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Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression
Yoo, Jung-Yoon,Choi, Kyung-Chul,Kang, HeeBum,Kim, Young Jun,Lee, Jeongmin,Jun, Woo Jin,Kim, Mi-Jeong,Lee, Yoo-Hyun,Lee, Ok-Hee,Yoon, Ho-Geun Elsevier 2010 FEBS letters Vol.584 No.11
<P><B>Abstract</B></P><P>This is the first report that L(3)mbt-like 2 (L3MBTL2) specifically interacts with the histone deacetylase domain of histone deacetylase 3 (HDAC3) via its MBT domain. Here, we show that L3MBTL2 selectively interacts with HDAC3, but not other class I HDACs. An in vitro peptide-binding assay demonstrated the specific association of HDAC3 with methylated histone-K20 tail and L3MBTL2. Furthermore, depletion of HDAC3 resulted in a decrease of methylated K20-H4, as well as an increase in acetylated histone H3. Consequently, HDAC3 knock-down selectively suppressed L3MBTL2-mediated transcriptional repression. Taken together, our results reveal the concerted action of both HDAC3 and L3MBTL2 in histone deacetylation and methylation-dependent transcriptional repression.</P><P><B>Structured summary</B></P><P>MINT-7719975: <I>L3MBTL2</I> (uniprotkb:Q969R5) and <I>HDAC3</I> (uniprotkb:O15379) <I>colocalize</I> (MI:0403) by <I>fluorescence microscopy</I> (MI:0416)</P><P>MINT-7719941, MINT-7719921: <I>L3MBTL2</I> (uniprotkb:Q969R5) <I>binds</I> (MI:0407) to <I>HDAC3</I> (uniprotkb:O15379) by <I>pull down</I> (MI:0096)</P><P>MINT-7719991: <I>HDAC3</I> (uniprotkb:O15379) <I>physically interacts</I> (MI:0915) with <I>L3MBTL2</I> (uniprotkb:Q969R5) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-7719958: <I>L3MBTL2</I> (uniprotkb:Q969R5) <I>physically interacts</I> (MI:0915) with <I>HDAC3</I> (uniprotkb:O15379) by <I>anti tag coimmunoprecipitation</I> (MI:0007)</P><P>MINT-7719897: <I>HDAC3</I> (uniprotkb:O15379) <I>physically interacts</I> (MI:0915) with <I>L3MBTL2</I> (uniprotkb:Q969R5) by <I>two hybrid</I> (MI:0018)</P>
축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향
정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1
The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.
윤양진,유국종,서국웅,정미라,강영택,이훈식,서국은 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-
The purpose of this paper is to select 7 male athletes and female athletes of high school, and to compare their active potential differences of upper arm muscles according to characteristic of a racket. the results obtained are as follows: 1. According to the accumulative distribution rate of racket material, graphite and wood material show better efficiency in case of brachio radialis muscle of male athletes, but the racket material shows no constant efficiency in brachii radialis muscle of female athletes. In case of flexor carpi radialis muscle, wood material provides better efficiency only for male athletes. In case of triceps brachii muscle, wood material gives better efficiency to males athletes and steel material gives better efficiency to females athletes. Especially in case of biceps brachii muscle, neither male nor female athletes are influenced by racket materials at impact. 2. In the muscle load rate according to racket material, wood has the highest muscle active potential and graphite has the lowest active potential. Therefore, graphite is thoght to be better in the efficiency of muscle load rate.
중량물 운반시 잡기유형과 부하단계에 따른 생리학적 연구
윤양진,이훈식,윤길환,정미라,이재규,이중숙,서국웅 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-
The purpose of this study was to examine physiological changes of the body according to various weight loads and the holding during carrying object. The experiments were conducted with utilizing physiological analyses for five male and five female adults as subjects. The results were as followed. 1. Any significant difference was not shown in heart rate, ventilation and amount of oxygen uptake of male subjects in the case of no load and 5kg. And also no significant difference was shown in expiratory exchange ratio of male subjects of no load, 5kg and 10kg, but in other measure items and other stages of weight was shown. 2. Significant differences were shown in heart rate, ventilation, defluxion of carbon dioxide, oxygen uptake per body weights, respiratory exchange rate, respiration rate and all other measure items of female subjects in all stages of load. 3. In the MMH job, there was no influence on male subjects up to 5kg loads, but there was an significant difference in male subjects in load walking from 5kg. It shows that even in 5kg weight MMH work, female subject's expiratory function was influenced. 4. 10kg load was the limit weight of female subjects and 15kg was of male subjects when they walked on treadmills with 4km/h velocity for 3 minutes, holding loads in the right and vertical types.
실리콘 중합체 - 메타아크릴산 중합체의 상호침투 가교고분자의 합성 및 성질에 관한 연구
윤구식,정미라,박유미 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.2
소수성 중합체인 실리콘과 수용성 중합체인 폴리메타아크릴산(PMAA)을 이용하여 친수성과 소수성을 함께 가진 양친성의 상호침투 중합체(IPN)를 합성하였다. DSC를 이용하여 합성한 중합체(IPN)의 열적 성질을 조사해 본 결과 IPN은 PMAA의 영역과 실리콘 중합체 영역의 두 상으로 분리되어 있었다. 증류수 속에서 중합체의 수팽윤도는 PMAA의 함량이 증가할수록 증가하였으며, pH에 따른 수팽윤도는 pH 4.0 < 증류수 < pH 7.2 < pH 10.7 순으로 증가하였다. 또한 용해성 파라미터 값을 달리하는 몇 가지 용매에 대한 중합체의 팽윤도를 구해본 결과 IPN내의 PMAA의 함량이 증가할수록 용해성 파라미터 값이 큰 물, 에탄올의 팽윤도 값이 커졌으며, 용해성 파라미터 값이 작은 옥탄의 평윤도는 반대의 현상을 나타내었다. 또한 부탄올의 팽윤도는 두가지 단순중합체에서는 낮았으나 IPN에서는 조금 증가하였다. The interpenetrating polymer networks(IPNs) composed of silicone polymer and poly(methacrylic acid)(PMAA) was prepared and characterized by FTIR and DSC. The IPN has the two separated phases which consist of silicone domains and PMAA domains. The sorption of water increased with increasing PMAA contents in the IPN, and at pH10.7 water was absorbed most and the second was at pH7.2. As increasing of the contents of PMAA in the IPN, the sorption of polar solvent was increased and that of nonpolar was decreased.
남중 육상경기 선수의 Foot Ratio와 체력과의 상관
윤길환,서국웅,이훈식,정미라,윤양진,박승범 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-
Foot ratio and physical fitness were measured and multiple-compared in the level of P<.05 on the subject of 28 prize winners from Men's part of middle school in the field and track events of the "P" youth athletic tournament in 1998 and 7 general students adopted by random sampling. These are conclusions from the result of relative analysis of foot length measured by X-ray, Medial longitudinal arch's height, foot ratio and physical fitness in the level of P<.05. 1. No significance was discovered in FR but throwing group is better than medium and long distance group. 2. Flexibility and endurance have meaning in physical fitness. The short distance group has better flexibility than the medium and long, throwing and general one. And medium and long distance/ throwing group have better endurance than general one. 3. FR and physical fitness show a negative correlation in the muscular strength of throwing group.
윤재철,김원,조규종,홍정석,이미우,장성은,오세현,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4
Primary aldosteronism is a syndrome characterized by hypertension, hypokalemia, suppressed plasma renin activity, and elevated serum aldosterone levels. Conn first described it 1955 in association with adrenal cortical adenoma(Conn's syndrome). Today, it can be divided into at least six distinctive sub-groups. The diagnosis of primary aldosteronism is usually suspected when the patient presents with poorly controlled hypertension with hypokalemia. The main issues in the evaluation of primary aldosteronism are to differentiate an adenoma from hyperplasia and to localize the adenoma. Basic hormonal studies and computed tomographic(CT) scanning can be used effectively for that differentiation. An adenoma is one of a few potentially curable forms of hypertension, and it is best treated by removing the adrenal tumor. We experienced a case of a typical adrenal adenoma. The patient was a 37-year-old male who had experienced in both his legs over a period of several days a weakness due to hypokalemia. He was diagnosed using basic hormonal studies and adrenal CT scanning. After, he received laparoscopic adrenalectomy and was discharged with improved condition.