프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

자가 골수 기질세포이식을 이용한 대퇴골두의 무혈성 괴사 및 장관골 골낭종의 치료

이승구,권순용,정진화,정도현,이주형,최숭욱 대한정형외과학회 골.연부조직이식학회 2003 대한골.연부 조직이식학회지 Vol.3 No.2

Plane Stress 상태와 Plane Strain 상태에서의 피로균열 성장 거동에 관한 연구

최용식,이주섭 成均館大學校 科學技術硏究所 1987 論文集 Vol.38 No.1

This paper is concerned with the fatigue crack growth rates for both the plane stress and the plane strain conditions. In general, the specimen surface may be assumed to satisfy the plane stress condition and inner part of specimen the plane strain condition. As the specimen material, PMMA was selected. Crack length was measured both at the inner part of specimen and on the specimen surface. Since PMMA is transparent, the inner part crack length could be measured exactly. Center cracked tension (CCT) specimens which were recommened by ASTM Standard E647-85 were used in the testing proceses. In order to analyze da/dN-ΔG relation, G-K relation was applied to both test conditions, the plane stress and the plane strain. From the experimental studies, following conclusions were obtained. 1) Concerning with the relation of da/dN-ΔK the value of m for plane strain condition is appeared greater than that of plane stress condition. 2) As the thickness increases, the difference between the value of m in the plane strain condition and in the plane stress condition becomes rather greater. 3) The power of the exponential relation between da/dN and ΔG; da/dN=C(ΔG)^m appears similar to that of the relation; da/dN=C'(ΔK)^m' ; m??m'. 4) The value of m is constant for plane stress condition. The value of m for PMMA is approximately 3.5.

大學敎育에 있어서 農村生活實習의 敎育效果와 地域社會에 미치는 影響

高凰京,鄭淳子,李因敦,安容泰,李動榮,金信一,李玉周 서울여자대학교 1975 서울여자대학논문집 Vol.- No.4

흑연-메소페이스핏치 복합재료의 열이방성

유승곤,김영일,이보성,주혁종 忠南大學校 産業技術硏究所 1986 산업기술연구논문집 Vol.1 No.1

In the development of thermal anisotropic materials with natural graphite powder and pitches as raw materials, extruding and hot-press method were investigated. Pitches should be reformed to mesophase pitch precursor by thermal pretreatment for using as a binder, and the heating rate was recommended within 0.2℃/min in the carbonization process. The tensile strength of axial direction of all specimens was about three times larger than that of radial direction and it could be increased about 25-60% by adding 1% chopped carbon fiber. The thermal expansion coefficient of axial direction was about 1/3-1/5 than that of radial direction and the thermal expansion was repressed by adding carbon fiber. The thermal conductivity of carbon fiber added specimens was increased with increasing the temperature, while that of without carbon fiber was decreased. The thermal conductivity of axial direction was about 8.0-4.58 times larger than that of radial direction by adding carbon fiber in the range of 0-400℃. As a general, properties of hot-pressed specimens were better than those of extruded specimens.

Comparison of Fusion with Cage Alone and Plate Instrumentation in Two-Level Cervical Degenerative Disease

Joo, Yong-Hun,Lee, Jong-Won,Kwon, Ki-Young,Rhee, Jong-Joo,Lee, Hyun-Koo The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.48 No.4

Objective : This study assessed the efficacy of anterior cervical discectomy and fusion (ACDF) with cage alone compared with ACDF with plate instrumentation for radiologic and clinical outcomes in two-level cervical degenerative disease. Methods : Patients with cervical degenerative disc disease from September 2004 to December 2009 were assessed retrospectively. A total of 42 patients received all ACDF at two-level cervical lesion. Twenty-two patients who underwent ACDF with cage alone were compared with 20 patients who underwent ACDF with plate fixation in consideration of radiologic and clinical outcomes. Clinical outcomes were assessed using Robinson's criteria and posterior neck pain, arm pain described by a 10 point-visual analog scale. Fusion rate, subsidence, kyphotic angle, instrument failure and the degenerative changes in adjacent segments were examined during each follow-up examination. Results : VAS was checked during each follow-up and Robinson's criteria were compared in both groups. Both groups showed no significant difference. Fusion rates were 90.9% (20/22) in ACDF with the cage alone group, 95% (19/20) in ACDF with the plate fixation group (p = 0.966). Subsidence rates of ACDF with cage alone were 31.81% (7/22) and ACDF with plate fixation were 30% (6/20) (p = 0.928). Local and regional kyphotic angle difference showed no significant difference. At the final follow-up, adjacent level disease developed in 4.54% (1/22) of ACDF with cage alone and 10% (2/20) of ACDF with plate fixation (p= 0.654). Conclusion : In two-level ACDF, ACDF with cage alone would be comparable with ACDF with plate fixation with regard to clinical outcome and radiologic result with no significant difference. We suggest that the routine use of plate and screw in 2-level surgery may not be beneficial.

양악 전방분절골절단술과 이부 성형술을 통한 개방교합의 치험례

황용인Yong-In Hwang,홍순민Sun-Min Hong,박준우Jun-Woo Park,이건주Gun-Joo Rhee,조형준Hyung-Jun Cho,천세환Se-Hwan Cheon,박양호Yang-Ho Park 대한구강악안면외과학회 2008 대한구강악안면외과학회지 Vol.34 No.3

Skeletal anterior open bite is a difficult problem to correct in orthodontic treatment. To treat adult patients who have skeletal anterior open bite, we considered two methods. Combination treatment of orthodontics & surgery and camouflage orthodontic treatment. In adults, treatment of severe skeletal anterior open bite consists mainly of surgically repositioning the maxilla or the mandible. However, camouflage therapy is often the treatment of choice for skeletal open bite patients who have mild to moderate skeletal discrepancies when growth modification is no longer possible. But excellent results generally require careful coordination of the orthodontic and surgical phases of treatment. This is a case report of a skeletal anterior open bite patients who were treated with orthodontic treatment and orthognathic surgery. First case was diagnosed as skeletal class I malocclusion & bimaxillary protrusion with anterior open bite, and finally treatment ended for removal of open bite with orthodontic procedure and bimaxillary anterior segmental osteotomy surgery. Second case was diagnosed as skeletal class II malocclusion with open bite & mandibular retrusion, and was treated with only camouflage orthodontics because she feared to have a surgery. In a regular follow up visit after debonding we proposed to the patient advanced genioplasty, and in her agreement her facial esthetics was improved through the surgery.

코로나 팬데믹 이후 치매 노인환자 비공식 가족돌봄의 실태와 영향 요인

이용주(Yong-Joo Rhee) 대한고령친화산업학회 2023 대한고령친화산업학회지 Vol.15 No.2

연구목적 본 연구는 팬데믹 이후 지역사회 치매노인환자 돌봄의 실태와 돌봄의 변화를 알아보고, 비공식 가족돌봄에 영향을 미치는 대한 요인을 알아보고자 하였다. 연구방법 한국고령화패널(KLoSA) 7차와 8차 데이터에서 치매로 진단 받거나 인지능력(K-MMSE)에서 치매로 의심되는 1,305명을 연구 대상자로 선정하였다. 총돌봄시간과 관련 요인을 총돌봄 양에 미치는 요인을 알아보기 위해 다중 선형회귀분석을 실시하였다. 연구결과 팬데믹 이후 가족구성원 수가 유의하게 증가하였다. 단독 독거노인과 단독 노인부부의 비율 감소하였고, 노인 부부와 자녀 동거가구와 노인 부부와 다른 가족 동거 가구 비율이 유의하게 증가하였다. 반면, 총돌봄시간은 팬데믹 이전 평균 6.17시간에서 5.08시간으로 감소를 보였다. 치매노인의 총돌봄 시간은 일상생활수행능력의 의존도, 우울증, 가구의 총소득과 양적인 유의한 상관관계를 나타났다. 결론 지역사회 치매 노인환자의 돌봄 요구에 영향을 미치는 요인과 돌봄자 및 가구 특성에 맞는 다양한 맞춤형 프로그램을 강화하는게 필요하다고 보여진다. Objective : This study aimed to examine the state and changes in caregiving for the older patients with dementia in the community after the pandemic and to identify factors affecting informal family caregiving. Methods : Using Korean Longitudinal Study of Aging (KLoSA) data from its 7th and 8th waves, 1,305 diagnosed or suspected dementia cases were examined. Multiple linear regression analysis explored factors influencing total care time. Results : Post-pandemic, family size significantly increased, with a decline in older people living alone or as couples and a notable rise in older couples living with children or other family. Despite this, total care time decreased from 6.17 to 5.08 hours. Care time for the older patients with dementia correlated significantly with daily living dependence, depression, and household income. Conclusion : The study emphasizes tailored programs, aligning with caregiver and household traits, to address the needs of local community dementia patients effectively.

Simple method for the temporal characterization of amplified spontaneous emission in femtosecond terawatt Ti:sapphire lasers

Cha, Yong-Ho,Lee, Yong-Woo,Nam, Sung Mo,Han, Jae Min,Rhee, Yong Joo,Yoo, Byung Duk,Lee, Byoung Chul,Jeong, Young Uk The Optical Society 2007 Applied Optics Vol.46 No.28

<P>We have analyzed the temporal characteristics of amplified spontaneous emission (ASE) in femtosecond terawatt Ti:sapphire lasers by using a simple method based on fast photodiodes. Instead of measuring ASE directly with fast photodiodes, we created a narrow gap in the spectrum of seed pulses and, after amplification, detected the pure ASE signal through the gap by using a fast photodiode covered with a bandpass filter with high transmission at the gap. Because the detected ASE signal was completely separated from amplified main pulses, preceding and even trailing ASEs could be characterized quantitatively in a single-shot measurement. We believe that our method is a good alternative or a complement to conventional methods for ASE measurements.</P>