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수학교육을 위한 웹 기반 진단-형성평가 시스템의 개발과 활용
유병훈,강수구 한국수학교육학회 2003 수학교육 Vol.42 No.5
In this paper, we studied how to organize and develop a web based diagnostic-formative evaluation system. We investigated the interest of students about the system and analyze their scores after we applied this system to 10-th grade students for 10 months.
T cell epitope 차폐에 의한 b_(4) peptide 면역응답방응에 대한 연구
최정순,이희종,공수강,리투,류용구,김효준 한양대학교 이학기술연구소 2005 이학기술연구지 Vol.8 No.-
Apo B-100 is a constitutive component of low density lipoprotein (LDL) of which functions in packaging, transport and absorption of lipids Extortive binding of anti B_(4)-antibody onto the Apo B-100 should inhibited the functions of Apo B-100 Previously we had showed that the peptide B_(4) induced antibodies recognized Apo B-100 and thus elicited anti-obesity effect In this study we compared the efficacy of antibody inducing immune responses by introducing additional peptides fused to the C-termninal of B_(4) peptide We constructed TB_(4) hybride peptide of B_(4) with preS2 of HBV and B_(4)N another epitope orientation of chimeric TB_(4) Among these three artificial peptides B_(4)N was the most efficient inducer of the antibody against B_(4) These result explains that the B cell epitope and T-helper cell epitope orientation is very important factor to determine the antigenicity to humoral immunity. Apo B-100은 LDL에서 지방을 포장, 흡수, 운반하는 기능을 수행하는 단백질이다. Apolipoprotein B-100(Apo B-100)에 대한 특이 항체의 결합은 LDL의 정상 기능을 방해한다. 선행 실험에서 Apo B-100의 모조 펩타이드인 B_(4)가 Apo-B-100을 교차 인식하는 항체를 유도하고, 비만 억제 효과를 나타내는 것으로 밝혀졌다. 본 연구에서 B_(4)펩타이드의 C-terminal부분에 펩타이드를 융합, 첨가하므로 면역반응에서 항체유도의 면역응답반응에 어떠한 효과를 나타내는지 비교해 보고자 하였다. B_(4)펩타이드의 N-말단에 HBV의preS2 펩티드를 융합시킨 B_(4)T의 N-말단데 또다른 B세포 에피도프 펩티드를 융합시킨 B_(4)N을 작성하였다, 세종류의 하이브리드 펩타이드 중에서 B_(4)N이 B_(4)에 대한 항체유도능이 가장 효율적이다,. 이상의 결과로 B cell epitope과 T-helper cell epitope의 방향성이 체액성 면역 반응에서 항원유도능을 결정하는 중요한 요소임을 확인하였다.
( Su Jin Yoo ),( Jeong Chan Lee ),( Young Kim ),( In Seol Yoo ),( Seung Cheol Shim ),( Kun Ho Kim ),( Seong Wook Kang ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.6
Giant cell arteritis (GCA) is a systemic vasculitis which typically occurs in persons over 50 years old. GCA is closely related to polymyalgia rheumatica (PMR). A temporal artery biopsy is the gold standard test for the diagnosis of GCA. Recently, there is increasing evidence for the role of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) in diagnosis of vasculitis. Here, we report on a case of a 67-year-old Korean male who was diagnosed with atypical GCA in subclinical stage concomitant with PMR by (18)F-FDG-PET. After treatment, abnormal findings of (18)F-FDG-PET were improved. (J Rheum Dis 2015;22:382-386)
Yoo, Su-Zi,No, Mi-Hyun,Heo, Jun-Won,Park, Dong-Ho,Kang, Ju-Hee,Kim, Joon-Hee,Seo, Dae-Yun,Han, Jin,Jung, Su-Jeen,Kwak, Hyo-Bum Korean Continence Society 2019 International Neurourology Journal Vol.23 No.S1
<P><B>Purpose</B></P><P>This study aimed to investigate the effects of single-bout exercise on mitochondrial function, dynamics (fusion, fission), and mitophagy in cardiac and skeletal muscles.</P><P><B>Methods</B></P><P>Fischer 344 rats (4 months old) were randomly divided into the control (CON) or acute exercise (EX) group (n=10 each). The rats performed a single bout of treadmill exercise for 60 minutes. Mitochondrial function (e.g., O<SUB>2</SUB> respiration, H<SUB>2</SUB>O<SUB>2</SUB> emission, Ca<SUP>2+</SUP> retention capacity), mitochondrial fusion (e.g., Mfn1, Mfn2, Opa1), mitochondrial fission (e.g., Drp1, Fis1), and mitophagy (e.g., Parkin, Pink1, LC3II, Bnip3) were measured in permeabilized cardiac (e.g., left ventricle) and skeletal (e.g., soleus, white gastrocnemius) muscles.</P><P><B>Results</B></P><P>Mitochondrial O<SUB>2</SUB> respiration and Ca<SUP>2+</SUP> retention capacity were significantly increased in all tissues of the EX group compared with the CON group. Mitochondrial H<SUB>2</SUB>O<SUB>2</SUB> emissions showed tissue-specific results; the emissions showed no significant differences in the left ventricle or soleus (type I fibers) but was significantly increased in the white gastrocnemius (type II fibers) after acute exercise. Mitochondrial fusion and fission were not altered in any tissues of the EX group. Mitophagy showed tissue-specific differences: It was not changed in the left ventricle or white gastrocnemius, whereas Parkin and LC3II were significantly elevated in the soleus muscle.</P><P><B>Conclusions</B></P><P>A single bout of aerobic exercise may improve mitochondrial function (e.g., O<SUB>2</SUB> respiration and Ca<SUP>2+</SUP> retention capacity) in the heart and skeletal muscles without changes in mitochondrial dynamics or mitophagy.</P>
홈헬스케어용 온열기기의 성능평가를 위한 표준시험방법 연구
박수강(Su-Kang Park),김재환(Jae-Hwan Kim),김용성(Yong-Sung Kim),유선국(Sun-Kuk Yoo),강영규(Yeong-Gyu Kang),정희교(Hui-Gyo Jeong) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7
홈헬스케어용으로 사용되는 온열기기의 오동작이나 안전사고에 대한 예방으로 품질향상과 안전성확보가 필요하며 이를 위한 시판전의 시험검사나 시판후의 수거검사시에 성능시험과 안전장치검사가 필요하다. 본 논문에서는 개인용온열기의 안전성 확보와 성능평가를 위한 표준시험방법을 연구하였다.