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Han-Lu Gao,Xuan Wang,Hong-Ru Sun,Jun-De Zhou,Shang-Qun Lin,Yu-Hang Xing,Lin Zhu,Hai-Bo Zhou,Ya-Shuang Zhao,Qiang Chi,Yu-Peng Liu 거트앤리버 소화기연관학회협의회 2018 Gut and Liver Vol.12 No.2
Background/Aims: Methylation status plays a causal role in carcinogenesis in targeted tissues. However, the relationship between the DNA methylation status of multiple genes in blood leukocytes and colorectal cancer (CRC) susceptibility as well as interactions between dietary factors and CRC risks are unclear. Methods: We performed a case-control study with 466 CRC patients and 507 cancer-free controls to investigate the association among the methylation status of individual genes, multiple CpG site methylation (MCSM), multiple CpG site heterogeneous methylation and CRC susceptibility. Peripheral blood DNA methylation levels were detected by performing methylation-sensitive high-resolution melting. Results: Total heterogeneous methylation of CA10 and WT1 conferred a significantly higher risk of CRC (adjusted odds ratio [ORadjusted], 5.445; 95% confidence interval [CI], 3.075 to 9.643; ORadjusted, 1.831; 95% CI, 1.100 to 3.047; respectively). Subjects with high-level MCSM (MCSM-H) status demonstrated a higher risk of CRC (ORadjusted, 4.318; 95% CI, 1.529 to 12.197). Additionally, interactions between the high-level intake of fruit and CRH, WT1, and MCSM on CRC were statistically significant. Conclusions: The gene methylation status of blood leukocytes may be associated with CRC risk. MCSM-H of blood leukocytes was associated with CRC, especially in younger people. Some dietary factors may affect hypermethylation status and influence susceptibility to CRC.
The Influence of Managerial Overconfidence on Earnings Management
Gao, Yu(고우),Han, Kil-Seok(한길석) 한국경영교육학회 2018 경영교육연구 Vol.33 No.3
[연구목적] 본 연구의 목적은 2009년부터 2017년까지 코스피 시장과 코스닥 시장에 상장된 기업을 대상으로 경영자의 과신성향이 이익조정에 미치는 영향을 검증하고자 하였다. [연구방법] 본 연구에서 경영자 과신은 자산 성장률을 종속변수로 하고 매출액성장율을 독립변수로 하여 산업-연도별 회귀분석을 수행한 후 잔차를 추출하여 측정하였다. 또한 이익조정측정치는 수정된 Jones모형과 Kothari모형과 Roychowdhury모형과 Cohen모형을 활용하여 각각 추출하였다. 이를 토대로 경영자 과신과 이익조정과의 관계를 분석하였다. [연구결과] 실증분석 결과는 경영자 과신성향이 이익조정에 유의적인 관계를 보이고 있어 경영자 과신성향이 이익조정에 영향을 미치고 있는 것으로 나타났다. [연구의 시사점] 본 연구의 분석결과에서 경영자가 과신성향을 갖는 경우 경영자의 이익조정이 높다는 것을 보임으로써 경영자의 성향은 이익조정에 관한 의사결정에 있어 고려해야 할 요소로 나타났다. 본 연구는 최근 행동경제에 관한 많은 연구가 진행되고 있으나 회계분야의 연구에서는 아직 초기 단계라 할 수 있는 경영자의 비합리적 행동인 경영자 과신과 이익조정과의 관계를 분석하였다는 점에 의의가 있다. [Purpose] The purpose of this study is to investigate the influence of managerial overconfidence on earnings management. [Methodology] We use a measure of managerial overconfidence from investment level-based measure. We measure earnings management four ways including the modified Jones model (Dechow et al., 1995), performance matched discretionary accrual model (Kothrai et al., 2005), Roychowdury model (Roychowdury, 2006) and Cohen model (Cohen et al., 2008). We employ OLS model to test the association between managerial overconfidence and earnings management. [Findings] We find that managerial overconfidence significantly and positively influence accrual earnings management and real earnings management respectively. [Implications] While there are many researches on earnings management motivation we employ behavioral finance research and explore earnings management from the irrational behavior dimension unlike the prior literature.
Han, Mi-Ryung,Zheng, Wei,Cai, Qiuyin,Gao, Yu-Tang,Zheng, Ying,Bolla, Manjeet K.,Michailidou, Kyriaki,Dennis, Joe,Wang, Qin,Dunning, Alison M.,Brennan, Paul,Chen, Shou-Tung,Choi, Ji-Yeob,Hartman, Mikae Oxford University Press 2017 Carcinogenesis Vol.38 No.5
<P>Over the past 20 years, high-penetrance pathogenic mutations in genes BRCA1, BRCA2, TP53, PTEN, STK11 and CDH1 and moderate-penetrance mutations in genes CHEK2, ATM, BRIP1, PALB2, RAD51C, RAD50 and NBN have been identified for breast cancer. In this study, we investigated whether there are additional variants in these 13 genes associated with breast cancer among women of Asian ancestry. We analyzed up to 654 single nucleotide polymorphisms (SNPs) from 6269 cases and 6624 controls of Asian descent included in the Breast Cancer Association Consortium (BCAC), and up to 236 SNPs from 5794 cases and 5529 controls included in the Shanghai Breast Cancer Genetics Study (SBCGS). We found three missense variants with minor allele frequency (MAF) < 0.05: rs80358978 (Gly2508Ser), rs80359065 (Lys2729Asn) and rs11571653 (Met784Val) in the BRCA2 gene, showing statistically significant associations with breast cancer risk, with P-values of 1.2 x 10(-4), 1.0 x 10(-3) and 5.0 x 10(-3), respectively. In addition, we found four low-frequency variants (rs8176085, rs799923, rs8176173 and rs8176258) in the BRCA1 gene, one common variant in the CHEK2 gene (rs9620817), and one common variant in the PALB2 gene (rs13330119) associated with breast cancer risk at P < 0.01. Our study identified several new risk variants in BRCA1, BRCA2, CHEK2, and PALB2 genes in relation to breast cancer risk in Asian women. These results provide further insights that, in addition to the high/moderate penetrance mutations, other low-penetrance variants in these genes may also contribute to breast cancer risk.</P>
Synthesis and Viscoelastic Behavior of Non-Stoichiometric Spinel Ferrite Particle Suspension
Han, Jae Kyeong,Han, Wen Jiao,Gao, Chun Yan,Dong, Yu Zhen,Choi, Hyoung Jin IEEE 2018 IEEE transactions on magnetics Vol.54 No.11
<P>Magnetorheological (MR) fluid with tunable and reversible phase transition is one of the most promising smart materials for engineering applications. In this paper, to improve the MR performance of ferrites, non-stoichiometric Zn-doped spinel ferrite (Zn<SUB>0.417</SUB>Fe<SUB>2.583</SUB>O<SUB>4</SUB>) nanoparticles with a high saturation magnetization and a truncated octahedron-like shape were synthesized using a thermal decomposition process. The crystallographic structure was analyzed using X-ray diffraction and field emission transmission electron microscope image. The Zn<SUB>0.417</SUB>Fe<SUB>2.583</SUB>O<SUB>4</SUB> had a high saturation magnetization value of 101 <TEX>$\text {A}\cdot \text {m}^{2}$</TEX>/kg at 933 kA/m, showing higher saturation magnetization than other ferrites. The MR characteristics of the Zn<SUB>0.417</SUB>Fe<SUB>2.583</SUB>O<SUB>4</SUB> particles suspended in silicone oil were studied using a rotation rheometer under various magnetic field strengths. This MR fluid exhibited typical MR characteristics, and its flow curves were fit well with the Herschel–Bulkley model.</P>
Gao, Bowei,Yao, Huifeng,Jang, Bomee,Zhu, Jie,Yu, Runnan,Cui, Yong,Wang, Fenghao,Hou, Junxian,Woo, Han Young,Hou, Jianhui The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.6
<P>Here, the crucial role of intermolecular π-π interactions in A-D-A-type acceptors is examined and a simple yet effective modulation method is presented. By side chain manipulation, two small molecule acceptors, IDT-C6 and IDT-PhC6, are designed and synthesized with different crystalline morphologies. Since <I>n</I>-hexyl side chains have less steric hindrance than hexylphenyl side chains, IDT-C6 exhibits enhanced intermolecular π-π interactions relative to IDT-PhC6. Benefiting from the improved charge transport properties of the IDT-C6-based device, a high PCE of 12.5% is recorded, whereas those of the IDT-PhC6-based device delivers a moderate PCE of just 5.6%.</P>