Characterization and mapping of a Prbs gene controlling spike development in Hordeum vulgare L.

Yi Shang,Jianming Yang,Jinghuan Zhu,Wei Hua,Junmei Wang,Qiaojun Jia 한국유전학회 2014 Genes & Genomics Vol.36 No.3

The barley mutant, poly-row-and-branchedspike (prbs) showed altered inflorescence morphology:complete conversion of the rudimentary lateral spikelets intwo-rowed barley into fully developed fertile spikeletssimilar to the six-rowed phenotype, and additional spikeletsin the middle of spike. Moreover, branched spikes emergedin progeny from a cross between the mutant and a sixrowedbarley cultivar. Morphological observation of thedevelopment of immature spikes of the mutant anddescendants with branched spikes showed that the Prbsgene is involved in spikelet development in the triplemoundstage. In mutant prbs, new meristems initiated atthe flanks of lateral spikelets and middle spikelet meristemswere converted to branch meristems, developing branchedspikes. These observations suggested that the Prbs geneplays a crucial role in spikelet initiation and identitymaintenance. The Prbs gene may be an important modifierin inflorescence differentiation from a panicle into a spike. The branched spikes emerging in hybrids from a crossbetween the mutant and six-rowed barley cultivar were notconferred by the gene vrs1 or Int-c, which decide spikemorphology in six-rowed barley. These results imply thatalthough six-row genes vrs1 and Int-c and prbs have similareffects on lateral spikelet development, they have differentfunctions in branched spikes. The Prbs gene wasmapped to chromosome 3H between SSR markerBmag0023 and marker Cbic60 at a genetic distance of 3.3and 5.4 centimorgans (cM), respectively.

Life-Style Habits in a High-Risk Area for Upper Gastrointestinal Cancers: a Population-Based Study from Shanxi, China

Cheng, Yi-Kun,Yao, Shang-Man,Xu, Yi-Ran,Niu, Run-Gui Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

Background: Cancer is a burden on humanity and ranks as a leading cause of morbidity and mortality in China. Shanxi province has its unique cancer patterns and the burden is increasing. In this study, we aimed to assess the pattern of dietary habits and life-style in Shanxi, a high-risk area for upper gastrointestinal cancers in China and further evaluate the trends in cancer incidence and mortality based on registered data. Materials and Methods: Data on lifestyle, diet, physical activity were obtained from the household health survey at Zhongyang from 2013 to 2015. Cancer diagnoses were reported to Shanxi Center for Disease Control and Prevention (SCDCP). Population-based cancer incidence data and mortality data of 2012 were collected from the SCDCP. All incidence and death rates were expressed per 100,000 populations. Univariate analysis was performed using the Chi-squared test or Fisher's exact test. Results: Overall, deficiencies in fresh fruits and vegetable food, and intake of hot food, salted food, or pickled food are serious problems in Shanxi, especially in rural areas. Upper gastrointestinal cancers were the most commonly diagnosed cancers, and the incidence in rural areas is higher than those in urban areas. Cervical cancer is the most common cancer for females. Moreover, the agespecific incidence exhibited an increased trend before 40 years old. Consistent with the previous literature, our epidemiological investigation results suggest that lifestyle, nutrition deficient, and infections were major risk factors for upper gastrointestinal cancers or cervical cancer in Shanxi. Facing a serious situation, we further explored defensible recommendations for the general public in order to promote changes in environments that support healthful eating and physical activity habits, to reduce cancer risk. Conclusions: Our results present the current cancer trends in Shanxi and its related etiologic risk factors and provide a theoretical basis to guide public health efforts to prevent and control cancers in the province.

Influence of the MACC1 Gene on Sensitivity to Chemotherapy in Human U251 Glioblastoma Cells

Shang, Chao,Hong, Yang,Guo, Yan,Liu, Yun-Hui,Xue, Yi-Xue Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

Background: This study was conducted to determine the influence of MACC1 expression on chemotherapy sensitivity in human U251 glioblastoma cells. Materials and Methods: Expression of the MACC1 gene in 49 cases of human brain glioma was determined by quantitative real-time PCR. Silencing effects of RNA interference on MACC1 was detected by Western-blotting. Flow cytometry methods and methyl thiazolyl tetrazolium assay (MTT) were used to determine the apoptosis and growth inhibitory rates of the U251 cells with MACC1 silencing. before and after treatment with cisplatin (DDP). Results: MACC1 mRNA in gliomas was up-regulated remarkably, to 158.8% of that in peri-cancerous tissues (P<0.05). The siRNA-MACC1 could inhibit the expression of MACC1 protein significantly (p<0.05), associated with an increase in apoptosis rate from 2.57% to 5.39% in U251 cells and elevation of the growth inhibitory rate from 1.5% to 17.8% (p<0.05 for both). After treatment with DDP at various concentrations (1, 3, $5{\mu}g/ml$), compared with control U251 cells, the apoptosis rate of MACC1-silenced U251 cells rose from 8.41%, 13.2% and 19.5% to 12.8%, 17.8% and 25.8%; the growth inhibitory rate increased from 16.2%, 19.3% and 24.5% to 23.7%, 28.4% and 36.3%. Conclusions: There is a notable relationship between over-expression of MACC1 and the characteristics of glioma cells. Silencing of MACC1 was found to enhance the apoptosis and growth inhibitory rates of U251 glioma cells, and thereby increase their sensitivity to DDP chemotherapy.

브롬화된 부틸고무의 탈브롬화 및 이성질체화 메커니즘에 대한 연구

Yi Bo Wu,Wen Li Guo,Shu Xin Li,Liang Ga Gong,Yu Wei Shang 한국고분자학회 2010 폴리머 Vol.34 No.1

Management of Gallstones and Acute Cholecystitis in Patients with Liver Cirrhosis: What Should We Consider When Performing Surgery?

( Shang Yu Wang ),( Chun Nan Yeh ),( Yi Yin Jan ),( Miin Fu Chen ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Gut and Liver Vol.15 No.4

Acute cholecystitis and several gallbladder stone-related conditions, such as impacted common bile duct stones, cholangitis, and biliary pancreatitis, are common medical conditions in daily practice. An early cholecystectomy or drainage procedure with delayed cholecystectomy is the current standard of treatment based on published clinical guidelines. Cirrhosis is not only a condition of chronically impaired hepatic function but also has systemic effects in patients. In cirrhotic individuals, several predisposing factors, including changes in the bile acid composition, increased nucleation of bile, and decreased motility of the gallbladder, contribute to the formation of biliary stones and the possibility of symptomatic cholelithiasis, which is an indication for surgical treatment. In addition to these predisposing factors for cholelithiasis, systemic effects and local anatomic consequences related to cirrhosis lead to anesthesiologic risks and perioperative complications in cirrhotic patients. Therefore, the treatment of the aforementioned biliary conditions in cirrhotic patients has become a challenging issue. In this review, we focus on cholecystectomy for cirrhotic patients and summarize the surgical indications, risk stratification, surgical procedures, and surgical outcomes specific to cirrhotic patients with symptomatic cholelithiasis. (Gut Liver 2021;15:517-527)

인공지능 음성사용자 인터페이스 사용성 평가 기준 검증 : 중국 내비게이션 VUI를 중심으로

주이모(Yi Mou Zhou),상님여(Lin Rru Shang),임현찬(Hyun Chan Lim),황미경(Mi Kyung Hwang) 한국멀티미디어학회 2021 멀티미디어학회논문지 Vol.24 No.7

Fluid Solid Coupling Analysis of Large Underground Oil Storage Caverns in Containment of Groundwater

Yang Shang-Yang,Li Shu-Cai,Xue Yi-Guo,Zhang Qing-Song 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.11

Triaxial compression tests had been performed to determine the properties of the rock mass around unlining underground crude oil a storage cavern which was the first one in China. The execution situation of the tunnel project and the seepage law of groundwater were taken into account. The stress and the seepage field around the tunnel in different working states were simulated by applying Comsol around a underground crude oil storage caverns. According to the test results, it was found that the excavation process may arise the local damage. The extension of the loose zone induced by excavation ranged from 0 to 15.6 m, depending on the buried depth of the caverns. According to numerical simulation results, the crown settlement and stress concentration was depended on the buried depth and the water pressure distribution after excavation of the main cavity. This research results can provide the reference for analysis on the stability of the underground cavities under low stress level and on the water sealed underground petroleum storage rock caverns.

High speed grinding characteristics and machinability of WC-10Co-4Cr coatings deposited via high velocity oxygen fuel spraying

Zhentao Shang,Cheng Xu,Guizhi Xie,Jun Yi,Han Huang 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.7

Tungsten carbide cobalt coatings are widely employed for fabricating the parts used in corrosive and abrasive environments. The coatings are often deposited on substrates via high velocity oxygen fuel spraying, which are relatively hard and brittle and difficult to machine. This work systematically investigated the effect of high speed grinding conditions on the removal characteristics and machinability of WC-10Co-4Cr coatings. The wheel speed was found to have significant effect on grinding force and temperature. The subsurface damage could be considerably reduced when the grinding conditions were judiciously selected. The high speed grinding process being developed produced a satisfactory subsurface damage layer of smaller than 15 mm without spalling and large cracking that were usually observed in conventional grinding, suggesting its suitability for post-processing of the coating/substrate system.

Radiotherapy combined with chemotherapy increases the risk of herpes zoster in patients with gynecological cancers: a nationwide cohort study

Peng-Yi Lee,Jung-Nien Lai,Shang-Wen Chen,Ying-Chun Lin,Lu-Ting Chiu,Yu-Ting Wei 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2

Objective: This study aimed to determine the effect of radiotherapy (RT) on the risk of herpeszoster (HZ) in patients with gynecological cancers via a nationwide population-based study. Methods: Based on patient data obtained from the National Health Insurance ResearchDatabase, 1928 gynecological cancer patients were identified with 1:1 matching for RT andnon-RT cohorts by age, index date, and cancer type. Another cohort consisting of 964 non cancer individuals matched was used as normal control. The incidence of HZ was comparedbetween cancer patients with and without RT. Age, comorbidities, cancer-related surgery andchemotherapy (CT), and cancer type were adjusted as confounders. Results: The risk of HZ in cancer patients was higher than that of non-cancer individuals(14.23 versus 8.34 per 1,000 person-years [PY], the adjusted hazard ratio [aHR]=1.38,p=0.044). In the cancer population, the incidence of HZ for the RT and non-RT cohorts was20.55 versus 10.23 per 1,000 PY, respectively (aHR=1.68, p=0.009). Age >50 years was anindependent factor for developing HZ. The 5-year actuarial incidence for patients receivingneither RT nor CT, RT alone, CT alone, and combined modalities was 5.4%, 6.9%, 3.7%,and 9.9%, respectively (p<0.001). In the RT cohort, the risk rose rapidly in the first year,becoming steady thereafter. Conclusion: This population-based study showed that gynecological cancer patientsreceiving RT combined with CT had the highest cumulative risk of HZ. Health careprofessionals should be aware of the potential toxicities.

Finite Element Analysis on Mechanical Behaviour of Yungui Railway Tunnel in Shallow and Unsymmetrical Strata

Yang Shang-Yang,Li Shu-Cai,Xue Yi-Guo,Zhang Qing-Song 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.10

Triaxial compression tests had been performed to determine the properties of the surrounding rock. The displacement and stress of surrounding rock had been analyzed according to Silin 2 at Yungui railway under three kinds of conditions: the initial state, excavation without supporting , and supporting after excavation. Plane strain FEM was established to analyze the stability of the surrounding rock. Contrasted the monitor measuring data, the results showed that the most unfavorable position in the tunnel was found at the ridge side of the arch, and the implementation of support afforded to ensure the stability of surrounding rock, and the design of the early support approach had the ability to meet the safety requirements. The results had certain significance for understanding the mechanical behavior of shallow tunnel in unsymmetrical strata. tunnel, mechanical behaviour, numerical simulation, deformation, stability.