Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

노화가 인체 중간엽 줄기세포로부터 조골세포로의 증식 및 분화에 미치는 영향

백기현,태현정,오기원,이원영,조정기,권순용,강무일,차봉연,이광우,손호영,강성구,김춘추 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.3

연구배경: 일반적으로 골다공증과 연관된 위험인자로는 연령, 폐경, 약물, 불충분한 칼슘섭취, 만성질환 및 운동부족 등이 있는데, 특히 노화가 진행할수록 골밀도가 감소하는 것은 잘 알려져 있다. 노화와 관련하여 진행되는 골소실은 조골세포 및 전구조골세포의 기능적 결핍에 의한 골형성의 감소가 주요한 요인으로 여겨지고 있다. 그 동안 연령이 조골모 세포의 양과 조골모 세포로부터 성숙조골세포로의 분화 및 증식에 미치는 영향에 대한 일부 보고들이 있었으나 아직 일치된 견해는 없는 형편이다. 방법: 다양한 연령의 사람으로부터 골수를 채취, 중간엽 줄기세포가 포함된 단핵세포를 분리한 후 조골세포로 분화하기 좋은 조건하에서 배양하였다. 대상군은다시 젊은군과 노령군으로 구분하여 다양한 변수를 비교 분석하였다. 일차배양에서는 CFU-F를 계수하여 골수내 중간엽 줄기세포의 수를 추산하였고, 칼슘측정을 통하여 기질의 무기화 정도를 비교하였다. 계대배양후 이차배양에서는 시기별로 알카리성 포스파타제 활성도를 측정하고 오스테오칼신 mRNA의 발현을 관찰하여 젊은군과 노령군 사이의 증식능 차이를 비교하였다. 또한 이차배양 시기별로 MTT 측정을 하여 양군간에 증식능 차이가 있는지 알아보았다. 결과: 1. 일차배양 15일째에 평균 CFU-F의 수는 젊은군에서 유의하게 많았다(젊은군 148.3±28.9, 노령군 54.3±9.1, p=0.02). CFU-F의 평균면적은 젊은군에서 넓은 경향을 보였으나 통계적으로 유의하지는 않았다. 2. 일차배양 17일 경과 후 양군간에 기질 칼슘 침착정도는 유의한 차이를 보이지 않았다(젊은군 103.6±50.6, 노령군: 114.0±56.5, p=NS). 3. 이차배양 10일째에 젊은군에서 알카리성 포스파타제 활성도가 고령군에 비해 유의하게 높았다(젊은군: 935.5±115.0 U/mg, 노령군: 578.4±115.7U/mg,p.0.05). 고령군에서는 시간 경과에 따른 변화가 미약했으며 전반적으로 알카리성 포스파타제의 활성도가 젊은군에 비해 낮았다. 4. 이차배양도중 오스테오칼신 mRNA의 발현은 배양시기별로 젊은군에 비해 고령군에서 더 낮은 경향을 관찰할 수 있었다. 5. 이차배양 10일과 15일에 젊은군에서 노령군보다세포증식이 유의하게 증가된 양상을 보였다(10앓 젊은군 0.73±0.05, 노령군 0.58±0.04, p=0.05, 15일; 젊은군 0.80±0.05, 노령군 0.70±0.03, p=0.05).결론: 이상의 연구에서 저자들은 노령군에서 젊은군보다 골수 내 중간엽줄기세포의 수가 적고, 노령군에서 유래한 전구조골세포의 성숙조골세포로의 증식 및 분화가 젊은군 보다 감소해 있는 것을 관찰할 수 있었다. Background: Osteoblasts originate from osteoprogenitor cells in bone marrow stroma, termed mesenchymal stem cells (MSCs) or bone marrow stromal cells. Each MSC forms colonies (colony forming units-fibroblasts [CFL-Fs]) when cultured ex vivo. There are some reports about the age-related changes of the number and osteogenic potential of osteoprogenitor cells, but any relationship has not been clearly established in humans. In this study, we counted MSCs using CFU-Fs count and examined the proliferative capacity and differentiation potential of osteoprogenitor cells. Finally, we analyzed how these parameters varied with donor age. Methods: Bone marrow was obtained from the iliac crest of young (n=6, 27.2±8.6 years old) and old (n= 10, 57.4k6.7 years old) healthy donors. Mononuclear cells, including MSCs, were isolated and cultured in osteogenic medium. In primary culture, we compared the colony-forming efficiency of MSCs between the two groups and determined the matrix calcification. When primary culture showed near confluence, the cells were subcultured. Alkaline phosphatase activity, osteocalcin expression by RT-PCR and proliferative potential by MTT assay were examined by the time course of secondary culture. Results: At the 15th day of primary culture, the mean number of CFU-Fs was significantly higher in the younger donors (young: 148.3±28.9, old: 54.3±9.1, p=0.02) and the mean size of CFL-Fs was also larger in the younger donors than the older donors. However, matrix calcification was not different between the two groups (young: 103.6±50.6, old: 114.0±56.5, p=NS). In secondary culture, alkaline phosphatase activities were significantly lower in the older donors. The younger donors showed peak alkaline phosphatase activity at day 10, while the older donors didn't showed a remarkable peak (young: 935.5±115.OU/mg, old: 578.4±115.7U/mg, p<0.05). Total cell number as a proliferative index increased progressively during the secondary culture and a significantly greater cell number was noted in the younger donors. Osteocalcin expression was generally upregulated in the younger donors, but this was not statistically significant. Conclusion: Our study shows that the number of osteoprogenitor cells is decreased during aging and that the proliferative capacity and differentiation potential of osteoprogenitor cells seem to be reduced during aging (J Kor SOC Endocrinol 18:296-305, 2003).

한국인의 하악 구치의 근관 형태에 관한 후향성 연구

정일영,금기연,이승종,이찬영 大韓齒科保存學會 1997 Restorative Dentistry & Endodontics Vol.22 No.2

A retrospective in vivo study of endodontically treated mandiblar molars was conducted. The radilographs and clinical records of mandibular molars that had been treated endodontically in the Dental hospital of Yonsei University from 1986 to July 1997 were reviewed and categorized. A total of 1751 cases were studied and following results were obtained. 1. The number of root canals in mandibular first permanent molar in d Korean population revealed three in 53.2%, four in 23.0%, two in 18.4%, C-shaped canal in 5.0%, and one in 0.4%. 2. In mandibular second molar, three canals was observed in 53.3%, four in 22.2%, two in 14.9%, C-shaped canal in 9.1%, and one in 0.6%. 3. In the results of the percentage of 4 canals of mandibular first molars at various age, before age 20, 37.7% was obtained whereas 19.3% after 30. 4. 7.94% of mandibular first molars examined were found to have three roots. 5. The mandibular second molar had C-shaped canals in 9.1%.

동적인 장면들에서 실린더 파노라마 영상 생성

정영기 호남대학교 정보통신연구소 2004 정보통신연구 Vol.14 No.-

Recently, panorama image is used in many fields as a tool to make virtual environment. Cylindrical panoramic image is generated by rotating the fixed the camera on the tripod horizontally, aligning and reorganizing this images. In generation of the cylindrical panoramic image, most of previous works assume the static scene. Although some previous works consider the dynamic scene, they require high cost computation. Consequently, we propose the method to generating the robust panoramic image from dynamic scenes in this paper. We applied the proposed algorithm to various images. We can reduce the calculation significantly and align the image efficiently.

동결온도가 진공포장 동결육의 품질에 미치는 영향

정인철,김도완,문귀임,강세주,김기영,문윤희 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.4

본 연구는 진공포장 동결육의 품질에 미치는 영향을 검토하기 위하여 수행하였다. 해동드립은 -3℃와 -20℃ 동결이 60일째 각각 5.23% 및 5.17%로 동결기간이 경과함에 따라 현저하게 증가하였다. 가열감량은 water bath와 pan에서 가열한 것이 모두 동결초기보다 동결기간이 경과함에 따라 현저하게 증가하였다. 그러나 -3℃와 -20℃ 사이에는 현저한 차이가 없었다. 염용성 단백질의 추출성은 동결기간이 지남에 따라 감소하였고, -20℃ 동결이 -3℃보다 추출성이 더 높았다. 수용성 단백질의 추출성은 동결기간이 경과하면서 증가하였고 -3℃ 동결이 -20℃보다 현저하게 높았다. 그리고 L, a 및 b값은 저장초기가 동결저장 중보다 높다. Myoglobin의 변성율은 -3℃ 동결이 -20℃보다 비교적 높게 나타났는데, -3℃ 동결의 15일째가 96.0%로 가장 높게 나타났다. 전단력가는 동결저장 중 현저한 변화가 없었고, 근원섬유의 소편화도는 동결초기보다 동결저장이 더 높았지만 동결저장 중에는 변화가 없었다. pH는 -3℃와 -20℃ 동결저장 모두 45일까지 감소하다가 그 이후에는 증가하는 경향이었다. This study was carried out to investigate the effects of freezing temperature on quality of vacuum packaging freezed beef. In case of thaw drip loss, the freezing of -3℃ and -20℃ were 5.23% and 5.17% to 60 days respectively, were increased significantly during freezing. The cooking loss of water bath and pan were increased significantly during freezing than the beginning of freezing, but were no different between -3℃ and -20℃. The salt soluble protein extractability was decreased during freezing, the -20℃ freezing was higher than -3℃ freezing. The water soluble protein extractability was increased during freezing, the -3℃ freezing was higher than -20℃ freezing. The L, a and b value of the beginning of freezing higher than during freezing. The myoglobin denatured percentage of the -3℃ freezing was higher than -20℃ freezing, the 15 days storage of -3℃ freezing was highest to 96%. The shear force value was not change during freezing, the myofibrillar fragmentation index during freezing was higher than the beginning of freezing, but was not change during freezing. The pH was decreased to freezing 45 days, after that increased.

의미론적인 장면해석을 통한 영상감시에 관한 연구

정영기 호남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.8 No.-

본 논문에서는 복잡한 배경을 가진 영상 시퀀스에서 이동물체를 검지하고 추적하는 알고리듬을 제안한다. 제안된 알고리듬은 이동 물체 검지, 물체 추적 및 움직임 분석 등의 세 부분으로 구성된다. 또한 감시 비디오의 검색을 위해 객체 단위의 특징을 이용한 새로운 비디오 색인 및 탐색 방법을 제안한다. 의미론적인 레벨에서 각각의 객체에 접근하기 위해 객체의 움직임 궤적 모델을 색인 인자(Key)로 미용하였다. 제안한 알고리듬은 MPEG7의 표준 영상 시퀀스 및 실제 도로 영상에 적용한 실험 결과를 통해 성능을 검증한다. In this paper, a object detection and tracking algorithm is presented which exhibits robust properties for image sequences with complex background. The proposed algorithm is composed of three parts: moving object detection, object tracking, and motion analysis. Also, we propose a new method of indexing and searching based on object-specific features at different semantic levels for video retrieval. The moving trajectory model is used as an indexing key for accessing the individual object in the semantic level. Computer simulation of the proposed scheme shows its robustness for MPEG-7 test image sequences.

毛髮 및 爪甲의 성장에 따른 단백성분의 산화

정영도,최기오,양성렬,이춘기,안봉환,이민화 한국노화학회 1992 한국노화학회지 Vol.2 No.1

복잡한 배경을 가진 영상 시퀀스에서의 이동 물체 검지 및 추적

정영기 호남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.9 No.-

본 논문에서는 복잡한 배경을 가진 영상 시퀀스에서 이동물체를 검지하고 추적하는 알고리듬을 제안한다. 제안된 알고리듬은 이동 물체 검지, 물체 추적 및 움직임 분석등의 세 부분으로 구성된다. 물체 움직임 검지 알고리듬은 시간적인 미디언 연산을 이용한 적응적 배경 방식을 이용하여 구현하였고, 이 방식은 실시간 처리에 적합하다. 움직임 분석 단계에서는 나무의 흔들림이나 빛의 반사등으로 인한 잡음 물체의 움직임을 제거하기 위한새로운 알고리듬이 제안된다. 또한, 칼만 필터에 기반한 다중 물체 추적 시스템을 설계하였다. 제안한 알고리듬은 MPEG7의 표준 영상 시퀀스 및 실제 도로 영상에 적용한 실험 결과을 통해 성능을 검증한다. In this paper, a object detection and tracking algorithm is presented which exhibits robust properties for image sequences with complex background. The proposed algorithm is composed of three parts: moving object detection, object tracking, and motion analysis. The moving object detection algorithm is implemented using a temporal median background method which is suitable for real-time applications. In the motion analysis, we propose a new technique for removing a temporal clutter, such as a swaying plant or a light reflection of a background object. In addition, we design a multiple vehicle tracking system based on Kalman filtering. Computer simulation of the proposed scheme shows its robustness for MPEG-7 test image sequences.

전립샘에 발생한 원발성 악성 림프종

기근홍,정유경,심재영 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.3

Primary malignant lymphoma of the prostate is extremely rare. This tumor should be rule out infiltration of lymphoma arising in the other site. We experience a case of diffuse large B-cell type of primary prostatic malignant lymphoma in an 70 year-old male. There is no extra-prostatic involvement III extensive staging work-up. Transrectal prostatic needle biopsy was performed. On microscopic examination, the atypical lymphocytes were diffusely infiltrated and replaced of the prostatic parenchyme. The atypical lymphocytes had scant cytoplasm and large nucleus with irregualr nuclear chromatin. Nucleoli were not distinct. Immunohistochernically, the tumor cells were reactive for LCA, CD20 and kappa light chain, but not reactive for CD3, UCHL-1 and Bcl-2. Histopathologic diagnosis is diffuse large B-cell lymphoma of the prostate.