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Epstein-Barr 바이러스 유행지역에서 두경부암 발생과의 연관성
김아영,노종렬,김진만,나기상,박찬일 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.3
Background and Objectives:A number of reports have suggested that Epstein-Barr virus (EBV) is associated with different forms of head and neck cancers (HNC) such as nasopharyngeal carcinoma, NK/T cell lymphoma and Burkitts lymphoma. We evaluated the association of EBV with HNC as a causative factor in an endemic area of the virus. Subjects and Method:Fresh specimens of HNC were obtained from 72 new patients between August 2003 and January 2005. In situ hybridization for EBER was performed with immunohistochemical staining of p53, Bcl-2 and LMP-1 and serologic tests on anti-viral capsid antigen (VCA) and anti-early antigen (EA)-D. The results of EBV positivity were analyzed according to tumor TNM stages, sites, pathology and smoking status. A correlation between EBV positivity and p53, Bcl-2, LMP-1 positive staining was investigated. Results:Nine (12% ) of the total 72 patients showed EBV positivity of tumor, depending mainly on pathology and sites, but not tumor staging, age, sex or smoking status:NPC (3), NK/T cell lymphoma (5), lymphoephithelial carcinoma of the parotid gland (1). All patients had sero-positivity of anti-VCA IgG but not anti-VCA IgM and anti-EA-D. There was a relationship between the presence of EBV, its oncoprotein (LMP-1) and oncogene (Bcl-2). Conclusion:Overall, the incidence of EBV positivity of HNC in an endemic area is not significantly different from the prior reports about non-endemic area. The associa-tion between EBV and LMP-1 or Bcl-2 may be helpful for understanding the role of viral oncogenes in the HNC. (Korean J Otolaryngol 2007 ;50 :235-9)
아데노바이러스 주입 후 백서의 비강과 부비동 점막에서의 발현 양상
유영화,박용진,강준명,강보성,최진 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.10
Background and Objectives:A potential use of gene therapy to deliver therapeutic peptides to the nasal mucosa has not ben sal cavity and paranasal sinus mucosa of the rat. Materials and Method:Ten male Sprague Dawley rats were used in this experi-ments, and adenovirus vectors containing gren fluorescent protein (GFP) were injected into rat via tail vein. On fourteen days after gene transfer, 10 rats were sacrificed. The turbinate, nasal septum and paranasal sinus mucosa were examined by fluore-scent microscope, and imunohistochemical analysis using anti-GFP antibody was performed. Results:septal mucosa after injection of adenovirus vector expressing GFP showed difused distribution of fluorescent produced by GFP. Immunohistochemical analysis showed that GFP expresion in the turbinate mucosa was localized to the largely ciliated co-lmnar epithelium and to some lamnina propria, and that in the septal mucosa, it was localized to the ciliated columnar epithelium. Expression in the turbinate mucosa was more obvious than that in the nasal septal mucosa. There was no expression in the paranasal sinus mucosa. Conclusion:turbinate and nasal septal mucosa. Gene therapy targeting mucosal epithelium can be a helpful method to treat patients with chronic inflamatory disease of the nasal mucosa such as alergic rhinitis or neoplasm of the nasal cavity. (Korean J Otor -hinolaryngol-Head Neck Surg 2007 ;50 :882-7)