아동의 ACE 및 IGF-1 유전자의 복합적 다형성에 따른 체력, 대사증후군 위험인자 및 12주 복합운동효과의 비교

김기진 ( Ki Jin Kim ),안나영 ( Na Young Ahn ),홍창배 ( Chang Bae Hong ),고진호 ( Jin Ho Go ),김상현 ( Sang Hyun Kim ),김재훈 ( Jae Hoon Kim ),변자영 ( Ja Young Byun ),주영식 ( Young Sik Ju ) 한국운동생리학회 2012 운동과학 Vol.21 No.1

The propose of the present study was to analyze physical fitness, metabolic syndrome risk factors and 12 week combined exercise intervention-mediated effects according to interaction between ACE and IGF-I gene polymorphism in children. We studied elementary school students (n=176) who were divided into 9 groups (192/192-II. ID. DD. 192/Non-II. ID. DD and Non-II. ID. DD) according to interaction between ACE and IGF-1 gene polymorphism. Subjects were measured the physical fitness. metabolic risk factors. Serum levels of IGF-I and ACE. ACE level in serum of 192/Non-DD group were significantly (p<.05) higher than 192/l92-II, 192/Non-I and Non-ID group. but IGF-I level in serum were not different among group. All physical fitness and exercise effects of physical fitness according to ACE and IGF-I gene polymorphism were not different among group. Triglyceride of 192/192-DD group were significantly (p<.05) higher than 192/192-II, 192/Non-II, -ID, -DO and Non-II group. In conclusion, we could not find the significant differences of physical fitness and 12 week exercise-mediated changes according to interaction between IGF-I and ACE gene polymorphism , but 12 week exercise-mediated changes of triglyceride concentration and insulin sensitivity showed a signficant difference according to interaction between IGF-I and ACE gene polymorphism.

무도종목 선수들의 유전자 다형성의 특성과 유, 무산소성 능력 및 골밀도와의 관련성

조현철 대한무도학회 2020 대한무도학회지 Vol.22 No.2

The purpose of this study is to investigate the characteristics and correlations of angiotensin 1-converting enzyme(ACE), alpha-actinin-3(ACTN-3) gene polymorphism of martial arts(judo, kendo, taekwondo) and their aerobic, anaerobic performance and bone mineral density(BMD). The subjects of the study were 143 elite martial arts athlete(judo=47, kendo=29, taekwondo=67) from University Y. Aerobic athletic ability was carried out to the all-out state by the Bruce protocol, and anaerobic athletic ability was executed by the Wingate Test, while dual energy x-lay absorptiometry(DEXA) was applied in BMD measurement. The results in this study were obtained as follows : The ACE gene characteristics according to were showed with II>ID>DD type in judo and taekwondo while kendo were ID>II>DD type. The ratio of genes to I type was twice as high as D type. ACTN-3 gene characteristics according to were showed with RX>RR>XX type in judo, kendo and taekwondo. The ratio of genes to R type was slightly higher than X type. It indicates from the above results, although there is no significant statistical difference between the ACE, ACTN-3 gene polymorphism but the sequence of genetic polymorphism is desirable to watch ACTN-3 rather than ACE focusing in martial arts specifics. And It's thought that gene polymorphrism is low in correlation to the aerobic and anaerobic power and bone density 본 연구는 무도 종목선수들의 ACE와 ACTN-3 유전자 다형성의 분포특성과 유·무산소성 파워 및골밀도와의 관련성을 규명하여 선수들의 체력예측, 경기력 향상 및 엘리트 선발을 위한 기초자료를제공하는 데 목적이 있다. 연구 대상은 Y대학교 남자 유도선수 47명, 검도 선수 29명, 태권도 선수67명, 총 143명으로 하였으며, 유산소 파워는 Bruce 방법을 이용한 점증부하 법으로, 무산소 파워는Wingate 방법으로 실시하였으며, 골밀도는 이중 에너지 엑스레이(DEXA)로 측정하고 혈액 채혈을 통해 ACE와 ACTN-3유전자 다형성을 분석하였으며, 이들의 특성과 유, 무산소성 파워 및 골밀도와의관련성을 분석한 결과 다음과 같은 결론을 얻었다. 유도 검도 태권도 선수들의 ACE 유전자 다형성은 유도의 경우 II>ID>DD 순으로, 검도의 경우ID>II>DD 순으로, 태권도의 경우 II>ID>DD 순으로 각각 나타났으며, 대립유전자(I와 D) 간에 비율은 I 형이 D형 보다 약 2배 정도 높은 것으로 나타났다. 유도 검도 태권도 선수들의 ACTN-3 유전자 다형성은 모두 RX>RR>XX 순으로 각각 나타났으며, 대립유전자(R와 XD) 간에 특성은 R형이 X형보다약간 높은 것으로 나타났다. ACE 유전자 다형성과 유, 무산소 운동능력 및 골밀도 간에는 유도선수에서만 유산소 파워 간에 유의한 상관(p<.05)이 나타났고, 태권도의 경우 ACTN-3 유전자 다형성과최대심박수에서 유의한 상관(p<.05)이 나타났다. 무산소 파워는 모든 변인에서 유의한 상관이 나타나지 않았으며, 골밀도에서는 태권도 선수들의 ACTN-3와 다리 골밀도에서만 유의한 상관(p<.01)이 나타났다. 이상의 결과를 미루어 볼 때 무도종목 선수들의 ACE 유전자 다형성의 특성은 I 대립유전자가 D 대립유전자보다는 약 2배 가까이 많았지만 ACTN-3 유전자 다형성은 R형과 X형 대립유전자가 거의비슷하거나 R형 대립유전자가 약간 많은 것으로 나타나 그 특성이 운동 종목에 따라 다른 것으로생각된다. 따라서 무도 종목 특성상 ACE보다는 ACTN-3형 유전자를 보는 것이 바람직할 것으로 사료되며, 유, 무산소성 운동능력 및 골밀도와의 관련성은 낮은 것으로 생각된다.

Relationship between angiotensin-converting enzyme gene polymorphism and muscle damage parameters after eccentric exercise

김주영,김창선,이주형 한국운동영양학회 2013 Physical Activity and Nutrition (Phys Act Nutr) Vol.17 No.2

This study was conducted to investigate the relationship between ACE gene polymorphism and muscle damage parameters after eccentric exercise. 80 collegiate males were instructed to take an eccentric exercise with the elbow flexor muscle through the modified preacher curl machine for 2 sets of 25 cycles (total 50 cycles). The maximal isometric strength, muscle soreness, creatine kinase (CK), and myoglobin (Mb) were measured before exercise, and 0, 24, 48, 72, and 96 hrs after exercise. The result showed that after the eccentric exercise, the maximal isometric strength significantly decreased by more than 50% (p < 0.001) and the muscle soreness, CK, and Mb significantly increased compared to those before the exercise (p < 0.001). The ACE gene polymorphism of the subjects was classified using real-time polymerase chain reaction (real-time PCR). The result showed that it consisted of 38 cases of type II (46.4%), 33 cases of type ID (43.4%), and 9 cases of type DD (10.2%). The Hardy-Weinberg equilibrium for ACE gene polymorphism was shown to have p = 0.653, which showed that each allele was evenly distributed. Although significant differences in the changes in the maximal isometric strength, muscle soreness, CK,and Mb were found according to time course (p < 0.001), no significant differences in the changes in the maximal isometric strength,muscle soreness, CK, and Mb were found according to ACE gene polymorphism. Furthermore, no significant difference in the changes in the muscle damage parameters was found according to interaction between ACE gene polymorphism and time course (p > 0.05). In conclusion, the level of the muscle damage parameters changed in the injured muscle after eccentric exercise, but these changes in the muscle damage parameters were not affected by ACE gene polymorphism. The result of this study indicates that ACE gene is not a candidate gene that explains muscle damage.

Relationship between angiotensin-converting enzyme gene polymorphism and muscle damage parameters after eccentric exercise

( Joo Young Kim ),( Chang Sun Kim ),( Joo Hyung Lee ) 한국운동영양학회 2013 Physical Activity and Nutrition (Phys Act Nutr) Vol.17 No.2

This study was conducted to investigate the relationship between ACE gene polymorphism and muscle damage parameters after eccentric exercise. 80 collegiate males were instructed to take an eccentric exercise with the elbow flexor muscle through the modified preacher curl machine for 2 sets of 25 cycles (total 50 cycles). The maximal isometric strength, muscle soreness, creatine kinase (CK), and myoglobin (Mb) were measured before exercise, and 0, 24, 48, 72, and 96 hrs after exercise. The result showed that after the eccentric exercise, the maximal isometric strength significantly decreased by more than 50% (p < 0.001) and the muscle soreness, CK, and Mb significantly increased compared to those before the exercise (p < 0.001). The ACE gene polymorphism of the subjects was classified using real-time polymerase chain reaction (real-time PCR). The result showed that it consisted of 38 cases of type II (46.4%), 33 cases of type ID (43.4%), and 9 cases of type DD (10.2%). The Hardy-Weinberg equilibrium for ACE gene polymorphism was shown to have p = 0.653, which showed that each allele was evenly distributed. Although significant differences in the changes in the maximal isometric strength, muscle soreness, CK, and Mb were found according to time course (p < 0.001), no significant differences in the changes in the maximal isometric strength, muscle soreness, CK, and Mb were found according to ACE gene polymorphism. Furthermore, no significant difference in the changes in the muscle damage parameters was found according to interaction between ACE gene polymorphism and time course (p > 0.05). In conclusion, the level of the muscle damage parameters changed in the injured muscle after eccentric exercise, but these changes in the muscle damage parameters were not affected by ACE gene polymorphism. The result of this study indicates that ACE gene is not a candidate gene that explains muscle damage.

기관지천식의 중증도에 따른 안지오테신 전환효서 유전자 다형에 관한 연구

조재연(Jae Youn Cho),차대룡(Dae Ryoung Cha),한선애(Seon Ae Han),이상엽(Sang Yeub Lee),이신형(Shin Hyung Lee),강세용(Sea Yong Kang),심재정(Jae Jeong Shim),강경호(Kyeong Ho Kang),유세화(Se Hwa Yoo),인광호(Kwang Ho In) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.4

Background: The angiotensin-converting enzyme (ACE) has a major role in the degradation of bradykinin, tachykinin, substance P which are associated with bronchial hyperresponsiveness and inflammation. The other role of ACE is the genesis of angiotensin II which causes bronchial smooth muscle contraction. The deletion polymorphism of ACE gene(DDtype) may be related to the high serum level of ACE. Objective: We studied to evaluate an association between the insertion /deletion polymorphism of the ACE gene and asthma, and its severity. Materials and methods: Sixty asthmatic patients and 44 healthy controls were enrolled. Severity of asthma was classified by the guideline of NHLBI/WHO workshop. The ACE genotypes of all the subjects were determined by polymerase chain reaction. Results: The distribution of ACE genotypes were not significantly different between healthy controls and asthma group (p)0.05). In asthmatic patients, the genetic polymorphism was similar between different severity groups (p) 0.05). Conchcsion: It is suggested that I/D polymorphism of the ACE gene may not be associated with development of asthma. The severity of asthma may not be influenced by I/D polymorphism of the ACE gene.

ACE gene polymorphism and renal responsiveness to ACE inhibitors in IgA nephropathy patients

(Sang Youb Han),(Young Joo Kwon),(Sang Kyung Jo),(Jin Ho Shin),(Dae Ryong Cha),(Won Yong Cho),(Heui Jung Pyo),(Hyoung Kyu Kim) 대한내과학회 2000 The Korean Journal of Internal Medicine Vol.15 No.1

We examined the renal responsiveness to ACE inhibitor in IgA nephropathy (IgAN) patients according to the grouping of ACE gene polymorphism. Sixty one patients diagnosed as IgAN by renal biopsy and prescribed with ACE inhibitors were enrolled. Genomic DNA was extracted from whole blood and PCR was performed. The I/D polymorphism was determined by the presence of the 287 bp fragment in intron 16 of chromosome 17. During the follow-up period (mean; 44.6 months, median: 44.5 months, 5 to 113 months), the blood pressure of 61 patients was controlled below 130/80 mmHg. The renal responsiveness was determined by the degree of changes of proteinuria at 12 months after initiation of ACE inhibitors and by the slope of reciprocal variation of the serum creatinine against follow-up duration {(1/Cr2-1/Cr1)/durations}. The distribution of the II, ID and DD genotype among 61 patients was 21, 16 and 24 patients, respectively. There were no differences among three genotypes in age, sex, the number of patients with initial blood pressure over 140/90 mmHg, initial serum creatinine level, the number of patients with initial azotemia( > 1.4 mg/dL) and with initial 24-hr proteinuria amount over 2.0 g. Significant anti-proteinuric effect of ACE inhibitor was found in IgAN(p=0.001), but no significant difference was found among genotypes. Significant difference (p=0.011) was noticed between II type and DD type in the slope of reciprocal variation of the serum creatinine against follow-up duration. In conclusion, efficacy of ACE inhibitors on renal function preservation in IgAN was more pronounced in DD genotype than II genotype.

공군사관생도의 ACE 유전자다형성에 따른 항공체력단련이 신체조성과 심폐지구력에 미치는 영향

김근수(Keun-Soo Kim),구명수(Myung-Soo Koo),우진희(Jin-Hee Woo) 한국생명과학회 2009 생명과학회지 Vol.19 No.9

본 연구는 대한민국 공군사관생도들을 대상으로 12주간 복합 트레이닝(유/무산소성 트레이닝, 공간지각 트레이닝)이 Angiotensin Converting Enzyme (ACE) gene polymorphism에 따른 신체조성과 심폐지구력 변화에 미치는 영향을 규명하는데 목적이 있었다. 연구결과, 12 주간 복합 트레이닝 후 신체조성은 ACE gene polymorphism에 따라 변화의 차이가 나타나지 않았으며, 심폐지구력은 I allele 집단(Ⅱ/ID genotype group)이 D allele 집단(DD genotype group)보다 트레이닝의 효과가 높게 나타났다. 본 연구 결과로 볼 때, 복합 트레이닝은 ACE gene polymorphism에 따라 심폐지구력 변화에 다르게 반응하고 있으며, I allele (Ⅱ/ID genotype group)를 가지고 있는 개체가 더 높은 트레이닝의 효과를 얻을 수 있음을 제시해 주고 있다. The purpose of this study was to investigate the effect of 12 weeks of combined training (aerobic/anaerobic training and space perception training) on changes in body composition (weight, % body fat, % muscle mass, BMI, WHR) and cardiorespiratory fitness according to the ACE gene polymorphism (Ⅱ: 7 men, ID: 8 men, DD: 6 men) in 21 senior Korea Air Force Academy cadets. The results of this study were as follows: body composition factors among ACE gene polymorphism groups and between pre-/post-training in all groups were not statistically significant. Cardiorespiratory fitness of the Ⅱ and ID groups was significantly lower after training (p<0.05). However, there was no statistically significant difference between pre-/post-training in the DD. In conclusion, this study suggests that cardiorespiratory fitness response to compound training may be affected by ACE genotypes.

유지 혈액투석 환자에서 B형 간염 항체 역가에 관한 연구

이영숙,최규복 대한신장학회 2005 Kidney Research and Clinical Practice Vol.24 No.4

배 경:유지 투석 환자에서 일정 수준 이상의 혈색소를 유지하기 위한 erythropoietin (EPO) 요구량은 개인차가 있으며 이는 여러 요인에 의해 결정된다. 한편, 안지오텐신 II는 EPO를 매개로 하여 적혈구의 분화를 촉진시키며 안지오텐신 II의 농도는 안지오텐신 전환효소의 유전자 다형성과 관련이 있다고 알려져 있다. 이에 저자들은 안지오텐신 전환효소의 유전자 다형성이 EPO 저항성과 상관관계가 있는지 여부와 EPO 저항성에 영향을 주는 인자들을 알아보고자 본 연구를 실시하였다. 방 법:안지오텐신 전환효소의 유전자 다형성 (II, ID, DD), EPO 요구량, EPO 저항 계수, high sensitivity CRP (hs-CRP), 페리틴, 알부민, 헤마토크리트, 부갑상선호르몬, Kt/V, nPCR, 원인 신질환, 안지오텐신 전환효소 억제제 및 안지오텐신 수용체 차단제 복용 유무, 체질량 지수, 성별, 나이, 투석기간 등의 자료를 수집하여 안지오텐신 전환효소의 유전자 다형성에 따른 각 임상 소견 및 검사실 소견을 비교하였다. EPO 저항 계수를 종속 변수로, 각 검사실 소견과 임상 소견을 독립 변수로 다중 선형 회귀 분석을 시행하였다. 결 과:본원에서 유지 혈액투석을 받는 199명 [남:여 94:105, 나이 61±13세, 투석기간 63 (3-287개월)] 중, DD군의 EPO 저항 계수는 II군과 ID군에 비해 의미있게 낮았다 (p=0.034). 그 외 나머지 인자에 관한 각 군간의 유의한 차이는 없었다. 다중 선형 회귀 분석시 non-DD형의 안지오텐신 전환효소의 유전자형 (non-DD vs. DD, p=0.027), 체질량 지수가 낮은 경우 (p<0.001), 여자인 경우 (p=0.001) 등이 EPO 저항 계수를 높이는 것으로 나타났다. 결 론:혈액투석 환자에서 안지오텐신 전환효소의 유전자 다형성이 EPO 용량을 결정하는 인자가 될 수 있으며 영양상태의 개선을 통하여 EPO 요구량을 줄일 수 있고 투여량을 결정할 때 성별에 따른 차이를 고려하여야 할 것으로 판단되었다. Background:Erythropoietin (EPO) requirement to reach a specified target hemoglobin level varies in patients on dialysis, the reasons being multifactorial. Angiotensin II has been shown to stimulate proliferation of early erythroid progenitors via erythropoietin and the plasma level of angiotensin II has been strongly associated with angiotensin converting enzyme (ACE) gene polymorphism. EPO resistance index (ERI, weekly rhEPO dose/hematocrit/body weight) is a collective responsiveness between EPO and hematocrit. We have evaluated whether ACE gene polymorphism might exert effect on ERI and also have analysed various laboratory parameters that could affect erythropoietin requirement in HD patients. Methods:We have compared various demographic data and laboratory parameters, including age, sex, months on dialysis, body mass index (BMI), EPO requirement, ERI, high sensitivity C-reactive protein (hsCRP), ferritin, albumin, hematocrit, iPTH, Kt/V, normalized protein catabolic rate (nPCR), cause of renal failure and whether or not patients were on ACE inhibitor or Angiotensin receptor blocker (ARB), in 199 patients on hemodialysis therapy [M:F 94:105, Age 61±13, duration of dialysis 63 (3-287 months)] according to ACE gene polymorphism (II, ID, DD). We also have assessed independent association of ERI with demographic variables and laboratory parameters using linear regression analysis. Results:There was statistically significant difference (p=0.034) in ERI in the II/ID group compared to the DD group and it was lower in the DD group. But there was no statistically significant difference in other demographic data and laboratory parameters according to ACE gene polymorphism. In the linear regression analysis, lower BMI (p<0.001), female gender (p=0.001), and ACE gene polymorphism (non-DD vs. DD, p=0.027) were determined to be independent factors affecting high ERI. Conclusion:ACE gene polymorphism could be determining factor of EPO requirement in patients on hemodialysis. Improving nutritional status might be helpful in reducing EPO requirement and we should consider the gender difference in determining EPO dose in patients on hemodialysis.

유지 혈액투석 환자에서 Erythropoietin 저항성에 영향을 미치는 유전적 요인과 환경적 요인들

이은경,김수희,장재원,최정,박태진,박종하,양원석,김순배,박수길,이상구,박정식 대한신장학회 2005 Kidney Research and Clinical Practice Vol.24 No.4

배 경:유지 투석 환자에서 일정 수준 이상의 혈색소를 유지하기 위한 erythropoietin (EPO) 요구량은 개인차가 있으며 이는 여러 요인에 의해 결정된다. 한편, 안지오텐신 II는 EPO를 매개로 하여 적혈구의 분화를 촉진시키며 안지오텐신 II의 농도는 안지오텐신 전환효소의 유전자 다형성과 관련이 있다고 알려져 있다. 이에 저자들은 안지오텐신 전환효소의 유전자 다형성이 EPO 저항성과 상관관계가 있는지 여부와 EPO 저항성에 영향을 주는 인자들을 알아보고자 본 연구를 실시하였다. 방 법:안지오텐신 전환효소의 유전자 다형성 (II, ID, DD), EPO 요구량, EPO 저항 계수, high sensitivity CRP (hs-CRP), 페리틴, 알부민, 헤마토크리트, 부갑상선호르몬, Kt/V, nPCR, 원인 신질환, 안지오텐신 전환효소 억제제 및 안지오텐신 수용체 차단제 복용 유무, 체질량 지수, 성별, 나이, 투석기간 등의 자료를 수집하여 안지오텐신 전환효소의 유전자 다형성에 따른 각 임상 소견 및 검사실 소견을 비교하였다. EPO 저항 계수를 종속 변수로, 각 검사실 소견과 임상 소견을 독립 변수로 다중 선형 회귀 분석을 시행하였다. 결 과:본원에서 유지 혈액투석을 받는 199명 [남:여 94:105, 나이 61±13세, 투석기간 63 (3-287개월)] 중, DD군의 EPO 저항 계수는 II군과 ID군에 비해 의미있게 낮았다 (p=0.034). 그 외 나머지 인자에 관한 각 군간의 유의한 차이는 없었다. 다중 선형 회귀 분석시 non-DD형의 안지오텐신 전환효소의 유전자형 (non-DD vs. DD, p=0.027), 체질량 지수가 낮은 경우 (p<0.001), 여자인 경우 (p=0.001) 등이 EPO 저항 계수를 높이는 것으로 나타났다. Background:Erythropoietin (EPO) requirement to reach a specified target hemoglobin level varies in patients on dialysis, the reasons being multifactorial. Angiotensin II has been shown to stimulate proliferation of early erythroid progenitors via erythropoietin and the plasma level of angiotensin II has been strongly associated with angiotensin converting enzyme (ACE) gene polymorphism. EPO resistance index (ERI, weekly rhEPO dose/hematocrit/body weight) is a collective responsiveness between EPO and hematocrit. We have evaluated whether ACE gene polymorphism might exert effect on ERI and also have analysed various laboratory parameters that could affect erythropoietin requirement in HD patients. Methods:We have compared various demographic data and laboratory parameters, including age, sex, months on dialysis, body mass index (BMI), EPO requirement, ERI, high sensitivity C-reactive protein (hsCRP), ferritin, albumin, hematocrit, iPTH, Kt/V, normalized protein catabolic rate (nPCR), cause of renal failure and whether or not patients were on ACE inhibitor or Angiotensin receptor blocker (ARB), in 199 patients on hemodialysis therapy [M:F 94:105, Age 61±13, duration of dialysis 63 (3-287 months)] according to ACE gene polymorphism (II, ID, DD). We also have assessed independent association of ERI with demographic variables and laboratory parameters using linear regression analysis. Results:There was statistically significant difference (p=0.034) in ERI in the II/ID group compared to the DD group and it was lower in the DD group. But there was no statistically significant difference in other demographic data and laboratory parameters according to ACE gene polymorphism. In the linear regression analysis, lower BMI (p<0.001), female gender (p=0.001), and ACE gene polymorphism (non-DD vs. DD, p=0.027) were determined to be independent factors affecting high ERI. Conclusion:ACE gene polymorphism could be determining factor of EPO requirement in patients on hemodialysis. Improving nutritional status might be helpful in reducing EPO requirement and we should consider the gender difference in determining EPO dose in patients on hemodialysis.

엘리트 남자 쇼트트랙 선수들의 ACE 유전자 다형성과 등속성 근기능의 관계

전용균,심경은,김완상 한국웰니스학회 2023 한국웰니스학회지 Vol.18 No.4

이 연구는 엘리트 남자 쇼트트랙 선수들을 대상으로 ACE 유전자 다형성에 따른 무릎관절 등속성 근기능의 관련성 규명하여 엘리트선수 발굴을 위한 기준을 제시하는 것이다. 국가 대표선발전 등위를 토대로 상위 20명 엘리트 쇼트트랙 스피드스케이트 남자선수(n = 20)를 선정하여 ACE 유전자 다형성에 따른 무릎관절 등속성근기능의 관련성을 밝히기 위해 실험한 결과 다음과 같은 결론을 얻었다. 첫째, 엘리트 쇼트트랙 선수들의 ACE 유전자 다형성에 따른 무릎관절 등속성 근기능 능력에서 우측 굴근 peak torque(NM)은 DD type과 II type에서 통계적으로 유의한 차이가 나타났다(p<.01). DD type이 가장 큰 수치를 나타냈으나 ID type과는 통계적으로 유의한 차이를 나타내지 않았다. 좌측 신근 fatigue index은 DD type과 ID type(p<.05), DD type과 II type(p<.01)이 통계적으로 유의한 차이를 나타냈다. 우측 굴근 fatigue index는 DD type과 II type에서 통계적으로 유의한 차이가 나타났다(P<.05). 따라서 엘리트 쇼트트랙 선수들의 ACE 유전자의 다형성 중 최대근력에서는 DD type이 fatigue index에서는 II type이 등속성 능력 운동 종목에 유리한 유전형이라고 판단된다. This study was conducted on elite male short track athletes based on ACE gene polymorphisms. Elite athletes by identifying the relationship between knee joint isokinetic muscle function It presents standards for excavation. Based on national team selection rankings, the top 20 elite short track speed skating male athletes (n = 20) were selected and tested for ACE gene polymorphism. As a result of an experiment to reveal the relationship between knee joint isokinetic muscle function, the following results were obtained: First, knee joint isokinetics according to ACE gene polymorphism in elite short track athletes. In muscle functional capacity, right flexor peak torque (NM) is statistically significant in DD type and II type. A significant difference appeared (p<.01). DD type showed the highest value. There was no statistically significant difference with ID type. Left extensor fatigue The index is statistically DD type and ID type (p<05), and DD type and IItype (p<.01). There was a significant difference. Right flexor fatigueindex was statistically significant in DD type and II type. A difference appeared (P<.05) Therefore, among the polymorphisms of the ACE gene in elite short track athletes, type DD in terms of maximum strength and type II in terms of fatigue index are considered to be advantageous genotypes for isokinetic ability exercise events.