12시간 이내의 치료적 유산을 위한 자궁경부 내 라미나리아 및 미소프로스톨 병합투여와 미소프로스톨 단독요법의 비교

신재은 ( Jae Eun Shin ),권지영 ( Ji Young Kwon ),이영 ( Young Lee ),신종철 ( Jong Chul Shin ),박인양 ( In Yang Park ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.4

Objective To compare the effectiveness of intracervical laminaria plus vaginal misoprostol and vaginal misoprostol only with variable dosages by analyzing the rate of spontaneous gestational sac expulsion for medical abortion within 12 hours. Methods This study was performed in 94 patients for missed abortion at Department of Obstetrics and Gynecology, St. Paul`s Hospital, the Catholic University of Korea for 5 years (2004-2008). Forty seven patients were managed with laminaria insertion and intravaginal misoprostol 200 μg, 400 μg, or 800 μg at admission or outpatient clinic. The others were treated with only misoprostol at the same dose. We analyzed the rate of spontaneous expulsion of gestational sac within 12 hours. Results In non-laminaria group, spontaneous expulsion rate increased according to the doses of misoprostol (4.2%, 37.5%, and 33.3%, in 200 μg, 400 μg, and 800 μg, respectively, P=0.028). Between groups with the same misoprostol doses, no difference was observed in the spontaneous expulsion of the fetal sac within 12 hours according to the use of laminaria. On multivariate logistic regression analysis, factors that were associated signifi cantly and independently with spontaneous expulsion of conceptus were misoprostol ≥400 μg and gestational age. Conclusion Treatment of missed abortion with 400 or 800 μg misoprostol vaginally is safe and acceptable method, and reduced the number of surgical interventions.

실험적 뇌탈출에 대한 연구

최운성,주정화,임창수,이훈갑,박상덕 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.2

Cerebral herniations were successfully produced in experimental animals during the expansion of intracranial balloon or laminaria. Visualizing structures deep in the brain, cat's heads were instantaneousely frozen with liquid nitrogen and were sectioned in the midline longitudinally. The cerebral herniations were assessed by measuring the distance between parts of various anatomical structures on the brain in mid-sagittal sectional plane. Transtentorial rostrocaudal herniation of the brain stem was evident and more marked in the group of bilateral parietal lesions than in the groups of frontal and temporal lesions. Infratentorial lesions produced transtentorial upward herniation of a part of anterior cerebellar vermis and downward herniation of the cerebellar tonsil through the foramen magnum. The risk of brain herniation was noted to be greater in rapid expanding lesions with balloon than the more slowly developing lesions with laminaria.

다시마 식이가 흰쥐에서 글리피지드의 체내동태에 미치는 영향

최한곤 ( Han Gon Choi ),장보현 ( Bo Hyun Jang ),이종달 ( Jong Dal Rhee ),유봉규 ( Bong Kyu Yu ),용철순 ( Chul Soon Yong ) 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Drug interactions with food, on occasion, lead to serious nutritional and functional changes in the body as well as alternations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increase risk of micovascular, macrovascurlar, and neuropathic complications. However, the precise mechanixm of diabetes mellitus remains unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo- or hyperglycemia and preventing complications. The purpose of this study was to investigate the effect of Laminaria japonica diet on the absorption, distribution, metabolism and excretion of glipizide which are frequently used in the treatment of diabetes. Diabetic rats induced by streptozotocin were employed in this study. Blood concentrations of oral hypoglycemic agents were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_a, t_1/2, C_max, t_max, and AUC. Administration of glipzide in normal rats treated with Laminaria japonica diet showed significant increase in AUC, k_a, t_1/2, t_max and decrease in C_max, compared to those without Laminaria japonica diet. This might result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption. Administration of glipizide in diabetic rats treated with Laminaria japonica diet showed significant increase in t_1/2 and t_max, and decrease in C_max, compared to those without Laminaria japonica diet. This might also result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption and flattened blood concentration of glipizide. The oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of glipizide caused by long-term Laminaria japonica diet.

다시마 분말 첨가 스펀지 케이크의 품질 특성

임은정,Lim, Eun-Jeong 한국식품영양학회 2012 韓國食品營養學會誌 Vol.25 No.4

This study was performed in order to investigate the quality characteristics of sponge cake made with Laminaria japonia powder. To evaluate the physical and sensory analysis, Laminaria japonia powder was added to wheat flour in various ratio (3, 5, 7, 9%, w/w). The specific gravity and loss rate increased with the addition of Laminaria japonia powder. The crude protein and ash levels in the sponge cakes increased linearly with the addition of 0~9 g of Laminaria japonia powder/100 g of wheat flour. For the crumb color values, lightness (L) and yellowness (b) decreased with the addition of Laminaria japonia powder, whereas redness (a) significantly increased (P<0.05). In the texture analysis, the hardness, gumminess and chewiness were increased; however, the cohesiveness and resilience were reduced by the addition of Laminaria japonia powder. When the sensory characteristics were evaluated, 5% Laminaria japonia sponge cake showed the highest sensory properties, except for color. Therefore, the results suggested that 5% Laminaria japonia sponge cake could be helpful in improving the physical quality as well as the taste.

다시마의 생리활성과 다시마 분말 첨가 쇼트브레드쿠키의 관능적 특성 연구

임은정(Lim Eun Jeong) 한국식공간학회 2014 식공간연구 Vol.9 No.1

The study was performed to investigate the biological activity of Laminaria japonia for developing functional food, and to evaluate the sensory characteristics of shortbread cookies adding powder of the Laminaria japonia. Laminaria japonia showed highest anti-complementary activity from 23 kinds of edible plants, sea weeds and chinese medicine, as results of tests. In order to examine its blood anti-coagulant effects, Laminaria japonia was extracted with cold water, methanol, hot water, HCl and NaOH. In general, the alkali extract of Laminaria japonia was approximately 13.7 times stronger than the control. The results of sensory characteristics of cookies containing various concentrations(0, 3, 5, 7 and 9%) of Laminaria japonia powder showed that 3% and 5% added samples was significantly more preferable in overall acceptability than others. In conclusion, addition of Laminaria japonia could be useful to improve the quality of cookies and add the functionality of food.

해대(海帶)의 기원에 대한 고문헌적 연구

최고야(Choi Goya),추병길(Choo Byungkil),문병철(Moon Byeongcheol),이혜원(Lee Hyewon),이아영(Lee Ayeong),김호경(Kim Hokyoung) 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.3

Haedae(海帶, haidai) is representative herb from seaweeds. but its origin is still confusing. Thus we analyzed its origin on the basis of classics of oriental medicine. The scientific name of Haedae corresponds to Zostera marina, according to the folkloric use. But, it is Laminaria japonica. according to its habitat, morphological feature, and the korean name on the medical books in Joseon since 17c. In the remote past, it seemed that two groups were segragated by the name of Zostera marina Haedae and Laminaria japonica Haedae. However, it is thought that this two trends were mixed up when medical knowledge was compiled in Song Dynasty era. Documental support inclined to Laminaria japonica, but it is too early to conclude that Laminaria japonica is the Haedae. To prove this hypothesis, further study is required to investige whether Laminaria japonica or Zostera marina has mentioned efficacies of Haedae used for the treatment of wen. San syndromes, edema. scrofula, etc. And we have need of research that solve the origin problem of Gonpo(Laminariae thallus) on the assumption that Laminaria japonica is Haedae.

주정농도에 따른 다시마 추출물의 생리활성 평가

김진,이창문,김춘성,이숙영 한국산학기술학회 2022 한국산학기술학회논문지 Vol.23 No.12

본 연구에서는 에탄올 농도를 달리하여 추출한 Laminaria japonica의 항산화 및 항염증 활성을 측정하였다. 0 % (0%E), 30 % (30%E), 50 % (50%E), 70 % (70%E) 및 90 % (90%E)조성 에탄올에 Laminaria japonica을 각각 첨가하여 추출물을 얻었다. GC-MS 분석 결과 Laminaria japonica의 추출물에서 파이토케미컬 성분을 확인하였다. 1.1-Diphenyl-2-picrylhydrazyl (DPPH)와 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)를 적용한 항산화 활성은 50%E 조건의 추출물에서 가장 높은 소거 활성을 확인하였다. Nitric oxide (NO)저해측정은 Lipopolysaccharide (LPS)로 유도된 RAW 264.7 세포에서 70%E 추출물이 1 mg/mL 농도에서 59.6 ± 2.67 %로 가장 높은 NO 저해를 나타냈다. 또한, Laminaria japonica 추출물은 섬유아세포의 세포이동을 촉진시켰다. 본 연구 결과, 50%E 및 70%E 조건에서 추출한 Laminaria japonica의 유효성분은 식품, 의약품 및 화장품의 잠재적인 기능성 소재로 활용될 수 있을 것으로 기대된다.

라미나리아를 이용한 경동맥-해면정맥동루의치료 : 증례 및 기술보고 Case Report and Technical Note

주정화,이기찬,이훈갑,임창수,차인호 대한신경외과학회 1985 Journal of Korean neurosurgical society Vol.14 No.4

Many different type of embolic material, such as muscles Gelfoam, porcelain, and detachable balloon, etc, has been used for the treatment of carotid-cavernous fistula. In an effort to achieve better results the authors used laminaria, a sea -weeds root, as a newly -tried embolus which has a unique characteristic of expanding gradually within 4 hours 3-4 times from its original width, but not in length, when in contact with any type of fluid. A very special feature of the laminaria is that the initial hard and coarserness is slowly transformed while expanding into a rounded softness as to allow no mechanical injury to the surrounding vessels of tissue. The laminaria was formed into a reversed bowling-pin shape measuring 8×1.5㎜ with tapered tail and a round head in which contains a silver clip as a radiographic marker. An extension of standard angiographic technique has been used to complete an alternative method of treatment. This technique involves introducing the cather harboring the laminaria by the percutaneous route either transfemoral or directly transcarotid and releasing the terminal internal carotid artery at the site of the fistula. Releasing a few of the shaped laminaria piece from the catheter tip has resulted in a successful obliteration of the fistula in 7 cases out of total 8 of carotid-cavernous fistula.

임신 일삼분기의 임신종결을 위한 질내 미소프로스톨 투여와 자궁경관내 라미나리아 삽입에 따른 자궁경관개대의 비교

리인숙(IS Rhee),이정재(JJ Lee),최승도(SD Choi),이해혁(HH Lee),남계현(KH Nam),이권해(KH Lee) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.8

Objective: To make a comparison of the effect of cervical dilatation for therapeutic abortion between vaginal administration of misoprostol and laminaria insertion into the cervix. Methods: Forty-five women received 100 μg of misoprostol as powder in the posterior vaginal fornix and laminaria were inserted into the cervix in forty-one women before curettage in first trimester pregnancy. We compared the effect of cervical dilatation and side effects. Results: The effect of cervical dilatation was not statistically different between the groups (8.2±2.5 versus 8.7±1.6 mm). The occurence of nausea, vomiting, diarrhea were none in both groups. Low abdominal pain was less frequent in the women receiving vaginal misoprostol than in those laminaria insertion (6.7% versus 22.0%). Vaginal bleeding was more frequent in the women receiving misoprostol than in those laminaria insertion (35.6% versus 22.0%). But the amount of vaginal bleeding was only minimal, it was not clinically significant. Conclusion: Vaginal administered misoprostol is as effective as laminaria insertion for cervical dilatation and curettage in the first trimester pregnancy.

Effect of Skin Regeneration of Laminariae Thallus Extract in HaCaT Cell and Zebrafish Larvae

Ye-Jin Lee,Ik Soo Lee,Young Sook Kim,Sang-Woo Ahn 한국생약학회 2024 Natural Product Sciences Vol.30 No.2

Many attempts are being made to find safe and therapeutic materials from natural sources. Laminariae Thallus is said to treat swelling of the face in the Dongui-Bogam and has been used in Traditional Korean Medicine to treat boils and chronic gallstones. Recently Laminariae Thallus has been utilized as a cosmetic material for its moisturizing and whitening properties. In this study, water and ethanolic extracts (30%, 50% and 80%) of Laminariae Thallus were prepared. Their regeneration effects were evaluated by cell proliferation and migration in human keratinocytes (HaCaT cells) and tail fin regeneration assay in zebrafish larvae. An 80% ethanol extract (100 μg/mL) of Laminariae Thallus was found to have the strongest ability on the migration of cells. In the tail fin regeneration experiment using zebrafish larvae, 80% ethanol extract (100 and 50 μg/mL) showed a high regeneration effect compared to the control. In conclusion, this study provides a scientific basis for the use of Laminariae Thallus extract for skin regeneration and suggests that it has great potential as a regenerative material for future natural cosmetics.