BCG를 대량 투여 받은 생쥐 가슴샘 겉질의 미세구조

고정식,안의태,박경호,우성임,한영복,경홍기 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.3

참외의 接木裁培에 관한 硏究

鄭淳宰,具禹書,鄭景泰 東亞大學校 大學院 1992 大學院論文集 Vol.17 No.-

Experiments wer conducted to investigate of rootstocksk on the growth, yield and quality of oriental melon cultivars and to find out problems associated with successful growing of grafted seedlings. Major results can be summarized as follows. 1. The percentage of healthy plants, sintozwa and chamtozwa were 100, while hongtozwa and chambak were less than 11.8. 2. The growth of oriental melon was promoted by non-grafted and sintozwa root stock. 3. Soluble solid contents of non-grafted and chamtozwa rootstock were hight than sintozwa rootstock. 4. Glucose and Fructose contents of sintozwa rootstock was hihter than chamtozwa rootstock. Whereas, sucrose contents of non-grafted was hiher than sintozwa, chamtozwa rootstock. 5. Grafting onto sintozwa rootstock increased the contents of most mineral element except Ca in the leaves.

인천지역 대학생에 의한 대학급식소의 급식서비스에 대한 품질 평가

우경자,한복진,노정옥 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.3

This study was conducted to investigate the quality assessment of performance of the university foodservice. Self administered questionnaires were collected from 305 students living in Incheon. Statistical data analysis was completed using a SPSS v. 10.0 program. The results were summarized as follows: 61.4% of male students and 48.1% of female students responded to have lunch regularly. Only 23.4% of male students and 14.1% of female students used the university foodservice daily. Reasons for the irregularity of lunch were responded as "lecture", "eating when I want" and "appointment with friends", etc. The quantity, temperature, nutritional value, appearance, hygiene, taste and freshness of foods and price of menus were evaluated as appropriate but using seasonal foods, number of side-dishes, etc. as unsatisfactory. Service speed, cloth hygiene, neatness and kindness of employee were evaluated as appropriate. For the facilities of foodservice, counter location, menu board and lighting facilities were evaluated as appropriate but heating facilities, disponsition of tables and chairs of dining hall were as unsatisfactory. Sanitation of floors and walls of dining hall, restroom and utensils, etc. was evaluated as low.

개에서 발생한 이혈종의 임상적 관리

이우철,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

A 14-year-old male pomeranian was present with swollen left ear. The swelling occurred from base to apex of pinna. Otitis externa persisted for two years. Hematological and serum biochemistry values were not remarkable. The surgery treatment was the most appropriate method among indwelling drain, surgical, and steroid treatment in the aural hematoma because the dog was very sensitive to touching pinna and the size of aural hematoma. Longitudinal incision was applied after general anesthesia. Cefovecin was injected to prevent secondary infection. The outcome of surgery was good. There was no evidence of recurrence for one year.

신경세포성장인자로서 척수운동신경세포의 손상에 미치는 한약재의 약류별 효능 및 기전에 관한 연구

鄭遇悅,朴承澤,成彊慶,李星根 대한동의병리학회 1998 동의생리병리학회지 Vol.12 No.2

산소자유기가 흰쥐의 배양 운동신경세포에 미치는 세포독성에 대한 기전을 규명하기 위하여 여러 농도의 산소자유기를 배양 신경세포에 처리한 후 산소자유기의 신경독성 효과를 분석하였으며 또한 산소자유기에 의하여 유발된 신경독성에 대한 한약재중 보혈약류와 보기약류의 대표적인 처방인 사군자탕과 사물탕의 신경세포독성의 방어효과를 MTT assay법에 의하여 조사하여 다음과 같은 결론을 얻었다. Xanthine oxidase(XO)와 hypoxanthine(HX)은 처리한 농도에 비례하여 배양 신경세포의 생존율을 현저하게 감소시켰으며, 또한 사물탕과 사군자탕이 XO/HX의 독성효과를 유의있게 방어하였다. 이상의 결과로부터 산소자유기는 배양 소의 희소돌기아교세포에 독성을 나타냈으며 사군자탕과 사물탕등의 한약추출물이 산소자유기의 독성을 방어하는데 효과적인 것으로 나타났다. In order to elucidate the neuroprotective effect of Sagunjatang and Samultang on oxidant-induced neurotoxicity in cultured rat spinal motor neurons, the colorimetric assay such as MTT assay was performed and light microscopic study was also carried out after cultured spinal motor neurons from neonatal rat were treated with the medium containing various concentrations of xanthine oxidase(XO) and hypoxanthine(HX) for 3 hours. In addition, protective effect of herb extracts on the neurotoxicity induced by oxygen radicals was examined in these cultures. The results were as follows : Cell viability of cultured rat spinal motor neurons which were exposed to various concentrations of 30mU/ml XO and 0.1mM HX for 3 hours, was decreased in a dose-dependent manner. MTT50 value was 30mU/ml XO and 0.1mM HX after motor neurons were incubated with various concentrations of XO/HX for 3 hours. Cultured spinal motor neurons showed degenerative changes such as the decrease of cell number and loss of cell processes when neurons were cultured in the medium containing 30mU/ml X0 and 0.1mM HX for 3 hours. Oxygen radicals were toxic on cultured rat spinal motor neurons by the decrease of cell viability. Herb extracts, Sagunjatang and Samultang prevented the oxidant-induced neurotoxicity significantly after spinal motor neurons were preincubated with herb extractions for 2 hours before exposure of oxygen radicals. These results suggest that oxygen radicals have neurotoxic effect on cultured spinal motor neurons derived from neonatal rat, and selective herb extracts such as Sagunjatang and Samultang are very effective in protecting the neurotoxicity induced by oxygen radicals.

항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

생체시료 중 스타틴계 약물 정량법의 최근 개발 동향

우경식,박정숙 충남대학교 약학대학 의약품개발연구소 2009 藥學論文集 Vol.24 No.-

Statins are reversible inhibitors of S-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, widely used for the treatment of hyperlipidemia as well as atherosclerosis. Recently, various brands of cholesterol lowering statin drugs have been frequently prescribed and dispensed to the patients for reducing morbidity and mortality related to coronary heart disease. Therefore, demands for development of reliable and sensitive analytical methods for statins in biological fluid have been increased to monitor the plasma concentrations of drugs. A lot of chromatographic-mass spectrometric methods for the quantification of presently available seven statins such as atorvastatin, simvastatin, lovastatin, pravastatin, fluvastatin, rosuvastatin, and pitavastatin have already been published. Of analytical methods, high performance liquid chromatography (HPLC) with tandem mass spectrometry (MS/MS) is the analytical technique of choice for the quantification of statins in biological samples. This review covers most of the analytical method used for quantification of statins, which are applied for plasma sample and suitable for therapeutic drug monitoring.

Aerobic Training이 女學生들의 肺機能 및 PWC170에 미치는 影響

全廷祐,金耕知 慶熙大學校 體育科學大學 1990 體育科學論叢 Vol.- No.3

The purpose of this study was to determine one effect of ten week of aerobic training on pulmonary function and physical work capacity The subject all female were collected from the K university The results of the study were as follow ; in the FVC the subjects improved from 3.29 ±0.22ml to 3.46 ±0.18ml after training with 5.2% increase. The subjects also improved from 2.48 ±0.21 to 2.67 ±0.2 in the FEV 1.0, from 5.86 ±0.42 to 6.28 ±0.58 in the PF. However all the values were statistically not significant in the PWC170 by kpm/min the subjects improved from 673.2 ±54 to 691.6 ±49, with 2.73% increase. In the PWC170 by kpm/kg/min the subject improved from 11.75 ±1.11 to 12.34 ±1.26, with 5.02% increase. The subjects also improved from 16.40 ±1.29 to 16.60 ±1.25 in PWC170 expressed by kpm/kg(L.B.M)/min all the values were however statistically no significant.

PWC170의 算出方法 評價에 關한 硏究

趙庚旭,金泰完,張鳳愚,張鍾仁 忠北大學校 平生體育硏究所 1985 平生體育硏究所 論文集 Vol.1 No.-

The purpose of this study is to estimate the maximal oxygen up-take and the physical work capacity by four experimental methods in PWC170. The subjects of this study start to pedal the bicycle ergometer at the three work loads; the first work rate with 450∼600kpm/min, the second work rate with 600∼750kpm/min, and the third work rate with 750∼900kpm/min. Each exercise bout is 6 minutes long. We used a pedal frequency of 50 revolutions per minute. The first method is the first and second work rates the second method the second and the third work rates the third method the first second and hird work rates and the fourth method an integration by the third work rate. We measured and recorded the heart rate during the last 30 seconds of every minute of exercise. Since the subjects worked in a steady state, it is not necessary that they should exercise exactly 6 minutes each time. If problems happened during the taking of heart rate or other data, we continued to exercise another 30 to 60 second. The estimation of maximal oxygen uptake and physical work capacity was conducted by work loads and heart rates during exercise. The results are as follows: 1. The estimation by four different, methods showed 2∼3 persentile difference in maximal oxygen uptake(1min, ml/kg/min) and PWC170(kpm/min, kpm/kg/min). 2. The estimation by four different methods did not show significant differene, therefore for the estimation we had better use simplified method for the first work rate and the second work rate.

골관절염 환자에서 관절내 Sodium Hyaluronate(Hyruan®)의 투여가 슬관절통에 미치는 영향

김훈정,임경준,위상우,정종달,유벙식,안태훈,소금영 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background : Sodium Hyaluronate has been found to be deficient in the synovial fluid of patients with osteoarthritis. We evaluate the effect of intraarticular Sodium Hyaluronate(Hyruan®) on the knee joint pain in patients with osteoarthritis. Method : Ten patients with osteoarthritis of the knee were participated in this study. Sodium Hyaluronate was injected into knee joints weekly for 5 weeks consecutively. Clinical evaluations were performed using visual analogue scale(VAS) for pain, tenderness and swollen joint counts weekly for the first 5 weeks and at 10 weeks postinjection. Result : VAS, tenderness and swollen joint were all significantly improved from 2 weeks to 10 weeks. There was no complication, except pain on injection site in two patients. Conclusion : Intraarticular injection of Sodium Hyaluronate has been shown to be effective on the treatment of patients with osteoarthritis of the knee.