한국 비만 여성의 신체 계측에 의한 체지방 추정

심경원,김지연,서희선,이홍수,이상화,강지현 대한비만학회 2002 The Korean journal of obesity Vol.11 No.2

연구배경 : 국내 비만 여성을 대상으로 비용이 적게 들고 단순하면서도 보다 정확하게 체지방률을 추정할 수 있는 체지방률 추정식을 작성함으로써 쉽게 체지방률과 조절해야하는 지방의 양을 판단할 수 있도록 하고자 한다. 방법 : 이대목동병원 비만클리닉을 처음으로 내원한 19세 이상의 성인 여자 607명 중 체질량지수가 25 kg/㎡ 이상인 500명을 연구대상으로 하여 목, 가슴, 허리, 엉덩이, 대퇴, 하퇴, 발목, 상완, 전완, 손목의 10부위의 둘레와 생체전기저항분석법 (bioelectrical impedance analysis, BIA) 방식의 체성분 분석기를 이용하여 체지방률을 측정하였다. 체지방률 추정식을 구하기 위해 BIA에 의한 체지방률을 종속변수로 하고 , 신체 둘레 계측기 및 신장, 체중, 체질량지수, 연령을 독립변수로 하여 단계별 다중회귀분석 (multiple stepwise regression)을 시행하였다. 결과 : 신장과 체중, 연령, 체질량지수 및 신체 둘레 측정치 중 체지방률을 반영하는 지표는 체질량 지수, 전완둘레, 신장, 엉덩이 둘레, 하퇴둘레였고, 이 다섯가지 지표를 이용한 체지방률 추정식은 66.1%의 예측력과 2.86%의 측정 오차를 나타냈다 (R^2=0.661, SEE=2.86). 결론 : 비만한 성인 여성에서 신장과 체중, 연령 및 신체 둘레 계측치를 이용한 본 연구의 추정식은 체지방률(%)을 적은 오차범위로 비교적 정확하게 반영하였다. Background : This study was conducted to develop a regression equation that accurately estimates body fat percentage using relatively easy and inexpensive method in adult obese Korean women. Method : Data were collected among 500 obese Korean women visiting obesity clinic in Ewha woman's university Mokdong hospital, Seoul, Korea. Height, weight, and circumferences at ten body sites (neck, chest, waist, hip, thigh, calf, ankle, arm, forearm, wrist) were measured s well as total body bioelectrical impedance. Results : The full regression equation estimates body fat percentage included six variables : BMI, forearm circumference, height, hip circumference, thigh circumference. This equation accounted for 66.1% of the variance in body weight measured by bioelectrical impedance, and their standard error of estimate was 2.86%. Conclusion : For the obese Korean women in this study, circumference measurements provided a s relatively good estimation of body fat percentage.

Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.

대학생의 쇼핑성향에 따른 백화점 의복 판매원의 평가 속성

김혜영,박하나,유연옥,이지혜,박혜선 배재대학교 자연과학연구소 2004 自然科學論文集 Vol.15 No.1

Pharmacokinetic comparison of two bazedoxifene acetate 20 mg tablet formulations in healthy Korean male volunteers

Ji-Sun Yeun,Hye-Su Kan,Minyu Lee,Namsick Kim,Tae-Young Oh,Seung-Kwan Nam,최윤석,In Sun Kwon,Jang Hee Hong 대한임상약리학회 2020 Translational and Clinical Pharmacology Vol.28 No.2

Bazedoxifene, used as bazedoxifene acetate, is a selective estrogen receptor modulatorthat selectively affects the uterus, breast tissue, bone metabolism, and lipid metabolism byantagonizing or enhancing estrogens in the estrogen receptor in the tissue. This study wasconducted as an open, randomized, two-period, two-treatment, crossover design to comparethe pharmacokinetic (PK) characteristics and tolerability of two bazedoxifene tablets whenadministered to 50 healthy Korean male volunteers. Enrolled subjects were randomlyallocated to 2 sequences of a single oral administration of a test drug and a reference drug,or vice versa with a 14-day washout period between the two doses. Serial blood sampleswere collected over 96 h for PK analysis. Plasma concentration of bazedoxifene was assayedusing liquid chromatography-tandem spectrometry mass. Forty-five participants completedthe study with no clinically relevant safety issues. The peak concentrations (Cmax, mean ±strandard deviation) of reference drug and test drug were 3.191 ± 1.080 and 3.231 ± 1.346ng/mL, respectively, and the areas under the plasma concentration‐time curve from 0 tothe last measurable concentration (AUClast) were 44.697 ± 21.168 ng∙h/mL and 45.902 ±23.130 ng∙h/mL, respectively. The geometric mean ratios of test drug to reference drug andtheir 90% confidence intervals for Cmax and AUClast were 0.9913 (0.8828–1.1132) and 1.0106(0.9345–1.0929), respectively. The incidence of adverse events between the two formulationswas similar. The present study showed that PK and tolerability of two bazedoxifene tabletformulations were comparable when administered to healthy Korean male volunteers.

Adiponectin Concentrations: A Genome-wide Association Study

Jee, Sun Ha,Sull, Jae Woong,Lee, Jong-Eun,Shin, Chol,Park, Jongkeun,Kimm, Heejin,Cho, Eun-Young,Shin, Eun-Soon,Yun, Ji Eun,Park, Ji Wan,Kim, Sang Yeun,Lee, Sun Ju,Jee, Eun Jung,Baik, Inkyung,Kao, Lind Elsevier 2010 American journal of human genetics Vol.87 No.4

<P>Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in <I>CDH13</I> on chromosome 16 (p = 1.69 × 10<SUP>−15</SUP> in the initial sample, p = 6.58 × 10<SUP>−39</SUP> in the second genome-wide sample, and p = 2.12 × 10<SUP>−32</SUP> in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10<SUP>−83</SUP>. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10<SUP>−58</SUP>) was even stronger in the third sample. A reporter assay that evaluated the effects of a <I>CDH13</I> promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in <I>CDH13</I> influence adiponectin levels in Korean adults.</P>

Bacillus subtilis HJ18-4를 이용하여 제조한 대맥장의 품질 특성

김지연(Ji Yeun Kim),이선영(Sun Young Lee),박나영(Na Young Park),최혜선(Hye Sun Choi) 한국식품과학회 2012 한국식품과학회지 Vol.44 No.6

별미장은 메주를 다른 방식으로 띄운다든가 대두 이외의 부재료를 섞어 특별한 맛을 낸 장 또는 계절에 따라 별미로 담아 먹는 단기장을 의미하며, 대맥장은 검정콩과 보리를 이용하여 만든 별미장이다. 본 연구에서는 효소 활성 및 항균 활성이 뛰어난 B. subtilis HJ18-4 균주를 이용하여 제조한 대맥장의 발효 중 품질 특성을 평가하였다. α-Amylase와 protease 활성은 발효 후 6 또는 9일째 급격히 상승했다가(41.45±0.3-42.72±0.16, 21.84±0.24-23.11± 0.35 unit/g), 이후 일정하거나 약간 감소하였으며, 환원당 함량은 α-amylase 활성과 일치하는 변화를 보여 발효 6일째 가장 높은 값을 나타내었으며 이후 감소하였다. 아미노태 질소 함량은 23일째 173.78±3.51-195.63±1.51 mg%까지 증가하다가 이후 비교적 일정하였으며, 암모니아태 질소 함량은 발효 후 6일째에 급격히 증가하였다가 9일째부터 다시 감소하였다. 혐기성 총균수와 유산균수는 발효 기간 중 약간 증가하였다가 감소하였으며, 유산균수가 7.91±0.05-8.17±0.02 log CFU/g으로 높은 값으로 나타났다. 효소 활성, 환원당 및 질소 함량, 혐기성 총균수와 유산균수는 처리구별 유의한 차이를 보이지는 않았으나 호기성 총균수와 B. cereus 생균수는 발효 30일에 B. subtilis HJ18-4 처리구가 대조구에 비하여 유의하게 낮은 수치를 보였으며, treat-2 보다 treat-1이 유의하게 낮았다. 다른 품질 특성은 비슷하면서 일반 세균과 B. cereus가 가장 낮게 검출되어 안전성이 우수한 treat-1의 경우, glutamic acid가 높은 값으로 나타나 관능적으로 우수할 것으로 판단되며, succinic acid와 lactic acid도 다량 검출되었다. 대맥장은 30일간 발효 시 가식 가능한 아미노태 질소가 생산되며, 암모니아태 질소 함량이 낮아져 불쾌취가 감소되고, 다량의 glutamic acid를 비롯한 아미노산과 유기산, 그리고 유산균이 풍부하여 관능성과 영양성이 우수한 것으로 평가되었다. 또한 B. subtilis HJ18-4 적용 메주를 이용하여 장을 제조하면 일반 세균과 B. cereus 억제 효과가 뛰어나 안전성이 확보되므로 여러 다른 장류에도 응용해 볼 수 있을 것이다. Black soybean paste (BSP) is a bealmijang manufactured with barley flour and black soybeans. This study investigated the quality characteristics of BSP prepared with Bacillus subtilis HJ18-4 (HJ18-4). α-Amylase and protease activities of BSP rapidly increased on day 6 and day 9, respectively, (41.45±0.3-42.72±0.16, 21.84±0.24-23.11±0.35 unit/ g) after which the activities were constant or decreased slightly. Amino type nitrogen contents increased until day 23 (173.78±3.51-195.63±1.51 mg %), whereas ammonia type nitrogen sharply decreased on day 9. On day 30, lactic acid bacteria counts were higher compared with the initial count (7.91±0.05-8.17±0.02 log CFU/g). Meanwhile, B. cereus and total aerobic counts in HJ18-4 added BSP were lower than that in the control. These results implied that BSP could be edible after 30 days of fermentation, and the addition of HJ18-4 in meju could contribute to the safety of the black soybean paste by the inhibition of B. cereus growth.

F-C9 : 2012서울시 수독물 급수과정별 시설에서의 수질 특성 조사

한지선 ( Ji Sun Han ),이은숙 ( Eun Sook Lee ),오승룡 ( Seoungr Young Ho ),이기선 ( Ki Sun Lee ),황동연 ( Dong Yeun Hwang ),장도일 ( Do Il Jang ),이경우 ( Kyung Woo Lee ),정번석 ( Bun Seok Jung ),이만호 ( Man Ho Lee ),최영준 ( Youn 한국물환경학회(구 한국수질보전학회) 2013 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2013 No.-

Ostwald Ripening Stability of Curcumin-Loaded MCT Nanoemulsion

Sun-Hyung Kim,Yeun-Sun Ji,Eui-Seok Lee,Soon-Taek Hong 한국식품영양과학회 2016 Preventive Nutrition and Food Science Vol.21 No.3

Curcumin is a flavonoid found in the rhizome of the turmeric plant (Curcuma longa L.) and has recently attracted interest because it has numerous biological functions and therapeutic properties. In the present study, we attempted to incorporate curcumin into medium-chain triglyceride (MCT) nanoemulsions (0.15 wt% curcumin, 10 wt% MCT oil, and 10 wt% emulsifiers) with various emulsifiers [polyoxyethylene (20) sorbitan monolaurate (Tween-20), sorbitan monooleate (SM), and soy lecithin (SL)]. The physicochemical properties of the nanoemulsions including the Ostwald ripening stability were investigated. The initial droplet size was found to be 89.08 nm for the nanoemulsion with 10 wt% Tween-20 (control), and when Tween-20 was partially replaced with SM and SL, the size decreased: 73.43 nm with 4 wt% SM+6 wt% Tween-20 and 67.68 nm with 4 wt% SL+6 wt% Tween-20 (prepared at 15,000 psi). When the nanoemulsions were stored for 28 days at room temperature, the droplet size increased as the storage time increased. The largest increase was observed for the control nanoemulsion, followed by the 4 wt% SL+6 wt% Tween-20 and 4 wt% SM+6 wt% Tween-20 systems. The Turbiscan dispersion stability results strongly supported the relationship between droplet size and storage time. The time-dependent increase in droplet size was attributed to the Ostwald ripening phenomenon. Thus, the Ostwald ripening stability of curcumin-loaded MCT nanoemulsions with Tween-20 was considerably improved by partially replacing the Tween-20 with SM or SL. In addition, curcumin may have acted as an Ostwald ripening inhibitor.

Effects of Improved Interior on Children’s Behavior

Yeun Sook Lee,Sun Mi Lee,Soo Hyun Choi,Ji Young Ahn 한국실내디자인학회 1995 한국실내디자인학회논문집 Vol.- No.5

Improvement of Methanol Dehydrogenases using Directed Evolution and Biological Methanol Sensor System for the Elimination of Formaldehyde

Ji-Yeun YI,Jung-Hoon SOHN,Seung Goo LEE,Sun Chang KIM,Bong Hyun SUNG 한국생물공학회 2013 한국생물공학회 학술대회 Vol.2013 No.10