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성기혜 ( Ki Hye Sung ),김민희 ( Min Hee Kim ),김은령 ( Eun Ryoung Kim ),심재원 ( Jae Won Shim ),이정주 ( Jung Ju Lee ),임재우 ( Jae Woo Im ),진현승 ( Hyun Seung Jin ) 대한주산의학회 2009 Perinatology Vol.20 No.3
목적: 최근 극소 저출생 체중아의 생존율의 개선으로 기관지폐 이형성증(bronchopulmonary dysplasia, BPD)이 늘고 있다. 다기관 연구에 의해 전국적인 BPD의 역학, 임상 양상과 각 병원 간의 차이를 조사하여 향후 우리나라의 BPD 감소와 중증도를 줄이는 것을 목적으로 본 연구를 시행하였다. 방법: 2005년 6월부터 2007년 5월까지 건국대학교병원, 영등포 성애병원, 강북삼성병원, 중앙대학교병원, 건양대학교병원, 강릉아산병원의 신생아 집중 치료실에 입원하였던 신생아 4,476명을 대상으로 하였다. BPD의 진단 기준은 비전형적인 BPD를 포함하여 병인적인 분류를 하고 있는 Ogawa 등의 분류법을 이용하여 신생아 호흡 곤란 증후군(respiratory distress syndrome, RDS)과 전형적 또는 미만성 혼탁의 방사선 소견, 산전 감염의 유무에 따라 6가지 type으로 분류하였다. 또한 전체 신생아의 출생체중 분포와 생존율, 각 출생체중 군별 BPD의 발생률, 병태 비율, 사망률 등을 조사하고, 이 후 재택 산소요법 시행 여부와 미숙아 망막증, 괴사성 장염 등의 합병증 여부를 조사하였다. 결과: 생후 28일째 산소 치료가 필요한 신생아는 89명이었고, 이 중 Ogawa 분류법에 의한 BPD 환아는 70명(1.6%)이었으며, 특히 1,500 g 미만의 환아 237명 중 60명(25.3%)이었다. 생후 28일 이상 생존율은 98.7%이고, 사망 예는 없었으며 평균 재원 기간은 97.8±51.2일(43~405일)이었다. BPD는 900~999 g, 1,000~1,249 g의 체중 군에서 발생률이 각각 15명(21.4%)으로 가장 높았으며, 교정 36주 이후에도 산소투여가 필요한 중증 BPD의 경우 900~999 g의 체중 군에서 7명(23.3%)로 가장 높았다. Ogawa 분류법으로 BPD의 각 병태 비율로는 RDS 이후에 나타나는 I, II형이 각각 전체의 17예(24.3%), 44예(62.9%)로 대다수를 차지하였다. 이외에도 III`형은 2예(2.9%), IV형은 2예(2.9%), V형은 5예(7.1%)이었고, III형, VI형은 없었다. 재택 산소요법은 8예에서 시행되어 전체의 11.4%였으며, 이 중 BPD I형이 7예로 87.5%를 차지하였다. 미숙아 망막증은 35명(50.0%)에서 발생하였으며, 700 g 이하 신생아에서 9예(26.5%)로 가장 많았다. 또한 괴사성 장염은 3명(4.3%)이었다. 결론: 본 연구는 국내에서 처음으로 진행된 BPD의 전국적인 다기관 역학 조사로, 대상 신생아의 Ogawa 분류에 의한 BPD 유병률은 1.6% 이었고 1,500 g 미만 신생아의 25.3%이었으며, 전체 신생아의 BPD 70명 중 Ogawa 분류의 I, II형이 각각 24.3%, 62.9%로 대다수를 차지하였다. Purpose: As the neonatal intensive care advanced, the incidence of neonatal bronchopulmonary dysplasia (BPD) has increased. We conducted a multi-center investigation of the prevalence of BPD in six hospitals to investigate the epidemiology of BPD in Korea. Methods: Retrospective reviews ware performed for survival rate, prevalence of BPD of total 4,476 newborn infants who were admitted to neonatal intensive care unit in Konkuk university hospital, Sung-Ae General hospital, Kangbuk Samsung hospital, Chung-Ang university hospital, Konyang university hospital, and Gangneung Asan hospital between June, 2005 and May, 2007. By Ogawa, BPD was defined as oxygen dependency at 28 days after birth, with respiratory distress symptoms and the change of chest x-ray finding, and classified as 6 subtypes. Classic BPD was defined as oxygen dependency at 36 weeks of postmenstrual age. Results: Survival rate at 28 day after birth was 98.7%. BPD infants by Ogawa classification were 70 (1.6% of overall newborn infants), classic BPD infants were 30 (0.7%). Especially, among 237 preterm infants with birth weight less than 1,500 gram who survived to 28 days of life, 60 (25.3%) had BPD by Ogawa classification and 23 (9.7%) had classic BPD. In Ogawa classification, infants with RDS as type I and II, were 17 infants (24.3%) and 44 infants (62.9%). Home oxygen therapy was performed 8 infants (11.4%). Prevalence of retinopathy of prematurity was 35 infants (50.0%), necrotizing enterocolitis was 3 infants (4.3%), and intraventricular hemorrhage was 6 infants (8.6%). Conclusion: Prevalence of BPD infants was 1.6% of overall newborn, 25.3% of preterm infants with birth weight less than 1,500 gram. Among 70 BPD infants, BPD by Ogawa classification with history of RDS as type I and II were 24.3%, 62.9% as the majority of BPD. This study would be the first report of epidemiology of Korean BPD infants by multi-center study.
[P113] Clinical and histopathologic features of 4 cases of adult-onset Still`s disease
( Sang-jin Cheon ),( Sung-min Park ),( Hyun-joo Lee ),( Hyun Ju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Gun-wook Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Adult-onset Still`s disease (AOSD) is a rare systemic inflammatory disorder characterized by classic clinical triad of persistent high spiking fever, arthralgia, and typical salmon colored maculopapular rash. Recently, comprehensive review of literature showed that cutaneous involvement occurs in about 80% of AOSD patients. However, clinical and histopathologic characteristics of skin lesion of AOSD are rarely reported in dermatologic literature. We experienced 4 cases of AOSD (M:F=1:3). The diagnosis is based upon the clinical and laboratory criteria. Among them, 2 patients clinically showed multiple persistent pruritic erythematous papules and plaque. Histopathologic examination of erythematous plaque revealed multiple dyskeratotic keratinocytes in the upper epidermis. The other 2 patients presented with disseminated pruritic urticarial rash. Histopathologic examination of urticarial lesion revealed perivascular and interstitial infiltrates with neutrophils and a few mononuclear cells in the dermis. Diagnosing of AOSD is difficult due to nonspecific symptoms and absence of characteristic laboratory test. Herein, we report rare cases of AOSD presenting with persistent pruritic papules and plaques and urticarial rash. And we considered that dyskeratotic keratinocytes in upper dermis of pruritic plaques and neutrophils infiltration in perivascular and interstitial infiltration may be clue for a suspicious of AOSD.
An analysis of characteristics of pigmented fungiform papillae of the tongue: single center study
( Sung-min Park ),( Tae-wook Kim ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk Ryu ),( Woo-haing Shim ),( Gun-wook Kim ),( Byung-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Hoon-soo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Pigmented fungiform papillae of the tongue (PFPT) is a rare benign pigmentary disorder of the tongue. In dark-skinned individuals, PFPT appears to be relatively common. However, limited data exist on PFPT in Korean patients. Objectives: To investigate the clinical characteristics of PFPT in Korean patients Methods: Patients diagnosed with PFPT between 1995 and 2016 at Pusan National University Hospital were included. Clinical characteristics of PFPT, dermoscopic findings, and comorbidities were reviewed. Results: Eighteen patients diagnosed as PFPT were enrolled. Male to female ratio was 1 : 5. The mean age at diagnosis was 39.6 years (range, 8-65 years). According to Holzwanger’s classification, type I was the most common (88.9%). PFPT was commonly concomitant with pigmentary disorders including mucosal melanotic macules, Laugier-Hunziker syndrome, Melasma, and melanonychia (6/18, 33.3%). Preceding oral inflammatory lesions were found in 3 patients (16.7%), and systemic diseases and infectious diseases existed in 2 patients respectively (11.1%). Dermoscopic examination was performed in 7 patients; Pigmented border with dichotomized vessels (Rose petal pattern, 71.4%), and diffuse pigmentation (cobblestone pattern, 57.1%) were common findings. Conclusion: Our study shows PFPT can coexist with pigmentary disorder. Female predominance, concomitant pigmentary disorders of PFPT shows sex hormone or susceptibility to abnormal pigmentation may play a role in pathogenesis of PFPT.
Woo Bin Park,Suji Kim,Soojin Shim,Han Sang Yoo 한국예방수의학회 2019 예방수의학회지 Vol.43 No.4
Although canine brucellosis has been known to be an important re-emerging zoonosis, the pathophysiological mechanisms of Brucella canis infection remains clues to be solved. Different culture models, single and co-culture models, were constructed with canine epithelial cells, D17 and macrophage, DH82 to investigate the induction of immune responses in in vivo B. canis infection. Expression of genes related with induction of immune responses, Th1, Th2 and Th17, was compared in the two different models after the bacterial infection. In this study, expression of cytokine genes, IL-1β, IL-5, IL-6, IL-10, IL-23, and TNF-α was quantified in the DH82 at different time points using RT-qPCR in the two different culture systems after the infection. Cytokine genes related with Th1, IL-1β and TNF-α and Th17, IL-6 and IL-23 were expressed with time-dependent manners in the both systems (p<0.05). However, increase of Th2-related cytokine genes expression was not detectable in the both systems by comparison with control. The expression of Th1 and Th17 related cytokine genes was earlier in single cell culture than those in co-culture model (p<0.05). In general, amounts of the expressed genes were shown higher in single cell model than those in co-culture models. This study indicate that Th1 and Th17-associated immune responses are central to B. canis infection in dogs. In addition, it suggests a specific role of epithelial cells in the B. canis infection in vivo, which should resolved in the further study.
( Sang-jin Cheon ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Hyun Ju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun- 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: More than 6 cafe-au-lait macules (CALMs) are initial clinical sign of neurofibromatosis type 1 (NF1). However, we often encounter patients with isolated multiple CALMs without accompanying other sign of NF1. Objectives: To investigate the characteristic pattern of multiple CALMs that might be suggestive NF1. Methods: Forty patients with more than 6 CALMs who visited Pusan National University Hospitals (Busan and Yangsan) from 2011 to 2017 were enrolled in this study. Among them, 23 patients were designated as NF1 (17 patients were detected by NF1 gene mutation test and 6 patients were detected by clinical criteria). The remaining 17 patients were diagnosed as isolated multiple CALMs. We compared number, shape, and distribution of CALMs in patients with NF1 and isolated multiple CALMs. Results: Number of CALMs was higher in patients with NF1 than isolated multiple CALMs patients (20.2 vs. 17.7). Especially, proportion of typical CALMs, defined as oval shape and smooth border, was higher in NF1 than isolated multiple CALMs patients (40.44% vs. 17.27%, p=0.036). In distribution, CALMs of NF1 patients were more scattered than isolated multiple CALMs patients (affecting body segment, 4.9 vs. 2.9, p=0.002). And Facial CALMs were more common in patient with NF1 than isolated multiple CALMs (63.2% vs. 18.8, p=0.016). Conclusion: High rate of typical CALMs, scattered distribution and facial CALMs might be suggestive features of NF1.
A Case of Cervical Chondrocutaneous Branchial Remnant Comprised of Hyaline Cartilage
( Sang-jin Cheon ),( Tae-wook Kim ),( Seong-min Park ),( Hyun-ju Lee ),( Hyunju Jin ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyang- 대한피부과학회 2019 Annals of Dermatology Vol.31 No.1
Shim, Woo Young,Park, Kyu Hyun,Jeung, Hei-Chul,Kim, Yong Tae,Kim, Tae Soo,Hyung, Woo Jin,An, Sung Hwan,Yang, Sang Hwa,Noh, Sung Hoon,Chung, Hyun Cheol,Rha, Sun Young D.A. Spandidos 2005 International journal of molecular medicine Vol.16 No.5
<P>Real-time TRAP assay was developed to improve the sensitivity and quantitative detection of telomerase activity in the body fluids of cancer patients. The sensitivity and clinical significance of the real-time TRAP assay was investigated. Real-time PCR protocol was modified by using ACX primer and SYBR green mixture from the process of TS primer extension. Real-time TRAP showed high correlation (r2=0.843, p=0.001) and sensitivity (25 times higher) compared to conventional TRAP. Of 164 samples, there were 8 positives in cytology (4.9%), 7 (4.3%) using the conventional TRAP, and 41 (25%) using real-time TRAP. In cytology positive samples, real-time TRAP showed a higher positivity than conventional TRAP (75% vs 63%) suggesting a higher sensitivity in the body fluids. There was a tendency towards a longer progression-free duration in telomerase negative patients than in positive patients, as determined by conventional and real-time TRAP. The diagnostic interval between the first positivity documentation and clinical progression was short in the order of real-time TRAP, conventional TRAP and cytology. In conclusion, real-time TRAP assay can detect telomerase activity at an earlier phase of cancer progression and can replace conventional TRAP assay for detecting the telomerase activity in body fluids.</P>