소목(Caesalpinia sappan) 추출물의 Streptococcus mutans에 대한 성장, 산생성, 부착 및 비수용성 글루칸 합성 억제에 미치는 영향

유용욱,유현희,김윤정,유미선,서세정,이황,이흥수 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.2

Streptococcus mutans is known as the causative bacterial playing the most important role in forming plaque and it is being noticed as major causative bacteria of dental caries. Therefore, development of more effective, substantial and safe preventive agent against dental caries and periodontal disease is honestly required. The present study was designed to investigate the effect of chloroform extract(CE), n-butanol extract(BE),methanol extract(ME) and water extract(WE) of Caesalpinia on the growth, acid production, adhesion, and insoluble glucan synthesis of Streptococcus mutans. The CE, BE, ME and WE decreased the growth and acid production of S.mutans than that of control, especially, the ME was more effective than other extracts. The effect of CE, BE, ME and WE on the adherences to saliva-coated hydroxyapatite bead(S-HA) were evaluated. At the concentration of 2,000 ㎍/㎖, the CE showed 32% rate of bacterial adherence to S-HA, whereas, other extracts of the same concentration producedgreater than 50% rate. The CE and BE were significantly decreased the reduction rates of water insoluble glucan formation from sucrose by crude glucosyltransferase of S.mutans. Thus, the application of C. sappan can be considered a useful and a practical method for the prevention of dental caries.

좌측흉수로 발현된 Boerhaave 증후군 1예

이준,변유미,조민근,조주연,원경준,김영대,박찬국,김만우,유재근,서홍주,이석기 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

구토 후 발생한 토혈을 주소로 내원한 환자에서 좌측 늑막 삼출 동반 시 식도 파열의 가능성을 고려하여 흉수 천자 및 지속적인 흉부 단순 촬영의 추적관찰이 필요하며 식도 파열이 배제된 후 환자의 생체 징후 및 토혈 양을 파악하여 내시경 검사 시기를 신중히 결정하는 것이 좋을 것으로 생각된다. 본 증례는 토혈을 주소로 내원하여 Mallory-Weiss 증후군 의심 하에 내시경을 통한 치료 시행 후 추적 관찰에 의해 진단된 Boerhaave 증후군을 경험하였기에 보고하는 바이다. Boerhaave's syndrome is a spontaneous perforation of the esophagus most commonly resulting from a sudden increase in intraesophageal pressure combined with negative intrathoracic pressure caused by straining or vomiting. Surgery should generally be performed within 24 hours because mortality approached 30 to 50 percent in which surgery was delayed. Therefore, early diagnosis and prompt surgical repair are critical for survival. We have experienced a case of Boerhaave's syndrome in a patient presenting with hematemesis with left pleural effusion without any signs or symptoms of pneumomediastinum or pneumothorax.

RAPD와 핵 리보솜 DNA ITS2 염기서열에 의한 한국산 전나무속 식물의 유전적 변이 및 계통유전학적 분석

정용환,한상현,오유성,고미희,고석찬,김문홍,오문유 濟州大學校 基礎科學硏究所 2001 基礎科學硏究 Vol.14 No.2

We analyzed the genetic variation and phylogenetic relationship among fourteen taxa of GenusAbies distributed in Korea using random amplified polymorphic DNA (RAPD) and internal transcribed spacer (ITS) 2 sequences of the nuclear ribosomal DNA (rDNA). RAPDs were used for identification of selected taxa by amplification using single 10-mer primers of arbitrary sequence. Fourteen taxa were clearly classified with 10 arbitrary primers, which generated 102 useful polymorphic bands that were evaluated according to the presence or absence of the fragments of equal size. The genetic distance between A. koreana for. chlorocarpa and A. koreana for. rubrocarpa was 0.127, showing the closest among any other pairs. By comparing the base sequences in the ITS2 region of the nuclear rDNA, genetic relationship was assesed among selected taxa. It showed twenty six sites of point mutation (base substitution) in 243 base pairs (bp) of ITS2 region. The G+C contents of ITS2 region were ranged from 58.3% to 61.7%. The value of nucleotide divergence among selected taxa was ranged from 0.4% to 9.8%. These results showed that RAPD and ITS2 sequence analysis was a useful tool for elucidating phylogenetic relationship and selection of specific marker in Abies species.

낙동강 원수의 생물활성탄 및 오존처리공정에 따른 수질 변화 및 폴리오바이러스의 제거특성

정은영,박홍기,이유정,정종문,정미은,홍용기,장경립,Jung Eun-Young,Park Hong-Ki,Lee You-Jung,Jung Jong-moon,Jung Mi-Eun,Hong Yong-Ki,Jang Kyoung-Lib 한국생명과학회 2005 생명과학회지 Vol.15 No.5

오존처리는 음용수중의 유해한 미생물을 소독하는 처리기술로 주로 이용되고 있으며, 생물활성탄 처리기술 역시 오염물질 제거를 포함한 음용수 제조과정에 여러 가지 이점을 제공한다. 이글의 병행처리는 원수중의 여러 물질을 제거하는데 효과적인 공정으로 간주되고 있다. 본 연구에서는 낙동강 하류의 매리취수장 원수를 사용하여 생물활성탄 정수처리공정 및 오존에 의한 수질 변화와 함께 폴리오바이러스 제거 효율을 조사하였다. 수질인자들은 BAC 여과를 거치면서 $NH^{+}_{4}-N$등을 포함한 모든 항목들은 거의 제거되는 것으로 나타났다. Pilot-plant를 이용한 정수처리공정별 폴리오바이러스 제거실험에서는 전오존 접촉에 의해 $96.8\%$, 침전단계에서$99.3\%$, 여과단계에서 $99.6\%$의 바이러스가 제거되었으며, 후오존을 거친 BAC 여과수 시료에서는 세포배양법과 ICC-PCR 방법에서 바이러스가 $100\%$ 제거되어짐을 확인할 수 있었다. 오존농도에 의한 폴리오바이러스 제거실험 결과 0.4mg/1에서 5분간 접촉되었을 때는 약 $61.1\%$ 이상이, 0.8mg/1에서 10분 이상 접촉시킨 후에는 바이러스의 $100\% $가 불활성화 되어졌음을 알 수 있었다. Ozonation is a disinfection technique of harmful mi-crobes commonly used in the treatment of drinking water. And Biological Activated Carbon (BAC) treatment also provides numerous benefits for drinking water utilities, including removal of micro- pollutants, improved treatment processes. The multiful-stage ozonation and BAC play roles as effective methods for removing several materials in raw water. Water quality variation in Nak dong river and the removal efficiency of viruses by ozonation-BAC process were investigated on pilot scale. During the period of survey, most of water quality parameters including $NH_{4}^{+}-N$ were highly improved after passing through the BAC. The removal efficiency of poliovirus type III in water treatment process using pilot-plant,$ 99.6\% $ of viruses were removed by pre-ozonation, sedimentation and sand filteration process, $ 100\% $ were removed after in BAC filteration step. In the removal survey of viruses by ozonation, ap-proximately $ 61.1\% $ or polioviruses were inactivated by ozone of 0.4 mg/l within 5 min. and $ 100\% $ were inactivated by ozone of 0.8 mg/l over 10 min.

Primary signet ring cell adenocarcinoma of the uterine cervix - Poor prognosis in an Asian young patient

( You Mi Hong ),( Kyoung Min Kim ),( Hwa Suk Lee ),( Dong Hyu Cho ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Primary signet ring cell adenocarcinoma of cervix is extremely rare, as only 18 cases has been reported worldwide so far. We report a case of uterine cervical primary signet ring cell adenocarcinoma in an young woman that showed poor prognosis. A 35-year-old woman was referred to our hospital for abnormal finding in her PAP smear test. Her past medical history was non-specific, including previous PAP smear being normal 2 years ago. Her pelvic MRI showed a 2.7 x 1.8 cm sized cervical cancer with parametrial invasion and multiple lymph node metastasis, staged as FIGO stage IIIB. Her endoscopy and colonoscopy showed non-specific finding except chronic atrophic gastritis and colon polyp. Mammogram, breast and thyroid sonography either showed no evidence of malignancy. Type III radical hysterectomy with bilateral salpingo-oophorectomy, pelvic lymph node dissection and paraaortic lymph node dissection was done 7 days after her initial visit. Over the course of 4 months, she had undergone 4 times of cisplatin and 5-fluorouracil combination as an adjuvant 1st line chemotherapy and 5 times of radiotherapy. 3 months after, she experienced a complete remission. But she readmitted due to sudden left leg weakness and headache only 10 months after complete remission. She was diagnosed as multiple brain metastasis on respiratory area and expired 3 days after readmission. As the primary signet ring cell adenocarcinoma of cervix is extremely rare, we believe the case report itself may have clinical significance. We expect that our report on treatment and prognosis of primary signet ring cell adenocarcinoma of cervix may aid help in making decision on similar cases.

Amniotic fluid embolism: a rare case of both maternal and neonatal good prognosis

( You Mi Hong ),( Jeong Heon Lee ),( Young Ju Jeong ) 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

Retroperitoneal schwannoma misdiagnosed as an ovarian malignancy

( You Mi Hong ),( Jeong Heon Lee ),( Young Ju Jeong ),( Chul Hee Rheu ),( Jong Hyun Kim ),( Dong Hyu Cho ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

A 55-year-old woman presented to the hospital with a three-month history of abdominal discomfort. A hard, fixed mass as large as a man's double fists was palpated in the right lower abdomen during pelvic examination. Contrast-enhanced abdominal computed tomography (CT) showed a 10 x 9 x 6.5-cm well-defined solid-cystic enhancing mass in right pelvic cavity. Positron emission tomography-computed tomography (PET-CT) showed an FDG-avid solid mass in the right ovarian fossa Under general anesthesia, exploratory laparotomy was performed upon suspicion of ovarian malignancy. The uterus and both adnexa showed normal appearance; however, a mass about the size of a man\'s double fists was detected in the right retroperitoneal space. No enlargement of lymph nodes around the mass or metastasis was found. Intraoperative frozen section analysis suggested a benign mesenchymal tumor. Complete surgical resection was carried out Macroscopic examination revealed a capsulated mass measuring 11 x 7 x 6.4 cm with solid bright-yellow areas A pathology examination revealed a retroperitoneal schwannoma with a highly ordered cellular component (Antoni A) and hypocellularity with predominantly loose myxoid component (Antoni B). Immunohistochemical staining of the sample yielded a typically positive result for S-100 in the tumor cell cytoplasm. The patient is currently alive 24 months after treatment without recurrence. Schwannomas consist only of Schwann cells and most often non-malignant tumors. They are relatively slow-growing and are usually located in the head, neck, and the extremities. Schwannomas are quite rare in the retroperitoneal region. They occur at all ages, although most cases are diagnosed in individuals between the ages of 20 and 60 years. A symptom of schwannomas is highly nonspecific and varies depending on the location and size of the lesion. The diagnosis of retroperitoneal schwannomas is often delayed and misdiagnosed as an adnexal tumor, especially located in the pelvic cavity. Clinically, retroperitoneal schwannoma is mostly asymptomatic; however, any symptoms are usually obscure such as abdominal discomfort or fullness, or neurological symptoms. Complete surgical resection is the treatment of choice and tumor recurrence is unusual after complete resection. However, conservative surgery may be performed to avoid damage to the surrounding blood vessels and nerve tissue. The prognosis of patients undergoing conservative surgery is not established.

Prenatal diagnosis of pericallosal lipma

( You Mi Hong ),( Young Ju Jeong ) 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

Developmental outcomes of very low birth weight infants with catch up head growth: A nationwide cohort study

( You Mi Hong ),( Dong Hyu Cho ),( Jin Kyu Kim ) 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

Infrapatellar Tendinitis that Improved by Ultrasonographic Guided Steroid Injection

Mi-Ra You · Hyun-Jong Lim · Hyung-Jin Park · Hong-Sung Choungh · Seong-Hyung Choi · Hyun-Sook Kim 조선대학교 의학연구원 2009 The Medical Journal of Chosun University Vol.34 No.4

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