,소병학,김세경,Lee Mi Jin,Kim Hyung Min,Kim Young Min,Lee Won Jae,So Byung Hak,Kim Se Kyung 대한임상독성학회 2003 대한임상독성학회지 Vol.1 No.1

Purpose: According as the accessibility about drugs becomes various, the occurrence of drug intoxication is increasing. Since report that doxylamine causes rhabdomyolysis often, drug-induced rhabdomyolysis is one of the most important complications in patients with drug intoxication. Acute renal failure (ARF)'s availability is important to the management in rhabdomyolysis, but report about rhabdomyolysis or ARF occurrence for whole intoxicated drugs is lacking up to now. Methods: This research did to 61 patient who had rhabdomyolysis of drug intoxication. First, object patients were divided into two gruops: doxylamine-ingested (Group I) vs non-doxylamine ingested (Group II). And then we analyzed on the early patient's clinical events and laboratory data. We used ROC curve to recognize'the early clinical factors that could forecast ARF appearance among these patients in addition. Results: Almost rhabdomyolysis was happened by doxylamine in drug intoxication ($55.7\%$). However, as compared to group II, group I showed better clinical course, lesser ARF occurrence and hemodialysis requirement. In group II, time was longer in hospital reaching from intoxication, the ARF occurrence rate was higher ($52.6\%$). Analyzing the ROC curve to useful initial factors, they were creatinine, uric acid and interval time from ingestion to hospital. These cut-off values were 1.44 mg/dL, 6.8 mg/dL and 5 hrs. Sensitivity for ARF estimate was $100\%$, specificity $69-98\%$. Conclusion: Compared to group II, Doxylamine-ingested group showed good clinical course. Creatinine, uric acid, interval time from ingestion to hospital aided in ARF estimate in drug-induced rhabdomyolysis.

Clinical Characteristics of Acute Drug Intoxication in Emergency Department

Kim In Byung,Chun Sung Pil,Kim Seung Whan 대한의생명과학회 2004 Biomedical Science Letters Vol.10 No.3

The number of acute drug intoxication who visiting to emergency department which is located near urban and rural area concomitantly is inclined to increase slightly, The purpose of this study was the investigation of methods and strategies of management of acute drug intoxication in emergency department Clinical trials were done on 92 cases of acute drug intoxication visiting to Emergency Department of Chungnam National University Hospital during 4 months from April to July 2003. 1. The total number of acute drug intoxication during this period was 92 patients, which presented 0.95% of all the emergency department visiting patients during the study. The intentional ingestions were observed in 84 cases (91.3%). 2. The maximal point of age distribution was 4th decade. The number of that was 21 cases (22.8%). 3. The number of patients who had ingested benzodiazepines and doxylamine succinates was 26 cases (28.2%), organophosphorus was 20 (21.7%), paraquat was 10 (10.8%), others were 36 (39.3%). 4. Five kinds of po1ydrug ingestion was observed in 3 cases, four kinds was observed in 3, three kinds was observed in 5 and co-ingestion of alcohol was observed in 28 cases (30.4%). 5. The mortality was occurred in 4 cases, 2 of them were caused by paraquat, 1 of them was caused by organophosphorus (OP), 1 of them was caused by acetic acid. 6. The gastric larvage as a mean of treatment modality was done in 57 cases (61.9%). The use of activated charcoal was done in 8 (8.69%). The maintenance of tracheal intubation was done in 6 (6.52%). 7. The mean observational period in emergency department was 8 hours 42 minutes in benzodiazepine and doxylamine succinate group, 21 hours 46 minutes in OP, 20 hours 39 minutes in other germicidal except OP, 23 hours 9 minutes in paraquat group. Without a drug information and intoxication center in Korea, We should minimize the exhaustion of medical resources by establishment of determinant criteria which can be seen in relatively less-complicated cases of acute drug intoxication. Thus, we should consider the introduction of simple toxicology treatment protocol and toxicologic observation unit in emergency department as possible means to reduce economical and social burdens.

Clinical Characteristics of Acute Drug Intoxication in Emeergency Department

Kim, In Byung,Chung, Sung Pil,Kim, Seung Whan THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.3

The number of acute drug intoxication who visiting to emergency department which is located near urban and rural area concomitantly is inclined to increase slightly. The purpose of this study was the investigation of methods and strategies of management of acute drug intoxication in emergency department. Clinical trials were done on 92 cases of acute drug intoxication visiting to Emergency Department of Chungnam National University Hospital during 4 months from April to July 2003. 1. The total number of acute drug intoxication during this period was 92 patients, which presented 0.95% of all the emergency department visiting patients during the study. The intentional ingestions were observed in 84 cases (91.3%). 2. The maximal point of age distribution was 4th decade. The number of that was 21 cases (22.8%). 3. The number of patients who had ingested benzodiazepines and doxylamine succinates was 26 cases (28.2%), organophosphorus was 20 (21.7%), paraquat was 10 (10.8%), others were 36 (39.3%). 4. Five kinds of polydrug ingestion was observed in 3 cases, four kinds was observed in 3, three kinds was observed in 5 and co-ingestion of alcohol was observed in 28 cases (30.4%). 5. The mortality was occurred in 4 cases, 2 of them were caused by paraquat, 1 of them was caused by organophosphorus (OP), 1 of them was caused by acetic acid. 6. The gastric larvage as a mean of treatment modality was done in 57 cases (61.9%). The use of activated charcoal was done in 8 (8.69%). The maintenance of tracheal intubation was done in 6 (6.52%). 7. The mean observational period in emergency department was 8 hours 42 minutes in benzodiazepine and doxylamine succinate group, 21 hours 46 minutes in OP, 20 hours 39 minutes in other germicidal except OP, 23 hours 9 minutes in paraquat group. Without a drug information and intoxication center in Korea, We should minimize the exhaustion of medical resources by establishment of determinant criteria which can be seen in relatively less-complicated cases of acute drug intoxication. Thus, we should consider the introduction of simple toxicology treatment protocol and toxicologic observation unit in emergency department as possible means to reduce economical and social burdens.

Clinical Characteristics of Acute Drug Intoxication in Emergency Department

In Byung Kim,Sung Pil Chung,Seung Whan Kim 대한의생명과학회 2004 Biomedical Science Letters Vol.10 No.3

The number of acute drug intoxication who visiting to emergency department which is located near urban and rural area concomitantly is inclined to increase slightly. The purpose of this study was the investigation of methods and strategies of management of acute drug intoxication in emergency department. Clinical trials were done on 92 cases of acute drug intoxication visiting to Emergency Department of Chungnam National University Hospital during 4 months from April to July 2003. 1. The total number of acute drug intoxication during this period was 92 patients, which presented 0.95% of all the emergency department visiting patients during the study. The intentional ingestions were observed in 84 cases (91.3%). 2. The maximal point of age distribution was 4th decade. The number of that was 21 cases (22.8%). 3. The number of patients who had ingested benzodiazepines and doxylamine succinates was 26 cases (28.2%), organophosphorus was 20 (21.7%), paraquat was 10 (10.8%), others were 36 (39.3%). 4. Five kinds of polydrug ingestion was observed in 3 cases, four kinds was observed in 3, three kinds was observed in 5 and co-ingestion of alcohol was observed in 28 cases (30.4%). 5. The mortality was occurred in 4 cases, 2 of them were caused by paraquat, 1 of them was caused by organophosphorus (OP), 1 of them was caused by acetic acid. 6. The gastric larvage as a mean of treatment modality was done in 57 cases (61.9%). The use of activated charcoal was done in 8 (8.69%). The maintenance of tracheal intubation was done in 6 (6.52%). 7. The mean observational period in emergency department was 8 hours 42 minutes in benzodiazepine and doxylamine succinate group, 21 hours 46 minutes in OP, 20 hours 39 minutes in other germicidal except OP, 23 hours 9 minutes in paraquat group. Without a drug information and intoxication center in Korea, We should minimize the exhaustion of medical resources by establishment of determinant criteria which can be seen in relatively less-complicated cases of acute drug intoxication. Thus, we should consider the introduction of simple toxicology treatment protocol and toxicologic observation unit in emergency department as possible means to reduce economical and social burdens.

대구 응급의료센터와 약물 중독 선택 키트를 이용한 진단테스트의 의료적인 유연성에 급성중독환자의 진단타입

이승진,임순옥,김태정,박민정,유종하 대한임상검사과학회 2013 대한임상검사과학회지(KJCLS) Vol.45 No.3

It is important to check the types of drugs when treating acute drug intoxication. This study researches the clinical characteristics and types of patients hospitalized in emergency medical center for drug addiction in 2009 and 2010. By applying a drug addiction selecting kit, it studied the flexibility and clinical efficiency during diagnosis and treatment. The study result shows, among the drugs causing addiction, Sedative accounts for 34.4%, Herdicide 23.5%, Analgesic 17.2%, Insectide 7.8% and else 17.2%. Sedative showed the highest proportion both in 2009 and 2010. Among the drug addicted patients, 39 cases did not know that the drugs are poisonous and among them, the drug addiction selecting kit was positive in 32 cases (82.0%). In 42 cases where addiction was suspicious, 25 cases (59.5%) were positive in the drug addiction selecting kit. In 57 cases of using drug addiction selecting kits, the cases in which benzodiazepine was positive, were 30 and the most frequently cases were as follows; Tricyclic Antidepressants (TCA) 13 cases, Amphetamines 3 cases, barbiturate 3 cases, and piate 3 cases. In the district using drug addiction kit meaningfully had Flumazenil injection much greater impact than the one not using the kit. This proves the efficiency of the kit (p<0.05). The uses of drug addiction selecting kits are for acute drug intoxicated patients and for providing objective and scientific information when emergency medical doctor are checking unchecked poisoning drugs. It is considered that drug addiction selecting kits would give help when treating the early stage of drug addicted patients in emergency medical treatment.

Type Analysis of Drug Intoxicated Patients in Daegu Emergency Medical Center and Medical Flexibility of Diagnostic Test Using Drug Addiction Selecting Kit

( Seung-jin Lee ),( Soon-ok Lim ),( Tae-jeong Kim ),( Min-jeong Park ),( Jong-ha Ryu ) 대한임상검사과학회 2013 대한임상검사과학회지(KJCLS) Vol.45 No.3

It is important to check the types of drugs when treating acute drug intoxication. This study researches the clinical characteristics and types of patients hospitalized in emergency medical center for drug addiction in 2009 and 2010. By applying a drug addiction selecting kit, it studied the flexibility and clinical efficiency during diagnosis and treatment. The study result shows, among thedrugs causing addiction, Sedative accounts for 34.4%, Herdicide 23.5%, Analgesic 17.2%, Insectide7.8% and else 17.2%. Sedative showed the highest proportion both in 2009 and 2010. Among the drug addicted patients, 39 cases did not know that the drugs are poisonous and among them, the drug addiction selecting kit was positive in 32 cases (82.0%). In 42 cases where addiction was suspicious, 25 cases (59.5%) were positive in the drug addiction selecting kit. In 57 cases of using drug addiction selecting kits, the cases in which benzodiazepine was positive, were 30 and the most frequently cases were as follows; Tricyclic Antidepressants (TCA) 13 cases, Amphetamines 3 cases, barbiturate 3 cases, and piate 3 cases. In the district using drug addiction kit meaningfully had Flumazenil injection much greater impact than the one not using the kit. This proves the efficiency of the kit (p<0.05). The uses of drug addiction selecting kits are for acute drug intoxicated patients and for providing objective and scientific information when emergency medical doctor are checking unchecked poisoning drugs. It is considered that drug addiction selecting kits would give help when treating the early stage of drug addicted patients in emergency medical treatment.

Type Analysis of Drug Intoxicated Patients in Daegu Emergency Medical Center and Medical Flexibility of Diagnostic Test Using Drug Addiction Selecting Kit

Lee, Seung-Jin,Lim, Soon-Ok,Kim, Tae-Jeong,Park, Min-Jeong,Ryu, Jong-Ha 대한임상검사과학회 2013 대한임상검사과학회지(KJCLS) Vol.45 No.3

It is important to check the types of drugs when treating acute drug intoxication. This study researches the clinical characteristics and types of patients hospitalized in emergency medical center for drug addiction in 2009 and 2010. By applying a drug addiction selecting kit, it studied the flexibility and clinical efficiency during diagnosis and treatment. The study result shows, among the drugs causing addiction, Sedative accounts for 34.4%, Herdicide 23.5%, Analgesic 17.2%, Insectide 7.8% and else 17.2%. Sedative showed the highest proportion both in 2009 and 2010. Among the drug addicted patients, 39 cases did not know that the drugs are poisonous and among them, the drug addiction selecting kit was positive in 32 cases (82.0%). In 42 cases where addiction was suspicious, 25 cases (59.5%) were positive in the drug addiction selecting kit. In 57 cases of using drug addiction selecting kits, the cases in which benzodiazepine was positive, were 30 and the most frequently cases were as follows; Tricyclic Antidepressants (TCA) 13 cases, Amphetamines 3 cases, barbiturate 3 cases, and piate 3 cases. In the district using drug addiction kit meaningfully had Flumazenil injection much greater impact than the one not using the kit. This proves the efficiency of the kit (p<0.05). The uses of drug addiction selecting kits are for acute drug intoxicated patients and for providing objective and scientific information when emergency medical doctor are checking unchecked poisoning drugs. It is considered that drug addiction selecting kits would give help when treating the early stage of drug addicted patients in emergency medical treatment.

도시지역 응급센터를 내원한 약물중독 환자

유지영,최옥경,김무수,정구영 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

Acute drug intoxication is a important part of emergency medicine. The outcome of intoxicated patients depends upon a kind of drug, a dose of drug, the time of initial management and the knowledge of variable drugs. Our study was made on 249cases of acute drug intoxication, who visited to emergency department of Ehwa Wonams University Mokdong Hospital during 15months from June 1994 to August 1995. The patients of early 10 months period were treated in department in IM and patients of late 5 months period treated in department of EM. The results were as follows : 1) Total nember of patients was 249 which is 0.59% fo total ED patients. The male to female ratio was 1:2 (81pts : 168 pts) The age distribution showed the highest incidences in 2nd (35%) and 3rd (23%) decades. 2) The most patients (78%) were visited to ED within 4 hour after drug ingestion. 3) The most common drug which activated charcoal was indicated was sedatives and hynotics (63%) The most common drug which activated charcoal was contraindicated was strong acid-alkali (4%) 4) The total mortality of intoxicated patients was 8%. 5) The outcomes of the patients( early 10 months vs. late 5 months) : the percentage of admission was 20% vs 24%, discharge against admission was 36% vs 46% discharge was 21% vs 22%, transfer to other hospital was 22% vs 9%

급성약물중독환자의 간호실무표준 개발 : 응급의료센터 내원환자 중심으로

이은경(Eun Kyung Lee),김희정(Hee Jung Kim),박선영(Sun Young Park) 대한여성건강학회 2008 여성건강 Vol.9 No.2

The purpose of this study is to present the desirable level of emergency nursing care of acute drug intoxication by identifying the roles and activities of nurse of emergency medical center as well as to raise the quality of nursing care of acute drug intoxication. The 143 activities of nurse of emergency medical center were identified through a review of literature and a state-of-the-practice survey. The 143 activities were classified into roles and tasks. The roles and tasks were developed to standards and criteria. To verify the content validity of the draft standards and criteria, emergency nursing experts were asked to rate each item of standards and criteria. The data analysis was conducted using the Content Validity Index(CVI). The final 8 standards and 38 criteria of acute drug intoxication care were developed through two rounds of content validity verification. The nursing care standards of acute drug intoxication can present the ideal nursing care and be used as a tool for the quality of nursing care of acute drug intoxication.