Gender-specific effect of uric acid on resting-state functional networks in de novo Parkinson's disease

Lee, Yoonju,Park, Yeong-Hun,Lee, Jae Jung,Sohn, Young H.,Lee, Jong-Min,Lee, Phil Hyu Elsevier 2018 Parkinsonism & related disorders Vol.52 No.-

<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>The pattern of resting-state networks is influenced by several factors besides the underlying pathological changes of Parkinson's disease (PD). Uric acid (UA), as an antioxidant, has a neuroprotective property against PD-related microenvironment; however, this effect would be gender-specific. We aimed to evaluate a gender-sensitive resting-state networks (RSN) according to the UA level in drug naïve de novo patients with PD to elucidate the role of antioxidant in cortical functional networks of PD.</P> <P><B>Methods</B></P> <P>This study enrolled 135 de novo patients with PD underwent functional magnetic resonance imaging (MRI). Based on the distribution, the serum UA level was stratified into tertiles in the PD patients by gender. With a seed-based approach, we investigated the pattern of RSN within the dorsal attention network (DAN), executive control network (ECN), and default mode network (DMN).</P> <P><B>Results</B></P> <P>Interaction analysis showed a significant interaction between the lowest (PD-L-UA) and the highest UA level (PD-H-UA) groups according to gender within the DAN, ECN, and DMN. Compared to the control subjects, male patients with PD-H-UA had higher cortical functional connectivity (FC), while female patients had lower cortical FC regardless of UA level within all seeds. In a direct comparison, male patients with PD-H-UA had increased FC than did those with PD-L-UA. However, there was no significant difference in FC between PD-L-UA and PD-H-UA in female PD patients.</P> <P><B>Conclusions</B></P> <P>These data suggest that RSN might be closely and gender-specifically associated with the status of serum UA in de novo PD patients.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We present fMRI data from 135 drug naïve de novo patients with PD. </LI> <LI> Male patients with higher UA levels had higher corticalfunctional connectivity. </LI> <LI> In contrast, female patients had lower functional networks regardless of UA level. </LI> <LI> Serum UA might influence RSN closely and gender-specifically in PD patients. </LI> </UL> </P>

Influence of Late School-age Children and Their Mothers’ Health Beliefs, Children’s Self-esteem, and Social Support on Health Behaviors of Children

( Lee Sujin ),( Lee Haejung ),( Lee Yoonju ),( Park Gaeun ),( Hyun Sookyung ) 부산대학교 간호과학연구소 2022 글로벌 건강과 간호 Vol.12 No.1

Purpose: This study aimed to investigate the predictors of late school-age children’s health behaviors in children and their mothers’ health beliefs, children’s self-esteem, and social support. Methods: A descriptive correlational study was conducted with 152 late school-age children from the 4th to 6th grades and their mothers in Korea. Data were collected from February 19 to March 5, 2020. The collected data were analyzed using t-test, ANOVA, Pearson’s correlation coefficient, and hierarchical multiple linear regression. Results: The average score for health behaviors was 3.35 out of 4.00. The highest subscale of health behavior was mental health, whereas the lowest was eating habits. After adjusting for the influences of the general characteristics of children and their mothers, children’s perceived benefits (β=.17, p=.005), perceived barriers (β=-.20, p=.001), self-efficacy (β=.19, p=.005), and mothers’ perceived severity (β=.18, p=.001) were significant predictors of health behaviors among late school-age children, accounting for 24.0% of the variance (R² change=.24, F=11.59, p<.001). The total explanatory power of the final regression model was 72.0% (adjusted R²=.72, F=24.98, p<.001). Conclusion: Children’s health beliefs were more important than mothers’ health beliefs in explaining the health behaviors of late school-age children. Nursing interventions should focus on perceived barriers, self-efficacy, and perceived benefits to improve health behaviors of late school-age children.

The latent classes and factors affecting quality of life among South Koreans with metabolic syndrome

Yoonju Lee,Yi Kyung Ha,Young-Suk Cho,Heejin Kim 한국데이터정보과학회 2018 한국데이터정보과학회지 Vol.29 No.1

The purpose of this study is to identify latent classes involving the health behaviors of patients with metabolic syndrome and to examine the effects of demographic characteristics and health- related lifestyles on their quality of life. The data was sourced from the database of the 2013 Korea health panel survey. Health behavior variables (smoking, drinking, body mass index, and physical activities) were dichotomously recategorized for latent class analysis. Two latent classes of metabolic syndrome, named ‘low physical actor’ and ‘low physical actor with smoking and alcohol’ were identified. Both latent classes showed statistically significant differences in demographic characteristics and EQ-5D index. Additionally, there were differences in the factors affecting quality of life between latent classes. This study’s findings suggest that a tailored intervention based on features of the latent classes is required to improve the lifestyle and quality of life of metabolic syndrome patients.

nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology

Lee, Sang-Eun,Kim, Yoonju,Han, Jeong-Kyu,Park, Hoyong,Lee, Unghwi,Na, Myeongsu,Jeong, Soomin,Chung, ChiHye,Cestra, Gianluca,Chang, Sunghoe National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.24

<P>Neural Abelson-related gene-binding protein 2 (nArgBP2) was originally identified as a protein that directly interacts with synapseassociated protein 90/postsynaptic density protein 95-associated protein 3 (SAPAP3), a postsynaptic scaffolding protein critical for the assembly of glutamatergic synapses. Although genetic deletion of nArgBP2 in mice leads to manic/bipolar-like behaviors resembling many aspects of symptoms in patients with bipolar disorder, the actual function of nArgBP2 at the synapse is completely unknown. Here, we found that the knockdown (KD) of nArgBP2 by specific small hairpin RNAs (shRNAs) resulted in a dramatic change in dendritic spine morphology. Reintroducing shRNA-resistant nArgBP2 reversed these defects. In particular, nArgBP2 KD impaired spinesynapse formation such that excitatory synapses terminated mostly at dendritic shafts instead of spine heads in spiny neurons, although inhibitory synapse formation was not affected. nArgBP2 KD further caused a marked increase of actin cytoskeleton dynamics in spines, which was associated with increased Wiskott-Aldrich syndrome protein-family verprolin homologous protein 1 (WAVE1)/p21-activated kinase (PAK) phosphorylation and reduced activity of cofilin. These effects of nArgBP2 KD in spines were rescued by inhibiting PAK or activating cofilin combined with sequestration of WAVE. Together, our results suggest that nArgBP2 functions to regulate spine morphogenesis and subsequent spine-synapse formation at glutamatergic synapses. They also raise the possibility that the aberrant regulation of synaptic actin filaments caused by reduced nArgBP2 expression may contribute to the manifestation of the synaptic dysfunction observed in manic/bipolar disorder.</P>

Identification of Lactic Acid Bacteria in Galchi- and Myeolchi-Jeotgal by 16S rRNA Gene Sequencing, MALDI-TOF Mass Spectrometry, and PCR-DGGE

( Yoonju Lee ),( Youngjae Cho ),( Eiseul Kim ),( Hyun-joong Kim ),( Hae-yeong Kim ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.7

Jeotgal is a Korean traditional fermented seafood with a high concentration of salt. In this study, we isolated lactic acid bacteria (LAB) from galchi (Trichiurus lepturus, hairtail) and myeolchi (Engraulis japonicas, anchovy) jeotgal on MRS agar and MRS agar containing 5% NaCl (MRS agar+5% NaCl), and identified them by using 16S rRNA gene sequencing and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) as culture-dependent methods. We also performed polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) as a culture-independent method to identify bacterial communities. Five samples of galchi-jeotgal and seven samples of myeolchi-jeotgal were collected from different regions in Korea. A total of 327 and 395 colonies were isolated from the galchi- and myeolchi-jeotgal samples, respectively. 16S rRNA gene sequencing and MALDI-TOF MS revealed that the genus Pediococcus was predominant on MRS agar, and Tetragenococcus halophilus on MRS agar+5% NaCl. PCR-DGGE revealed that T. halophilus, Tetragenococcus muriaticus, and Lactobacillus sakei were predominant in both types of jeotgal. T. halophilus was detected in all samples. Even though the same species were identified by both culture-dependent and -independent methods, many species identified by the culturedependent methods were not in the bacterial list identified by the culture-independent methods. The distribution of bacteria in galchi-jeotgal was more diverse than in myeolchijeotgal. The diverse LAB in galchi- and myeolchi-jeotgals can be further studied as candidates for starter cultures to produce fermented foods.

Monotone Iterative Method for Nonlinear Partial Differential Equation with Fractional-order Time Derivative

Yoonju Lee,Hongwon Choi,Young-Hee Kim,Sangkwon Chung 한국산업응용수학회 2009 한국산업응용수학회 학술대회 논문집 Vol.4 No.2

Erratum to “The latent classes and factors affecting quality of life among South Koreans with metabolic syndrome”

Yoonju Lee,Yi Kyung Ha,Young-Suk Cho,Heejin Kim 한국데이터정보과학회 2018 한국데이터정보과학회지 Vol.29 No.2

Association between Coping Profiles and Cardiac Health Behavior among Patients with Coronary Artery Disease: A Latent Profile Analysis

Lee, Yesul,Lee, Yoonju,Choe, Jeong Cheon,Jeong, Hyesun,Jung, Sunyoung 한국성인간호학회 2024 성인간호학회지 Vol.36 No.3

Purpose: The aim of this study was to identify the coping profiles of patients with coronary artery disease and to examine their associations with cardiac health behavior. Methods: In this cross-sectional study, data from 203 patients undergoing percutaneous coronary intervention for coronary artery disease were analyzed. Data collection occurred between September 2020 and June 2021, utilizing self-report questionnaires and electronic medical records at a cardiology outpatient clinic. Descriptive statistics, latent profile analysis, and logistic regression were employed for data analysis. Results: The Type I coping profile was characterized by the greater use of most coping strategies, particularly problem-focused approaches, relative to the other profiles. The Type II coping profile exhibited below-average use of all coping strategies, except for substance use. The Type III coping profile displayed higher tendencies toward venting, self-blame, denial, behavioral disengagement, and substance use compared to the other profiles. Patients with the Type I coping profile displayed greater engagement in cardiac health behavior than those with Type II and Type III, as indicated by odds ratios of 2.57 (95% confidence interval=1.31~5.07) and 7.19 (95% confidence interval=2.10~24.56), respectively. Conclusion: Participation in cardiac health behavior varies according to the coping profiles of patients with coronary artery disease. Healthcare providers should recognize and support appropriate coping strategies in these patients to promote healthy behaviors. A longitudinal study investigating how changes in coping profiles relate to cardiac health behavior could assist patients with coronary artery disease in maintaining such behaviors.

HMM을 이용한 음성인식 시스템의 전처리에 관한 연구

이윤주(Yoonju Lee),오세영(Seyoung Oh),이순규(Soonkyu Lee),배명진(Myungjin Bae) 대한전자공학회 1999 대한전자공학회 학술대회 Vol.1999 No.11

국내 대학모델전공자의 DISC 행동유형

이윤주(Lee, YoonJu) 한국모델콘텐츠학회 2020 한국모델콘텐츠학회지 Vol.1 No.2

이 연구는 국내 모델전공자의 DISC 행동유형을 알아보기 위한 목적에서 이루어졌다. 이를 위하여 서울과 경상 북도, 전라남도 소재의 4년제 및 2년제 대학에서 모델을 전공하는 대학생을 모집단으로 선정하였다. 표본추출은 비확률적 표집방법(non-probability sampling) 중 하나인 편의표본표집법(convenience sampling)을 사용하여 표본을 추출하였고, 설문작성은 연구대상자가 읽고 직접 작성하는 자기평가기입법(self-administration method) 을 통해 이루어졌다. 자료처리는 빈도분석(frequency analysis), 탐색적 요인분석(Exploatory Factory Anaysis: EFA)과 신뢰도 분석, K-군집분석을 실시하였다. 그 결과 대학모델전공자는 사교형(I형)이 77명(32.9%)으로 가 장 많은 분포도를 보였으며, 그 다음은 주도형(D형)이 70명(29.9%), 안정형(S형)이 52명(22.2%), 신중형(C형)이 35명(15.0%) 순으로 나타났다. 결론적으로 대학모델전공자에 있어서도 다양한 행동유형을 나타남을 확인할 수 있었고, 대학모델전공자의 행동유형을 제시함으로써 향후 지도 철학, 커리큘럼(curriculum) 등을 구성하는데 실 증적 자료가 될 것으로 사료된다 This study aimed to investigate the differences of major satisfaction level and class participation according to the behavioral types of DISC in the model majors in Korea. To do so, the university students majoring in model were selected as the study population in the colleges and universities located in Seoul, North Gyungsang Province, and South Cholla Province. Samples were selected using convenience sampling which is one of non-probability sampling methods and the survey forms were collected after preparations by self-administration method which the study subjects read and answered directly. Upon the survey results from October 2017 to June 2018 for 9 months, the total number of respondents was 238 and 234 survey forms were used as the final analysis excluding 4 data with continuous answers which would lower the reliability of the study. Data processing to verify the study problems was performed by frequency analysis, Exploratory Factory Analysis(EFA), reliability analysis using Cronbach's a coefficient from internal consistency test, K-cluster analysis, and one way ANOVA. Based on the study methods and data analysis, the following results were deducted: First, I type= Influence (n=77) was the most prevalent while C type = Conscientiousness (n=32) was the least upon the distribution result of DISC types among the model majors in Korea. Second, the major satisfaction level of I type=Influence (M=4.19) was higher than those of S type = Steadiness (M=3.79) and D type = Dominance (M=3.71) upon the result of post-hoc analysis (Scheffe) according to the behavioral types of DISC among the model majors in Korea (F=7.655***). Third, C type = Conscientiousness (M=3.82) and I type = Influence (M=3.53) showed higher class participation than D type = Dominance (M=3.15) and S type - Steadiness (M=3.11) upon the result of post-hoc analysis (Scheffe) according to the behavioral types of DISC among the model majors in Korea (F=14.602***). Overall, it was found through this study that various behavioral types were shown in the model majors and class satisfaction and participation rate were different by the behavioral types. Hence, this study implicates the needs of customized teaching methods and curricula to meet a variety of behavioral types