항진균물질을 생산하는 Streptomyces fimbriatus AF21-3의 분리 및 동정

장주현,김정완,이우윤,윤영준,이경림,김승곤,이태수 인천대학교 2000 基礎科學論文集 Vol.11 No.1

Actinomycetes were isolated from soil to find new antibiotics. An active antimicrobial compound was isolated from the culture filtrate of Actinomycetes AF 21-3. The Actinomycetes strain which showed strong antifungal activity against Candida tropicalis and Microsporum gypseum was identified as Streptomyces fimbriatus and named as Streptomyces fimbriatus AF 21-3.

부하순환 하에서 제V급 복합레진 수복물의 미세변연누출에 대한 재접착제의 효과에 관한 연구

윤연희,김영재,김정욱,장기택,이상훈,김종철,한세현 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.3

저점도의 레진을 복합레진 수복물 위에 도포하는 것은 미세누출방지와 변연 완전성(integrity) 유지를 위한 한 방법이다. 하지만 장기간 관찰하면, 수복물은 저작압에 의한 영향을 받게 되는데, 저점도의 레진으로 수복물 변연부를 재접착(rebonding)하였을 때 저작압에 의한 응력에 견디면서 계속하여 수복물에 긍정적인 영향을 주는지에 대한 연구는 미흡한 실정이다. 본 연구는 부하순환(load cycling) 하에서 제Ⅴ급 수복물의 미세변연누출에 대한 재접착제 (rebonding agent)의 효과를 알아보고자 하였다. 40개의 건전한 소구치의 협면에 제Ⅴ급 와동을 형성하고 제조사의 지시대로 광중합복합레진으로 수복하였다. 20개씩 무작위로 나누어 표면전색을 하지 않는 Ⅰ군과 표면을 산부식 후 재접착한 Ⅱ군으로 설정하였다. 열순환 후 각 군에서 10개씩의 하위군 (A군=No load cycling군, B군=Load cycling군)으로 나누어 이중 B군의 시편에 1 Hz의 속도로 수직력이 4-100까지 100,000회의 부하순환을 가하였다. methylene blue용액에 침윤시켜 변연의 미세누출릉도를 평가하여 다음과 같은 결과를 얻었다. 1. 교합변연에서는 재접착과 무관하게 유의한 차이가 없었다(ⅠA-ⅡA군, ⅠB-ⅡB군) (p>0.05). 2. 치은변연의 경우는 부하순환을 하지 않은 군의 경우 재접착을 한 군(ⅡA군)이 재접착을 하지 않은 군 (ⅠA군)에 비해 더 적은 미세누출결과를 보였다(p<0.05). 3. 치은 변연에서 부하순환을 시행한 군의 경우에는 재접착을 한 군(ⅡB군)과 재접착을 하지 않은 군 (ⅠB군)과 유의차가 없는 비슷한 미세누출의 결과를 보였다(p>0.05). One clinical technique recommended f3r improving marginal integrity is "rebonding" or application of unfilled resins to the surface of composite restoration. But continuously the restorations are affected with occlusal load. There is room for doubt that the rebonding agent has the positive effect on microleakage in spite of the stress generated by the occlusal load. This study determined the effect of rebonding on microleakage of Class Ⅴ resin composite restorations under load cycling. Class Ⅴ cavities were prepared on the buccal surface of 40 sound extracted premolars and restored with a hybrid light-cured resin composite according to manufacturers' directions. They wert randomly divided into two groups consisting of 20 samples a control(group Ⅰ), without surface sealing, and the other group (group Ⅱ) in which margins were etched and rebonded. After thermocycling, each of groups was divided into subgroups (group A, B), and load cycling(total 100,000 cycles with 4-100N load at a rate of 1 Hz) were applied on the group B. Assessment of microleakage utilized methylene blue dye penetration. The following results were obtained : 1. In the occlusal region, no significant difference was noted in the scores regardless of whether or not the rebonding agent was used (group ⅠA-ⅡA, ⅠB-ⅡB) (p>0.05). 2. In the cervical region, the control group with rebonding (group ⅡA) showed the better result than the group without rebonding (group ⅠA) (p<0.05). 3. In the cervical region, the rebonded group with load cycling(group ⅡB) showed similar results to the groupf·ithout rebonding(group ⅠB) and no significant difference was noted(p>0.05).

공분산구조분석법을 활용한 통행수단, 활동 및 통행행태에 대한 인과성 평가

장태연,김대영,김정호,권진영 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

Activities done by individual are usually classified into obligatory and discretionary ones. Simple or complex trip pattern is performed as these activities are linked and various travel modes are used. Individuals try to link several trips as a type of chain to save transportation resources such as travel distance or time, which consequently produces complex trip pattern. These changes in urban transportation environment and less studies on activity-based characteristics make difficult to forecast trips resulting from trip linkage behavior. The purpose of study is to analyze possible causal relationships among activities, travel mode choices and travel patterns, assuming that they are directly influenced by individual or household attributes. Two kinds of models are established to achieve this purpose. One is the allocation model for mode choice for activities by three stage least square estimation method under the restricted conditions. The other is covariance structure model(LISREL) to analyze direct and indirect effect among attributes. As a result, the allocation of travel modes is mainly influenced by variables such as gender, education level, marriage, and children under 13 years old. In LISREL, it is shown that those variables well explain an exogenous personal attributes and only family income do an exogenous household attributes. While trip pattern attributes is well reflected by travel mode attributes, it is less reflected by activity attributes.

HTTP/1.1의 영속 커넥션 적정 해제 타이밍 분석 연구

장욱희,정윤찬 가톨릭대학교 자연과학연구소 2001 자연과학논문집 Vol.22 No.-

웹의 응용 계층 프로토콜인 HTTP(Hyper Text Transfer Protocol)에는 1.0과 1.1의 두 가지 버전이 있다. 이 두 가지 버전의 가장 큰 차이점은, HTTP/1.0이 잦은 TCP 커넥션 설정 과정을 거치는 것과 달리 HTTP/1.1은 일단 TCP 커넥션이 설정되면 클라이언트로부터의 연속적인 문서 요구를 영속 커넥션을 통하여 지속적으로 받아들이고 응답한다는 것이다. 이러한 영속 커넥션을 유지함에 있어서 발생하게 되는 HTTP/1.1의 문제점은 영속 커넥션을 끊어야 하는 시점에 관한 것이다. 이 논문에서는 실제 환경의 모의 실험을 통하여 서버에서는 어떤 조건에서 영속 커넥션을 끝내는 것이 클라이언트에게 적절한가를 정량적으로 분석해 보았다. 클라이언트로부터의 문서 검색요청 빈도, 영속 커넥션에서의 연속적인 평균 요청수, 연속적인 요청들간의 평균 간격 그리고 영속 커넥션 해제 시점에 대한 서버에서의 상태 버퍼 유지수 및 강제 해제 발생 비율을 실험한다. 결론적으로 실험 결과에 의한 적절한 영속 커넥션 해제 시점을 제안한다. The most significant feature in HTTP/1.1 is that once a connection is established, unlike the HTTP/1.0, which constantly required to re-establish its connection, Consecutive Document Retrievals can be processed through the Persistent Connection. The crucial point of this Persistent Connection in HTTP 1.1, is to determine the best moment to terminate the Persistent Connection. Simulations have performed for the quantitative analysis to determine what condition would be appropriate for the Client to terminate Persistent Connection in this thesis. The experiments are included to obtain the frequency of Consecutive Document Retrievals, the number of Consecutive Document Retrievals of a Persistent Connection, Think Times, average number of state buffer for Closing Time of a Persistent Connection in Server and rate of closing overhead connection. As a conclusion, is suggested on the basis of the results of these simulations. an Optimal Closing Time for a Persistent Connection will be recommended.

위에 공존하는 선암종과 유상피평활근육종

김정연,고재수,조경자,장자준 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.4

태양광 발전시스템의 최대전력추적을 위한 DC/DC 컨버터 제어

최연옥,서진연,장용해,정삼용,조금배 조선대학교 에너지.자원신기술연구소 1999 에너지·자원신기술연구소 논문지 Vol.21 No.2

Solar energy converters were used to convert the electrical energy from the solar arrays to a stable and reliable power source. The object of this paper is to analyze and design DC/DC converters of different types in a solar energy system in order to investigate the performance of the converters. A simple method which combines a discrete time control and a PI compensator is used to track the maximum power point of the solar array. The system is kept to operate close to MPPT's thus the maximum possible power transfer from the solar array is achieved. Experimental tests were carried out for buck, boost and buck-boost converters using a simple maximum power point tracking algorithm.

멸치액젓의 휘발성 향기성분에 관한 연구

차용준,박지영,장성민,김훈,김소정 창원대학교 생활과학연구소 1998 생활과학연구 Vol.- No.2

Volatile flavor components in salt-fermented anchovy sauce were analyzed by simultaneous steam distillation-solvent extraction/gas chromatography/mass spectormetry. Ninety-eight compounds were detected in sample. These compounds were composed mainly of aldehydes(13). ketones(6), alcohols(16), aromatic compounds(21), N-containing compounds(7), esters(5), S-containing compounds(5) and miscellaneous compounds(25). Among these, 3-(methythio)propanal, 2-ethyl-3.5-dimethylpyrazine, dimethyl disulfide and dimethyl trisulfide having high odor values were supposed to be playing to be a major role in the overall aroma of salt-fermented anchovy sauce.

뇌성마비 장애자를 위한 교육용 소프트웨어 제작에 관한 연구

이상윤,권중장 경성대학교 공학기술연구소 2002 공학기술연구지 Vol.9 No.-

In this paper, studied characteristics of students having cerebral infantile paralysis. And, suggest an implementation method of the educational software using multimedia informations such as text, icon(button), sound, image, etc and effective usages such as the types of the educational softwares, the composition of a picture, a teacher's control window, various working files, integrated teaching materials, games, songs. By experimental result, we know that the proposed method is very useful.

만성 C형 간염 환자에서 페그인터페론 알파2a와 리바비린 병합 치료중 발생한 벨마비 1예

김일환,장제혁,유충헌,최규남,고정해,김윤정,서광원,김지현,박성재,박은택,이연재,이상혁,설상영 인제대학교 2008 仁濟醫學 Vol.29 No.-

페그인터페론과 리바비린 병합요법은 만성 C형 간염의 일차 치료법이다. 저자들은 만성 C형 간염 환자에서 페그인터페론 과 리바비린 병합 요법 중에 발생한 벨마비 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 5년 전부터 만성 C형 간염을 앓아온 48세 남자이며, PEG-IFN α-2a 135μgm 피하주사 주1회와 하루 1200㎎의 리바비린을 투여하였다. 치료시작 후 9개월째 환자는 오른쪽 안면의 근력약화를 호소하였으며 벨마비로 진단되었다. 페그인터페론과 리바비린 병합요법을 지속하면서 관찰하였다. 환자의 벨마비는 페그인터페론 치료를 중단하지 않았음에도 3개월후 증상이 회복되고 이후 벨마비 재발 없이 현재 경과관찰 중이다. 만성 C형 간염에서 페그인터페론과 리바비린 병합 요법시 벨마비의 발생 가능성을 염두에 두어야 하겠다. A Case of Bell's Palsy Associated with Combination Therapy of Pegylated Interferon Alfa-2a (PEG-IFN) and Ribavirin for Chronic Hepatitis C Virus Infection Pegylated interferon alfa(PEG-IFN α) and ribavirin therapy is the first line treatment for chronic hepatitis C. Mild complications of the therapy are common, but more serious complications are rare. We report here a case of Bell's palsy that occurred in a patient with chronic hepatitis C virus infection during combination therapy of PEG-IFN α-2a and ribavirin. The patient was 49-year-old man with chronic hepatitis C (genotype 1b) for 8 years. He had compensated liver cirrhosis with splenomegaly. Therapy with PEG-IFN α- 2a 135mcg/week and ribavirin 1200mg/day was initiated. After 9 months of the therapy, the patient showed a loss of muscular tone on the right side of his face. A diagnosis of Bell's palsy was made. The Bell's palsy resolved over 3 months despite continuation of the combination therapy.

양극성 장애와 Monocyte Chemoattractant Protein-1 유전자 다형성

배치운,김태석,장우영,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter-2518 and BD. Methods : Patients with BD (n=92) in accordance with DSM-FV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method. Results : Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587 ; p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups. Conclusion : Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD.