40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

유치 및 초기 영구치아의 치수 신경분포

김영진,남순현,김현정,이재문,이인정 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.2

유치 및 초기 영구치의 치수신경분포 및 변화를 평가하기 위하여 교정치료를 위해 발치한 치근흡수가 비교적 적은 유치,정상 탈락기의 유치,맹출중인 교합하지 않은 제 1소구치,맹출이 완료되어 교합하고 있는 1소구치를 대상으로 neurofilament protein(NEP)을 이용한 면역조직화학적 방법으로 관찰하여 다음과 같은 결과를 얻었다. 치근흡수가 비교적 적은 유치에서도 영구치와 유사한 신경총의 존재와 신경분포 형태가 관찰되었으나,영구치에 비해 그 신경분포 밀도가 낮았으며 분지형성 또한 미약하게 나타났고,전상아질로 진입하는 섬유의 수가 적었다. 정상탈락기의 유치에서는 신경의 변성으로 소포(vesicle),단절(fragmentation)등이 관찰되었으며,그 신경분포가 현저히 감소되어 나타났고,총상의 형태도 소실되었다. 교합하지 않은 제 1소구치에서 치수내의 신경은 말단가지의 숫자가 적고,치수 조상아 세포 경계에 도달하였으며,비교적 가는 신경 섬유가 많았다. 교합하고 있는 제 1소구치에서 치수내의 신경은 말단이 조상아층으로 진출하고,어떤 신경섬유는 전상아질층까지 진입하였으며,비교적 굵은신경 섬유의 분포가 많아졌다. The purpose of this study was to investigate the distribution of nerves in the dental pulp of early extracted primary teeth,normal exfoliated teeth,partially-erupted,nonfunctional,premolars,and erupted,functional,premolars.Numbers of sample were 10 teeth in each group. The distribution of nerves in the dental pulp were investigated by means of immunohistochemistry for detection of neurofilament protein(NFP). The results were as follows: The early extracted primary teeth exhibited patterns of innervation similar to those observed for young permanent teeth.The plexiform arrangement of fibers was not evident in the primary teeth.Most nerves appear to terminate about the odontoblasts. As primary teeth began to undergo root resorption,degenerative changes such as vesicles and fragmentation appear in nerves.The quantity of neural tissue also decreased.In teeth in which the roots were almost completely resorbed only a small number of nerves remain. There was a decrease in the number of terminal branches in the pulp of the partiallyerupted,nonfunctional,premolars and those present reached the pulpo-odontoblastic border. The nerve terminals in the pulp of the erupted,functional,premolars were traced to the dentinal tubule and a few nerve fibers formed loops in the predentin.

한국인 인슐린 비의존형 당뇨병 및 이차성 당뇨병 환자에서 글루코키나제 유전자 변이

남재현(Jae Hyun Nam),이현철(Hyun Chul Lee),김연의(Youn Euy Kim),권석호(Suk Ho Kwon),윤용석(Yong Suk Yoon),박석원(Suk Won Park),원영준(Young Jun Won),차봉수(Bong Su Cha),송영득(Young Duk Song),이은직(Eun Jig Lee),임승길(Sung Kil Lim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6

N/A Objectives: Mutations in the glucokinase (GCK) gene are considered a possible cause of maturity-onset diabetes of the young. The purpose of this study was to evaluate the contribution of this gene to the development of non insulin dependent diabetes mellitus (NIDDM), gestational diabetes mellitus (GDM) and post-renal transplantation diabetes mellitus (PTDM). Method: Identification of GCK mutation was attempted on 39 NIDDM patients, 2 GDM patients and 58 selected renal allograft recipients with PTDM and 45 normal controls. The exons in the GCK gene were examined by polymerase chain reaction (PCR), followed by analysis of single-stranded DNA conformational polymorphism (SSCP). The abnormal bands were also confirmed by DNA sequencing analysis. The exons of affected family members were also investigated for mutations of the GCK gene. Results: Two of the 58 PTDM patients (3.4%) were found to have CKK mutations. One had the mutation on exon 5 and the other on intron 7. One control subject had the mutation on intmn 9. The mutation of exon 5 was identified as a substitution of CCT (proline) for CTT (leucine) at codon 164, which has not ever reported before. The family members of the PFDM patient with mutation of exon 5 were analyzed by PCR followed by SSCP, and two of them revealed the same mutation. The abnormal band on the SSCP analysis of exon 7 was identified as the insertion of base C/T at the 39th nucleotide in intron 7. Two family members of this patients also had same band on SSCP. The one mutation of 45 normal controls was CT located at the 8th nucleotide in intron 9, which was a common polymorphism. Conclusion: We found GCK mutations in subjects with PTDM and we speculate that these mutations may be one of the contributing cause of PTDM.

급성 파라쿼트 중독에서 혈중 파라쿼트 농도

박승민,김세현,최수진,김현,이완구,김영남,이광영,이영희,신성혜 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: Paraquat is a bipyridyl compound, and when ingested, concentrated paraquat can cause either rapid death from multisystem failure and cardiovascular shock or delayed death from progressive pulmonary fibrosis. Paraquat is poorly absorbed by inhalation, but when ingested orally, severe illness can occur. Death usually occurs within 2 days if more than 50 ㎎/㎏ of paraquat is ingested . The most important prognostic indicator is the quantity of paraquat absorbed, as shown by the plasma paraquat concentration, and the prognostic indication depends mostly on the description given by the patients and their families about the amount of paraquat ingested, which is often underestimated or overestimagted. For these reasons, we tried to compare the plasma paraquat concentrations with amount of paraquat described by patients or their families. Methods: We reviewed the medical records of 59 patients with acute paraquat poisoning from February 1998 through February 1999, the paraquat concentrations in plasma were measured at Presbyterian Medical Center by using high performance liquid chromatography. Results: There was a striking discrepancy between the plasma paraquat concentration and the ingested amount described by the patients or their families. Conclusion: We recommend that the plasma paraquat concentration be measured in patients being treated for acute paraquat poisoning.

Oxolamine Acetate(Pebron)의 鎭咳效果에 對한 臨床硏究

南松鉉,沈永秀,金建烈 최신의학사 1983 最新醫學 Vol.26 No.11

Familial hypophosphatemia 환아의 증례보고 : A CASE REPORT

남순현,조윤정,김은정,김현정,김영진 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

가족성 저인산혈증(famiial hypophosphatemia)은 근위 세뇨관의 인산 재흡수 기전의 결핍으로 혈청 칼슘 농도는 정상이나 혈청 인산 농도가 낮아져 저인산혈증을 나타내는 가장 흔한 유전성 구루병이다. 혈청 인산이 낮음에도 불구하고, 소변으로의 인산 배출이 증가되어 있고 혈청 알칼리성 인산 분해 효소의 상승이 현저하다. 주로 반성 우성 유전이며 보통 남아에서 여아보다 임상 증상이 심하다. 이러한 가족성 저인산혈증 환자의 전신적 소견으로는 앞이마의 돌출, 사각형 머리, 작은 키, 휜 다리가 나타나며, 치과적 소견으로 치조백선과 치낭의 비박, 얇은 법랑질, 확장된 치수강과 근관, 치근단 농양과 치주 농양의 높은 발생률, 원인불명의 치근단 희박화 골염이 나타난다. 본 증례는 유치 충치 치료를 위해 내원한 환아가 임상적으로 작은 키와 휜 다리, 방사선적으로 많이 확장된 치수강과 근관이 관찰되어 소아과에 의뢰한 바 가족성 저인산혈증으로 진단받아 그 임상적 소견과 치과적 치료에 대해 보고하는 바이다. Familial hypophosphatemia is the most common hereditary rickets which occur hypophosphatemia as the calcium concentration in the blood serum is normal but the phosphate concentration in the blood serum decreases by dysfunction of renaltubular phosphorus reabsorption. In spite of the low concentration of phosphate in the blood serum discharge of phosphate by urine and alkaline phosphatase increases remarkably. It is a sex-linked and normally male show severe clinical symptoms than female. This kind of familial hypophosphatemia patients show frontal bossing. square head, short of status for general finding, and for dental finding, thinning of limina dura and dental follicle, thin and hypoplastic enamel, enlarged pulp chamber and canal, high occurance rate of periapical and periodontal abscess and unknown cause of rarefying osteitis. This case is to report about the clinical finging and dental treatment of a child patient, who came to the hospital for treatment of deciduous teeth caries but was refered to pediatrics because the child showed clinically short of status, bow-leg and radiographically enlarged pulp chamber and canal, there as diagnosed as familial hypophosphatemia.

돌발성 난청의 임상적 분석

남부현,강갑진,성열웅,송영복 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Sudden hearing loss is an abrupt onset of sensorineural hearing loss over a period of hours or a few days without definite cause. The cause and its pathophysiology have not been fully determined, and the treatmnet is controversial at present. The purpose of this study is to seek the best modality of treatment by clinical and stastical analysis of 48 patients (28 male and 20 female) diagnosed as a sudden hearing loss from January 1993 to October 1995. The therapeutic results of the 48 patients were 20 cases (41.7%) of complete recovery, 3 cases (6.2%) of partial recovery, 4 cases (8.3%) of slight recovery and 21 cases (43.8%) of no improvement. Early treatment within a week of onset, ascending or flat types of audiogram, and normal ABR were favorable prognostic factors in recovery of hearing. The presence of accompanying vestibular symptom (ie, vertigo) and profound hearing loss on initial audiogram were poor prognostic factors. However, the gender and the age of the patients did not affect on the hearing result.

經皮 電鍼刺戟이 成人男性의 脈波傳達時間에 미치는 影響

남동현,박영재,박영배 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Background and purpose : Pulse examination(脈診) is often one of the most important parts of the four examination(四診) and is crucial to pattern discernment(辨證) in oriental medicine. We have made a profound study of pulse examination. In this paper, we studied the effect of electrical dermal stimulation on pulse transit time(PTT) of healthy men as part of efforts to reveal the relatinship between pulse wabe pattern and PTT. Methods : Electrical stimulation with a frequency of 40Hz for 1 min was given respectively to Sugu(GV26; 水溝) of 8 males. The PTT were measured with ECG and photoplethysmogram before and every 5min, 10min, 1min after electrical dermal stimulation. Polygraph and Acqknowledge software(BIOPAC System, Inc. U.S.A) were used in measuring PTT. Results : Mean PTT increased in statistically significance 5min, 10min, 15min all after electrical dermal stimulation. Conclusion : Electrical dermal stimulation with a frequency of 40Hz at Sugu point(GV26) increased PTT

초음파에 의한 압력용기의 연취성천이온도 평가

남영현 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.5

파괴적인 방법으로 재료나 설비의 기계적 성질을 평가하기 위해서는 많은 경비와 시간이 소요되므로 비파괴적인 방법을 이용한 재료의 기계적 성질 평가가 주목을 받고 있다. 본 논문에서는 초음파 특성을 이용하여 열처리 온도와 조건에 따른 기계적 성질 변화를 평가하였다. 초음파의 감쇠계수는 열처리 온도가 높을수록 결정립의 크기가 커지므로 증가하였다. 초음파의 감쇠계수는 열처리(담금질, 탬퍼링, 용접후열처리)가 진행됨에 따라 감소하였다. 초음파 속도는 담금질과 탬퍼링/PWHT한 시편에서 40㎧의 차이를 보이고 있었다. 감쇠계수와 인성과의 상관성은 매우 좋으며 이러한 상관관계는 단조한 압력용기의 비파괴 평가에 이용할 수 있으며, 더욱이 현장 적용에 효율적으로 응용할 수 있을 것이다. It is useful to use NDE methods to assess the mechanical properties of materials since destructive methods are time-consuming and usually require cutting of sample from the material/component, In the present research, ultrasonic characteristics have been utilized to evaluate changes of mechanical properties due to heat treatment because the grain size increased in size as the temperature. The attenuation coefficient decreased as the heat treatment has been progressed (quenched, tempered, PWHT). In the case of ultrasonic velocity measurement, velocity measurement, velocity difference between quenched and tempered/PWHT was 40 m/s. There was a good relationship between the attenuation coefficient and the toughness. The relationship can be used for the nondestrucitve evaluation of the forged reactor vessels. Moreover, the method may be effectively used in the field application.

색상 측정 기기를 이용한 복합레진 적층 수복과 단일 수복의 색상 비교 분석

송영상,김자현,이빈나,장지현,장훈상,황윤찬,오원만,황인남 大韓齒科保存學會 2012 Restorative Dentistry & Endodontics Vol.37 No.2

Objectives: This study analyzed the difference in color caused by different thickness in enamel layer of composite resins when applied with single and layering placement technique, and evaluated if the results agreed with the shade guide from the manufacturers to verify reliability of the color matching process of the manufacturers. Materials and Methods: For single composite resin samples, 6 mm diameter and 4 mm thickness cylindrical samples were fabricated using Ceram-X mono (DENTSPLY DeTrey) and CIE L*a*b* values were measured with spectrophotometer. Same process was done for layering compositie resin samples, making 3 dentinal shade samples, 4 mm thickness, for each shade using Ceram-X duo (DENTSPLY DeTrey) and enamel shade resins were layered in 2 mm thickness and CIE L*a*b* values were measured. These samples were ground to 0.2 mm thickness each time, and CIE L*a*b* values were measured to 1 mm thickness of enamel shade resin. Results: Color difference (△E*) between single and layering composite resin was 1.37 minimum and 10.53 maximum when layering thicknesses were between 1 mm and 2 mm and 6 out of 10 same shade groups suggested by manufacturer showed remarkable color difference at anythickness (△E* > 3.3). Conclusion: When using Ceram-X mono and duo for composite resin restoration, following the manufacturer's instructions for chossing the shade is not appropriate, and more accurate information for Ceram-X duo is needed on the variation and expression of the shades depending on the thickness of the enamel. (Restor Dent Endod 2012;37(2):84-89)