Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines

Lin Ang,Hye Won Lee,Jun-Yong Choi,Junhua Zhang,Myeong Soo Lee 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.2

Background: Coronavirus disease 2019 (COVID-19) is pandemic and has caused illness to many people worldwide. This review aimed to summarize and analyze the herbal formulae provided by the guidelines for their pattern identifications (PIs) and compositions of herbs to treat patients with COVID-19. Methods: We searched 7 data sources for eligible traditional medicine guidelines up to March 6, 2020 and found a total of 28 traditional medicine guidelines that provide treatment measures for COVID-19. Results: Of the 28 guidelines, there were 26 government-issued Chinese guidelines and 2 Korean guidelines. After standardizing the terminology of the PIs and herbal formulae, there were 8 PIs and 23 herbal formulae for the mild stage, 11 PIs and 31 herbal formulae for the moderate stage, 8 PIs and 21 herbal formulae for the severe stage, and 6 PIs and 23 herbal formulae for the recovery stage in the Chinese guidelines. In the Korean guidelines, there were 4 PIs and 15 herbal formulae for the mild stage, 3 PIs and 3 herbal formulae for the severe stage, and 2 PIs and 2 herbal formulae for the recovery stage. In the frequency analysis of herbs, Glycyrrhizae Radix et Rhizoma, Armeniacae Semen Amarum, Ephedrae Herba, and Gypsum Fibrosum were found to be the herbs with the high frequency of usage in the Chinese guidelines. Conclusion: This review can be used as guidance for the traditional medicine treatment of COVID-19. Clinical evidence is needed in the future to evaluate the efficacy of traditional medicine.

틱장애에 대한 한약 대조군 연구의 최근 동향 (2007년 중국 임상 논문에서)

강문수 ( Mun Su Kang ),조이현 ( Yi Hyun Cho ),김락형 ( Lak Hyung Kim ) 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.2

Objective : This study was designed to analyze the herbal medicine case-control studies of tic disorder in traditional chinese medicine. Method : For this study, we searched the studies on tic disorder, which had been published 2007, through web-site CNKI(中國知識基礎設施工程 http://www.cnki.net). There were 15 herbal medicine case-control studies and we focused on those studies. Results : 1. DSM-Ⅳ(7 studies), CCMD(5 studies) and ICD-10(3 studies) were frequently used in the diagnosis of tic disorder. 2. Paeonia radix alba, Uncariae ramulus et uncus and Glycyrrhizae radix were frequently used in treatment. Moreover Scorpio, Gastrodiae rhizoma, Pinelliae rhizoma and so on were used. 3. Treatment results were assessed by improvement of symptom, YGTSS and so on. 4. Herbal medicine treatment was more effective than western medicine treatment in most studies, and side effects of herbal medicine were far less than those of western medicine. Conclusion : There have been reported many herbal medicine treatment studies of tic disorder in traditional chinese medicine. We believe that these studies can be applied to the clinical practices in Korean medicine.

최근 5년간의 콜레스 골절의 한약 치료에 대한 체계적 문헌고찰: China National Knowledge Infrastructure, PubMed를 중심으로

노희정 ( Hui Jeong Noh ),박도연 ( Do-yeon Park ),박혜선 ( Hye Sun Park ),김선종 ( Seon Jong Kim ) 한방재활의학과학회 2024 한방재활의학과학회지 Vol.34 No.1

Objectives The purpose of this study was to investigate the effectiveness and safety of herbal medicine treatment for Colles fractures through a systematic review and to provide evidence for applying herbal medicine treatment. Methods We searched for papers published from January 1, 2018 to October 18, 2023, in PubMed and China National Knowledge Infrastructure based on the keyword ‘Colles fracture’, ‘Chinese traditional medicine’, ‘Chinese medicine’, ‘herbal medicine’, ‘drugs, chinese herbal’, ‘kampo’, ‘decoction’, ‘capsule’, ‘powder’. Results A total of 51 studies were searched at first research. Then the studies were screening according to the criteria, and 13 studies were finally selected. The oriental medical intervention analyzed in this study was an orally administered herbal medicine. Conclusions Studies have shown that herbal medicine has a significant effect on Colles fractures. However, all studies were assessed as having a high risk of bias. In the future, further well-designed studies are needed to demonstrate the effectiveness of herbal medicine for Colles fractures and reduce the risk of bias. (J Korean Med Rehabil 2024;34(1):97-108)

Overview of Cochrane reviews on Chinese herbal medicine for stroke

Maoling Wei,Deren Wang,Deying Kang,Myeong Soo Lee,Tae-Young Choi,Lin Ang,Eunhye Song 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.1

Background: Stroke is a major health issue worldwide. Since Chinese herbal medicine is widely used for the treatment of stroke, there is a need to evaluate its efficacy as an alternative treatment option. The aim of this paper is to carry out an overview of Chinese herbal medicine for the treatment of stroke by summarizing and evaluating all existing Cochrane reviews. Methods: The Cochrane Database of Systematic Reviews was searched from its inception date to August 2019 using “stroke” and “herbal medicine” or “traditional medicine” as search terms. For the methodological quality assessment of the Cochrane reviews, the Assessment of Multiple Systematic Reviews (AMSTAR) tool was used. Results: Eight Cochrane reviews that evaluated the efficacy of herbal medicine for the treatment of stroke were included in this overview. There were 71 randomized controlled trials, with 5770 patients in total. The AMSTAR scores of the Cochrane reviews included in this study ranged from 9 to 11 with a mean score of 10. Three reviews met all the 11-item criteria of the AMSTAR. All reviews presented potential efficacy of herbal medicine for stroke treatment in terms of improvement of neurological deficit. Conclusions: This overview reveals the potential efficacy of herbal medicines for the treatment of stroke in terms of neurological deficit improvement. However, due to the high risk of bias in the reviews’ studies, an affirmative conclusion for the recommendation of herbal medicine for clinical practice could not be drawn.

CONSORT-CHM 2017 지침에 근거한 대한한의학회지 및 회원학회지에 투고된 경구투여 한약 중재를 활용한 무작위 배정 비교 임상 연구(RCT)의 양적, 질적 평가 연구

문세훈,조정호,최승관,한윤희,우현준,전병현,하원배,이정한 대한한방내과학회 2023 大韓韓方內科學會誌 Vol.44 No.6

Objectives: This study aims to explore the current usage status of orally administered Korean herbal medicine in randomized controlled trials (RCTs) published in the Journal of Korean Medicine and member journals using the CONSORT-Chinese Herbal Medicine Formulas 2017 (CONSORT-CHM 2017) checklist. Methods: We searched the OASIS, RISS, and KMBASE archives as well as the websites of the Journal of Korean Medicine and 45 member journals to identify RCTs that used herbal interventions. Two independent researchers searched and categorized the RCTs and performed a quantitative evaluation by journal, study design, and target disease, as well as qualitative evaluation of the literature using CONSORT-CHM 2017. Results: After the search, 66 articles were selected. The quantitative evaluation resulted in 13 articles (19.6%) that were published in the Journal of Korean Medicine and 12 articles (18.1%) in the Journal of Internal Korean Medicine. In terms of study design, 62 articles (93.9%) were parallel, 4 articles (6%) were crossover, and 2-arm parallel study designs were the most common in 45 articles (68.2%). In terms of the study participants, physiological characteristics and mechanisms in healthy individuals were the most common in 21 studies (31.8%) and obesity in 9 studies (13.6%). In terms of assessing completeness in the CONSORT-CHM 2017 items, 29 articles were rated high, 31 were rated moderate, and 6 were rated low. Items 4a, 6a, and 7a had low reporting rates (≤ 30%), while items 2a, 2b, and 12a were completely reported in all studies. Conclusion: Future RCTs using orally administered Korean herbal medicine need to be reported completely, and the CONSORT-CHM 2017 checklist can be a helpful tool for this purpose.

종설(綜說) : 항비만에 대한 본초약물의 최근 연구 동향 분석

정성효 ( Sung Hyo Jung ),노성수 ( Seong Soo Roh ),김미려 ( Mi Reo Kim ) 대구한의대학교 제한동의학술원 2013 東西醫學 Vol.38 No.2

Objects : This study was designed to suggest research direction for development of alternative herbal anti-obesity drug through analysis of trend in obesity studies with herbal medicine. Methods : We searched papers on ‘www.pubmed.com’ , and then filtered using keywords, obesity and (herbal, oriental medicine, traditional Chinese medicine, traditional Korean medicine, medicinal plant), in articles reported for recent 5 years between 2009 and Sep. 2013. Results : Total article found in the web site were 73 and they were analysed by system of study as in vivo(68%), in vitro(18%), in vivo and in vitro(14%). Used as a material in vivo system, by mouse(41%), rat(33%), human(22%), hamster(2%) and rabbit(2%). The used effective plants classified by medicinal plant(37%) and oriental herbal medicine(63). Entered channels and properties were dominant spleen & lung, sweet & warm in antiobesity-related oriental medicine respectively. In addition to these plants belonged in herbal to tonifying, clear hearts, releas the exterior, mainly. Conclusion : These result suggest availability of herbal medicine as a candidate materials of anti-obesity drug according to oriental therapeutic principles.

만성 췌장염의 한약 치료에 대한 최근 중의 임상 연구 동향 고찰

박채현,김민정,박재우,고석재 대한한방내과학회 2023 大韓韓方內科學會誌 Vol.44 No.4

Objectives: This study summarizes current trends and results in clinical studies on herbal medicine treatments for chronic pancreatitis. Methods: Studies published from 2014 to 2023 were searched for on the China National Knowledge Infrastructure (CNKI), PubMed, and KMbase using the keywords “chronic pancreatitis”, “herbal medicine”, “herb”, “만성 췌장염”, and “한약”. The studies were analyzed according to year, study design, characteristics of the patients, and traditional Chinese medicine (TCM) intervention. Results: In total, 23 studies were selected. There were 21 randomized controlled trials and 2 case-control studies. The most common herbal prescriptions were Qingyi-tang (淸胰湯), Radix Bupleuri (柴胡), Radix Paeoniae Alba (白芍藥), Radix Glycyrrhizae (甘草), Radix Scutellariae (黃芩), and Rhei Rhizoma (大黃). In all the studies, herbal medicine treatments were effective in the treatment of chronic pancreatitis, and efficacy was assessed using clinical symptoms, physicochemical examination, radiological examination, and relapse. Conclusions: Herbal medicine treatment can be an effective treatment for chronic pancreatitis and has potential in clinical practice.

자간전증의 국외 중의학 치료 고찰

강유림,황덕상,이창훈,장준복,이진무 대한한방부인과학회 2023 大韓韓方婦人科學會誌 Vol.36 No.4

Objectives: The purpose of this study is to review the overseas clinical study trends on Chinese Medicine treatment for Pre-eclampsia. Methods: We searched articles published from Pubmed, Embase and CNKI. The period was set from 2004 to 2023. Searched keywords were “Pre-eclampsia”, “Preeclampsia”, “Chinese medicine”, “Herbal medicine”, “子癎前期”, “子癎前症”, “中藥”, “中醫”. Results: 21 articles were finally selected. There were 16 RCTs, 3 case control studies, 2 case series. 2 articles used both acupuncture and western medicine, 19 articles used both herbal medicine and western medicine. 風池 (GB20), 太衝 (LR3), 足三里 (ST36) were the most frequently used acupoints, Paeoniae Radix alba (白芍藥) is the most frequently used in herbal medicine treatment. Conclusions: Our review found that chinese medicine combined with western medicine is more effective for alleviating symptoms of pre-eclampsia.

뇌전증의 병인, 변증, 한약 치료에 대한 고찰 -한국, 일본, 중국 데이터베이스를 중심으로 -

김혜연,김태환,한주희,방미란,장규태,이진용,김효인,이동헌,이선행 대한한방소아과학회 2024 대한한방소아과학회지 Vol.38 No.3

Objectives This study aimed to establish a foundation for research on Korean medicine for epilepsy by analyzing its etiology, syndrome differentiation, and the use of herbal medicines. Methods Articles were extracted from five databases in Korea, Japan, and China: the Oriental Medicine Advanced Searching Integrated System (OASIS), Citation Information by the National Institute of Informatics (CiNii), Chinese National Knowledge Infrastructure (CNKI), Wangfang Database, and Chinese Scientific Journal Database (VIP). The etiology, syndrome differentiation, and herbal medicines used for epilepsy were investigated. Results A total of 64 articles were selected, including seven clinical studies, 16 case reports, and 41 reviews. Epilepsy is a complex disease with various etiologies, and among the five viscera, syndrome differentiation mainly involved the liver, spleen, and kidney, with pathological factors that included phlegm, wind, and blood stasis. Frequently used herbal medicines included Modified Jeongganhwan, Sihogyejitang, Yukgunjatang, and Sihogayonggolmoryotang. Conclusions This study analyzed epilepsy’s etiology, syndrome differentiation, and herbal treatments. Further evidence is needed to better understand the efficacy and safety of Korean herbal medicine for treating epilepsy

한국과 중국의 코로나-19 진료지침의 한약에 대한 비교분석 및 고찰

양승보,정아람,Seung-Bo Yang,Aram Jeong 대한한방내과학회 2023 大韓韓方內科學會誌 Vol.44 No.3

COVID-19 is an acute infectious disease caused by SARS-CoV-2 that has infected more than 700 million people around the world and left many deaths. In Korea and China, Korean medicine and Traditional Chinese Medicine were used to treat COVID-19, and the key element between them was herbal medicine. Clinical guidelines for herbal medicine have been published in Korea and China. In this review, the Korean and Chinese guidelines were compared and analyzed. This review was based on the latest revised clinical guidelines. The Korean guidelines covered all three guidelines published by The Association of Korean Medicine and The KM Professor Council of Internal Medicine of the Respiratory System. The Chinese guideline was published by the China National Health Commission. Based on research trends, a comprehensive comparison was made of the suggested prescriptions for each severity of COVID-19. It is expected that this review will be used as a reference for the treatment of COVID-19 or new infectious diseases in the future.