유산소와 저항성의 복합운동이 대사증후군 중년여성의 인슐린저항성, C-반응성 단백 및 체력에 미치는 영향

김종휴,노종철,강설중 대한운동학회 2013 아시아 운동학 학술지 Vol.15 No.2

[INTRODUCTION] The purpose of this study was to investigate the effects of aerobic and resistance exercise on insulin resistance, C-reactive protein, and physical fitness in middle-aged women with metabolic syndrome. [METHOD] Participants were randomly assigned combine exercise group(n=10), and control exercise group(n=10). The exercise group performed for 60 min(consisting of aerobic exercise for 30 min and resistance exercise 30 min) per day, for 3 day per, week for 12 weeks. Metabolic risk factor, insulin resistance, C-reactive protein and physical fitness were measured at before and after 12 weeks from each group. [RESULT] First, The metabolic syndrome risk factors(weight, %fat, waist circumference, systolic blood pressure, diastolic blood pressure, triglyceride, and HDL-Cholesterol) were significantly improved after 12 weeks exercise program. Second, The blood glucose, insulin, and HOMA-IR were significantly decreased after 12 weeks exercise program. Third, The C-reactive were significantly decreased after 12 weeks exercise program. Fourth, The physical fitness(VO2max, muscle strength and muscle endurance) were significantly increased after 12 weeks exercise program. [CONCLUSION] Combined exercise program has beneficial effects on insulin resistance, C-reactive, and physical fitness in middle-aged women with metabolic syndrome. [서론] 본 연구는 유산소와 저항성의 복합운동이 대사증후군 중년여성의 인슐린저항성, C-반응성 단백 및 체력 변화에 대한 것이다. [방법] 연구대상자는 대사증후군으로 진단된 중년여성을 운동군(n=10)과 대조군(n=10)으로 구분하여 12주간 주 3회, 유산소 운동(30분)과 저항성 운동(30분)을 실시하였다. [결과] 첫째, 복합운동에 의해 비만지표(체중, 체지방율, 허리둘레), 유리지방산, 중성지방 및 수축기와 이완기 혈압은 유의하게 감소되었으며 HDL-콜레스테롤은 유의하게 증가되었다. 둘째, 복합운동에 의해 혈당과 인슐린 수치를 낮추어 인슐린저항성 지표, HOMA-IR이 유의하게 감소되었다. 셋째, 복합운동에 의해 C-반응성 단백은 유의하게 감소하였다. 넷째, 복합운동에 의해 심폐지구력, 근력 및 근지구력은 유의하게 증가되었다. [결론] 유산소와 저항성의 복합운동은 대사증후군 관리에 유용한 운동 프로그램으로 적용할 수 있다고 생각된다.

알츠하이머병과 고감도 C-반응성 단백과의 연관성

왕민정(Min-Jeong Wang),김영도(Young-Do Kim),조현지(Hyun-Ji Cho),송인욱(In-Uk Song),정성우(Sung-Woo Chung) 대한임상노인의학회 2012 대한임상노인의학회지 Vol.13 No.4

연구배경: 고감도 C-반응성 단백(hs-CRP)는 대한 잘 알려진 염증에 반응하는 생체지표로써 염증질환들의 급성시기에 증가된 혈중 농도를 보이게 된다. 염증은 알츠하이머병, 혈관성 치매와 같은 인지장애를 보이는 질환에서 중요한 역할을 한다고 알려져 있으나 알츠하이머병과의 연관성은 혈관성 치매에 비해서 아직 미미한 연관성을 가진다고 보고되고 있다. 따라서 저자들은 알츠하이머병의 발병과 진행에 있어서 hs-CRP의 연관성을 명확히 하고자 본 연구를 시행하였다. 방법: 54명의 알츠하이머병 환자와 91명의 연령과 성별을 고려한 정상군을 본 연구에 등록하였다. 모든 선택군에서 hs-CRP를 측정하여 정상군과 알츠하이머병을 가진 환자군과 차이를 비교 분석하였다. 또한 환자군에서는 신경심리검사를 시행하여 인지저하의 심한정도 및 진행정도를 평가하였고 hs-CRP와의 관련성을 분석하였다. 결과: 혈중 hs-CRP는 알츠하이머병 환자군에서 정상군보다 높은 혈중 농도를 보여주었다. 하지만 치매의 심한정도를 평가한 신경심리검사와 hs-CRp와의 연관성은 통계적으로 의미있는 결과를 보이지 못했다. 더욱이 hs-CRP에 대한 알츠하이머병에서의 Odds ratio는 2.455 (95% CI 1.779∼3.386)를 보였다. 결론: 본 연구에서 저자들은 혈중 hs-CRP 농도와 알츠하이머병 발병에 관련이 있음을 제안할 수 있었고 혈중 증가된 hs-CRP 농도가 알츠하이머병의 발병의 위험인자로써도 역할을 할 수 있음을 추정할 수 있었다. 하지만 알츠하이머병에서의 악화를 예측하는 인자로써 작용한다는 근거는 명확히 찾을 수 없었다. 따라서 이를 명확히 하기 위해서는 향후 대규모의 환자 연구가 반드시 필요할 것으로 생각된다. Background: High-sensitivity C-reactive protein (hs-CRP) is a sensitive systemic marker of inflammation, and increased levels of hs-CRP are associated with inflammatory reactions. Inflammation is believed to play a pivot role in cognitive decline, Alzheimer’s disease (AD), and vascular dementia. However, previous several studies have suggested weak relationship between hs-CRP and AD development, though a strong relationship with vascular dementia development. Therefore, we studied to clarify a role of hs-CRP in development and progression of AD. Methods: We recruited 54 AD patients and 91 healthy controls. Venous blood samples for hs-CRP measurement were obtained from all subjects. All AD patients underwent neuropsychological tests for evaluating of diagnosis and progression of dementia. We analyzed correlation between hs-CRP and AD development as well as progression (severity) of cognitive decline. Results: Serum hs-CRP levels in AD patients showed higher concentration than those in healthy controls. But we did not find significant association between hs-CRP and neuropsychological tests for evaluation of dementia severity. However, the odds ratio with a 95% confidence interval (CI) of the AD by hs-CRP was 2.455 (95% CI 1.779-3.386). Conclusion: In this study, we could suggest that there are significant association between hs-CRP and AD and also assume that increased hs-CRP level could play a role in risk factor of AD development. However, hs-CRP as prognostic factor of progression was unclear because this study showed that there was no significant relationship between hs-CRP and progression of AD.

조기분만 시 조직학적 융모양막염 유무에 따른 혈청 C-반응성 단백질, 태반 내 interleukin-6, 지 질과산화도 및 단백산화도

윤대석 ( Dae Seok Yoon ),김윤하 ( Yoon Ha Kim ),김철홍 ( Chul Hong Kim ),조문경 ( Moon Kyoung Cho ),김종운 ( Jong Woon Kim ),조혜연 ( Hye Yon Cho ),김석모 ( Seok Mo Kim ),강우대 ( Woo Dae Kang ),이기호 ( Ki Ho Lee ),송태복 ( Tae B 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.1

Objective: To evaluate predictive value of maternal serum white blood cells (WBCs), C-reactive protein (CRP) levels, placental interleukin-6 (IL-6), lipid peroxide, and protein carbonyl levels in preterm birth according to histologic chorioamnionitis (HCA). Methods: This cohort study included 45 cases of preterm delivery with preterm labor and intact membranes (preterm labor [PTL] group; n=16) and preterm premature rupture of membranes (preterm premature rupture of membranes [PPROM] group; n=29). Blood samples at admission and placental sample at postpartum were collected. HCA was diagnosed in the presence of neutrophils infiltration into the subamnionic space. Results: The incidence of HCA was significantly higher in PPROM group than PTL group. Maternal serum WBC and CRP levels at admission, and placental IL-6, lipid peroxide, and protein carbonyl levels in HCA group were significantly higher than group without HCA. Maternal serum CRP levels at admission, and placental IL-6, lipid peroxide, and protein carbonyl levels of PPROM group with HCA were significantly higher than PPROM group without HCA. Maternal serum CRP levels at admission of 7 days and more latency period (n=14) were significantly lowered than those of less than 7 days latency period (n=15). The cut-off points of CRP determined with the receiver operating characteristic curves was 0.875 mg/dL. Perinatal morbidity such as respiratory distress syndrome, intraventricular hemorrhage, pneumonia in HCA group was significantly higher than group without HCA. Conclusion: Maternal serum CRP on admission may be possible a predictor for duration of the latency period in PPROM.

편측 및 양측 슬관절 전치환술후 C-반응성 단백 수치의 변화 양상

이수찬(Su-Chan Lee),윤지열(Ji-Yeol Yoon),정광암(Kwang-Am Jung),남창현(Chang-Hyun Nam),정숭현(Soong-Hyun Jung) 대한정형외과학회 2009 대한정형외과학회지 Vol.44 No.4

목적: 슬관절 전치환술 후 C-반응성 단백(C-reactive protein, CRP) 수치의 술 후 기간에 따른 변화 양상을 조사하였다. 또한 감염과 관련되어 CRP값이 의미 있게 차이를 보이는 술 후 기간을 조사하였다. 대상 및 방법: 편측 혹은 양측 동시 슬관절 전치환술을 시행 받은 2,315예에 대해 술 후 6개월까지 CRP 변화 양상을 기간 별로 나누어 후향적으로 분석하였다. 배제된 심부감염 19예의 CRP 변화 양상을 전체 조사군과 비교하였다. 결과: 슬관절 전치환술 후 CRP값은 술 후 3일 이내 최고값을 보이고 이후 감소하여 술후 15-28일 구간에서 정상화 되었다. 술 후 14일까지 편측군보다 양측 동시 수술군에서 CRP가 의미있게 증가되어 있었다(p<0.01). 그 이후의 CRP는 두 군 간의 차이가 없었다. 심부감염 증례군과 비교 시 술 후 8일 이후 CRP 차이가 통계적 의의를 보였다. 결론: 슬관절 전치환술 후 구간별 CRP 변화 양상은 감염에 대한 추시 관찰에 유용하며, 술 후 8일 이후 큰 차이를 보이거나 술 후 4주 이후도 CRP가 증가되어 있는 증례에서는 염증성 관절염이 아닌 경우 감염 가능성에 대해 유의해야 한다. Purpose: The objective of this study was to determine the patterns of C-reactive protein (CRP) changes during the postoperative period after total knee replacement (TKR), and to determine the CRP changes associated with infection after TKR. Materials and Methods: A retrospective analysis of the pattern of CRP changes during the first 6 postoperative months was conducted on 2,315 patients who underwent unilateral or simultaneous bilateral TKR. This data was also compared with the pattern of CRP changes which occurred in 19 patients with a deep prosthesis infection who were not enrolled in the main study. Results: The CRP levels peaked 3 days postoperatively, and then decreased to baseline levels at 15-28 days postoperatively. Within 14 days postoperatively, the CRP levels were significantly higher in the simultaneous bilateral TKA group than in the unilateral group (p<0.01). Thereafter, no significant difference in CRP levels existed between two groups. After the 8<SUP>th</SUP> postoperative day, a significant difference in CRP level existed between patients with and without deep prosthesis infections. Conclusion: CRP changes post-TKR provide an effective means of monitoring of infections. In cases of non-inflammatory arthritis in which the CRP levels are significantly difference after the 8<SUP>th</SUP> postoperative day or are elevated after the 4<SUP>th</SUP> postoperative week, an infection should be suspected.

60대 고령자들의 유산소 운동과 근저항 훈련이 C-reactive protein(CRP) 농도 및 심혈관계질환 위험인자에 미치는 영향

이윤관 ( Yoon Kwan Lee ) 한국스포츠정책과학원(구 한국스포츠개발원) 2003 체육과학연구 Vol.14 No.3

고령자 10명을 대상으로 16주간 유산소 복합트레이닝 전 후 CRP와 심혈관질환 위험인자의 변화를 알아보고자 하였다. 운동은 유산소 운동과 저항운동을 하였고, 운동강도는 유산소 운동 HRmax 50%로 20분, 저항운동 HRmax 60-70%로 10분간 주 5일 실시하였다. 트레이닝 전 후 체지방, 체액, 체질량지수, 혈당, CRP, 총콜레스테롤, 중성지방, 저밀도지단백, 동맥경화지수, 안정 시 심박수, 운동 후 심박수, 운동전 후 수축기혈압은 유의하게 감소를 나타내었고, 고밀도지단백, 운동시간은 유의하게 증가를 나타내었다. 각 위험인자의 운동전과 운동후의 CRP와 심혈관질환 위험인자간의 값을 비교했을 때 체질량지수, 운동전 후 수축기혈압, 고밀도지단백, CRP가 유의하게 나타났으며, 총콜레스테롤, 중성지방, 글루코스, 저밀도지단백, 동맥경화지수, 심박수는 통계적으로 유의하게 나타나지 않았다. 이러한 결과는 CRP가 높은 사람은 심혈관질환의 위험성에 대해 예의 주시할 필요성을 나타낸다. 향후 이에 대한 전향적인 연구가 더 필요하리라 생각된다. The purpose of this study was to examine the effect of combined training on the relationship between C-reactive protein (CRP) and cardiovascular risk factor in the elderly. The training program was separated aerobic training and resistance training. The aerobic training was 50%HRmax(Intensity), 20 minutes and the resistance training was 60-70% of 10 minutes a day(Duration), 5 days a week(Frequency) during 16 weeks. The results obtain were as fallow ; Body Fat(BF), Body Fluid(BFU), body mass index (BMI), Glucose(GC), CRP, total cholesterol (TC), triglycerid (TG), low density lipoprotein cholesterol (LDL-c), atherogenic index (AI), heart rate(HR) rest, heart rate(HR) peak, systolic blood pressure (SBP) rest and SBP peak decreased signify as a result of 16 weeks training. High density lipoprotein cholesterol (HDL-c) increased signify after the training. CRP was not related to BF, BFU, GC, TC, TG, LDL-c, AI, HRr and HRp among cardiovascular risk factor, but was related to BMI, HLD-c, SBPr and SBPp. This results indicated that even if the CRP was a person with CRP should be aware of the risk involved for cardiovascular diseases.

대한민국 성인에서 혈중 비타민 E의 농도와 혈중 고감도 C-반응성 단백 농도(High-Sensitivity C-Reactive Protein)의 연관성: 국민건강영양조사 자료 이용

김준태,김선미 대한가정의학회 2020 Korean Journal of Family Practice Vol.10 No.6

Background: Inflammation plays a major role in atherothrombosis, and measuring inflammatory markers such as high-sensitivity C-reactive protein(hs-CRP) may provide a novel method for identifying individuals at high risk of plaque rupture. Atherogenesis results from the oxidation of lipids inlow-density lipoprotein (LDL). Vitamin E facilitates the reduction in LDL-oxidation, and increases the antioxidant defense system. Therefore, our studyaimed to examine the relationship between vitamin E and hs-CRP levels in Korean adults. Methods: We used data from the Seventh Korea National Health and Nutrition Examination Survey (2016–2018). The study population includedhealthy adults aged >20 years. We investigated age, blood pressure, glucose levels, total cholesterol, triglyceride, high-density lipoproteincholesterol, low-density lipoprotein cholesterol, body mass index, serum vitamin E, and serum hs-CRP levels. We analyzed the relationship betweenserum vitamin E and serum hs-CRP levels using multiple regression tests. Results: On statistical analysis, vitamin E levels showed a positive correlation with hs-CRP levels in the female group and the total of the unadjustedmodel. However, the R2value is low. After adjustment for factors that may affect hs-CRP, no significant correlation was observed between serumvitamin E and serum hs-CRP levels. Conclusion: No significant correlation was observed between serum vitamin E and serum hs-CRP levels. Further research is needed on this topic. 연구배경: 고감도 C-반응성 단백(high-sensitive C-reactive protein, hsCRP)은 전신염증반응 표지자로서 죽상경화판(atherosclerotic plaque)의 불안정성을 나타내며, 미래의 심혈관 질환의 중증도와 예후를가늠할 수 있는 인자로 알려져 있다. 한편, LDL 콜레스테롤의 산화가 죽상경화증을 유발하는 것으로 보고되었으며, 비타민 E는 항산화 및 항염증 반응으로 LDL 콜레스테롤의 산화를 막아주는 것으로알려져 있다. 이에 혈중 비타민 E 농도와 hs-CRP 농도의 연관성을조사하고자 하였다. 방법: 제7기(2016–2018) 국민건강영양조사에 참여한 만 20세 이상의성인 중 질환이 있는 대상을 제외한 남성 1,718명, 여성 2,007명을 대상으로 하였다. Hs-CRP에 영향을 줄 수 있는 연령, 혈압, 혈당, 총콜레스테롤, 중성지방, HDL 콜레스테롤, LDL 콜레스테롤, BMI, 흡연, 음주에 대한 변수를 보정하면서, 혈중 비타민 E 농도와 혈중 hsCRP 농도의 연관성을 분석하였다. 결과: 변수를 보정하지 않는 모델 1 (model 1)에서는 여성 그룹과 전체 그룹에서 혈중 비타민 E와 혈중 hs-CRP 농도와의 유의한 양의상관관계가 있는 것으로 나타났으나, R2의 값이 작아 유의성은 없는것으로 보인다. 변수를 보정한 모델 2 (model 2), 모델 3 (model 3)은남성 그룹, 여성 그룹 및 전체 그룹에서 통계적으로 유의성이 없었다. 결론: 결과적으로 혈중 비타민 E 농도와 혈중 hs-CRP 농도와는 연관성이 없었다. 향후 이 주제에 대한 추가적 연구가 필요할 것으로생각된다

유산소성 운동이 백혈구, 혈청 알부민 및 C-반응성 단백 농도에 미치는 영향

변재철 ( Jae Chul Byun ) 한국스포츠정책과학원(구 한국스포츠개발원) 2003 체육과학연구 Vol.14 No.4

본 연구의 목적은 30분간의 유산소성 운동이 백혈구 수, 알부민 및 C-반응성 단백(CRP) 농도에 어떠한 영향을 미치는가를 알아보는데 있다. 피험자들은 실험기간에 어떠한 질병이나 어떠한 약물도 섭취하지 않는 22-25세의 사람으로 24명을 대상으로 하였다. 이들 중 12명은 현재 마라톤 동호회에서 주당 35-70km 정도 거리와 주당 3-6일간 달리기를 규칙적으로 실시해 온 사람들이다(experiment group). 반면에 다른 한 집단은 규칙적인 신체적 훈련이나 달리기를 실시해 본 경험이 없는 12명을 대상으로 선정하였다(control group). 피험자들은 트레드밀 위에서 최대심박수의 60-75% 수준에서 30분간 달리기를 실시한 후 백혈구 수, 알부민, CRP 수준을 평가하였다. 본 연구 결과, 단련자들이 비단련자들에 비해 최대산소섭취량이 유의하게 높았고 (p<.05). 30분 동안 달린 거리도 많았다(p<.05). HDL-C과 LDL-C 수준은 규칙적으로 달리기를 실시해 온 단련자와 비단련자간에 차이가 없었다. 그리고 백혈구 수, 혈청 알부민 농도에 있어서는 두 집단모두 각 시기(운동 전, 운동 직후, 회복기)에 따라 유의한 차이가 나타났으며, CRP의 농도에 있어서도 단련자들이 비단련자들에 비해 유의하게 낮게 나타났다(p<.05). 결론적으로, 본 연구에서 규칙적인 운동으로 인한 신체적 활동수준의 증가와 빈번한 운동을 실시하는 사람들은 동일한 강도의 운동을 실시하더라도 규칙적인 운동을 실시하지 않는 사람에 비해 혈중 급성염증반응 인자인 CRP와 WBC의 수준을 감소시켜줄 수 있을 것이며, 알부민의 수준을 증가시켜 관상동맥심장질환의 위험으로부터 벗어날 수 있거나 그러한 위험이 줄어들 수 있을 것으로 사료된다. The purpose of this study was to verify the effects of white blood cell, albumin and C-reactive protein by during 30 minutes aerobic exercise. None of them has any illness and use of any medication during the experiment. Twelve healthy males marathon club runners aged between 22-25 years. The subjects were moderately trained running between 35km and 70km/week, and they were trained running between 3-6 days/week (Experiment group). The other subjects this study were 12 males who did not regular any excercise (Control group). The WBC, albumin and C-reactive protein were evaluated before and after during 30 minutes on treadmill running (60%-75% of HRmax). The present study showed that VO2max, distance of run in experiments group was higher than control group, there were significant differences between groups(p<.00l). There was significant difference on serum total cholesterol (p<.05), HDL-C and LDL-C levels were no significant differences between groups. There were significant differences on WBC, serum albumin level between at each time (before, immediately after exercise, and recovery, p<.001, respectively). And there was significant difference on plasma CRP level between at each time, and there was lower on CRP level in experiment group than control group (p<.05). Consequently, the present study has demonstrated that increasing levels of regular physical activity and frequently exercise training may prevent or lower coronary heart disease (CHD) risk by reducing inflammatory markers.

한국인에서 Framingham 관상동맥 위험 점수와 C-반응성 단백의 연관성

석준호 ( Jun Ho Seok ),김웅 ( Ung Kim ),이상희 ( Sang Hee Lee ),홍그루 ( Geu Ru Hong ),박종선 ( Jong Seon Park ),신동구 ( Dong Gu Shin ),김영조 ( Young Jo Kim ),심봉섭 ( Bong Sup Shim ) 대한내과학회 2007 대한내과학회지 Vol.73 No.3

Background: The Framingham coronary risk score is a simplified coronary prediction tool developed to enable clinicians to estimate cardiovascular risk. C-reactive protein (CRP), a marker of low-grade inflammation, has been extensively studied in several large, prospective, epidemiological studies. However, few studies are available that have directly compared CRP levels with the Framingham coronary risk score. Methods: A total of 13,052 individuals that visited our hospital for comprehensive medical tests between January 2002 and June 2003, were enrolled in the study (7,978 men, 5,074 women, mean age 44.8±11.0 years). Plasma samples were assayed for determination of CRP level by using a clinically validated high-sensitive assay. The Framingham coronary risk score was calculated by using previously published algorithms that used baseline cardiac risk factors including age, HDL cholesterol level, total cholesterol level, smoking status, blood pressure, and history of diabetes. Pearson correlation coefficients relating these individual risk factor scores and a total score were calculated. The CRP levels were divided into different categories; into 4 groups based on the quartiles of the CRP levels and 3 groups based on the baseline CRP levels of <0.1 mg/dL, 0.1 to 0.3 mg/dL and >0.3 mg/dL. The CRP levels were compared with the Framingham coronary risk score and the Framingham 10-year coronary heart disease risk according to each group. Results: CRP levels significantly correlated with the Framingham coronary risk score (r(total)=0.373, p<0.01; r(men)=0.351, p<0.01; r(women)=0.378, p<0.01). The CRP levels also correlated with individual components of the Framingham coronary risk score, which included age (r(total)=0.302, p<0.01; r(men)=0.330, p<0.01; r(women)=0.287, p<0.01), blood pressure (r(total)=0.275, p<0.01; r(men)=0.214, p<0.01; r(women)=0.270, p<0.01) and HDL-cholesterol level (r(total)=0.221, p<0.01; r(men)=0.198, p<0.01; r(women)=0.221, p<0.01). Furthermore CRP levels correlated with calculated the Framingham 10-year coronary heart disease risk (r(total)=0.366, p<0.01, r(men)=0.301, p<0.01, r(women)=0.420, p<0.01). The Framingham coronary risk score and calculated Framingham 10-year coronary heart disease risk increased with each increasing CRP level category(quartiles and risk, p<0.01). Conclusoins: The CRP level correlated well with the Framingham coronary risk score and is a useful factor for predicting cardiovascular risk in Korean patients.(Korean J Med 73:283-292, 2007)

비허혈성 확장성 심근증 환자에서 C-반응성 단백의 의의에 관한 전향적 연구

장혁재,정재훈,최정현,김민철,양형모,최태영,최소연,윤명호,황교승,신준한,탁승제,최병일 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.5

치료 저항성 조현병 환자와 치료 반응성 조현병 환자간의 CRP를 포함한 염증 표지자 비교

이혁준,정명훈,홍나래,전덕인 대한생물치료정신의학회 2019 생물치료정신의학 Vol.25 No.3

Objectives:The present study is to investigate inflammatory markers and associated clinical factors between treatment resistant schizophrenia and non-treatment resistant schizophrenia. Methods:Of the 116 schizophrenia subjects who were hospitalized for acute symptomatic treatment, 19 patients (16%) were treated with clozapine as a treatment resistant schizophrenia(TRS) and 97 patients(84%) were treated with other atypical antipsychotics as a non-treatment resistant schizophrenia(Non-TRS). Various inflammatory markers including C-reactive protein(CRP) and clinical factors were retrospectively evaluated with electrical medical records. Results:There were significant differences between two groups in disease duration( p =0.015), number of admission ( p =0.003), Clinical Global Impression( p <0.001) but other demographic and clinical variables including previous antipsychotics use did not show significant differences. In terms of hematologic profiles, TRS group demonstrated higher CRP level( p =0.006), lower neutrophil count( p =0.012), and lower hemoglobin level( p =0.003) compared with non-TRS group. Body mass index was significantly correlated with CRP(r=0.318, p =0.001). Conclusion:The elevated level of serum CRP in TRS suggests that treatment resistance in schizophrenia may be associated with inflammatory response. However, retrospective study design and small number of subjects could limit this interpretation.