Analysis of Spatial and Temporal Protein Expression in the Cerebral Cortex after Ischemia-Reperfusion Injury

Yuan-Hao Chen,Yung-Hsiao Chiang,Hsin-I Ma 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.2

Background and Purpose Hypoxia, or ischemia, is a common cause of neurological deficits in the elderly. This study elucidated the mechanisms underlying ischemia-induced brain injury that results in neurological sequelae. Methods Cerebral ischemia was induced in male Sprague-Dawley rats by transient ligationof the left carotid artery followed by 60 min of hypoxia. A two-dimensional differential proteome analysis was performed using matrix-assisted laser desorption ionization-time-of-flightmass spectrometry to compare changes in protein expression on the lesioned side of the cortexrelative to that on the contralateral side at 0, 6, and 24 h after ischemia. Results The expressions of the following five proteins were up-regulated in the ipsilateralcortex at 24 h after ischemia-reperfusion injury compared to the contralateral (i.e., control)side: aconitase 2, neurotensin-related peptide, hypothetical protein XP-212759, 60-kDa heatshock protein, and aldolase A. The expression of one protein, dynamin-1, was up-regulatedonly at the 6-h time point. The level of 78-kDa glucose-regulated protein precursor on the lesioned side of the cerebral cortex was found to be high initially, but then down-regulated by 24 hafter the induction of ischemia-reperfusion injury. The expressions of several metabolic enzymes and translational factors were also perturbed soon after brain ischemia. Conclusions These findings provide insights into the mechanisms underlying the neurodegenerative events that occur following cerebral ischemia.

Novel Heterogeneous Recommender using Deep Representations for Music Streaming Services

Yuan-Hao Chan,Jia-Wei Chang,Hung-Min Sun,Chiu, Ching-Yi 한국정보기술학회 2019 Proceedings of The International Workshop on Futur Vol.2018 No.1

Microstructure and Magnetic Properties of Fe-doped MnBi Permanent Magnet Alloys

Yuan-Hao Tu,Qiong Wu,Hong-Liang Ge,Zi-Sheng Wang,Min-Xiang Pan,Yu Zhao 한국자기학회 2021 Journal of Magnetics Vol.26 No.2

Characteristics of a CMA Adaptive Array with Inverted-F Antennas under the Consideration of Signal Polarization

Hao Yuan,Toshiyuki Maeyama,Tatsuaki Hamai 대한전자공학회 1998 대한전자공학회 심포지엄 논문집 Vol.3 No.-

Cellular Particle Swarm Scheduling Algorithm for Virtual Resource Scheduling of Cloud Computing

Hao Yuan,Changbing Li,Maokang Du 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.3

The virtual resource scheduling is an important topic in the field of cloud computing. Based on particle swarm scheduling algorithm, this paper introduces cellular automata theory to construct a new cellular particle swarm scheduling algorithm. This approach through mathematical modeling for virtual resource scheduling of cloud computing and complete the final search configuration based on directional optimization objective function. Experimental results show that the proposed method has more excellent scheduling performance, in the case of changes in resources, can be also kept stable scheduling balance.

A Novel Precision Synchronization Control via Adaptive Jerk Control with Parameter Estimation for Gantry Servo System

Hao Yuan,Ximei Zhao 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.1

This article presents a novel precision synchronization control method and corresponding control design using adaptive jerk control (AJC) with parameter estimation to improve the synchronous performance for gantry servo system with parametric variations and unknown disturbances. Initially, cross-coupled control (CCC) is provided to realize the synchronous cooperation of two parallel permanent magnet linear synchronous motors (PMLSMs), and the coupled system model is transformed into a state-space form. Consequently, the filtered errors based on synchronous error and position tracking error are established to simultaneously guarantee that both the synchronous error and position tracking error converge to zero asymptotically. Then, AJC is proposed to handle the uncertainty. More specifically, an adaptive feedback gain is involved in the AJC for improving the robustness, without requiring a priori knowledge of the uncertainty. A novel adaptation law is introduced to update the adaptive feedback gain. Moreover, a terminal attractor is incorporated into the adaptation law to improve the convergence even with noise. Therefore, the chattering phenomenon are significantly alleviated. Meanwhile, parameter estimation is employed to address the model parametric variations. Experimental results demonstrate the efficiency and superior performance of the precision synchronization control method.

Mobile Cloud Computation Offloading Switch Based on Decision Value Model

Hao.Yuan,Changbing. Li,Maokang. Du 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.9

A method had been constructed for mobile cloud computation offloading switch based on decision value model. In this method, two important ratios had been built: one is the calculation ratio which are offloaded on a proxy server completed tasks time and at the mobile node completed tasks time. Another is the calculation ratio which is offloaded on proxy server completed tasks energy and at the mobile node completed tasks energy. And then, decision value function was produced by combining with these two ratios. Finally, consider the optimization switch problem of computing tasks between different proxy servers. Experimental results show that the proposed method has a smaller time consumption and energy consumption by comparing with random offloading switch and minimum time-based offloading switch, and battery remaining of mobile node can be used rationally.

Is Social Quality Related to Subjective Well-Being in Shanghai? An Analysis of Economic and Social Structural Factors

HAO YUAN,MAYANK-KUMAR GOLPELWAR 서울대학교 사회발전연구소 2012 Journal of Asian Sociology Vol.41 No.1

Based on an empirical survey in Shanghai, this study tests the effects of four domains of social quality (SQ) viz. economic security, social inclusion, social cohesion, and social empowerment on subjective well-being (SWB). The results show that home ownership and income are important determinants of SWB, though the latter is not as strong a predictor of SWB as the former. Apart from the economic determinants, social cohesion (e.g., political trust) as well as social inclusion (e.g., involvement with social and cultural organizations) can influence people"s SWB to a high degree. Additionally, social alienation and loneliness are negatively related to SWB. Even the degree to which people can express themselves freely relates directly to their SWB level. Results also show that the more people see success as a result of self-effort, the higher their SWB level.

Elimination of Multi-axis Interference in Industrial Robot Fault Detection

Hao Yuan,Jungho Park(박정호),Yunhan Kim(김윤한),Byeng D. Youn(윤병동) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12

중국 IT기업의 포용적 리더십이 종업원에 혁신행동에 미치는 영향

원호(Hao Yuan),이염남(Yannan Li),정준의(Junyi Zheng) 리더십학회 2022 리더십연구 Vol.13 No.2

Covid-19는 디지털 세계화와 경제의 디지털 전환을 가속시켰다. 특히 IT기업은 어느시기 보다 혁신에 대한 간절함이 더 커지고 있다. 이에 포용적 리더십은 하나의 “포용 및참여”를 강조하는 개념으로써 종업원의 혁신행동을 유발하는 요인으로 주목받고 있고 신세대 종업원에게 적합한 리더십 유형 중 하나다. 현재 학계에서는 포용적 리더십과 그것이 종업원 혁신행동에 미치는 직접적인 영향을 주제로 한 연구들이 활발히 진행되고 있다. 그러나 기존의 연구들이 주로 포용적 리더십과 종업원 혁신행동간의 내재적 작용 기제에 대하여 기술하고 있는 것에 반해, 본 연구는 양자 사이의 보다 구체적이고 직접적및 간접적인 상관관계를 밝히기 위해, 포용적 리더십이 오류관리분위기(EMC)와 자기효능감을 통해 종업원의 혁신행동에 어떤 영향을 끼치는지에 대하여 집중적으로 다루었다. 본연구는 조직의 오류관리분위기(EMC)와 종업원의 자기효능감을 매개변수로 선정하여 다중매개 변수를 기초로 포용적 리더십이 혁신행동에 대해 갖는 이중경로 작용기제의 이론개념 모델을 설계하였다. 중국의 IT 기업의 재직 종업원들을 대상으로 2021년 4월에서 6 월까지 2개월간 온라인 설문 조사를 진행한 후, SPSS 21.0과 AMOS 24.0 활용하여 설문조사 데이터에 대한 실증 분석을 시행하였다. 통계 분석 결과에 따르면, 포용적 리더십은혁신행동, 오류관리분위기(EMC) 및 자기효능감에 대하여 모두 긍정적인 영향을 미치는것으로 나타났으며 또한, 오류관리분위기(EMC) 및 자기효능감 역시 포용적 리더십과 혁신행동에 대해 매개효과를 미치고 있는 것으로 검증되었다. 이러한 결과는 코로나 시기불확실성을 대응하기 위해 끊임없이 혁신하고 도전해야 하는 기업 및 관리자들에게 도움이 될 것이다. 혁신에 있어서 실수의 용납 및 장려, 자기효능감을 가질 수 있도록 리더로서의 개방성, 효율성, 접근용이성의 중요성을 인식해야 한다. Covid-19 represents a challenge for digital globalization and the digital transformation of economies. In particular, IT companies are more desperate for innovation than ever before. Inclusive leadership is based on the concept of "fully inclusive and Participation" attracting attention as a leader capable of inducing innovative behavior. And it can adapt to the independent needs of new generation employees. Currently, a large amount of literature studies inclusive leadership and its direct impact on employees' innovative behaviors. However, few studies have explored the internal mechanism of action between inclusive leadership and innovative behavior. This study investigates how inclusive leadership influences employees' innovative behavior through error management climate and self-efficacy. Taking error management climate and self-efficacy as intermediary variables, the author constructs a theoretical, conceptual model of the dual-path mechanism of inclusive leadership on employees' innovative behavior based on multiple mediating variables. The author conducts an online questionnaire survey of on-the-job employees of Chinese Internet technology companies and adopts SPSS21.0 and AMOS 24.0 to carry out an empirical analysis of the questionnaire survey data. The result shows that inclusive leadership has a significant positive impact on employees' innovative behavior, error management climate, and self-efficacy. Meanwhile, error management climate and self-efficacy also reflect the intermediary effect in the relationship between inclusive leadership and employee innovative behavior.