성인 원발성 초점성 사구체 경화증의 예후인자

송영수,최훈영,유태현,강신욱,이중민,정현주,이호영,한대석,최규헌 대한신장학회 2004 대한신장학회잡지 Vol.23 No.1

사설 골프연습장 회원들의 스포츠사회화 요인과 생활적응 및 삶의 질의 관계

최영수(Choi Young-Soo),한정훈(Han Jung-Hun) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.4

This study aims at discovering the relationship between life Adaptation and Quality of Life with Sports Socialization by Golf Interest Group Members for Golf Practice Range . Objects for this study were adults who live in young-dong area as of 2008 and participate in Golf Interest Group Members for Golf Practice Range. 316 people were sampled through stratified cluster random sampling after sampling framework was set up. Only valid samples were encoded according to a certain coding guidelines. After inputting each of the coded data into computer, the researcher computed the data according to analytical purpose through the Statistics program of SPSS 14.0 version for Windows. On the basis of the above research method and findings, the induced conclusion was as follows: There were some reciprocal influences in the relationship between life Adaptation and Quality of Life with Sports Socialization Golf Interest Group Members for Golf Practice Range.

Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

나노/마이크로 압입 시험에 의한 플라즈마 세라믹 용사코팅의 특성 평가

최세영(Se-Young Choi),채영훈(Young-Hun Chae),김석삼(Seock-Sam Kim) 한국트라이볼로지학회 2003 한국트라이볼로지학회 학술대회 Vol.36 No.-

The most controversial topics in plasma sprayed ceramic coating systems are recently mechanical properties such as bond strength, cohesive strength, toughness and so on. In this research, critical fracture load(Pc) and interface toughness(Ks) of four coatings materials were computed from the applied load, crack length and Young's modulus data which were measured by micro-vickers and nano indentation test. It is reasonable to consider the Pc value as comparison data of bond strength, and the Kc value, considering a trace of indent in the interface, was computed by a modified (E/H)I<SUP>½</SUP> ratio. In the case of the high loads (9.8N and 19.6N) in the Al₂O₃+13%TiO₂ coating, the critical point(Pco) at which the coating was broken was found. Also, used by a XRD phase analysis, we checked a change of coating' s properties, predicting a possible change of the phases in plasma sprayed coating.

호흡기계 감염에 대한 Broncho-vaxom^�의 임상적 효과

최호경,이건수,서종진,정용헌 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

Thirty children with respiratory tract infections, 17 with acute and chronic bronchitis, 5 with sinusitis, 4 with rhinitis, 3 with asthma, 1 with tonsillitis, were given Broncho-vaxom^?? one capsule per day on an empty stomach for 1 month to evaluate the efficancy of the drug on acute and chronic respnatory tract infections in children. After the medication, we observed the changes of clinical symptoms, and side effects. The results are as follows; 1. The symptomatic improvements after Broncho-vaxom^?? administration were as follows; expectoration(80%), fever(72%), rhinorrhea(67%), hoarseness(67%), and coughing(65%). 2. Combined treatment with antibiotics was necessary in 19 cases(63%). 3. The degree of response were observed as mild improvement in 3 cases(10%), moderate improvement in 13 cases(84%), and excellent improvement in 1 cases(47%). 4. The side effect of Boncho-vaxom was not observed during this study.

O-링 테스트의 정량화에 관한 연구

최기훈,여인철,김영탁 중앙대학교 생산공학연구소 2000 생산공학연구소 논문집 Vol.9 No.2

신체의 건강진단을 위해서는 값비싼 장치의 전문지식이 요구된다. 따라서 장비를 갖춘 병원과 같은 특정 장소에서 전문지식을 가진 의사를 만나기 위해 시간과 노력을 들여 이동해야만 한다. 그러나 최근에는 간단하게 진단을 할 수 있는 장치가 개발되어 있다. 0-링 테스트는 특별한 장치가 없이도 간단한 지식으로 건강진단 및 약물이나 음식물의 이해 여부를 판단할 수 있는 유효한 진단방법으로 인식되고 있다. 하지만 이 테스트 법은 검사자의 경험과 주관에 의존하므로 결과에 대한 신뢰성과 객관성이 문제시되고 있다. 본 연구에서는 0-링 테스트 시스템을 고안하여 테스트결과가 객관적이고 정량적으로 나타나도록 하여, 손쉽게 결과를 판단 할 수 있게 하고자 한다. It is usual that the medical examination of human body need special knowledge and equipments. Thus we have to spend time and energy on going to special place such as hospital where doctors and equipments are. Which often cause missing a good chance of medical treatment as well as giving us inconvenience. However many simple and convenient equipments were developed for checking our health conditions recently. 0-ring test is accepted as one of useful methods to examine our health conditions. Also the test is recognized as a useful means to judge, without any special equipment and medical knowledge, if some medical substances or foods are beneficial or harmful to our health. However, the judgement may be incorrect because it depend on doctor's subjective point of view. In this study, we developed an automatic 0-ring test machine which enable us to check our health conditions objectively and quantitatively. The validity of the idea to develope the machine was proved by experiments.

평면운동모델을 이용한 LMG 상에서 이송되는 Cross Head의 사행동 해석

최영휴,김성훈,정택수 國立 昌原大學校 産業技術硏究所 2002 産技硏論文集 Vol.16 No.-

In this paper, a simple 2 D.O.F. planar motion model is proposed in order to analyze the snake motion of a cross head assembly travelling on linear huide rails. In the proposed mathematical model, the head assembly and a ball screw are assumed to be rigid, but the rear-panel of the machining center is assumed to be flexible. The equations of motion of the proposed model are derived and solved by Runge-Kutta method to determine vibration responses of the head assembly due to some applied traction forces.

O-링 테스터의 측정팁 구조개선

최기훈,여인철,김영탁 중앙대학교 미래신기술연구소 2001 미래신기술연구소 논문집 Vol.10 No.2

It is usual that the medical examination of human body need special knowledge and equipments. Thus we have to spend time and energy on going to special place such as hospital where doctors and equipment are. Which often cause missing a good chance of medical treatment as well as giving us inconvenience. However may simple and convenient equipments were developed for checking our health conditions recently. O-ring test is accepted as one of useful methods to examine our health conditions. Also the test is recognized as a useful means to judge if some medical substances or foods are beneficial or harmful to our health without any special equipment and medical knowledge. An automatic O-ring test machine has been developed[11]. However the tester have a problem that the pattern of applied force to the O-ring is different from that of manual case. In this study, the reaction force tip is modified and the validity of the tip is verified through experiments.

중추에서 Prostaglandin계가 Renin-angiotensin System에 미치는 영향

최영태,김종승,문성호,오형균,김재훈,전제열,염철호,윤평진 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1

Role of prostaglandins on the renin-angiotensin system in the central nervous system was examined in normotensive and 2-kidney, 1 clip (2K1C) hypertensive rats. The experiment was done under thiopental (50 ㎎/㎏, IP) anesthesia. Captopril and indomethacin were injected into the right lateral cerebral ventricle. Arterial blood pressure and heart rate were recorded from the femoral artery. Intracerebroventricular (ICV) captopril (1 ㎎) caused a decrease in mean arterial pressure in both normotensive and 2K1C hypertensive rats. The depressor response to captopril was more sensitive in hyper-tensive rats than in normotensive rats. Indomethacin treatment (ICV, 200 ㎎) altered the depressor response to captopril neither in normotensive nor in hypertensive rats. These results suggest that the cardiovascular effect of renin-angiotensin system in the central nervous system may not be mediated via prostaglandin systems in normotensive and 2KlC hypertensive rats.

흰쥐 내후야의 아미노산 함량에 대한 복측 또는 배측 뇌 해마 제거 영향

최석형,김종규,양훈모,민영기 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

This study was planned to analyze amino acids in the entorhinal cortex of dorsal and ventral hippocampectomized rats by high performance liquid chromatography (HPLC). Male albino rats were used. Under chloral hydrate anesthesia (20%, 2 ㎖/㎏ body weight), a hole was made in each parietal bone about 4 mm lateral to the sagittal suture, and 4 mm rostral to the lambda suture. The cortical tissue on each side was removed and, through this opening, the hippocampal tissue anterodorsal and posteroventral to the hippocampal flexures on both sides was removed by aspiration. This preparation served as the dorsal and the ventral hippocampal animals, respectively. The cortical control animal received the same surgery short of hippocampectomy. The normal rats served as normal control animal. One week later, the animals were sacrificed by decapitation in the cold room. Two to three milligrams of tissue was obtained from the entorhinal cortex in one side of the brain. The tissue samples were homogenized and centrifuged. Then content of each amino acid was measured by HPLC from the brain tissue. 1) The contents of aspartate were decreased significantly more in the dorsal and ventral hippocampal groups than in the normal and the cortical control groups, while there were no significant differences between the 2 hippocampal and 2 control groups. 2) The contents of glutamate were decreased significantly more in the dorsal hippocampal group than in the normal and the cortical control groups. The contents of glutamate were increased significantly more in the ventral hippocampal group than in the dorsal hippocampal, the normal control, and cortical control groups. while there was no significant difference between the 2 control groups. It is inferred from the above mentioned results that glutamate and aspartate of many amino acids may he used as a excitatory transmitter in entorhinal cortex, and that the dorsal hippocampus may be facilitatory to the entorhinal cortex, but the ventral hippocampus would be inhibitory/facilitatory to the cortex.