Fenofibrate Increases Radiosensitivity in Head and Neck Squamous Cell Carcinoma via Inducing G2/M Arrest and Apoptosis

Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.

Bridge widening with composite steel-concrete girders: application and analysis of live load distribution

Yang, Yue,Zhang, Xiaoguang,Fan, Jiansheng,Bai, Yu Techno-Press 2015 Advances in concrete construction Vol.3 No.4

A bridge widening technology using steel-concrete composite system was developed and is presented in this paper. The widened superstructure system consists of a newly built composite steel-concrete girder with concrete deck and steel diaphragms attached to the existing concrete girders. This method has been applied in several bridge widening projects in China, and one of those projects is presented in detail. Due to the higher stiffness-to-weight ratio and the rapid erection of composite girders, this widening method reveals benefits in both mechanical performance and construction. As only a few methods for the design of bridges with different types of girders are recommended in current design codes, a more accurate analytical method of estimating live load distribution on girder bridges was developed. In the analytical model, the effects of span length, girder pacing, diaphragms, concrete decks were considered, as well as the torsional and flexural stiffness of both composite box girders and concrete T girders. The study shows that the AASHTO LRFD specification procedures and the analytical models proposed in this paper closely approximate the live load distribution factors determined by finite element analysis. A parametric study was also conducted using the finite element method to evaluate the potential load carrying capacities of the existing concrete girders after widening.

Calcium Sensitization Induced by Sodium Fluoride in Permeabilized Rat Mesenteric Arteries

Yang, En-Yue,Cho, Joon-Yong,Sohn, Uy-Dong,Kim, In-Kyeom The Korean Society of Pharmacology 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.1

It was hypothesized that NaF induces calcium sensitization in $Ca^{2+}$-controlled solution in permeabilized rat mesenteric arteries. Rat mesenteric arteries were permeabilized with $\beta$-escin and subjected to tension measurement. NaF potentiated the concentration-response curves to $Ca^{2+}$ (decreased $EC_{50}$ and increased $E_{max}$). Cumulative addition of NaF (4.0, 8.0 and 16 mM) also increased vascular tension in $Ca^{2+}$-controlled solution at pCa 7.0 or pCa 6.5, but not at pCa 8.0. NaF-induced vasocontraction and $GTP{\gamma}S$-induced vasocontraction were not additive. NaF-induced vasocontraction at pCa 7.0 was inhibited by pretreatment with Rho kinase inhibitors H1152 or Y27632 but not with a MLCK inhibitor ML-7 or a PKC inhibitor Ro31-8220. NaF induces calcium sensitization in a $Ca^{2+}$ dependent manner in $\beta$-escin-permeabilized rat mesenteric arteries. These results suggest that NaF is an activator of the Rho kinase signaling pathway during vascular contraction.

Sliding Mode Control of Three-Phase Four-Leg Inverters via State Feedback

Yang, Long-Yue,Liu, Jian-Hua,Wang, Chong-Lin,Du, Gui-Fu The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.5

To optimize controller design and improve static and dynamic performances of three-phase four-leg inverter systems, a compound control method that combines state feedback and quasi-sliding mode variable structure control is proposed. The linear coordinate change matrix and the state variable feedback equations are derived based on the mathematical model of three-phase four-leg inverters. Based on system relative degrees, sliding surfaces and quasi-sliding mode controllers are designed for converted linear systems. This control method exhibits the advantages of both state feedback and sliding mode control. The proposed controllers provide flexible dynamic control response and excellent stable control performance with chattering suppression. The feasibility of the proposed strategy is verified by conducting simulations and experiments.

중국 중학생이 지각한 부모 및 교사의 자율성지지, 기본심리욕구, 사회정서역량 간의 관계 연구

( Yang Yue ),신태섭 ( Tae Seob Shin ) 인하대학교 교육연구소 2021 교육문화연구 Vol.27 No.1

본 연구의 목적은 자기결정성이론에 기반하여 부모 및 교사의 자율성 지지가 기본심리욕구를 매개로 중국 청소년의 사회정서역량에 미치는 영향을 살펴보는 데 있다. 이를 위해 중국 산동성 쯔보시 중학교 3학년 434명의 데이터를 사용하여 부모 및 교사의 자율성 지지와 중학생의 사회정서역량 간의 관계에서 중학생의 기본심리욕구의 매개효과를 확인하였다. 본 연구의 주요 결과는 다음과 같다. 첫째, 부모의 자율성 지지가 교사의 자율성 지지보다 중학생의 기본심리욕구 및 사회정서역량에 더 큰 영향을 미치는 것으로 나타났다. 둘째, 중학생의 기본심리욕구가 충족될수록 중학생의 사회정서역량 수준이 높아지는 것으로 나타났다. 셋째, 중학생이 지각한 부모 및 교사의 자율성 지지가 많을수록 중학생의 사회정서역량 수준이 높아졌다. 특히 중학생이 지각한 부모의 자율성 지지는 교사의 자율성 지지보다 중학생의 사회정서역량에 더 직접적인 영향을 주었다. 넷째, 부모와 교사의 자율성 지지는 중학생의 기본심리욕구를 충족시켜 사회정서역량에 긍정적 영향을 미쳤다. 이때 역시 부모의 자율성 지지는 교사의 자율성 지지보다 중학생의 기본심리욕구를 더 충족시키고 사회정서역량에 보다 큰 영향을 주는 것으로 나타났다. 연구 결과는 중학생의 사회·정서적 역량을 개발하기 위해 교사뿐만 아니라 부모의 역할이 필수적이고, 특히 중국에서 부모의 사회정서학습에 대한 인식 개선과 부모 교육 확대의 필요를 시사한다. Purpose of this study was intended to examine the effect of parent and teacher's autonomy support on adolescent's social and emotional competencies, focusing on the mediating effect of basic psychological needs based on self-determination theory. Data of 434 students in Zibo city in Shandong Province were used in the analysis of a structural equation modeling. The main results of this study are as follows. First, the more basic psychological needs of middle school students they were met, the higher level of social and emotional competencies of middle school students have. Second, the more parents and teachers' autonomy supported middle school students perceived, the higher level of social and emotional competencies of middle school students they had. In particular, parental autonomy support perceived by students had a more direct impact on the social and emotional competencies. Lastly, parents' autonomy support stimulated middle school students' basic psychological needs more than teachers' autonomy support, and has a greater influence on social and emotional competencies of middle school students. In conclusion, in order to develop the social and emotional competencies of middle school students, the role of parents as well as teachers is essential, suggesting the need to raise awareness of parent education in China and to expand and implement parent education at national level.

The “hot Taiwanese girl” persona : The dynamics of politics and femininity in Taiwan

Yue Yang Asian Center for Women's Studies : Ewha Womans Uni 2023 Asian Journal of Women's Studies(AJWS) Vol.29 No.1

Originating in social media, an unconventional gendered political persona, “hot Taiwanese girl (la tai mei),” of the incumbent President of Taiwan Tsai Ing-wen has become well-known in Taiwan and beyond. Drawing on frameworks of femininity in politics and political persona on social media, this study scrutinizes this persona as an empowering political tool. Using critical discourse analysis, this study examines Dwagie’s rap song, “Hot Taiwanese Girl,” where the persona was created and the media, cultural and political contexts to reveal that it was used to construct understandings about crossstrait conflicts, create a collective Taiwanese identity and win the political favor of voters in election campaigns of Tsai and the Democratic Progressive Party. While this served to subvert the stereotypes of women in politics, the power to interpret femininity remains in the masculine domain. Through the prism of the “hot Taiwanese girl,” this paper seeks to unravel the dynamics between femininity and politics, thereby exploring how the representation of femininity is contingent on the political agenda and its appeals to audiences. 源自社交媒体的“辣台妹”,作为台湾现任领导人蔡英文带有非传统性别意味的角色塑造(persona-building) 在台湾内外广为人知。在参考了政治中女性气质的体现以及社交媒体上政治角色塑造的框架后,本文对角色塑造作为一种赋权的政治工具进行了解读。本文用批判性话语分析(critical discourse analysis),考察了“辣台妹”在台湾嘻哈艺人大支的同名说唱歌曲中的角色起源,以及其媒 介、文化和政治背景。本文探析了“辣台妹”在建构对两岸冲突的理解,创造台湾人的集体认同,争取选民对蔡英文和民进党的支持中的作用。虽然“辣台妹”有助于改变女性在政治中的刻板印象但该角色也显示了诠释女性气质的权力仍在男性的场域。通过“辣台妹”的案例,本文阐释了女性气质与政治之间的动态关系,从而解释了女性气质在政治中的展现取决于政治议程及选民偏好

Anti-fouling characteristic of carbon nanotubes hollow fiber membranes by filtering natural organic pollutants

Yue Yang,Sen Qiao,Ruofei Jin,Jiti Zhou,Xie Quan 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.4

Membrane fouling is a universal problem for conventional membrane filtration that usually causes a deterioration in membrane performance. We used electro-assisted carbon nanotubes hollow fiber membranes (CNTs-HFMs) to investigate the anti-fouling properties using natural organic pollutants. Benefiting from the electro-assistance, the permeation flux of humic acid solution using CNTs-HFMs was 190.20 L/(m2·h·bar), which was about 1.5- and 4.4- times higher than those of CNTs-HFMs without electro-assistance and traditional polyvinylidene fluoride hollow-fiber membranes (PVDF-HFMs). And the permeation fluxes of bovine serum albumin, sodium alginate and supernatant of anaerobic bioreactor also presented similar results. The average COD removal rate of CNTs-HFMs (66.8%) at 1.0 V was higher than that of CNTs-HFMs without electro-assistance and PVDF-HFMs, which can be attributed to the formation of electrostatic repulsive force. It could reduce the deposition of pollutants on membrane surface under electroassistance.

GC–MS analysis of chemical constituents and determination of the total antioxidant capacity of adult powder of Periplaneta americana

Yang Zhen,Xie Jiqin,Huang Feiyun,Yang Yu,Zhang Xiuyue,Yue Bisong 한국곤충학회 2022 Entomological Research Vol.52 No.2

Edible insects are alternative sources of high protein. Southeast Asia, South America, Africa, and Europe have recorded edible insects and, especially in Europe and America, there are factories that produce insects as food. In some areas of China, there has also been the habit of eating insects since ancient times. Periplaneta americana is an insect with the homology of medicine and food. In recent years, its medicinal and nutritional functions have attracted extensive attention and research. Its adult powder has been certified as a health product. It not only contains a variety of proteins but also is rich in fatty acids. The composition and antioxidant function of adult powder extract was analyzed in this study. Using adult P. americana powder as the raw material, it was extracted with n-Hexane, dichloromethane, and ethyl acetate, respectively. Gas chromatography–mass spectrometry (GC–MS) removed a total of 60 compounds, and many active components were extracted from P. americana powder for the first time. The parts and relative content of each extracted sample were obtained, and the total antioxidant capacity (T-AOC) of each extracted piece was determined, among which the antioxidant activity of ethyl acetate was the highest.

Metabonomics study on the hot syndrome of traditional Chinese medicine by rapid resolution liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry

Yang Wang,Li M,Yi Sun,Liman Yang,Hao Yue,Shuying Liu 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7

The hot syndrome refers to any feverish conditionsduring a pathological development, a sub-healthphenomenon, and is a potential risk for human health. Themetabonomics study on the hot syndrome may provideinsight into understanding of its pathology and play a rolein the prevention and treatment of its related diseases. Inthis paper, the rats were dosed with the hot syndromeprescription, ginseng and water. The corresponding urinesamples were identified by rapid resolution liquid chromatographycombined with quadrupole time-of-flight tandemmass spectrometry. More than 1,000 metaboliccompounds from different urine samples could be furtherdifferentiated by principal component analysis. As a result,the rat body temperature and weight were recognized as thehot syndrome related factors. Some specific metaboliteshave been discovered as a pattern of the potential biomarkers for the hot syndrome. The results showed thatginseng cannot cause the hot syndrome in a reasonabledose, but the hot syndrome prescription can. It is suggestedthat ginseng cannot be used only as a tradition Chinesemedicine but also as a nutrient. The work showed metabonomicsmethod is a valuable tool in studying mechanismof the hot syndrome.

A Theoretical Method to Predict Crack Initiation in Stabilizing Piles

Yang Yu,Yue-quan Shang,Hong-yue Sun 대한토목학회 2014 KSCE JOURNAL OF CIVIL ENGINEERING Vol.18 No.5

Stabilizing pile is a kind of underground structure, in which the crack initiation on the pile shaft is more dangerous than the crackon the interior concrete structure. A crack discriminant in displacement form was deduced by introducing the subgrade reactionmethod and reinforced concrete theory, in which the head displacement of stabilizing pile was the main parameter. Therefore, thehead displacement of stabilizing pile in critical state of cracking (critical head displacement) can be obtained according to the crackdiscriminant. Subsequently, the predicting crack initiation in stabilizing pile could be achieved by comparing measured headdisplacement with critical head displacement of the stabilizing pile. The crack discriminant was tested and verified in Hongyanlandslide project, Zhejiang province, China. Based on the field measurements at Hongyan landslide project, some stabilizing pileswere critically stressed to initiate the crack.