12시간 이내의 치료적 유산을 위한 자궁경부 내 라미나리아 및 미소프로스톨 병합투여와 미소프로스톨 단독요법의 비교

신재은 ( Jae Eun Shin ),권지영 ( Ji Young Kwon ),이영 ( Young Lee ),신종철 ( Jong Chul Shin ),박인양 ( In Yang Park ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.4

목적 임신 첫 삼분기 계류유산 치료에 있어 12시간 이내에 자연적으로 태낭이 배출되는 빈도를 분석함으로써 라미나리아와 미소프로스톨을 사용하는 경우과 미소프로스톨만을 사용하는 경우의 효과를 비교하고자 하였다. 연구방법 최근 5년간 계류유산으로 진단받고 치료적 임신 종결을 시행받은 94명을 분석 대상으로 하여 후향적으로 분석하였으며, 이 중 47명은 라미나리아를 사용하였으며 이들은 미소프로스톨 사용량에 따라 200 μg, 400 μg, 800 μg 군으로 각기 나누었으며 라미나리아를 사용하지 않은 군도 같이 분류하였다. 각 군에서 치료 시행 후 12시간 이내에 태낭이 자연 배출되는 경우를 통계 분석하였다. 결과 라미나리아를 사용하지 않은 그룹에서 자연배출 빈도는 미소프로스톨의 용량에 따라 증가하였다(각각 200 μg, 400 μg과 800 μg에서 4.2%, 37.5%과 33.3%, P=0.028). 같은 미소프로스톨 용량의 그룹 간 비교에서, 라미나리아 사용 여부에 따른 12시간 이내 자연배출의 빈도는 차이가 없었다. 다변량 로지스틱 회귀 분석에 따르면, 유산물의 자연 배출 빈도는 400 μg 용량 이상의 미소프로스톨과 임신 재태 연령과 의미있고 독립적으로 관련이 있었다. 결론 계류유산 치료에 있어 질내로 삽입하는 미소프로스톨은 효과적이고 안정적인 약제로 사용할 수 있으며, 12시간 이내 자연적으로 태낭이 배출되는 확률은 400 μg, 800 μg을 사용하는 경우 가장 높았다. Objective To compare the effectiveness of intracervical laminaria plus vaginal misoprostol and vaginal misoprostol only with variable dosages by analyzing the rate of spontaneous gestational sac expulsion for medical abortion within 12 hours. Methods This study was performed in 94 patients for missed abortion at Department of Obstetrics and Gynecology, St. Paul`s Hospital, the Catholic University of Korea for 5 years (2004-2008). Forty seven patients were managed with laminaria insertion and intravaginal misoprostol 200 μg, 400 μg, or 800 μg at admission or outpatient clinic. The others were treated with only misoprostol at the same dose. We analyzed the rate of spontaneous expulsion of gestational sac within 12 hours. Results In non-laminaria group, spontaneous expulsion rate increased according to the doses of misoprostol (4.2%, 37.5%, and 33.3%, in 200 μg, 400 μg, and 800 μg, respectively, P=0.028). Between groups with the same misoprostol doses, no difference was observed in the spontaneous expulsion of the fetal sac within 12 hours according to the use of laminaria. On multivariate logistic regression analysis, factors that were associated signifi cantly and independently with spontaneous expulsion of conceptus were misoprostol ≥400 μg and gestational age. Conclusion Treatment of missed abortion with 400 or 800 μg misoprostol vaginally is safe and acceptable method, and reduced the number of surgical interventions.

실험적 뇌탈출에 대한 연구

최운성,주정화,임창수,이훈갑,박상덕 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.2

Cerebral herniations were successfully produced in experimental animals during the expansion of intracranial balloon or laminaria. Visualizing structures deep in the brain, cat's heads were instantaneousely frozen with liquid nitrogen and were sectioned in the midline longitudinally. The cerebral herniations were assessed by measuring the distance between parts of various anatomical structures on the brain in mid-sagittal sectional plane. Transtentorial rostrocaudal herniation of the brain stem was evident and more marked in the group of bilateral parietal lesions than in the groups of frontal and temporal lesions. Infratentorial lesions produced transtentorial upward herniation of a part of anterior cerebellar vermis and downward herniation of the cerebellar tonsil through the foramen magnum. The risk of brain herniation was noted to be greater in rapid expanding lesions with balloon than the more slowly developing lesions with laminaria.

다시마 식이가 흰쥐에서 글리피지드의 체내동태에 미치는 영향

최한곤,장보현,이종달,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Drug interactions with food, on occasion, lead to serious nutritional and functional changes in the body as well as alternations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increase risk of micovascular, macrovascurlar, and neuropathic complications. However, the precise mechanixm of diabetes mellitus remains unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo- or hyperglycemia and preventing complications. The purpose of this study was to investigate the effect of Laminaria japonica diet on the absorption, distribution, metabolism and excretion of glipizide which are frequently used in the treatment of diabetes. Diabetic rats induced by streptozotocin were employed in this study. Blood concentrations of oral hypoglycemic agents were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_a, t_1/2, C_max, t_max, and AUC. Administration of glipzide in normal rats treated with Laminaria japonica diet showed significant increase in AUC, k_a, t_1/2, t_max and decrease in C_max, compared to those without Laminaria japonica diet. This might result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption. Administration of glipizide in diabetic rats treated with Laminaria japonica diet showed significant increase in t_1/2 and t_max, and decrease in C_max, compared to those without Laminaria japonica diet. This might also result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption and flattened blood concentration of glipizide. The oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of glipizide caused by long-term Laminaria japonica diet.

다시마 분말 첨가 스펀지 케이크의 품질 특성

임은정,Lim, Eun-Jeong 한국식품영양학회 2012 韓國食品營養學會誌 Vol.25 No.4

다시마 분말을 밀가루 중량에 대해서 3%, 5%, 7%와 9%의 비율로 첨가하여 제조한 스펀지 케이크의 물리적 관능적 특성을 검토해본 결과, 다시마 분말 첨가 스펀지 케이크의 수분함량은 첨가구간의 유의적 차이는 없었으며, 조단백질 함량은 대조구가 가장 낮았고, 다시마 분말 첨가량이 증가할수록 증가하였다. 조지방 함량은 대조구와 다시마 분말 첨가구 간의 유의적 차이가 없었다. 회분 함량은 대조구가 가장 낮은데 비해 다시마 분말 첨가량이 증가할수록 유의적으로 증가한 것을 볼 수 있었다. 다시마 분말 첨가 스펀지 케이크의 탄수화물 함량은 대조구와 첨가구 간의 유의적 차이는 없었다. 비중은 대조구가 가장 낮게 나타났으며, 대조구에 비해 다시마 분말 첨가군의 비중이 유의적으로 증가하는 것으로 나타났다. 굽기 손실은 대조구가 가장 낮았고, 9% 첨가구가 가장 높게 나타났으며, 반죽 수율은 대조구가 가장 높았고, 9% 첨가구가 가장 낮았다. 다시마 첨가에 의하여 케이크의 색은 다소 어둡고 푸른색을 띄는 변화를 보였다. 밝은 정도를 나타내는 L값은 대조군이 다른 첨가군들에 비해 유의적으로 높게 평가되었고, 다시마 첨가량이 증가할수록 유의적으로 감소하여 다시마 분말 9% 첨가구가 가장 어두운 색을 나타내었다(p<0.05). 적색도를 나타내는 a값도 다시마 분말 첨가량이 증가할수록 유의적으로 증가하였다. 황색도를 나타내는 b값은 다시마 분말 첨가량이 증가함에 따라 유의적으로 감소하였다(p<0.05). 다시마 분말 첨가량에 따른 스펀지 케이크의 texture 특성으로 경도(hardness), 탄력성(springiness), 응집성(cohesiveness), 점착성(gumminess), 씹힘성(chewiness), 회복탄력성(resilience)을 검토해본 결과, 3%, 5%와 7% 첨가구는 대조구와 비교하여 그 물리적 특성이 비슷하거나 큰 차이가 없었으나, 9% 첨가구의 경우 스펀지 케이크의 texture로서 바람직하지 않은 것으로 나타났다. 스펀지 케이크의 외관은 다시마 분말 첨가량이 증가할수록 부피와 높이가 감소하였으며, 가운데 부분이 약간 주저앉은 것을 확인할 수 있었다. 스펀지 케이크의 전반적 기호도, 색, 향기, 조직감, 맛에 대한 관능적 특성을 조사한 결과, 3%와 5% 첨가구에 대한 전반적 기호도와 맛에 대한 선호도가 높은 것으로 유의성(p<0.05) 있는 결과가 나타났다. 다시마 분말 첨가 스펀지 케이크의 개발 가능성 검토를 위해 다시마 분말을 다양한 수준으로 첨가한 케이크를 제조하여 물리적 관능적 특성을 검토해본 결과, 다시마 분말 3% 첨가 스펀지 케이크와 5% 첨가 스펀지 케이크가 물리적 특성과 관능적 특성을 모두 만족시킬 수 있는 첨가량임을 확인할 수 있었다. This study was performed in order to investigate the quality characteristics of sponge cake made with Laminaria japonia powder. To evaluate the physical and sensory analysis, Laminaria japonia powder was added to wheat flour in various ratio (3, 5, 7, 9%, w/w). The specific gravity and loss rate increased with the addition of Laminaria japonia powder. The crude protein and ash levels in the sponge cakes increased linearly with the addition of 0~9 g of Laminaria japonia powder/100 g of wheat flour. For the crumb color values, lightness (L) and yellowness (b) decreased with the addition of Laminaria japonia powder, whereas redness (a) significantly increased (P<0.05). In the texture analysis, the hardness, gumminess and chewiness were increased; however, the cohesiveness and resilience were reduced by the addition of Laminaria japonia powder. When the sensory characteristics were evaluated, 5% Laminaria japonia sponge cake showed the highest sensory properties, except for color. Therefore, the results suggested that 5% Laminaria japonia sponge cake could be helpful in improving the physical quality as well as the taste.

다시마의 생리활성과 다시마 분말 첨가 쇼트브레드쿠키의 관능적 특성 연구

임은정(Lim Eun Jeong) 한국식공간학회 2014 식공간연구 Vol.9 No.1

The study was performed to investigate the biological activity of Laminaria japonia for developing functional food, and to evaluate the sensory characteristics of shortbread cookies adding powder of the Laminaria japonia. Laminaria japonia showed highest anti-complementary activity from 23 kinds of edible plants, sea weeds and chinese medicine, as results of tests. In order to examine its blood anti-coagulant effects, Laminaria japonia was extracted with cold water, methanol, hot water, HCl and NaOH. In general, the alkali extract of Laminaria japonia was approximately 13.7 times stronger than the control. The results of sensory characteristics of cookies containing various concentrations(0, 3, 5, 7 and 9%) of Laminaria japonia powder showed that 3% and 5% added samples was significantly more preferable in overall acceptability than others. In conclusion, addition of Laminaria japonia could be useful to improve the quality of cookies and add the functionality of food.

해대(海帶)의 기원에 대한 고문헌적 연구

최고야(Choi Goya),추병길(Choo Byungkil),문병철(Moon Byeongcheol),이혜원(Lee Hyewon),이아영(Lee Ayeong),김호경(Kim Hokyoung) 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.3

Haedae(海帶, haidai) is representative herb from seaweeds. but its origin is still confusing. Thus we analyzed its origin on the basis of classics of oriental medicine. The scientific name of Haedae corresponds to Zostera marina, according to the folkloric use. But, it is Laminaria japonica. according to its habitat, morphological feature, and the korean name on the medical books in Joseon since 17c. In the remote past, it seemed that two groups were segragated by the name of Zostera marina Haedae and Laminaria japonica Haedae. However, it is thought that this two trends were mixed up when medical knowledge was compiled in Song Dynasty era. Documental support inclined to Laminaria japonica, but it is too early to conclude that Laminaria japonica is the Haedae. To prove this hypothesis, further study is required to investige whether Laminaria japonica or Zostera marina has mentioned efficacies of Haedae used for the treatment of wen. San syndromes, edema. scrofula, etc. And we have need of research that solve the origin problem of Gonpo(Laminariae thallus) on the assumption that Laminaria japonica is Haedae.

주정농도에 따른 다시마 추출물의 생리활성 평가

김진,이창문,김춘성,이숙영 한국산학기술학회 2022 한국산학기술학회논문지 Vol.23 No.12

본 연구에서는 에탄올 농도를 달리하여 추출한 Laminaria japonica의 항산화 및 항염증 활성을 측정하였다. 0 % (0%E), 30 % (30%E), 50 % (50%E), 70 % (70%E) 및 90 % (90%E)조성 에탄올에 Laminaria japonica을 각각 첨가하여 추출물을 얻었다. GC-MS 분석 결과 Laminaria japonica의 추출물에서 파이토케미컬 성분을 확인하였다. 1.1-Diphenyl-2-picrylhydrazyl (DPPH)와 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)를 적용한 항산화 활성은 50%E 조건의 추출물에서 가장 높은 소거 활성을 확인하였다. Nitric oxide (NO)저해측정은 Lipopolysaccharide (LPS)로 유도된 RAW 264.7 세포에서 70%E 추출물이 1 mg/mL 농도에서 59.6 ± 2.67 %로 가장 높은 NO 저해를 나타냈다. 또한, Laminaria japonica 추출물은 섬유아세포의 세포이동을 촉진시켰다. 본 연구 결과, 50%E 및 70%E 조건에서 추출한 Laminaria japonica의 유효성분은 식품, 의약품 및 화장품의 잠재적인 기능성 소재로 활용될 수 있을 것으로 기대된다.

라미나리아를 이용한 경동맥-해면정맥동루의치료 : 증례 및 기술보고 Case Report and Technical Note

주정화,이기찬,이훈갑,임창수,차인호 대한신경외과학회 1985 Journal of Korean neurosurgical society Vol.14 No.4

Many different type of embolic material, such as muscles Gelfoam, porcelain, and detachable balloon, etc, has been used for the treatment of carotid-cavernous fistula. In an effort to achieve better results the authors used laminaria, a sea -weeds root, as a newly -tried embolus which has a unique characteristic of expanding gradually within 4 hours 3-4 times from its original width, but not in length, when in contact with any type of fluid. A very special feature of the laminaria is that the initial hard and coarserness is slowly transformed while expanding into a rounded softness as to allow no mechanical injury to the surrounding vessels of tissue. The laminaria was formed into a reversed bowling-pin shape measuring 8×1.5㎜ with tapered tail and a round head in which contains a silver clip as a radiographic marker. An extension of standard angiographic technique has been used to complete an alternative method of treatment. This technique involves introducing the cather harboring the laminaria by the percutaneous route either transfemoral or directly transcarotid and releasing the terminal internal carotid artery at the site of the fistula. Releasing a few of the shaped laminaria piece from the catheter tip has resulted in a successful obliteration of the fistula in 7 cases out of total 8 of carotid-cavernous fistula.

부정자궁출혈 환자에서 자궁내막소파술을 위한 Misoprostol 의 질내투여와 라미나리아 삽입의 비교

이동욱(Dong Ook Lee),금형용(Hyung Yong Keum),김종철(Jong Chul Kim),이윤혁(Yoon Hyuk Lee),정우철(Woo Chuel Jung),이성원(Sung Won Lee),조용(Yong Cho),노의선(Eu Sun Ro) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8

N/A Objective : To compare cervical dilatation efficacy and safety of intravaginal misoprostol with that of cervical laminaria tent insertion in endometrial curettage due to abnormal uterine bleeding Method : Patients requesting endometrial curettage due to abnormal uterine bleeding were randomized into two group. In group I (n=53), 100 μg tablet of misoprostol was placed in the posterior vaginal fornix at midnight. In Group Ⅱ (n=54), laminaria tent number 5 was inserted in cervical canal at midnight. Endometrial curettage was performed on the next morning. The degrees of cervical dilatation were measured by Hegar dilator just before endometrial curettage. Both groups were compared about cervical dilatation efficacy and side effect. Result : The degrees of cervical dilatation were 8.8±1.1 mm in group I and 9.3±1.9 mm in group Ⅱ. There was no significant statistical difference. (P=0.134) The mean intervals from the use of misoprostol or laminaria to endometrial curettage were 704±140 minutes in group I and 829±156 in group Ⅱ. In group I, mild fever (less than 38℃) was observed in four women and one complained mild abdominal pain. In group Ⅱ, five women revealed mild fever and fifty women complained abdominal discomfort. All didn't need any medication or special therapy. Conclusion : Intravaginal misoprostol was appeared as efficacious as laminaria tent in cervical dilatatory effect before endometrial curettage in abnormal uterine bleeding patients. It was considered more convenient, safer and more cost effective method compared than cervical laminaria tent in cervical preparation before endometrial curettage.

Comparing the effects of vaginal misoprostol, laminaria, and extra amniotic saline infusion on cervical ripening and induction of labor

( Zohreh Tabasi ),( Elaheh Mesdaghinia ),( Masoumeh Abedzadeh-kalahroudi ),( Mojtaba Sehat ),( Aida Panahandeh ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.3

Objective This study aimed to compare the effects of vaginal misoprostol, laminaria, and extra-amniotic saline infusion (EASI) on cervical ripening. Methods This randomized controlled trial was conducted on 195 women with singleton pregnancies and unripe cervices. Participants were randomly allocated to 3, 65-person groups: a misoprostol, a laminaria, and an EASI group. The interventions in the misoprostol, laminaria, and EASI groups included a single 25-μg vaginal misoprostol suppository, an intracervical laminaria, and a transcervical Foley catheter, respectively. The groups were compared with each other regarding time intervals from labor induction to labor active phase and delivery, cervical dilation, Bishop scores 6 hours after induction, delivery type, length of hospital stay, and complications. Results There were no significant differences among the groups regarding maternal ages, gestational ages, body mass indices, baseline cervical dilations, and Bishop scores (P>0.05). Six hours after induction, the Bishop score and cervical dilation were significantly greater in the EASI group than in the other 2 groups (P<0.001). Moreover, time intervals from labor induction to labor active phase and delivery in the EASI group were significantly short (P<0.001). The rates of cesarean section, fetal distress, placental abruption, and meconium staining in the misoprostol group were significantly high (P<0.05), and the length of hospital stay in the EASI group was significantly short (P<0.001). Conclusion EASI is a safer and more effective method for cervical ripening. Considering its inexpensiveness, easy accessibility, and greater effectiveness, EASI is recommended for cervical ripening.