측두하악 증후군에 대한 침치료 군과 추나치료 군의 임상적 고찰

김태수,김창연,이기하,엄태웅,정영훈,고영탁,Kim, Tae-Soo,Kim, Chang-Yun,Lee, Ki-Ha,Um, Tae-Woong,Jung, Yung-Hoon,Kho, Yung-Tak 척추신경추나의학회 2006 척추신경추나의학회지 Vol.1 No.1

Objectives : The purpose of study was to compare and analyze the effects of the distance Acupuncture and the Chuna on Temporomandibular Disorder. Methods : Clinical studies were done on 31 patients who were treated with Temporomandibular Disorder at Dept. of Acupuncture & Moxibusition of Hospital of Ha-na Oriental Medicine from May 23 2005 to Apr 30 2006. Subjects were divided Into two group, Distance acupuncture group and Chuna group. In Distance acupuncture group, we treated patients with Wijungyug(胃正格) or Damjungyug(膽正格). In Chuna group, we treated patients with Distraction & Translation technique. For evaluating Function of Temporomandibular joint of Patients, we use the Modified Craniomandibular Index(mCMI) before treatment and after 6th treatment. Results : In Mandibular Movement(MM) of patients, the patients of Acupuncture Group were more effective than Chuna group. In TMJ noise(TN) of patients, the patients of Chuna Group were more effective than Acupuncture group. Conclusions : The Distance acupuncture may be better effect on Mandibular Movement and The chuna maybe better effect on TMJ noise.

참당귀의 흰쥐 4-Vessel Occlusion 전뇌허혈에 대한 신경방어효과

김영옥,하니나,부영민,박선영,박주영,유영법,신준식,안덕균,김호철 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : Angelicae Radix, the root of Angelica gigas N_AKAI (Umbelliferae) , which has been used to nourish the blood(補血), regulate menstruation(調經), relieve pain and promote bowel movements(崩漏) and activate blood circulation for the treatment of fatigue, headache, constipation and blood troubles in traditional Korean medicine. It's flavour and channel tropism is sweet(甘), pungent(辛), warm(溫), acting on the lung, heart and spleen(肺, 心, 脾). The purpose of study we report here was to determine the neuroprotective effect of Angelica gigas on global ischemia induced by 4-vessel occlusion in Wistar rats. Methods : Angelica gigas extracts was lyphilized after extraction with 85% methanol. We induced 4-VO for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. Results : The results showed that Angelica gigas had significantly neuroprotective effects (100, 250 and 500mg/kg of AR extracts, p<0.001) compared with control group. Each neuroprotective ratio was about 66.1, 79.3 and 78.6% respectively. Immunohistochemical data partially explained the protective effects of Angelica gigas via attenuation of COX-2 induction in hippocampus. Conclusion : Angelica gigas gas neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats and the attenuation of COX-2 induction is thought to be its possible mechanism.

쓰가루 單一品種 果園을 위한 꽃사과 受粉樹 利用에 관한 硏究

沈慶久,河有美,金健澔,朴永洙 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.1

Crabapples potentially useful as pollenizers in single-cultivar 'Tsugaru' orchard was evaluated for their flowering times and pollen germination(%). Their efficiency in the setting of fruits following controlled pollinations on 'Tsugaru' at private orchard in Sang ju was also examined. The obtained results are as follows, (1) Flowering times of Malus spp. 'Almey' and Malus spp. `Pioneer X' were from April 30 to May 1 and had the same flowering time of 'Tsugaru'. (2) Pollen germination(%) of crabapples using as pollenizers of 'Tsugaru' was over 90% of Malus spp. 'Almey' and Malus spp. 'Pioneer X' respectively. (3) Percentages of fruit setting in 'Tsugaru' crossed with Malus spp. 'Almey' and with 'Pioneer X' showed 99.3% respectively. (4) There was no statistically significant difference in the fruit skin color, fruit diameter (cm), fruit. height (cm), fruitt index, fruit weight(g), soluble solid(˚BX), acidity(pH), fruit hardness (kg/㎠), and seed numbers of 'Tsugaru' crossed with 'Pioneer X' and 'Almey'. (5) On the bases of flowering times, pollen germination, efficient fruit set, promising of fruit skin solour, and no statistically significant difference in fruit quality, Malus spp. 'Almey' and 'Pioneer X' are promising as pollenizers for single-cultivar 'Tsugaru' orchard.

미국 및 캐나다 地域에서 栽培, 販賣되고 있는 무궁화 品種에 關한 硏究

沈慶久,河有美,朴永洙,金健澔 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.1

This sutdy was carried out to examine the present distribution and status of Hibiscus cultivars by analyzing the US and Canadian market. The obtained results are summerized as follow : 1. At present, a total of 28 cultivars of Hibiscus are on the market. Among these, twenty four are diploids and four are triploids. The hottest cultivars in the market is a triploid `Diana' sold by 21 different companies. It is followed by 'Ardens' and 'Jeanne d'Arc', following `Red Heart', `Blue Bird', 'Woodbridg e', and 'Helene'. 2. As a conservation or display purpose, several cultivars are ketp in three different arboretums in the US. These include 5 cultivars, `Blue Bird', `Celestial Blue', `Collie Mullens', 'Lucy', and `Ruber Plena', in Arnold Arboretum, and one each, 'Variegatus', at the USDA national arboretum and, `Banner' at Morton arboretum in Chicago. 3. The avarage price for triploid cultivars is $6.00 for each seedling. The recently developed cultivars like 'Helene' and 'Minerva' cost $16.00 per seedling possibly due to their plant patent right. Other cultivars produced by cuttings cost $2.00 to $ 3.00 per seedling. 4. In Canada, there are nine cultivars on the market; being diploids and one triploid, `Diana'. 5. As for the distribution of different cultivars by climatic zone, twelve cultivars are being grown in temperate area like Ohio and Iowa. However, many other cultivars are being cultivated in wamer Southern state like Galifornia. Five cultivars are reported to grow in the relatively cool area like Wisconsin and Minnesota. Even in cold area like Canada, 5 cultivars such as `Anemonaeflorus'(2n), `Ardens'(2n), 'Jeanne d'Arc'(2n), and `Luky'(2n), and 'Paeoniflorus'(2n) at Ontario and there is colder than Hamkyung Do in north Korea.

山間村의 所得增大를 위한 適地産業 開發方案

李康寧,高永杜,金正敎,河浩成,姜奉淳,朴道秉,姜淮 慶尙大學校 1978 論文集 Vol.17 No.2

This study attempts to analysis the present situation of farm management and the related industriesin order to present the suitable industries for promoting the farmers' income in mountain area. This study is based on the survey data obtained from 30 sample mountain vellages in 10 Guns located in central, wetern and northen Kyeougnam Province, where lots of mountain vellages are scattered here and there. Major findings obtained from the analysis are summarized as follows: 1) Area of cultivated land in mountian villages was generally smaller than that in plain vellages. BUt major finding of thes tudy indicated that the standard of living in the study area depended upon not only the size of cultivated land but also the skills of management to understand exavtly the regional and togographical situaltion, to utilize the developmental resources effectively, and to diversify income sources. This means that upbringing of competent Saemaul leaders is very important for promoting the income of mountain villages. 2) Various crops were being planted in a samll scale inmountain area. And those crops except rice adn barley were planted for self-sufficiency. Therefore, it is desired to select and cultivate intensively the kinds of crops which are regionally adn topographically suitable for maximizing farm inceomes of subsistant farmers. 3) The survey found out that in mountain area the farming of extensive fruits like chestnuts, persimmons, etc. is more favorable than that of intensive fruits like apples, pears, etc. 4) Because of topographical inappropriateness and lack of fertile cultivates land in mountain area, mowt vegetables, except onions in a few regions, were growing in a small scales for self-sufficiency. And the future of the vegetable cultivationin mountain area is also gloomy. 5) Since various grasses are abundantly growing in the wild in mountain area, the mountain villages are suitable for raising the herbivorous animals. Therefore it is recommeded to encourage raising the herbivorous animals, especially cattle, as one of the major income sources in mountain area. 6) It is true that sericulture has greartly contributed to the economic growth in mountain area with aboundant land suitable for mulberry trees. Recenly sericulture has, however, been shrinking due to the barriers of silk exportation. Without the barriers of silk exportation, sericulture will still play an important role on providing one of the major sources tom mountain villages. 7) The miscellaneous trees in most forest around the mountain villages were growing planlessly. Those parts of the forest are needed to be renewed by planting the useful, endurable, and regionally and topographically suitable kinds of trees.

肺內血管硬化症과 肺胞纖維化를 隨伴한 肺動脈血栓症 : 一例報告 Report of a case

石世一,李寧均,李河,李聖浩,李聖洙,金勇一 醫藥係社 1961 綜合 醫學 Vol.6 No.8

Aminopeptidase M 저해제인 Valistatin과 des-Asp^4-Amastatin을 생산하는 방선균 SL20209의 특성 및 동정

고학룡,전효곤,정명철,서현효,김홍중,박용하,고영희 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

Aminopeptidase M 저해제인 valistatin과 des-asp^4-amastatin을 생산하는 방선균 분리주 SL20209의 특성을 조사하고 수리동정을 실시하였다. 형태적, 배양학적 및 생리적 특성으로 부터 SL20209는 방성균 중에서도 Streptomyces 속에 속하는 것으로 나타났으며, 43개의 분류단위 특성으로 TAXON program을 이용하여 수리동정한 결과, 주군집 29의 Streptomyces 중 Streptomyces griseoplanus와 가장 근접한 것으로 나타났다. 따라서, 분리주 SL20209를 S. griseoplanus SL20209로 동정하였다. Characterization and numerical identification were carried out for an actionmycetes SL20209. Morphological, cultural and physiological properties of SL20209 which produced valistatin and des-asp^4-amastatin as inhibitors of aminopeptidase M were evaluated. The isolate was identified to be the genus of Streptomyces. Fourty-three taxonomic units were analysed by using a TAXON program. The isolate was classified into the major cluster 29 of Streptomyces and best-matched to Streptomyces griseoplanus.

Outcome of Multipair Donor Kidney Exchange by a Web-Based Algorithm

Kim, Beom Seok,Kim, Yu Seun,Kim, Soon Il,Kim, Myoung Soo,Lee, Ho Yung,Kim, Yong-Lim,Kim, Chan Duck,Yang, Chul Woo,Choi, Bum Soon,Han, Duck Jong,Kim, Yon Su,Kim, Sung Joo,Oh, Ha-Young,Kim, Dae Joong American Society of Nephrology 2007 Journal of the American Society of Nephrology Vol.18 No.3

<P>Donor kidney exchange is an established method to overcome incompatibility of donor-recipient pairs (DRP). A computerized algorithm was devised to exchange donor kidney and was tested in a multicenter setting. The algorithm was made according to the consensus of participating centers. It makes all possible exchange combinations not only between two incompatible DRP but also circularly among three DRP and selects an optimum set of exchange combinations, considering several factors that can affect the outcome of the exchanged transplant. The algorithm was implemented as a web-based program, and matching was performed five times. Fifty-three DRP were enrolled from five transplant centers. The numbers of DRP that were enrolled in each matching were 38 (25:13), 39 (34:5), 33 (31:2), 32 (28:4), and 34 (30:4) (carryover:newcomer). The numbers of generated exchange combinations were 4:11, 3:17, 2:12, 2:3, and 2:3 (two-pair exchange:three-pair exchange), and the numbers of DRP in selected exchange combinations were six, 12, six, five, and four in each matching. The numbers of DRP with blood type O recipient or AB donor were five and one, respectively, in selected exchange combinations. Six DRP of two-pair exchange combinations and six DRP of three-pair exchange combinations underwent transplantation successfully. Computerized algorithm of donor kidney exchange was tried not only between two incompatible DRP but also circularly among three DRP. It showed that the algorithm has potential to improve the outcome of donor kidney exchange, especially for disadvantaged DRP with blood type O recipients or AB donors.</P>

Occurrence and characterization of oseltamivir-resistant influenza virus in children between 2007-2008 and 2008-2009 seasons

Kim, Seoung Geun,Hwang, Yoon Ha,Shin, Yung Hae,Kim, Sung Won,Jung, Woo Sik,Kim, Sung Mi,Oh, Jae Min,Lee, Na Young,Kim, Mun Ju,Cho, Kyung Soon,Park, Yeon Gyeong,Min, Sang Kee,Lee, Chang Kyu,Kim, Jun Su The Korean Pediatric Society 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.4

Purpose: There was a global increase in the prevalence of oseltamivir-resistant influenza viruses during the 2007-2008 influenza season. This study was conducted to investigate the occurrence and characteristics of oseltamivir-resistant influenza viruses during the 2007-2008 and 2008-2009 influenza seasons among patients who were treated with oseltamivir (group A) and those that did not receive oseltamivir (group B). Methods: A prospective study was conducted on 321 pediatric patients who were hospitalized because of influenza during the 2007-2008 and 2008-2009 influenza seasons. Drug resistance tests were conducted on influenza viruses isolated from 91 patients. Results: There was no significant difference between the clinical characteristics of groups A and B during both seasons. Influenza A/H1N1, isolated from both groups A and B during the 2007-2008 and 2008-2009 periods, was not resistant to zanamivir. However, phenotypic analysis of the virus revealed a high oseltamivir $IC_{50}$ range and that H275Y substitution of the neuraminidase (NA) gene and partial variation of the hemagglutinin (HA) gene did not affect its antigenicity to the HA vaccine even though group A had a shorter hospitalization duration and fewer lower respiratory tract complications than group B. In addition, there was no significant difference in the clinical manifestations between oseltamivir-susceptible and oseltamivir-resistant strains of influenza A/H1N1. Conclusion: Establishment of guidelines to efficiently treat influenza with oseltamivir, a commonly used drug for treating influenza in Korean pediatric patients, and a treatment strategy with a new therapeutic agent is required.

The Complementary Role of Serum Alpha-Fetoprotein Estimation in Evaluating and Predicting Response to Nivolumab in Patients with Hepatocellular Carcinoma

( Ha Il Kim ),( Ju Hyun Shim ),( Jiyoon Kim ),( Jihye Lim ),( Jonggi Choi ),( Danbi Lee ),( Kang Mo Kim ),( Young-suk Lim ),( Han Chu Lee ),( Young-hwa Chung ),( Yung Sang Lee ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Serum alpha-fetoprotein (AFP) level has been found to be a useful marker for predicting responsiveness to locoregional or systemic therapies in patients with hepatocellular carcinoma (HCC). We aimed to evaluate whether changes in serum AFP could accurately reflect response and predict prognosis in nivolumab-treated patients with the disease. Methods: In this study, a total of 84 HCC patients who had baseline serum AFP of ≥20 ng/mL and received an over 8-week course of nivolumab treatment between 2017 and 2019 were included. We defined ‘response to therapy’ as a result assessed at 8 weeks after nivolumab. Radiological response was evaluated by the RECIST criteria with CT images; and serological response was based on AFP changes from baseline (decrease and increase by 20% or 50%). Prognostic effect of AFP response was evaluated by overall survival analysis. Results: Baseline characteristics of 84 patients were as follows: 68 Child-Pugh class A, 1 treatment-naïve, 33 portal invasion, 73 distant metastasis, 81 BCLC stage C, and 66 serum AFP ≥200 ng/ml. AFP response defined as >20% (n=6) or >50% (n=5) reduction in the value was agreed upon objective responses by RECIST (complete or partial response; n=7) in 86% and 71%, respectively. There were also agreements in 93% and 85%, respectively between progressive disease on CT scans (n=55) and serological progression by >20% (n=51) or >50% (n=47) increase in AFP level. After 8 weeks of treatment, responders and progressors determined by a cut-off of 20% for AFP change independently predicted overall survival of patients (adjusted hazard ratios, 0.39 and 2.95, respectively), as did those by RECIST (0.24 and 4.56, respectively; Ps<0.05). Conclusions: Serological response criteria using 20% changes in serum AFP had good performance in predicting clinical outcomes in patients with AFP-producing HCC receiving nivolumab. Serial AFP measurement could be useful particularly for non-measurable infiltrative HCC in the relevant setting.