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RISS 인기검색어
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- 저자 : Zhaoxin Wu (검색결과 3 건)
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The Effect of Melatonin on Mitochondrial Function in Endotoxemia Induced by Lipopolysaccharide
Liu, Jing,Wu, Fengming,Liu, Yuqing,Zhang, Tao,Tang, Zhaoxin Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.6
This study examined the metabolism of free radicals in hepatic mitochondria of goats induced by lipopolysaccharide (LPS), and investigated the effects of melatonin (MT). Forty-eight healthy goats ($10{\pm}1.2\;kg$) were randomly selected and divided into four groups: saline control, LPS, MT+LPS and MT. The goats within each group were3 sacrificed either 3 or 6 h after treatment and the livers removed to isolate mitochondria. The respiration control ratio (RCR), the ADP:O ratio, the oxidative phosphorylation ratio (OPR), the concentration of $H_2O_2$ and the activities of Complex I-IV were determined. The mitochondrial membrane potential ($\Delta\psi_m$) was analyzed by flow cytometry. The results showed that RCR, O/P and OPR of the LPS group decreased (p<0.05), as well as activities of respiratory complexes, whereas the generation of $H_2O_2$ in Complex III increased (p<0.05) after 3 h, while Complex II and III increased after 6 h. Also, it was found that the mitochondrial membrane potential of the LPS group declined (p<0.05). However, pre-treatment with MT attenuated the injury induced by LPS, which not only presented higher (p<0.05) RCR, O/P, OPR, and respiratory complex activities, but also maintained the $\Delta\psi_m$. Interestingly, it is revealed that, in the MT+LPS group, the generation of $H_2O_2$ increased firstly in 3 h, and then significantly (p<0.05).decreased after 6 h. In the MT group, the function of mitochondria, the transmenbrane potential and the generation of $H_2O_2$ were obviously improved compared to the control group. Conclusion: melatonin prevents damage caused by LPS on hepatic mitochondria of goats.
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Stable Amorphous Bis(diarylamino)biphenyl Derivatives as Hole-Transporting Materials in OLEDs
Zhanfeng Li,Zhaoxin Wu,Wen Fu,Dongdong Wang,Peng Liu,Bo Jiao,Xiaoli Lei,Guijiang Zhou,Yuying Hao 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.5
Stable bis(diarylamino)biphenyl derivatives N4,N4'-di(biphenyl-4-yl)-N4,N4'-bis(2- methylbiphenyl-4-yl)biphenyl-4,4'-diamine (TPD-Ph) and N4,N4'-bis(2',4'-difluoro- 2-methylbiphenyl-4-yl)-N4,N4'-bis(2',4'-difluorobiphenyl-4-yl)biphenyl-4,4'-diamine (TPD-(2,4)-F) were synthesized and characterized. High thermal stability (Td ≥ 480°C and Tg ≥ 108°C) in combination with reversible oxidation process render the both promising candidates as hole-transporting materials for organic light-emitting devices. The device with structure of ITO/TPD-Ph/Alq3/LiF/Al presented the highest current efficiency of 4.2 cd A−1 and good operational stability even under the high current density of 350 mA cm−2, which outperformed TPD or NPB-based devices.
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Jiangtao Xu,Qiong Zhang,Zhaoxin Li,Yuhang Gao,Zhiyu Pang,Yina Wu,Geng Li,Dongyong Lu,Lijuan Zhang,Detang Li 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.1
Allergic rhinitis (AR) is an IgE-mediated chronic inflammatory disease of the allergic nasal mucosa. It has a significant effect on quality life; most patients with AR also suffer from sleep disorders, mood disorders, and deterioration in social relationships. As increasing numbers of medicinal plants show productive anti-inflammatory activity against inflammatory diseases, there is growing interest in natural medicinal plant ingredients. To this end, we selected Astragalus polysaccharides (APS) to evaluate its anti-inflammatory effect on ovalbumin-induced AR rats, and we further explored its impact on NLRP3 inflammasome activation and NOD2-mediated NF-κB activation. We found that APS can alleviate the nasal symptom of AR rats and attenuate pathological alterations. APS also reduced the inflammatory cytokine levels. APS not only inhibited the NLRP3 inflammasome activation but also inhibited NF-κB activation by decreasing NOD2 expression and blocking the phosphorylation of NF-κB (p65). In conclusion, APS can effectively improve the inflammatory symptoms of nasal mucosa in AR rats, which may be mediated by the inhibition of NLRP3 inflammasome activation and NOD2-mediated NF-κB activation. These findings indicate that APS has the potential to be used as a therapeutic agent for AR.
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