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Epigenetics: Linking Nutrition to Molecular Mechanisms in Aging
Park, Joo Hyun,Yoo, Yeongran,Park, Yoon Jung The Korean Society of Food Science and Nutrition 2017 Preventive Nutrition and Food Science Vol.22 No.2
Healthy aging has become a major goal of public health. Many studies have provided evidence and theories to explain molecular mechanisms of the aging process. Recent studies suggest that epigenetic mechanisms are responsible for life span and the progression of aging. Epigenetics is a fascinating field of molecular biology, which studies heritable modifications of DNA and histones that regulate gene expression without altering the DNA sequence. DNA methylation is a major epigenetic mark that shows progressive changes during aging. Recent studies have investigated aging-related DNA methylation as a biomarker that predicts cellular age. Interestingly, growing evidence proposes that nutrients play a crucial role in the regulation of epigenetic modifiers. Because various nutrients and their metabolites function as substrates or cofactors for epigenetic modifiers, nutrition can modulate or reverse epigenetic marks in the genome as well as expression patterns. Here, we will review the results on aging-associated epigenetic modifications and the possible mechanisms by which nutrition, including nutrient availability and bioactive compounds, regulate epigenetic changes and affect aging physiology.
Epigenetics: Linking Nutrition to Molecular Mechanisms in Aging
Joo Hyun Park,Yeongran Yoo,Yoon Jung Park 한국식품영양과학회 2017 Preventive Nutrition and Food Science Vol.22 No.2
Healthy aging has become a major goal of public health. Many studies have provided evidence and theories to explain molecular mechanisms of the aging process. Recent studies suggest that epigenetic mechanisms are responsible for life span and the progression of aging. Epigenetics is a fascinating field of molecular biology, which studies heritable modifications of DNA and histones that regulate gene expression without altering the DNA sequence. DNA methylation is a major epigenetic mark that shows progressive changes during aging. Recent studies have investigated aging-related DNA methylation as a biomarker that predicts cellular age. Interestingly, growing evidence proposes that nutrients play a crucial role in the regulation of epigenetic modifiers. Because various nutrients and their metabolites function as substrates or cofactors for epigenetic modifiers, nutrition can modulate or reverse epigenetic marks in the genome as well as expression patterns. Here, we will review the results on aging-associated epigenetic modifications and the possible mechanisms by which nutrition, including nutrient availability and bioactive compounds, regulate epigenetic changes and affect aging physiology.
YeongRan Lee,MyungHa Lee,SookKyoung Park 한국재난정보학회 2013 한국재난정보학회 논문집 Vol.9 No.4
본 연구의 목적은 간호대학생을 위한 재난간호역량 측정할 수 있는 도구를 개발하기 위함이다. 자료수집은 270명의 간호대학생을 대상으로 실시하였으며, 재난간호역량의 핵심개념 도출, 예비도구의 문항개발, 내용타당도 검정 및 본 조사 도구의 문항 선정, 도구의 신뢰도와 타당도 평가과정을 거쳐 재난간호지식 11문항, 재난간호기술 11문항으로 구성된 재난간호역량 도구를 개발하였다. 이 도구는 앞으로 간호학생의 재난간호 역량을 확인하고 관련요인을 파악하는 연구에 활용될 수 있을 것이다.
녹차뿌리 특화 사포닌의 천연 계면 활성력을 이용한 새로운 안티폴루션 기작 연구
나혜원 ( Hye-won Na ),이영란 ( Yeongran Lee ),박준성 ( Jun Seong Park ),이태룡 ( Tae Ryoung Lee ),김형준 ( Hyoung-june Kim ) 대한화장품학회 2018 대한화장품학회지 Vol.44 No.1
녹차(Camellia sinensis L.)는 약용으로도 널리 사용되어 왔다. 하지만, 대부분의 연구는 녹차 잎을 연구의 대상으로 이루어졌으며, 지금까지도 잎 외의 다른 부분은 연구가 많이 이루어지지 않았다. 본 연구에서는 외부환경의 미세먼지(particulate matter 2.5; PM2.5)에 의한 normal human epidermal keratinocytes(NHEKs)의 손상을 뿌리 추출물이 효과적으로 보호할 수 있는 효과를 확인하였다. 30년 된 녹차뿌리 표본은 아모레퍼시픽의 Dolsongi tea field에서 채취되었으며 70%의 에탄올로 추출한 녹차 뿌리 추출물은 총 순수 사포닌 함량이 54%로, 인삼 추출물보다 더 많은 사포닌을 함유한 것을 확인하였다. 그리고 PM2.5에 의한 손상으로부터의 보호 효과를 평가하기 위해 건선환자의 특이적 바이오 마커인 IL-36G를 관찰한 결과 IL-36G mRNA 발현량은 PM2.5 처리시 녹차 뿌리 추출물 처리를 통해 IL-36G 식의 유의적인 감소를 확인할 수 있었다. 결론적으로, 30년 된 녹차뿌리 추출물은 사포닌 함량이 높은 자연 계면 활성제로 사용될 수 있으며, 또한 피부질환마커인 IL-36G 발현의 억제를 통해 PM2.5에 의해 유발되는 손상에 대한 보호 효과가 있음을 알 수 있었다. Green tea (Camellia sinensis L.) has been widely explored for its medicinal applications. However, most of the studies had targeted the green tea leaf, while other parts remained unexplored. In this study, protective effect of green tea root extract on Normal Human Epidermal Keratinocytes (NHEKs) against the damage induced by an external stimulant (PM2.5) was confirmed. Thirty-year-old green tea root samples were collected from Amorepacific’s Dolsongi tea field and green tea root extract was prepared with 70% ethanol. Total crude saponin content in green tea root extract was 54%, which is much higher than that in ginseng extract. Our results suggest that green tea root extract can be used as a natural surfactant in cosmetics. For evaluating its protective effect against the damage induced by PM2.5, IL-36G was used as a biomarker. IL-36G mRNA expression level increased remarkable upon PM2.5 treatment in NHEKs. Moreover, IL-36G was recently reported to be expressed in psoriasis lesions. Results showed significant decrease of IL-36G expression by treatment of green tea root extract. In conclusion, thirty-year-old green tea root extract can be used as a natural surfactant with a high saponin content and may have protective effect against the damage induced by PM2.5.
Factors Associated with Insomnia among the Elderly in a Korean Rural Community
WooJung Kim,Wontak Joo,Jiwon Baek,SungYun Sohn,Namkoong Kee,Yoosik Youm,HyeonChang Kim,YeongRan Park,SangHui Chu,EunLee 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.4
Objective-Sleep disturbance is common in the elderly, which is result from multi-factorial causes encompassing socio-demographic, behavioral, and clinical factors. We aimed to identify factors associated with insomnia among the elderly in a rural community in South Korea, a country with a rapidly growing aged population. Methods-This cross-sectional study used the data from the second wave of the Korean Social life, Health and Ageing Project, which is a cohort study of individuals living in a typical rural community in South Korea. Socio-demographic, behavioral, and clinical characteristics were obtained through face-to-face interviews. Various factors suspected to be associated with insomnia were compared between elderly participants with and without insomnia, and multiple logistic regression analyses were conducted to identify independent risk factors for insomnia. Results-We found that 32.4% of 509 participants (72.8±7.7 years old) had insomnia. Female sex [odds ratio (OR)=2.19], low education level (OR=2.44), current smoking (OR=2.26), number of chronic diseases (OR=2.21 for 2-3 chronic diseases; OR=2.06 for 4 or more chronic diseases), and depression (OR=2.53) were independently associated with insomnia. Conclusion-We found that sex, education, chronic disease, and depression independently increase the risk of insomnia of the elderly in a Korean rural community. To overcome the elderly’s insomnia, interventions should target modifiable factors such as depression. To promote active aging, longitudinal studies of factors associated with insomnia among the elderly should be performed in different regions and communities.