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한국인 만성 B형 간염 바이러스 ( HBV ) 보유자에서 HBV 유전자형 - 일차 중합 효소 반응법에 의한 온전한 B 형 간염 바이러스 증폭 및 그의 염기 서열 -
김학철(Haak Cheoul Kim),서검석(Geom Suk Seo),김용성(Youg Sung Kim),송우건(Woo Gun Song),문형배(Hyung Bae Moon),조지현(Jie Heun Cho) 대한내과학회 2001 대한내과학회지 Vol.61 No.5
Background : Hepatitis B virus (HBV) is major source of chronic liver disease in Korea. However this virus might have different nucleotide sequence according to races, different region, etc. Recently the novel method that allows sensitive amplification with dramatically decreased mis-incorporation has developed. We determined to get the major form of HBV nucleotide sequence from whole sequencing data of 26 Korean HBV carriers. Methods : HBV DNA were collected from 26 Korean chronic HBV carriers. We used the novel PCR with pfu for the amplification of HBV DNA, and specific primers were made with combination sequence bases of non-HBV part and HBV parts which were located head and tail in the virion. Then whole length of HBV were directly sequenced and analysed. Result : HBV DNA was consisted of 3215 bases in 20 cases of 26 Korean chronic HBV carriers. And the remainder had smaller or larger number due to deletion, insertion or both in pre-S2 and S gene. They were 99.03% homology of their nucleotide sequence and belong to genotype C. The variability of nucleotide sequence was significantly higher in the singly coding region (SCR) than doubly coding region (DCR), and also high in pre-S1 and pre-S2 gene among the DCR. Hot-spots were more frequently found in the SCR, pre-S1 and pre-S2 gene. Conclusion : In Korean chronic HBV carriers, HBV is consisted of 3215 nucleotides, and belongs to genotype C. And it might exist one genotype with the variability in Korea.(Korean J Med 61:479-488, 2001)
비흡연 승모판협착증 환자에서 승모판협착 정도에 따른 폐기능검사 결과
두영철(Young Cheoul Doo),고윤석(Youn Suck Koh),김우성(Woo Sung Kim),김재중(Jae Joong Kim),박성욱(Seong Wook Park),박승정(Seung Jung Park),이종구(Jong Koo Lee),김원동(Won Dong Kim) 대한내과학회 1991 대한내과학회지 Vol.41 No.1
Pulmonary function studies were performed in 30 non-smoking patients with mitral stenosis in order to determine the relationship between hemodynamic and pulmonary function parameters and the degree of pulomary function abnormalities in relation to the severity of mitral stenosis. Our results were as follows: 1) The forced vital capacity(FVC), forced expiratory volume in 1 second(FEV,), mean forced expiratory flow in 25-75% (FEF25-76%), and vital capacity(VC) were in the lower limits of normal range. Total lung capacity(TLC) and diffusing capacity(DLco) were within normal limits with increased residual volume(RV). On exercise test, the maximum oxygen uptake (VO2 max) and anaerobic threshold(AT) decreased. 2) FVC (r=0.50, p<0.01), FEV1 (0.53, p<0.01), FEF25-75% (r=0.41, p<0.05), VC (r=0.58, p<0.001), and VO, max (r=0.51, p<0.01) were significantly correlated with the mitral valve area (MVA). TLC (r = -0.46, p<0.05) and AT (r= -0.44, p<0,05) were inversely correlated significantly with left atrial pressure and pulmonary arterial pressure, 3) FVC, FEV1, VC, and VO2 max in Group III (MVA < 0.75 cm) were below normal range and significantly lower than those in Group I (MVA?1.0 cm2) and Group II (0.75?MVA<1.0cm2). We conclude that the degree of defect in pulmonary function and exercise capacity depend on the mitral valve area.
Yoon, Sung-Hwan,Kim, Myung-In,Chung, Kwang,Jung, Seunggon,Kook, Min-Suk,Park, Hong-Ju,Oh, Hee-Kyun,Kim, Su-Gwan,Kim, Young-Kyun,Cho, Yong-Seok,Kim, Woo-Cheoul,Yang, Choon-Mo Korean Academy of Dental Science 2013 Journal of korean dental science Vol.6 No.2
Purpose: The purpose of this study was to evaluate the survival and success rates of Korean Osstem implants US II Plus, GS II following loading period. Materials and Methods: Dental records were obtained in total 201 patients who were treated with Korean Osstem implants US II Plus, GS II on both maxillary and mandibular anterior and posterior areas in six different clinics for 2 years from January 2007 to December 2008. Total 430 implants were evaluated clinically and radiographically using predefined success criteria prospectively and following results were obtained. Result: US II Plus, GS II implants showed high survival rates of more than 99% and high success rates more than 90% independent of loading period. As a result of cross analysis to evaluate clinical significance between implant loading period and success rate, the P-value of US II Plus was 0.10 (P>0.05), and the P-value of GS II was 0.17 (P>0.05), which showed no statistical significance. Bone quality, smoking, and edentulous state are factors that can affect the survival and success rates following differently loaded implants, but did not significantly affect in this study. Conclusion: These results suggest that selection of loading period of Korean Osstem implants US II Plus, GS II would be done carefully considering implant install area, the quality alveolar bone, the state of edentulous ridge and experience of operator, though they showed clinically good results on both maxillary and mandibular anterior and posterior areas.
위장관 ( 胃腸管 ) : 상부 위장관 내시경 검사시 동맥혈 산소 포화도의 변화에 관한 연구
민영일(Young Il Min),이영상(Young Sang Lee),김해련(Hae Ryun Kim),고윤석(Youn Suck Koh),김명환(Myung Hwan Kim),두영철(Young Cheoul Doo),정영화(Young Hwa Joung),양석균(Suk Kyun Yang),김우성(Woo Sung Kim),김원동(Won Dong Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
N/A Gastrointestinal endoscopy is one of the most frequent procedures, but relatively little is known about its pulmonary effects. Pulse oximeter is a convenient and non-invasive methods which monitors SaO2 and pluse rate. So, we studied the change of SaO2 and pluse rates during esophagogas-troduodenoscopy in the patients with impaired plumonary function and normal controls by pluse oximeter. In conclusion, the drop in SaO2 during endoscopy could occur in the pulmonary disease patients with mild to moderate imparied pulmonary function, but this change was transient and recovered rapidly during examination. So, we suppese that specific therapy such as O2 supply may not be requried durging endoscopy in these patients.
만성 B형 간염 바이러스 보유자에서 Core Promoter의 다양성
김학철,김용성,서검석,송우건 대한소화기학회 1999 대한소화기학회지 Vol.34 No.5
Background/Aims : The core promoter (CP) is included in X-gene of hepatitis B virus (HBV), and is composed of a upstream regulatory sequence (URS) and a basic core promotor (BCP) which is regulated by URS. Nucleotide (nt) mutation of CP might influence the expression of precore mRNA and pregenomic mRNA and the activity of liver disease. Thus, we investigated the relation between the nucleotide mutations in CP and their effects on HBeAg status, and severity of disease in chronic B viral liver disease. Methods : Samples were obtained from 7 chronic asymptomatic carriers, 9 patients with chronic hepatitis and 20 cirrhotic patients with HBV. Polymerase chain reaction and DNA analysis for CP were performed. Results : Cirrhotic group was older than asymptomatic carrier group and chronic hepatitis group. In BCP, point mutations were observed in 10 positions. Among them, nts 1753, 1762 and 1764 were frequently mutated, and the mutations at the nts 1762 and 1764 were accompanied (double mutation). In URS, point mutations were observed in 19 positions. Among these, nt 1653 (α-box) had significantly high mutation rate and the mutation at nt 1653 was closely associated with mutations at nts 1762/1764 in chronic liver disease and HBeAg (-) groups. Conclusions : The α-box of URS is closely related with double-mutation in BCP and HBeAg status in chronic B viral liver disease.
만성 B형 간염 바이러스 보유자에서 X-유전자 부위의 염기 변이
김학철,김지웅,송우건 대한소화기학회 2001 대한소화기학회지 Vol.37 No.4
Background/Aims: X-gene product of hepatitis B virus (HBV) is known to cis-/trans-activate a number of cellular and viral promotors. We studied the mutations of X gene and investigated the relationship between the mutations and the severity of disease in chronic HBV carriers. Methods: HBV DNA samples were obtained from the sera of 11 chronic asymptomatic carriers (ASC group), 16 chronic hepatitis patients (CH group), and 23 cirrhotic patients with HBV (LC group). PCR and direct sequencing analysis were performed for X gene. Results: LC group was older than ASC group and CH group. In X gene, there were many mutation points and 17 hot-spots were found. Their variability was 1.17%. The mutations were not found in the direct repeat (DR) and TATA box binding portion (TBP), but hot-spots were found frequently in the 2nd TATA-box area, negative regulatory element (lNRE) and C/EBP. The nucleotide mutations occurred frequently at 1762 and 1764 nucleotide. The associated mutations at 1762 and 1764 nucleotide were accompanied by the mutation at one of 1653, 1613 and 1631 nucleotide. Even in those accompanied mutation, there were not interlinked between them, but has trend to cross-link between them. Conclusions: DR and TBP portion in X gene might be an essential portion for HBV, and especially the 2nd TATA-box, NRE and C/EBP might be related to the severity of liver disease. Moreover there might be inter-, or cross-linked relationship between the mutations.