아토피 피부염에서 아토피 지표의 의의

이영진(Young Jin Lee),강혜영(Hye Young Kang),정병주(Byeong Ju Jeong),김규언(Kyu Earn Kim),이기영(Ki Young Lee),이수영(Soo Young Lee) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1994 소아알레르기 및 호흡기학회지 Vol.4 No.2

N/A To evaluate the clinicopathologic importance and relationship of atopic dermatitis with atopic index such as allergy skin testing and serum total IgE concentration, skin scratch testing with 63 allergens of Tarii company (Japan) were performed in 342 children with atopic dermatitis and serum total IgE was determined by FAST method, The number of children with non-atopic atopic dermatitis characterized by normal level of serum IgE and negative reactions in all allergens was 71(20.8%) and the number of children with atopic atopic dermatitis which is characterized by elevated serum IgE level and positive reaction in more than one allergen on skin testing was 177(51.8%). Excluding the cases of 154 patients who show coexistence of possible allergic diseases such as bronchial asthma and allergic rhinitis, the number of verified atopic atopic dermatitis by atopic indices was 23(6.7%), Coexistence of allergic respiratory diseases such as bronchial asthma and allergic rhinitis with atopic dermatitis were 87,0% in atopic atopic dermatitis and' 54.9% in non-atopic atopic dermatitis. There was significant coexistenee rate of respiratory diseases such as bronchial asthma and allergic rhinitis in atopic atopic dermatitis. In studying severity of atopic dermatitis, the number of children of moderate to severe atopic dermatitis was much more in atopic atopic dermatitis significantly. Significantly higher rate of moderate to severe atopic dermatitis was present in atopic atopic dermatitis compared to non-atopic atopic dermatitis. Also a higher rate of moderate to severe atopic dermatitis was present in the group of serum IgE leve1 greater than the sum of the mean of each age and two-standard deviation . The most common positive skin reaction of allergy skin testing was Dermatophagoides farinae(93.3%). There was no significant differences in skin reactions of DF, DP, HD, yeast, alternaria and cockroach regardless of coexistence of respiratory disease. It is suggested that there was a non-atopic factor besides an atopic factor which is related to atopic dermatitis. Further studies should be needed to discover pathogenesis and mechanism of atopic dermatitis in these cases.

Macrophage Raw 264.7 세포와 아토피성 피부염이 유도된 NC/Nga Mice에서 AF-343에 의한 염증 억제 효과와 피부 보습 효과에 관한 연구

김범준,임윤영,김형미,박은주,김명남,최창숙,박기문,김현석,김종근,홍연표,조수묵 대한의진균학회 2010 대한의진균학회지 Vol.15 No.2

Background: Inflammatory response on LPS and IFN-γ induced Macrophage Raw 264.7 cells was secreted NO (nitric oxide) and PGE2 (prostaglandin E2) though expression of iNOS and COX-2. And many pro-inflammatory cytokines (TNF-α, IL-1β, IL-6 etc.) was secreted on LPS and IFN-γ induced Macrophage Raw 264.7 cells, too. Atopy dermatitis was inflammatory skin disease with pruritus,xeroderma and specific eczema. Objective: We sought to effect of anti-inflammation and skin hydration of AF-343 on Macrophage Raw 264.7 cells and NC/Nga mice with Atopic Dermatitis. Methods: The immune response of Raw 264.7 cells were induced by LPS and IFN-γ. Then LPS and IFN-γ induced Raw 264.7 cells was measured NO, PGE2 production after treatment of different concentrations for AF-343. The related genes (iNOS, COX-2) for NO, PGE2 production were detected using Western blot in LPS and IFN-γ induced Raw 264.7 cells after treatment of different concentrations for AF-343. Pro-inflammatory cytokines were detected, too. NC/Nga mice as Atopy dermatitis model was induced atopy dermatitis. Then NC/Nga mice with atopy dermatitis were performed oral administration of AF-343 for 1weeks. After oral administration of AF-343, TEWL was measured on skin tissues of NC/Nga mice with atopy dermatitis according to whether were performed oraladministration of AF-343 or not. And pro-inflammatory cytokines and IgE was measured in serum,protein of skin tissues of NC/Nga mice. Skin tissues of NC/Nga mice were performed H&E staining,immunohistochemical staining for PCNA, Involucrin and filaggrin. Results: LPS and IFN-γ induced Raw 264.7 cells was decreased NO, PGE2 production in dose-dependent after treatment of different concentrations for AF-343. The expression level of iNOS,COX-2 protein was decreased in dose-dependent, too. The related pro-inflammatory cytokines in media with LPS and IFN-γ induced Raw 264.7 cells were decreased after treatment of different concentrations for AF-343. TEWL level of NC/Nga mice skin (back, ear) with atopy dermatitis according to whether were performed oral administration of AF-343 or not was decreased in NC/Nga mice with atopy dermatitis group was performed oral administration by AF-343. When NC/Nga mice group with atopy dermatitis was performed oral administration by AF-343, induced pro-inflammatory cytokines and IgE expression in serum, protein of back, ear skin tissues of each NC/Nga mice group was decreased. H&E stained Skin tissues of NC/Nga mice was confirmed that thickness of epidermis, dermis were decreased in NC/Nga mice group with atopy dermatitis was performed oral administration by AF-343 than NC/Nga mice group with atopy dermatitis. The expression of PCNA, involucrin and filaggrin were decreased in NC/Nga mice group with atopy dermatitis was performed oral administration by AF-343than NC/Nga mice group with atopy dermatitis as results of immunihistochemical staining using specific antibodies such as PCNA as cell proliferation marker, involucrin and filaggrin as keratinocytes differentiation markers for skin tissues (back, ear) of NC/Nga mice. Conclusion: We confirmed effect of anti-inflammation and skin hydration of AF-343 on Macrophage Raw 264.7 cells and NC/Nga mice with Atopic Dermatitis. In conclusion, AF-343 is expecting as therapeutics for atopic dermatitis.

아토피 피부염의 유발 원인에 관한 연구

박성애 ( Sung Ea Park ),허용 ( Yong Heo ) 대구가톨릭대학교 자연과학연구소 2009 자연과학연구논문집 Vol.7 No.1

Atopic dermatitis word in the plural implies that people with this disease than the normal, sensitive to certain food antigens or antigen inhalation causes allergic to react. Recently associated with atopic dermatitis and international journals, textbooks, research institutes and national institutions were reviewed over a leg 50 of the report. Outside the journal ``http://www.ncbi.nlm.nih.gov/sites/entrez/`` in the keyword "atopic dermatitis" in the Journal of the search was mainly shot, possession of controversial research that many or the number of subjects too few papers that were excluded if possible. causes of atopic dermatitis, atopic dermatitis and prevention research literature on the subject of investigation and international research trends, National Health Insurance Corporation through the release of the records has developed a statistical basis. Domestic Journal the Korea Research Foundation deungjaeji and the search was mainly of listed candidates, the existing research is being published in journals, or preferably of the present scientific evidence, or through double-blind clinical trial results, including the Journal of the order to select mainly was. The skin associated with atopic dermatitis confined to the management plan is considered reasonable in the Abstract and the report, the Institute released information was abbreviated. The prevalence of atopic dermatitis over the health impact of environmental factors were central to the investigation. The cause of atopic dermatitis, research and prevention of atopic dermatitis on the subject of research literature on survey research, and international trends, national health insurance said one of the basic materials has created a statistical survey, prevalence of atopic dermatitis in children through the causes of trends for research study was as follows. First, the basic statistical data of National Health Insurance Corporation study analyzed data for children 5-7 years old 5 to the prevalence of atopic dermatitis, 14.9%, age 6 to 12.9%, 7 to 9.8% was to appear. Secondly, based on data of National Health Insurance Corporation from 2003 to 2007 the average prevalence of atopic dermatitis in children`s gender for the remaining 9.7% to 9.4% of the girls that if the prevalence has increased. Third, the father and the child with atopic dermatitis, atopic dermatitis, the incidence was 66.6%, 45.9% is not the mother if the child has atopic dermatitis, atopic dermatitis, the incidence of 70.0%, 45.7% in the eopeun atopic dermatitis This survey was a large genetic effect. The higher the education of parents of children with atopic dermatitis shows up as a low incidence of breast milk, your child`s atopic dermatitis suyuhan 52.1% in the feeding rate is not higher than 40.5% were surveyed. Was no significant difference in food preferences. Fourth, the environmental impact of indoor smoke from the 55.5% incidence of atopic dermatitis in children as the smoking does not significantly higher than the survey was 46.9%.

눈꺼풀 피부염의 원인 질환에 대한 연구

홍광철 ( Kwang Cheol Hong ),김성현 ( Seong Hyun Kim ),김명신 ( Myoung Shin Kim ),이운하 ( Un Ha Lee ),박현수 ( Hyun Su Park ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.8

Background: The eyelids are uniquely susceptible to inflammation. Although eyelid dermatitis is common by various causes, there are few comprehensive studies on this disease in the Korean literature. Objective: The purpose of this study was to analyze the causative disease for eyelid dermatitis in Koreans. Methods: Medical records of patients with eyelid dermatitis treated between 2006 and 2011 were reviewed. Results: Four hundred and five patients (152 males and 303 females) were enrolled in this study, and the mean age of onset was 32.7 (range: 0∼84). The most common causes of eyelid dermatitis were allergic contact dermatitis (42.6%), atopic dermatitis (27.9%), irritant contact dermatitis (12.7%), seborrheic dermatitis (8.6%), insect bite (2.4%), etc., in the order of frequency. In the 194 patients of eyelid dermatitis caused by allergic contact dermatitis, 98 patients (50.5%) were in the 30`s to 50`s, and 120 patients (94.5%) of the 127 patients with atopic dermatitis were under thirty years of age. The frequency of causative diseases for eyelid dermatitis in men were atopic dermatitis (44.7%), allergic contact dermatitis (23.7%) and irritant contact dermatitis (12.5%), and those in women were allergic contact dermatitis (52.1%), atopic dermatitis (19.5%) and irritant contact dermatitis (12.9%). There was a seasonal variation with frequency in fall (30.3%) and spring (26.4%). Among the 341 patients who were followed up, 294 patients (86.2%) showed good response to treatment, but 64 patients (21.8%) of the improved 294 patients relapsed. Four patients experienced adverse effects including irritation (3 cases) and folliculitis (1 case) after using topical glucocorticoids. Conclusion: The frequency of eyelid dermatitis decreased by age. Eyelid dermatitis was more common in women, but the ratio of males to females was increased compared with previous reports. The most common causes of eyelid dermatitis were allergic contact dermatitis, atopic dermatitis and irritant contact dermatitis, which were similar with the results of previous reports. Eyelid dermatitis was more common in fall and spring. The recurrence rate was relatively high, but adverse effects of topical corticosteroids were unusual. This study will be useful for clinicians when treating patients with eyelid dermatitis. (Korean J Dermatol 2013;51(8):579∼585)

Clinical Characteristics of Lichen Amyloidosis Associated with Atopic Dermatitis: A Single Center, Retrospective Study

오승민,안혜진,신민경 대한피부과학회 2023 Annals of Dermatology Vol.35 No.6

Background: Lichen amyloidosis is a chronic pruritic skin disorder associated with atopic dermatitis, however, the pathogenetic link between these two conditions remains to be elu- cidated. Only limited research has been performed on patients diagnosed with both pruritic dermatological conditions. Objective: This study aimed to analyze the clinical features of lichen amyloidosis associated with atopic dermatitis. Methods: We conducted a matched case-control study of incident lichen amyloidosis with atopic dermatitis between March 2020 and February 2022. Among the 2,481 patients with atopic dermatitis, 20 patients diagnosed with lichen amyloidosis and atopic dermatitis were included as case patients, and 20 patients diagnosed with atopic dermatitis were enrolled as controls. The controls were matched to cases (1:1) by age and sex. We retrospectively re- viewed the medical records of the patients. Results: The prevalence of lichen amyloidosis associated with atopic dermatitis was approxi- mately 0.8%, with a male:female sex ratio of 2.33:1. The recorded onset of lichen amyloidosis associated with atopic dermatitis was more common in adult patients, with moderate-to- severe atopic dermatitis. Lichen amyloidosis lesions in patients with atopic dermatitis were most commonly found on the extremities, sparing the head and neck region. The presence of lichen amyloidosis had no significant impact on severity of atopic dermatitis. Conclusion: In patients with lichen amyloidosis associated with atopic dermatitis, the clini- cal manifestations of lesions are similar to those of conventional lichen amyloidosis lesions in terms of morphology and regional distribution. Further research is required to elucidate the link between the pathogenesis of these two pruritic dermatological conditions.

Characteristic Clinical Features of Korean Atopic Dermatitis Patients with Interleukin-17 Receptor A Gene Mutation

( Jong Won Lee ),( Kwangmin Yu ),( Hyeyoung Lee ),( Eung Ho Choi ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.4

Background: Th17 cytokines such as interleukin-17 and interleukin-22 are expressed in atopic dermatitis lesions. Previous studies have reported increased levels of interleukin-17A, -17E, and -17F in patients with atopic dermatitis. As interleukin-17A, -17E and -17F act through a common receptor composed of interleukin-17RA, it is speculated that interleukin-17RA gene (IL17RA) mutation could affect the clinical characteristics of atopic dermatitis. Objective: This study aimed to characterize the clinical features of atopic dermatitis according to the presence of an IL17RA mutation in patients with atopic dermatitis. Methods: We performed reverse blot hybridization assay to detect IL17RA mutations in Korean patients with atopic dermatitis. The clinical features of atopic dermatitis were compared between atopic dermatitis patients with and without IL17RA mutation. Results: Of 332 patients with atopic dermatitis, 27 (8.1%) were found to have IL17RA mutation compared to 8 of 245 controls without atopic diseases (3.27%), which was statistically significant. Furthermore, 272 of atopic dermatitis patients (81.9%) had extrinsic type atopic dermatitis and 60 (18.1%) had intrinsic type. All patients with IL17RA mutations had extrinsic type. In addition, atopic dermatitis with IL17RA mutation was associated with longer disease duration, more frequent keratosis pilaris, higher blood eosinophil count, higher serum total immunoglobulin E level, higher house dust mite allergen-specific immunoglobulin E levels, and more need for systemic treatment than that in patients without IL17RA mutation. Conclusion: IL17RA mutation is associated with the more severe extrinsic type atopic dermatitis. So, it may predict the progress to severe atopic dermatitis. (Korean J Dermatol 2021;59(4):290∼295)

동물모델에서 cytokine 조율을 통한 한약의 항아토피피부염 효능과 임상적 응용에 대한 고찰

박영철 ( Yeong Chul Park ),임정대 ( Jung Dae Lim ),박용기 ( Yong Ki Park ),윤미숙 ( Mi Sook Yoon ),이선동 ( Sun Dong Lee ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.4

Objectives : There is a pressing need to determine the clinical and scientific validity of herbal therapies for animal model with atopic dermatitis since some differences in systemic cytokine polarization between in animal model and in patients with atopic dermatitis has been reported. New studies for tang, medicinal herb itself or effective ingradients of medicinal herb showing anti-atopic dermatitis effectiveness are reviewed in terms of cytokine regulation. Methods : Those herbal therapies used to treat atopic dermatitis in animal model were introduced and the expression pattern of cytokine and the activity of mast cell were compared in both animal model and patients with atopic dermatitis. Results : In case of atopic dermatitis in human, there is a biphasic pattern of cytokine expression in atopic dermatitis, with acute skin inflammation associated with a predominance of IL-4 and IL-13 expression from Th2 cells, and chronic inflammation associated with increased IL-5 from Th2-cells and IFN-γ from Th1-cells. However, a pattern of cytokine expression in animal model with atopic dermatitis is not matched well to the biphasic pattern of cytokine expression in patients with atopic dermatitis. In addition, a kind of cytokine is different by animal model with atopic dermatitis. These differences would make herbal medicines, showing their effectiveness on atopic dermatitis, difficult to apply to patients with atopic dermatitis. Conclusion : The pattern of local cytokine expression plays an important role in modulating tissue inflammation, and in atopic dermatitis this pattern depends on the acuity or duration of the skin lesion. Thus, in order to develop medicinal herb itself or effective ingradients of medicinal herb showing anti-atopic dermatitis effectiveness, biphasic pattern of cytokine expression should be considered in animal model with atopic dermatitis.

Basement membrane status in urticarial dermatitis: immunohistochemical analysis comparing with adult-onset atopic dermatitis

( Hyung-jin Park ),( Yong-yon Won ),( Tae In Kim ),( Hyeongwon Choi ),( Ki-heon Jeong ),( Ji-youn Sung ),( Min Kyung Shin ),( Mu-hyoung Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Urticarial dermatitis has urticarial and eczematous features with varying predominance at different times. Many clinicians still consider cases as other dermatitis including adult-onset atopic dermatitis due to the overlap occasionally found between them. Objectives: To evaluate the basement membrane status in urticarial dermatitis and compared it with those in normal skin and adult-onset atopic dermatitis. Methods: Basement membrane thickness was evaluated using Periodic-Acid-Schiff (PAS) staining, and immunohistochemical staining of type IV collagen and integrin α6 was performed to study basement membrane, in urticarial dermatitis, adult-onset atopic dermatitis, and normal skin. Results: Urticarial dermatitis and normal groups did not show significant difference in PAS-positive basement membrane thickness (p=0.374) and mean grades of staining intensity for type IV collagen (p=0.539) and integrin α6 in basement membrane (p=0.839). Basement membrane thickness and the mean grades of staining intensity for type IV collagen and integrin α6 in basement membrane of adult-onset atopic dermatitis group were significantly lower than those observed in normal and urticarial dermatitis groups (all, p<0.05). Conclusion: Basement membrane status in urticarial dermatitis was intact compared with normal skin. Histological parameters using special staining can be useful criteria in differentiating urticarial dermatitis from adult-onset atopic dermatitis.

경증 천식 환아에서 아토피피부염의 동반이 하기도 호산구 염증에 미치는 영향

이지현 ( Ji Hyun Lee ),이세규 ( Se Kyu Lee ),김영진 ( Yeong Jin Kim ),송도영 ( Do Young Song ),강임주 ( Im Ju Kang ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.3

Background and Objective: Atopic dermatitis is a risk factor for the development, severity, and persistence of childhood asthma. We performed this study to investigate the effect of coexistence of atopic dermatitis on eosinophilic lower airway inflammation and bronchial hyperresponsiveness in mild persistent asthma. Method: Sixsty-four patients with asthma without atopic dermatitis and 94 patients with asthma and atopic dermatitis were enrolled in this study. Sputum induction test, the methacholine challenge test and MAST CLA Korea Panel were performed. Sputum eosinophilic cationic protein (ECP), sputum eosinophils and allergen sensitization were compared between the groups. Bronchial responsiveness (BR) index for bronchial hyperresponsiveness was determined and compared between the groups. Result: The risk of sensitization to food and house dust mite allergen was higher in asthmatics with atopic dermatitis than in asthmatics without atopic dermatitis. In asthmatics with atopic dermatitis, sputum eosinophils and ECP level, BR index were significantly higher than in asthmatics without atopic dermatitis. The severity of atopic dermatitis significantly correlated with BR index and sputum eosinophils in asthmatics with atopic dermatitis. Conclusion: These results suggest that bronchial hyperresponsiveness and eosinophilic lower airway inflammation may be higher in asthmatics with atopic dermatitis than in asthmatics without atopic dermatitis and influenced by the severity of atopic dermatitis. (Korean J Asthma Allergy Clin Immunol 2006;26:206-212)

아토피 피부염에서 혈중 Interferon-γ , Interleukin-4 , Interleukin - 5 및 Interleukin - 10의 농도

이기영(Ki Young Lee),노건웅(Geun Woong Noh) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1998 소아알레르기 및 호흡기학회지 Vol.8 No.1

목 적 : 아토피 피부염은 알레르기 기전에 의한 만성 질환으로 interferon(IFN)-γ의 생성능이 감소하여 있고, interleukin(IL)-4의 생성능이 증가하여 있다. IFN-γ와 IL-4로 대변되는 Th1/Th2 세포의 불균형으로 인하여 IgE 생성이 증가하는 것으로 알려져 있는데, IgE의 증가는 아토피 피부염의 주요한 문제점으로 알려져 있다. 아토피 피부염에서 cytokine의 생성능에 관한 연구가 많지만, 실제 혈중농도에 관하여는 아직 확실하게 보고되어 있지 않다. 본 연구의 목적은 아토피 피부염에 관여하는 것으로 알려진 IFN-γ, IL-4 및 IL-5와 Th2 세포에서 생성되는 것으로 잘 알려져 있는 IL-10의 혈중 농도가 아토피 피부염에서 임상적으로 정상에 비하여 의의있는 변화를 나타내는지를 알아보기 위하여 본 연구를 시행하였다. IgE의 생성에 관여하는 것으로 알려진 IFN-γ와 IL-4의 농도가 혈중 IgE 농도와 상관관계가 있는지 살펴보았다. 대상 및 대상 : 아토피 피부염 환자군은 Hanifin과 Rajka의 기준을 만족시키는 아토피 피부염 환자 105명과 정상인 40명을 대조군으로 하였다. 대상자로부터 정맥혈 10ml을 채취하고 일반 혈액검사, 총 호산구수 및 혈중 IgE치를 측정하였다. 검체들에서 혈장을 분리하고 ELSIA법을 이용하여 IFN-γ, IL-4, IL-5 및 IL-10의 농도를 측정하여 정상 대조군과 비교하였다. 결 과 : 백혈구에서 호산구의 비 및 총 호산구의 수, 그리고 혈중 IgE 치 모두 아토피 피부염 환자군에서 의미있게 증가하였으나, 혈중 백혈구의 수에는 두군에서 차이가 없었다. IFN-γ의 혈중 농도는 아토피 피부염 환자군의 경우에 0.58±2.12pg/ml, 정상 대조군 5.20±2.60pg/ml으로 아토피 피부염에서 의미있게 낮았다(P<0.01). IL-4의 혈중 농도는 아토피 피부염 환자군에서 1.00±2.05pg/ml이었으나, 정상 대조군에서는 검출되지 않았고 (P<0.001), IL-5의 혈중 농도는 아토피 피부염에서 2.18±1.96pg/ml이었으나, 정상 대조군에서는 검출되지 않았다(P<0.001), IL-10의 혈중 농도는 아토피 피부염에서 2.36±3.38pg/ml, 정상 대조군에서는 9.78±4.52pg/ml로 아토피 피부염에서 정상 대조군에 비하여 오히려 낮은 결과를 보였다(P<0.01). 혈중 IgE치와 IFN-γ 및 IL씨의 혈중 농도간에는 유의한 상관관계를 보이지 않았다. 결 론 : 아토피 피부염에서 IFN-γ 및 IL-10의 혈중 농도는 정상보다 낮고, IL-4 및 IL-5 혈중 농도는 높다. 아토피 피부염에서 IFN-γ, IL-4, IL-5 및 IL-10의 혈중농도는 임상적으로 의미가 있다. 혈중 IFN-γ 및 IL-4 농도는 혈중 IgE치와 유의한 상관관계를 보이지 않았다. Purpose: There is reduced IFN-γ production with increased IL-4 production in atopic dermatitis. IgE production is known to increase from an imbalance of IFN-γ and IL-4 production. IgE overproduction is regarded as a major problem in the pathogenesis of atopic dermatitis. In this study we evaluated the significances of plasma IFN-γ, IL-4, IL-5 and IL-10 concentrations in atopic dermatitis. Also the correlation between IL-4 and IgE levels as well as IFN-γ and IgE levels were tested. Methods : One hundred and five(105) atopic dermatitis patients who fulfilled the criteria of Hanifin and Rajka were tested as an atopic dermatitis patient group. Forty(40) normal controls who have not had any personal or family history of allergic diseases were tested as a normal control group. Routine hematologic tests, plasma IgE levels and total eosinophil counts were tested in both groups. Also plasma IFN-γ, IL-4, IL-5 and IL-10 concentrations were measured using high-sensitive IL-4, IL-5, IL-10 and IFN-γ ELISA kits in both groups. Results : There was no noticeable difference in WBC counts between the atopic dermatitis group and the normal control group. In comparison, eosinophil percents in WBC and total eosinophil counts were significantly high in the atopic dermatitis group. Plasma IgE levels were also markedly elevated in the atopic dermatitis group. Plasm IFN-γ levels were significantly low in the atopic dermatitis group(0.58±2.12 pg/ml) as compared with normal control group(5.20±2.60pg/ml)(P<0.01). IL-4 and IL-5 were not detected in normal controls. But in the atopic dermatitis group plasma IL-4 concentration was 1.00±2.05pg/ml and IL-5 was 2.18±1.96pg/ml. Plasma IL-10 concentration was significantly low in the atopic dermatitis group(2.36±3.38 pg/ml) as compared with the normal control group(9.78±4.52pg/ml)(P<0.01). Conclusions : Plasma IFN-γ, IL-4, IL-5 and IL-10 levels were clinically significant in atopic dermatitis. However, plasma IL-10 levels of the atopic dermatitis was lower as compared to that of the normal subject. There was no significant correlation among plasma IFN-γ, IL-4 levels, and blood IgE levels.