프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

자가 골수 기질세포이식을 이용한 대퇴골두의 무혈성 괴사 및 장관골 골낭종의 치료

이승구,권순용,정진화,정도현,이주형,최숭욱 대한정형외과학회 골.연부조직이식학회 2003 대한골.연부 조직이식학회지 Vol.3 No.2

Plane Stress 상태와 Plane Strain 상태에서의 피로균열 성장 거동에 관한 연구

최용식,이주섭 成均館大學校 科學技術硏究所 1987 論文集 Vol.38 No.1

This paper is concerned with the fatigue crack growth rates for both the plane stress and the plane strain conditions. In general, the specimen surface may be assumed to satisfy the plane stress condition and inner part of specimen the plane strain condition. As the specimen material, PMMA was selected. Crack length was measured both at the inner part of specimen and on the specimen surface. Since PMMA is transparent, the inner part crack length could be measured exactly. Center cracked tension (CCT) specimens which were recommened by ASTM Standard E647-85 were used in the testing proceses. In order to analyze da/dN-ΔG relation, G-K relation was applied to both test conditions, the plane stress and the plane strain. From the experimental studies, following conclusions were obtained. 1) Concerning with the relation of da/dN-ΔK the value of m for plane strain condition is appeared greater than that of plane stress condition. 2) As the thickness increases, the difference between the value of m in the plane strain condition and in the plane stress condition becomes rather greater. 3) The power of the exponential relation between da/dN and ΔG; da/dN=C(ΔG)^m appears similar to that of the relation; da/dN=C'(ΔK)^m' ; m??m'. 4) The value of m is constant for plane stress condition. The value of m for PMMA is approximately 3.5.

大學敎育에 있어서 農村生活實習의 敎育效果와 地域社會에 미치는 影響

高凰京,鄭淳子,李因敦,安容泰,李動榮,金信一,李玉周 서울여자대학교 1975 서울여자대학논문집 Vol.- No.4

흑연-메소페이스핏치 복합재료의 열이방성

유승곤,김영일,이보성,주혁종 忠南大學校 産業技術硏究所 1986 산업기술연구논문집 Vol.1 No.1

In the development of thermal anisotropic materials with natural graphite powder and pitches as raw materials, extruding and hot-press method were investigated. Pitches should be reformed to mesophase pitch precursor by thermal pretreatment for using as a binder, and the heating rate was recommended within 0.2℃/min in the carbonization process. The tensile strength of axial direction of all specimens was about three times larger than that of radial direction and it could be increased about 25-60% by adding 1% chopped carbon fiber. The thermal expansion coefficient of axial direction was about 1/3-1/5 than that of radial direction and the thermal expansion was repressed by adding carbon fiber. The thermal conductivity of carbon fiber added specimens was increased with increasing the temperature, while that of without carbon fiber was decreased. The thermal conductivity of axial direction was about 8.0-4.58 times larger than that of radial direction by adding carbon fiber in the range of 0-400℃. As a general, properties of hot-pressed specimens were better than those of extruded specimens.

양악 전방분절골절단술과 이부 성형술을 통한 개방교합의 치험례

황용인Yong-In Hwang,홍순민Sun-Min Hong,박준우Jun-Woo Park,이건주Gun-Joo Rhee,조형준Hyung-Jun Cho,천세환Se-Hwan Cheon,박양호Yang-Ho Park 대한구강악안면외과학회 2008 대한구강악안면외과학회지 Vol.34 No.3

Skeletal anterior open bite is a difficult problem to correct in orthodontic treatment. To treat adult patients who have skeletal anterior open bite, we considered two methods. Combination treatment of orthodontics & surgery and camouflage orthodontic treatment. In adults, treatment of severe skeletal anterior open bite consists mainly of surgically repositioning the maxilla or the mandible. However, camouflage therapy is often the treatment of choice for skeletal open bite patients who have mild to moderate skeletal discrepancies when growth modification is no longer possible. But excellent results generally require careful coordination of the orthodontic and surgical phases of treatment. This is a case report of a skeletal anterior open bite patients who were treated with orthodontic treatment and orthognathic surgery. First case was diagnosed as skeletal class I malocclusion & bimaxillary protrusion with anterior open bite, and finally treatment ended for removal of open bite with orthodontic procedure and bimaxillary anterior segmental osteotomy surgery. Second case was diagnosed as skeletal class II malocclusion with open bite & mandibular retrusion, and was treated with only camouflage orthodontics because she feared to have a surgery. In a regular follow up visit after debonding we proposed to the patient advanced genioplasty, and in her agreement her facial esthetics was improved through the surgery.

Comparison of Fusion with Cage Alone and Plate Instrumentation in Two-Level Cervical Degenerative Disease

Joo, Yong-Hun,Lee, Jong-Won,Kwon, Ki-Young,Rhee, Jong-Joo,Lee, Hyun-Koo The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.48 No.4

Objective : This study assessed the efficacy of anterior cervical discectomy and fusion (ACDF) with cage alone compared with ACDF with plate instrumentation for radiologic and clinical outcomes in two-level cervical degenerative disease. Methods : Patients with cervical degenerative disc disease from September 2004 to December 2009 were assessed retrospectively. A total of 42 patients received all ACDF at two-level cervical lesion. Twenty-two patients who underwent ACDF with cage alone were compared with 20 patients who underwent ACDF with plate fixation in consideration of radiologic and clinical outcomes. Clinical outcomes were assessed using Robinson's criteria and posterior neck pain, arm pain described by a 10 point-visual analog scale. Fusion rate, subsidence, kyphotic angle, instrument failure and the degenerative changes in adjacent segments were examined during each follow-up examination. Results : VAS was checked during each follow-up and Robinson's criteria were compared in both groups. Both groups showed no significant difference. Fusion rates were 90.9% (20/22) in ACDF with the cage alone group, 95% (19/20) in ACDF with the plate fixation group (p = 0.966). Subsidence rates of ACDF with cage alone were 31.81% (7/22) and ACDF with plate fixation were 30% (6/20) (p = 0.928). Local and regional kyphotic angle difference showed no significant difference. At the final follow-up, adjacent level disease developed in 4.54% (1/22) of ACDF with cage alone and 10% (2/20) of ACDF with plate fixation (p= 0.654). Conclusion : In two-level ACDF, ACDF with cage alone would be comparable with ACDF with plate fixation with regard to clinical outcome and radiologic result with no significant difference. We suggest that the routine use of plate and screw in 2-level surgery may not be beneficial.

Simple method for the temporal characterization of amplified spontaneous emission in femtosecond terawatt Ti:sapphire lasers

Cha, Yong-Ho,Lee, Yong-Woo,Nam, Sung Mo,Han, Jae Min,Rhee, Yong Joo,Yoo, Byung Duk,Lee, Byoung Chul,Jeong, Young Uk The Optical Society 2007 Applied Optics Vol.46 No.28

<P>We have analyzed the temporal characteristics of amplified spontaneous emission (ASE) in femtosecond terawatt Ti:sapphire lasers by using a simple method based on fast photodiodes. Instead of measuring ASE directly with fast photodiodes, we created a narrow gap in the spectrum of seed pulses and, after amplification, detected the pure ASE signal through the gap by using a fast photodiode covered with a bandpass filter with high transmission at the gap. Because the detected ASE signal was completely separated from amplified main pulses, preceding and even trailing ASEs could be characterized quantitatively in a single-shot measurement. We believe that our method is a good alternative or a complement to conventional methods for ASE measurements.</P>

Development of a 10-TW, 27-fs Ti:sapphire Laser System at KAERI

Lee Yong Woo,Yi Jonghoon,Cha Yong Ho,Han Jae Min,Jeong Young Uk,Lee Byoung Chul,Nam Sung Mo,Rhee Yong Joo,Yoo Byung Duk 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.1

We have developed a 10-TW Ti:sapphire laser system for the study of laser-driven radiation sources at Korea Atomic Energy Research Institute. The laser system utilized only one pump laser (1.5-J energy at 532 nm) for the amplifiers and produced 27-fs, 300-mJ pulses at a 10-Hz repetition rate. The whole laser system composed of an oscillator, a pulse stretcher, three amplifiers, and a pulse compressor was installed on a 1.5 m × 3.0 m optical table with a separate vacuum chamber for the pulse compressor. A broad amplified spectrum supporting a 20-fs pulse duration was obtained at 10-TW level and was compared with simulated results.頂?

사망한 노인을 개호한 배우자의 장기간 영향에 관한 연구

이용주 ( Yong Joo Rhee ) 대한보건협회 2014 대한보건연구 Vol.40 No.3

Objectives : This study examines spouses’ depressive symptoms before and after end-of- life-care and its long-term effects. Methods : Health and Retirement Study (HRS), EXIT surveys were used to identify spouses of decedents who lived at homes before death from 1996 to 2004. The HRS measures depressive symptoms with a short version of the standard Center for Epidemiologic Studies Depression scale (CES-D). We identified active depression (CES-D>= 3). Logistic regression for multivariate analyses was used to examine the factors of depressive symptoms prior and post EOL care. Results : Among 1,335 spouses providing end-of-life care for the past ten years, 69.44 % were female and 78.95% were white. The average age was 79.12 years. The average CES-D scores significantly increased from two years before their spouses’ death (2.13) and at the time period of their spouses’ death (2.80) (p<0.001). Over half (60.00%) had active depressive symptoms at the time of their spouses’ death. The rate decreased 2 years later (40.75%). Primary caregiver, spouses who had memory problem, psychiatric problems, diabetes were more likely to suffer from depressive symptoms post to EOL care period. Conclusion : This study provides evidence of the intensity of end-of-life care and long- term effect on spouse caregivers` depressive symptoms.