축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

Insulin resistance mediates high-fat diet-induced pulmonary fibrosis and airway hyperresponsiveness through the TGF-β1 pathway

Park, Yoon Hee,Oh, Eun Yi,Han, Heejae,Yang, Misuk,Park, Hye Jung,Park, Kyung Hee,Lee, Jae-Hyun,Park, Jung-Won Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.5

<▼1><P>Prior studies have reported the presence of lung fibrosis and enhanced airway hyperresponsiveness (AHR) in mice with high-fat-diet (HFD)-induced obesity. This study evaluated the role of TGF-β1 in HFD-induced AHR and lung fibrosis in a murine model. We generated HFD-induced obesity mice and performed glucose and insulin tolerance tests. HFD mice with or without ovalbumin sensitization and challenge were also treated with an anti-TGF-β1 neutralizing antibody. AHR to methacholine, inflammatory cells in the bronchoalveolar lavage fluid (BALF), and histological features were evaluated. Insulin was intranasally administered to normal diet (ND) mice, and in vitro insulin stimulation of BEAS-2b cells was performed. HFD-induced obesity mice had increased insulin resistance, enhanced AHR, peribronchial and perivascular fibrosis, and increased numbers of macrophages in the BALF. However, they did not have meaningful eosinophilic or neutrophilic inflammation in the lungs compared with ND mice. The HFD enhanced TGF-β1 expression in the bronchial epithelium, but we found no differences in the expression of interleukin (IL)−4 or IL-5 in lung homogenates. Administration of the anti-TGF-β1 antibody attenuated HFD-induced AHR and lung fibrosis. It also attenuated goblet cell hyperplasia, but did not affect the AHR and inflammatory cell infiltration induced by OVA challenge. The intranasal administration of insulin enhanced TGF-β1 expression in the bronchial epithelium and lung fibrosis. Stimulating BEAS-2b cells with insulin also increased TGF-β1 production by 24 h. We concluded that HFD-induced obesity-associated insulin resistance enhances TGF-β1 expression in the bronchial epithelium, which may play an important role in the development of lung fibrosis and AHR in obesity.</P></▼1><▼2><P><B>Obesity: A trigger for asthma onset</B></P><P>Insulin resistance may be an important causative factor underlying the increased risk of asthma and other respiratory issues in obese individuals. Obesity doubles the likelihood of developing asthma, with symptoms that are more difficult to control than in non-obese patients. The connection between these conditions is poorly understood, but researchers led by Jung-Won Park, Yonsei University College of Medicine, Seoul, South Korea, have identified a potential mechanism. They demonstrated that a signaling molecule called TGF-β1 contributes to airway sensitivity and tissue scarring in a mouse model of diet-induced obesity. Subsequent experiments showed that treatment with insulin also gives rise to increased TGF-β1 production in the mouse lung. Since insulin resistance is a common feature of obesity, resulting in abnormally high levels of circulating insulin, this could also account for the increased risk of respiratory problems.</P></▼2>

가네트를 활용한 고강도 콘크리트의 황산염저항성 특성 연구

윤종문,윤요현,박정민,김화중 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The purpose of this study is about to characteristic of sulfate resist performance following precipitation age of high strength concrete using the garnet minute power. Experiment was compared to the weight change and compressive strength to follow that unit water content 160kg/m³, W/B 30%, 35% and fine aggregate ratio(S/A) 40%, 42%, 44%, admixture(garnet minute power. fly ash) 0%, 10%, 20% and precipitation age. We got the conclusion of the downside through the experiment. Garnet concrete was appeared that was superior to sulfate resist performance by the increasing of garnet. Case of the W/B 30%. garnet concrete did not get up the diminution of weight to follow that small mixing ratio of S/A and expressed diminution of weight the increasing in ratio of S/A. Consequently. If we should make concrete as condition of optimum mixture. we will be expected the effect of sulfate resist performance.

ATHB12, an ABA-lnducible Homeodomain-Leucine Zipper (HD-Zip) Protein of Arabidopsis, Negatively Regulates the Growth of the Inflorescence Stem by Decreasing the Expression of a Gibberellin 20-Oxidase Gene

Ora Son,허윤선,김윤경,이현정,김성한,김미란,남경희,이명석,김부용,박종범,박정안,이석찬,Atsushi Hanada,Shinjiro Yamaguchi,이인정,김승기,윤대진,Eva So¨derman,천충일 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

Cubic B-Spline과 Quintic B-Spline 補間函數의 特性에 관한 硏究

윤경현,金定鐘 慶南大學校 附設 工業技術硏究所 1984 硏究論文集 Vol.2 No.-

本 論文에서는 工學이나 自然科學에서 使用되는 補間函數 中에서 cubic B-spline과 Quintic B-spline의 特性을 硏究하였다. 數直的 列로서f(χ)=cos(2πx)에 대한 각각의 結果를 SHARP-80MB micro computer system으로 비교하였다. Among the varous interpolating polymomials that used in engineering and natural science, we study about the characteristics of cubic B-spline and quintic B-spline interpolating polynomials. As an numerical example, we introduce f(χ)=cos2πx and compared each results with SHARP 80-MB micro computer system.

레이저 스페클간섭법에 있어서 스페클크기와 측정 한계에 관한 연구

윤성운,김경석,양승필,정현철,김정호,이도윤 한국공작기계학회 1996 한국생산제조학회지 Vol.5 No.1

The high coherence of laser beam has made it possible to observe interference effects even in the light scattered from rough surfaces. That's why, when object with a scattering surface is illuminated with laser light, we do see a speckled appearance due to random interference. This sort of unique property of laser speckle has brought into existence the new noncontacting techniques such as speckle metrology method of measuring deformation, displacement, and vibration etc of objects with high optical sensitivity. The measurable range of speckle metrology especially used to measure in-plane information, however, is limited by some factors, the so-called strain, rotation, tilt of surface and out of displacement perpendicular to the plane of analysis. This restrictions severly limits the measurable range of speckle metrology by causing the decorrelation of speckle patterns. It is the purpose of this paper to give a survey on the measurable limitation of speckle photography method that is one of speckle metrology. Namely we will discuss the mutual relationships and problems of each limitations adding the restriction of the largest and smallest displacement measurable with speckle methods.

저용량의 클로자핀에 의해 경련이 유발된 정신분열증 환자 4례

윤준현,김정진,백인호 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.3

Clozapine은 추세외로 증상과 지연성 운동장애를 거의 일으키지 않는 비전형 항정신병 약물로서 치료 저항성 정신분열증 환자들의 치료에 우수한 효과가 있는 것으로 알려져 있다. 그러나 기존의 항정신병 약물로 치료를 받고 있는 환자들의 약 1%에서 경련이 발생하는 것과 비교해서 clozapine를 투여받는 환자들은 경련의 발생 비율이 보다 높은 것으로 알려져 있다. 또한 이러한 경련은 clozapine의 투여에 의해 점차적으로 경련의 역치가 낮아져 발생하게 되므로 clozapine의 용량이 증가함에 따라 경련의 발생 비율도 함께 증가하는 것으로 보고되어져 왔다. 저자들은 정신분열증 환자들에게 clozapine을 투여하던 중 이전의 보고들과는 달리 저용량에서 전신성 경련이 발생한 환자 4례를 경험하였다. 본 증례에서는 경련이 clozapine을 증량하여 투여한 직후에 발생하였기 때문에, 약물의 용량보다는 clozapine 투여 후에 혈중 clozapine 농도가 급격히 증가하는 것에 기인한 것으로 생각되었다. 본 증례를 통해 저자들은 치료 저항성 정신분열증 환자들에게 clozapine을 투여할 경우 고용량 투여, 급격한 증량에 주의한다면 경련을 최소화할 수 있다고 생각하였다. Clozapine is an atypical antipsychotics that has shown to be effective in treating patients with refractory schizophrenia and those with intolerance to currently available antipsychotics. It also appearer to be less likely to cause extrapyramidal symptoms and tardive dyskinesia. But clozapine has been associated with an unusual high incidence of seizures in patients with no previous history of ictal episodes. Seizures occur in approximately 1% of patients treated with antipsychotic drugs. But the prevalence is higher with clozapine. Clozapine-induced seizures are reported to occur in a dose-related manner by progressively lowering the seizure threshold on most all patients as the dose is increased. But seizure does not usually necessitate discontinuation of clozapine treatment. We experienced four cases of seizure induced by low doses of clozapine treatment in schizophrenic patients. Since most of the seizures have occured soon after increase of a clozapine dose, they may have related more to rapid increase in blood clozapine levels than to that of dose. It is also possible that dose did not accurately predict blood levels for these patients. The possibility of seizures should not pose a barrier a barrier to clozapine treatment for patients with refractory psychotic disorders. The risks and morbidity of seizures can be minimized through attention to clinical management.

부직포활성슬러지법에 의한 하수와 침출수처리에 관한 기초연구

정유진,고현웅,김경순,윤태경,성낙창 한국환경과학회 2003 한국환경과학회지 Vol.12 No.10

In this study, it was performed using submerged nonwoven bioreactor(SNBR) for removal of organic matter, nitrogen and phosphate under different aeration intervals(intermittent aeration). We applied the SNBR at the cheap nonwoven fiber module instead of the expensive membrane. The SNBR was mainly made up of an activated sludge reactor and a transverse flow nonwoven module. with an innovative configuration being in application between them. In case of sewage, the aeration conditions experimented consist of continuous aeration and 60min/60min, 120min/60min, 120min/120min of aeration/nonaeration time intervals, respectively. In case of landfill leachate, the intermittent aeration condition was 120min/120min at aeration/nonaeration. Consequently. a high COD removal rate (about 94%) was achieved in sewage and leachate. Although nutrient removal rate was relatively high without any additional chemicals.

3-Cyano 및 3-Carbomethoxy Chromone과 Allenylstannane과의 반응

鄭大一,宋有淨,崔舜圭,李龍均,安賢淑,윤구식 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.2

t-Butyldimethylsilyl triflate 존재에서 3-Cyano 및 3-Carbomethoxy Chromone(1a,b)과 Allenylstannane(2) 과의 반응에서 Chromone의 C-2위치에 propargyl기가 도입된 유도체(3a,b)를 합성하였다. 합성한 유도체의 상대적 구조는 ¹H-NMR을 통해 분석하였으며, T.S구조의 모델을 통하여 가능한 메카니즘을 제시하였다. Reaction of 3-Cyano and 3-Carbomethoxy Chromone(1a,b) with Allenylstannane(2) in the presence of tert-butyldimethylsilyl triflate afforded the corresponding the propargylation product(3a,b) in the moderate yield. The relative stereochemistry of 3a,b are obtained on the basis of ¹H-NMR analysis. And the possible reaction mechanism are suggested by the molecular models in the transition state.