Case Report : Two Cases of Chronic Idiopathic Intestinal Pseudo-obstruction with Different Clinical Features

( Byoung Hwan Lee ),( Na Young Kim ),( Sung Bum Kang ),( Kyoung Ho Lee ),( Jane C. Oh ),( Sun Mi Kim ),( Young Soo Park ),( Dong Ho Lee ) 대한소화관운동학회 2010 Journal of Neurogastroenterology and Motility (JNM Vol.16 No.1

Chronic intestinal pseudo-obstruction (CIPO) is a rare disorder characterized by a severe impairment of gastrointestinal propulsion in the absence of mechanical obstruction. We experienced a case of chronic pseudo-obstruction in the initial phase mimicking acute pseudo-obstruction, which was treated medically. This ongoing case was compared to another recurrent and intractable case successfully treated with surgery and diagnosed as hypoganglionosis. These two cases showed different clinical features and therapeutic approaches for CIPO; one with the first episode of CIPO mimicking Ogilvie`s syndrome; the other with recurrent episodes of CIPO with typical features. In conclusion, CIPO is a difficult disorder with various clinical manifestations and different treatment modalities, therefore individualized diagnostic and therapeutic approaches are needed.(J Neurogastroenterol Motil 2010;16:83-89)

노래 부르기가 만성 폐쇄성 폐질환 환자(COPD)에 미치는 영향 : 체계적 고찰 및 메타분석

김성애 대구대학교 특수교육재활과학연구소 2020 특수교육재활과학연구 Vol.59 No.3

본 연구는 만성 폐쇄성 폐질환의 폐 재활 프로그램으로써 노래 부르기의 효과를 확인하고자 체계적 문헌고찰과 메타분석을 실행하여 임상 및 연구에 유용한 정보를 제공하고자 하였다. PubMed, CINAHL, Web of Science, PsyInfo, Embase, Cochrane Library 데이터베이스에서 문헌을 검색하고 2000년에서 2020년 사이에 영어로 출판된 저널로 범위를 정하였다. 주요 검색 용어로 “singing” OR “choir” OR “Music OR music therapy” AND “Lung Diseases” OR “Lung Diseases” OR “Pulmonary Disease” OR “Chronic Obstructive” “Chronic Obstructive Pulmonary Disease” OR “Chronic Pulmonary Emphysema”를 사용 하였다. 최종적으로 포함된 4편의 연구는 모두 무작위 대조군 임상연구(RCTs: Randomized Controlled Test trials)로 노래 중재의 빈도는 6 주에서 24 주에 걸쳐 일주일에 1-2번 이었다. 노래 프로그램은 60 분이었고 이완 운동, 호흡 운동, 발성, 노래로 구성되었다. 건강 관련 삶의 질에 대한 결과는 2 편의 연구, 우울관련 결과는 3 편의 연구에서 각각 확인되었다. 호흡 곤란의 주요 결과는 기저 호흡 곤란 지수(BDI)를 사용한 1 편의 연구가 있었다. 노래 부르기는 효율적이고 지속 가능한 방식으로 폐 재활을 유지하는 것에 도움이 되고 환자의 질병과 관련된 삶의 질, 질병과 관련된 우울감과 관련하고 물리적 경험에 긍정적인 영향을 미치는 것으로 확인되었다. 본 연구는 외국문헌을 바탕으로 만성 폐쇄성 폐질환을 위한 노래 부르기의 효과를 분석하고 호흡 재활 분야에서의 적용 가능성을 제시한데 의의가 있다.

Determinants of Nicotine Dependence in Chronic Obstructive Pulmonary Disease

( Yun Su Sim ),( Jin Hwa Lee ),( Ki Uk Kim ),( Seung Won Ra ),( Hye Yun Park ),( Chang-hoon Lee ),( Deog Kyeom Kim ),( Kyeong-cheol Shin ),( Sang Haak Lee ),( Hun Gyu Hwang ),( Joong Hyun Ahn ),( Yong 대한결핵 및 호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.3

Background: Smoking cessation is the most powerful intervention to modify progress of chronic obstructive pulmonary disease (COPD), and nicotine dependence is one of the most important determinants of success or failure in smoking cessation. We evaluated nicotine dependence status and investigated factors associated with moderate to high nicotine dependence in patients with COPD. Methods: We included 53 current smokers with COPD in the Korean Obstructive Lung Disease II cohort enrolled between January 2014 and March 2016. Nicotine dependence was measured by using Fagerstrom test for nicotine dependence (FTND). Cognitive function was assessed by Korean version of Montreal Cognitive Assessment. Results: The median FTND score was 3, and 32 patients (60%) had moderate to high nicotine dependence. The median smoking amount was 44 pack-years, which was not related to nicotine dependence. Multiple logistic regression analysis revealed that high education status (odds ratio, 1.286; 95% confidence interval, 1.036-1.596; p=0.023), age <70 (odds ratio, 6.407; 95% confidence interval, 1.376-29.830; p=0.018), and mild to moderate airflow obstruction (odds ratio, 6.969; 95% confidence interval, 1.388-34.998; p=0.018) were related to moderate to high nicotine dependence. Conclusion: Nicotine dependence does not correlate with smoking amount, but with education level, age, and severity of airflow obstruction. Physicians should provide different strategies of smoking cessation intervention for current smokers with COPD according to their education levels, age, and severity of airflow obstruction.

Determinants of Nicotine Dependence in Chronic Obstructive Pulmonary Disease

Sim, Yun Su,Lee, Jin Hwa,Kim, Ki Uk,Ra, Seung Won,Park, Hye Yun,Lee, Chang-Hoon,Kim, Deog Kyeom,Shin, Kyeong-Cheol,Lee, Sang Haak,Hwang, Hun Gyu,Ahn, Joong Hyun,Park, Yong Bum,Kim, Yu-Il,Yoo, Kwang Ha The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.3

Background: Smoking cessation is the most powerful intervention to modify progress of chronic obstructive pulmonary disease (COPD), and nicotine dependence is one of the most important determinants of success or failure in smoking cessation. We evaluated nicotine dependence status and investigated factors associated with moderate to high nicotine dependence in patients with COPD. Methods: We included 53 current smokers with COPD in the Korean Obstructive Lung Disease II cohort enrolled between January 2014 and March 2016. Nicotine dependence was measured by using Fagerstrom test for nicotine dependence (FTND). Cognitive function was assessed by Korean version of Montreal Cognitive Assessment. Results: The median FTND score was 3, and 32 patients (60%) had moderate to high nicotine dependence. The median smoking amount was 44 pack-years, which was not related to nicotine dependence. Multiple logistic regression analysis revealed that high education status (odds ratio, 1.286; 95% confidence interval, 1.036-1.596; p=0.023), age <70 (odds ratio, 6.407; 95% confidence interval, 1.376-29.830; p=0.018), and mild to moderate airflow obstruction (odds ratio, 6.969; 95% confidence interval, 1.388-34.998; p=0.018) were related to moderate to high nicotine dependence. Conclusion: Nicotine dependence does not correlate with smoking amount, but with education level, age, and severity of airflow obstruction. Physicians should provide different strategies of smoking cessation intervention for current smokers with COPD according to their education levels, age, and severity of airflow obstruction.

Determinants of Nicotine Dependence in Chronic Obstructive Pulmonary Disease

심윤수,이진화,김기욱,나승원,박혜윤,이창훈,김덕겸,신경철,이상학,황헌규,안중현,박용범,김유일,유광하,정인아,오연목,이상도 대한결핵및호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.3

Background: Smoking cessation is the most powerful intervention to modify progress of chronic obstructive pulmonary disease (COPD), and nicotine dependence is one of the most important determinants of success or failure in smoking cessation. We evaluated nicotine dependence status and investigated factors associated with moderate to high nicotine dependence in patients with COPD. Methods: We included 53 current smokers with COPD in the Korean Obstructive Lung Disease II cohort enrolled between January 2014 and March 2016. Nicotine dependence was measured by using Fagerstrom test for nicotine dependence (FTND). Cognitive function was assessed by Korean version of Montreal Cognitive Assessment. Results: The median FTND score was 3, and 32 patients (60%) had moderate to high nicotine dependence. The median smoking amount was 44 pack-years, which was not related to nicotine dependence. Multiple logistic regression analysis revealed that high education status (odds ratio, 1.286; 95% confidence interval, 1.036–1.596; p=0.023), age <70 (odds ratio, 6.407; 95% confidence interval, 1.376–29.830; p=0.018), and mild to moderate airflow obstruction (odds ratio, 6.969; 95% confidence interval, 1.388–34.998; p=0.018) were related to moderate to high nicotine dependence. Conclusion: Nicotine dependence does not correlate with smoking amount, but with education level, age, and severity of airflow obstruction. Physicians should provide different strategies of smoking cessation intervention for current smokers with COPD according to their education levels, age, and severity of airflow obstruction.

만성폐쇄성폐질환의 유병률 및 사회 경제적 부담

안태준,윤형규 대한의사협회 2018 대한의사협회지 Vol.61 No.9

Chronic obstructive pulmonary disease (COPD) is a common respiratory disease characterized by persistent respiratory symptoms and irreversible airflow obstruction. It is caused by smoking, occupational exposure, and air pollution. It shows a high prevalence, both in South Korea and worldwide. The global COPD prevalence is 11.7%, and a similar prevalence has been reported in South Korea. In the Korea National Health and Nutrition Examination Survey 2010- 2016, the prevalence of COPD was found to be between 13.1% to 14.6%. The prevalence of COPD is increasing continuously. Aging, male sex, smoking, and air pollution are risk factors of COPD. However, COPD is strikingly underrecognized given its prevalence. Three million people die annually due to COPD, and the mortality burden of COPD is increasing along with population aging. The socioeconomic burden of COPD is becoming enormous.

Evaluation and interpretation of transcriptome data underlying heterogeneous chronic obstructive pulmonary disease

Ham, Seokjin,Oh, Yeon-Mok,Roh, Tae-Young Korea Genome Organization 2019 Genomics & informatics Vol.17 No.1

Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease, featured by airflow obstruction. Recently, a comprehensive analysis of the transcriptome in lung tissue of COPD patients was performed, but the heterogeneity of the sample was not seriously considered in characterizing the mechanistic dysregulation of COPD. Here, we established a new transcriptome analysis pipeline using a deconvolution process to reduce the heterogeneity and clearly identified that these transcriptome data originated from the mild or moderate stage of COPD patients. Differentially expressed or co-expressed genes in the protein interaction subnetworks were linked with mitochondrial dysfunction and the immune response, as expected. Computational protein localization prediction revealed that 19 proteins showing changes in subcellular localization were mostly related to mitochondria, suggesting that mislocalization of mitochondria-targeting proteins plays an important role in COPD pathology. Our extensive evaluation of COPD transcriptome data could provide guidelines for analyzing heterogeneous gene expression profiles and classifying potential candidate genes that are responsible for the pathogenesis of COPD.

Evaluation and interpretation of transcriptome data underlying heterogeneous chronic obstructive pulmonary disease

함석진,오연목,노태영 한국유전체학회 2019 Genomics & informatics Vol.17 No.1

Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease, featured by airflow obstruction. Recently, a comprehensive analysis of the transcriptome in lung tissue of COPD patients was performed, but the heterogeneity of the sample was not seriously considered in characterizing the mechanistic dysregulation of COPD. Here, we established a new transcriptome analysis pipeline using a deconvolution process to reduce the heterogeneity and clearly identified that these transcriptome data originated from the mild or moderate stage of COPD patients. Differentially expressed or co-expressed genes in the protein interaction subnetworks were linked with mitochondrial dysfunction and the immune response, as expected. Computational protein localization prediction revealed that 19 proteins showing changes in subcellular localization were mostly related to mitochondria, suggesting that mislocalization of mitochondria-targeting proteins plays an important role in COPD pathology. Our extensive evaluation of COPD transcriptome data could provide guidelines for analyzing heterogeneous gene expression profiles and classifying potential candidate genes that are responsible for the pathogenesis of COPD.

Polymorphisms in <i>PDE4D</i> are Associated with a Risk of COPD in Non-Emphysematous Koreans

Yoon, Hyoung-Kyu,Hu, Hae-Jin,Rhee, Chin-Kook,Shin, Seung-Hoon,Oh, Yeon-Mok,Lee, Sang-Do,Jung, Seung-Hyun,Yim, Seon-Hee,Kim, Tae-Min,Chung, Yeun-Jun Informa Healthcare 2014 COPD Vol.11 No.6

<P>Despite extensive effort, only a few chronic obstructive pulmonary disease (COPD)-associated genes have been suggested, indicating that there must be additional risk-associated loci. Here we aimed to identify additional COPD-associated SNPs and to explore the potential relationship between COPD subgroups and the SNPs in the Korean population. We performed a genome-wide association study (GWAS) with 990 Korean individuals; 102 COPD cases and 544 controls for GWAS using Affymetrix SNP array 5.0, and 173 COPD cases and 171 controls for replication. After validating the candidate single nucleotide polymorphisms (SNP), we performed subgroup analysis by disease phenotype. Through GWAS, we identified a novel SNP in the <I>phosphodiesterase-4D</I> (<I>PDE4D</I>) gene [rs16878037 (C>T), <I>p</I> = 1.66 ◊ 10<SUP>−6</SUP>] that was significantly associated with COPD. This signal in <I>PDE4D</I> was successfully replicated in the independent set (<I>p</I> = 0.041). When we combined the discovery and replication data, the association signal became more significant (<I>p</I> = 5.69 ◊ 10<SUP>−7</SUP>). In the COPD subgroup analysis, the T allele of rs16878037 was significantly more frequent in COPD patients without severe diffusion capacity impairment (mild mixed and obstruction-dominant group) than in patients with severe impairment (severe mixed and emphysema-dominant groups). This result supports that <I>PDE4D</I> polymorphisms might be involved in the susceptibility to COPD especially in non-emphysematous individuals and that they could also affect the responsiveness of the PDE4 inhibitor treatment.</P>

Chronic Intestinal Pseudo-Obstruction Caused by Intestinal Adenocarcinoma in a Mixed-Breed Dog

Heesup Moon,Subin Hong,Sangyeoun Kim,Sungguon Park,Taehwan Kim,Na-Hyun Kim,이재훈 한국임상수의학회 2016 한국임상수의학회지 Vol.33 No.4

A 9-year-old, mixed-breed, castrated male dog presented with a one-week history of severe vomiting. Abdominal radiography showed a dilated small intestine loop. Abdominal ultrasonography showed small-intestinedistension up to 5 cm in diameter without mechanical obstruction. During exploratory laparotomy, an aperistaltic ilealsegment was resected. There was no narrowed cavity in the resected plane. Histopathologic and immunohistochemicalfindings confirmed visceral myopathy due to intestinal adenocarcinoma in the ileum and revealed partial destructionof the longitudinal and circular muscles with fibrosis. Chronic intestinal pseudo-obstruction caused by adenocarcinomawas diagnosed after considering the above investigative results.