Diagnostic usefulness of a T cell-based assay for latent tuberculosis infection in kidney transplant candidates before transplantation

Kim, S.-H.,Lee, S.-O.,Park, I.-A.,Park, S.J.,Choi, S.-H.,Kim, Y.S.,Woo, J.H.,Park, S.-K.,Park, J.S.,Kim, S.C.,Han, D.J. Blackwell Publishing Inc 2010 Transplant infectious disease Vol.12 No.2

<P>S.-H. Kim, S.-O. Lee, I.-A. Park, S.J. Park, S.-H. Choi, Y.S. Kim, J.H. Woo, S.-K. Park, J.S. Park, S.C. Kim, D.J. Han. Diagnostic usefulness of a T cell-based assay for latent tuberculosis infection in kidney transplant candidates before transplantation.Transpl Infect Dis 2010: <B>12:</B> 113–119. All rights reserved</P><P>Background</P><P>The presence of latent tuberculosis (TB) infection (LTBI) should be evaluated before kidney transplantation. Although a new T cell-based assay for diagnosing LTBI gave promising results, this assay has not yet been compared with the tuberculin skin test (TST) for diagnosing LTBI in renal transplant candidates before transplantation.</P><P>Patients and methods</P><P>All adult patients admitted to a single institute for renal transplantation over a 1-year period were prospectively enrolled. A clinically predictive risk of LTBI was defined as: (i) recent close contact with a person with pulmonary TB; (ii) abnormal chest radiography; (iii) a history of untreated or inadequately treated TB; or (iv) a new infection (i.e., a recent conversion of TST).</P><P>Results</P><P>Of 209 renal recipients, 47 (22%) had a positive TST≥5 mm, 21 (10%) had a positive TST≥10 mm, 65 (30%) had a positive T-SPOT.<I>TB</I> test, and 25 (12%) had an indeterminate T-SPOT.<I>TB</I> test. The induration size of TST was significantly associated with a high positivity rate on T-SPOT.<I>TB</I> (<I>P</I><0.001). Agreement between T-SPOT.<I>TB</I> test and TST≥10 mm was fair (<I>k</I>=0.24, 95% confidence interval 0.11–0.36). However, neither univariate nor multivariate analysis showed any association between the clinical risk for LTBI and positivity on T-SPOT.<I>TB</I> or TST.</P><P>Conclusion</P><P>T-SPOT.<I>TB</I> test was more frequently positive than TST in renal transplant candidates. However, further longitudinal studies are awaited to determine whether the ability of T-SPOT.<I>TB</I> assay to detect LTBI in renal transplant recipients can better predict the development of TB than can TST after transplantation.</P>

역사이클하중하에서의 균열길이 측정법에 따른 파괴저항곡선의 평가

원종일,우흥식,석창성 한국산업안전학회 1998 한국안전학회지 Vol.13 No.4

J-R curve tests were performed on 1T compact specimens of SA516 Gr. 70 carbon steels under reverse cyclic loading. A Direct-Current Potential Drop (DCPD) method, one of the nondestructive techniques to detect flaw of structure, is being increasingly used for monitoring crack initiation and stable crack growth in typical fracture mechanics specimens for J-R testing. In many aspects this method is simpler than the unloading compliance method. The objective of this paper is to evaluate the J-R Curve according to the crack length measurement techniques under reverse cyclic loading. In order to prove the reliability and repeatability of the DCPD method, the crack length measured by using DCPD method was compared to one determined from unloading compliance. Consequently, this DCPD method correlated well with J-R curves and crack extension measurements determined from unloading compliance method.

대학생 자녀를 둔 중년여성의 자아존중감, 자녀와의 관계, SNS 이용강도가 우울에 미치는 영향

우지원,김가은,김경미,남주희,박지인,범준희,이나경,조소연,조은경,최영윤,김석선,길민지 이화여자대학교 간호과학대학 2017 이화간호학회지 Vol.- No.51

Purpose: This study aims to identify the effects of self-esteem, relationship with children, Social Networking Services(SNS) use intensity on depression in middle-aged women with college-age children, and to provide basic data for the health promotion of middle-aged women. Method: A sample of 133 middle-aged people was purposely selected from parents of university students. Questionnaires used for this study were CES-D(The Center for Epidemiological Studies-Depression Scale), Self-esteem Scale, Relationship with Children Scale, SNS Intensity Scale. The collected data was analyzed by SPSS 21 with descriptive statistics, independent t-test, ANOVAs, Pearson correlation, multiple regression. Result: Self-esteem was correlated with relationship with children (r=0.385, p<0.01) and depression (r=-0.440, p<0.01). Relationship with children was correlated with depression(r=-0.402, p<0.01). As a result, a factor having the greatest influence on the subject's depression degree was self-esteem(β=-0.335), followed by relationship with children(β=-0.274). Conclusion: The result of this study suggested that depression in middle-aged women is closely related to self-esteem and relationship with children. This result can be used in Nursing by developing the theoretical basis for education program related to enhancing self-esteem and relationship with children.

Constant Output Control of Solar Power Generation System by the Digital I-PD Controller

Sin, D.R.,Hwang, Y.M.,Noh, I.B.,Woo, J.I. 동아대학교 생산기술연구소 2001 生産技術硏究所硏究論文集 Vol.6 No.1

본 논문에서는 독립형 태양광 발전 시스템에서 PWM기법에 의한 DC_-DC 컨버터의 듀티비를 조절하고 순시가변입력으로부터 일정 DC 출력을 얻기 위하여 디지털 I_-PD제어기를 제안한다. 이 제안된 제어기는 입력 전압의 변화에 부합하는 순시정정루프에 의한 샘플링 주기마다 안정한 일정 출력을 얻을 수 있다. 이 시스템은 오차의 급변치를 검출하기 위하여 디지털 비례선형 I_-PD 계어기로 구성되어 있다.

1987년 한국에서 발생한 렙토스피라병의 혈청역학적 조사

이증훈,박영수,이우곤,김석용,정선식,우준희,박성광,박경희,송영욱,김선영,기정일,최두혁,강성귀,김주완,최강원,김우열,최명식,최인학,장우현,윤성열 대한감염학회 1988 감염 Vol.20 No.3

Human leptospirosis was an unfamiliar disease in Korea until 1984 that outbreak of leptospirosis occurred among farmers and soldiers after field works for harvesting rice. During that time, Lee and Jo confirmed the first Korean cases of leptospirosis by serological test, isolation of causative agent and autopy findings. Afterward several outbreaks occurred also during autumn especially after flood in every years and some characterisitcs of leptospirosis in Korea such as clinical manifestations, serotypes and seroepidemiological features has been revealed by many investigators. Because of the major mode of transmission between rodents and human is by direct contact with leptospiral urine of rodents or contaminated soil by the urine, leptospirosis in Korea has been primarily a disease of person in occupations heavily exposed to contaminated soil or infected urine such as farmer, army and etc. Therefore it seems that leptospirosis is one of the main communicable diseases to be controlled urgently in Korea, for an agricultural people account for almost half of total Korean people. For clarifying the seroepidemiological patterns of human leptospirosis in Korea by sex, month region and main reacting serovars of L. interrogans among acute febrile disease occurred in 1987, 1,773 patient's sers with acute febrile episodes were tested by microagglutination test using 19 representative strains of leptospiral serogroup as antigen. All of those sera were collected from 10 collaborative clinics located in Kyunggi, Kangwon, Chungbuk, Chungnam, Chonbuk, Chonnam province and Seoul. The results wee summerized as follows. 1) Among 1,773 sera of patients with acute febrile episodes, 219 (12.4%) were seropositive to L. interrogans, 487(27.5%) to R. tsutsugamushi, 241(13.6%) to R.typhi and 160(90.0%) to Hantaan virus. 2) Among seropositives to L.interrogans, the male outnumbered the female, 65% and 35%. 3) For age distribution, 26.9% of seropositives to L.interrogans were fifties, 19.6% were forties, 9.1% were sixties, 5.9% were thirties and 4.1% were twenties. 4) Eighty three percent of seropositives had occurred between September and October in 1987 with a peak in September. 5) Main leptospiral serovars reactive to patient's sera were Icterohaemorrhagiae(54.3%), Canicola(31.0%), CH-48(13.2%), Tarassovi(0.9%)and Cynopteri(0.5%). 6) For regional distribution, 65.8% of seropositives to L.interrogans were residents from Chonbuk, 12.3% were Chonnam, 7.3% were Chungnam, 5.5% were Kyunggi and 1.4% were Kangwon.

Phase I Clinical Study of Q-35, A New Oral Quinolone Antimicrobial Agent-Multiple Dose Trial

Yim, D. S 大韓臨床藥理學會 1995 臨床藥理學會誌 Vol.3 No.1

Beijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from <i>Sargassum binderi</i> (Sonder ex J. Agardh)

Fernando, I.P. Shanura,Jayawardena, Thilina U.,Kim, Hyun-Soo,Lee, Won Woo,Vaas, A.P.J.P.,De Silva, H.I.C.,Abayaweera, G.S.,Nanayakkara, C.M.,Abeytunga, D.T.U.,Lee, Dae-Sung,Jeon, You-Jin Academic Press 2019 Environmental research Vol.172 No.-

<P><B>Abstract</B></P> <P>Particulate matter (PM) air pollution has gradually become a widespread problem in East Asia. PM may cause unfamiliar inflammatory responses, oxidative stress, and pulmonary tissue damage, and a comprehensive understanding of the underlying mechanisms is required in order to develop effective anti-inflammatory agents. In this study, fine dust collected from Beijing, China (CPM) (size < PM13 with majority < PM2.5) was evaluated for its oxidative stress- and inflammation-inducing effects, which cause cell damage, in A459 human lung epithelial cells. Oxidative stress was marked by an increase in intracellular ROS levels and the production of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and heme oxygenase-1 (HO-1). Upon induction of oxidative stress, a marked increase was observed in the expression of key inflammatory mediators such as COX-2 and PGE<SUB>2</SUB> and the pro-inflammatory cytokines TNF-α and IL-6 via NF-kB and MAPK pathways. Cellular damage was marked by a reduction in viability, increased lactate dehydrogenase (LDH) release, formation of apoptotic and necrotic bodies, accumulation of sub-G1 phase cells, and DNA damage. Apoptosis was found to be mediated via the activation of caspases through the mitochondria-mediated pathway. Fucosterol, purified from the brown alga <I>Sargassum binderi</I> (Sonder ex J. Agardh) by bio-assay-guided fractionation and purification, exhibited potential therapeutic effects against CPM-induced detrimental effects. Further studies could focus on developing fucosterol, in forms such as steroidal inhalers, against PM-induced pulmonary tissue inflammation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fine dust air pollution is a major reason of pulmonary complications in East Asia. </LI> <LI> Dust particles induce oxidative stress and inflammation damaging the lung epithelial cells. </LI> <LI> Fucosterol suppressed the dust induced cell damage by inhibiting oxidative stress and inflammation. </LI> <LI> Fucosterol may have beneficial effects in alleviating adverse respiratory effects of air pollution. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Photo-catalytic activity of hydrophilic-modified TiO₂ for the decomposition of methylene blue and phenol

Cha, B.J.,Woo, T.G.,Park, E.J.,Kim, I.H.,An, J.E.,Seo, H.O.,Kim, Y.D. Elsevier 2017 Current Applied Physics Vol.17 No.11

<P>We applied hydrophilic surface modification to P-25 TiO2 nanoparticles via thermal deposition of polydimethylsiloxane (PDMS), followed by annealing at 800 degrees C under vacuum conditions. This process yielded a thin layer consisting of hydrophilic organic functional groups (e.g., -C = O) as well as SiOx structures on the surface of TiO2. Compared to bare TiO2, the surface-modified TiO2 showed a higher adsorption capacity and photo-catalytic decomposition rate toward methylene blue. However, regarding the photo-catalytic decomposition of phenol, total mineralization of phenol was more complete when bare TiO2 was used as a photo-catalyst, whereas partial oxidation of phenol (i.e., into hydroquinone) was more dominant and total oxidation of phenol was supressed in the presence of surface-modified TiO2. Overall, one cannot simply say that hydrophilic modification of TiO2 leads to a higher affinity to H2O molecules with a higher yield of strongly-oxidizing agents (OH radicals) to increase the photo-catalytic activity in aqueous solutions. Our results imply that a subtle balance of the adsorption energy or rates of H2O, reactants, and reaction intermediates can be important factors for determining the photo-catalytic reaction rate. Different types of photo-catalyst surface modification can be beneficial or detrimental depending on the reaction. It is highlighted that one should be wary of evaluating the overall photocatalytic activities of dissimilar catalysts based on the results of only a couple of reactions. (C) 2017 Elsevier B.V. All rights reserved.</P>

Construction and Commissioning of the KSTAR Helium Distribution System

Lee, Y.J.,Park, Y.M.,Kim, Y.S.,Jang, H.S.,Kwag, S.W.,Chang, Y.B.,Park, H.T.,Woo, I.S.,Song, N.H.,Bang, E.N.,Ha, T.H.,Baek, S.,Kim, M.K.,Kim, W.C.,Oh, Y.K.,Bak, J.S. IEEE 2009 IEEE transactions on applied superconductivity Vol.19 No.3

<P>The KSTAR components requiring cryogenic helium coolant for superconducting magnet operations are connected to the helium refrigeration system (HRS) through the helium distribution system (HDS), the final helium distribution station. Twenty eight cryogenic valves including 4 quench protecting valves, many sensors such as temperature sensors, pressure transmitters, and flowmeters are mounted on the system. The HDS has to control the 4.5 K supercritical helium (600 g/s) for 30 superconducting coils and their superconducting bus-lines, 55 K helium (270 g/s) pressurized to 18 bars for the thermal shields and the gravity supports, and a maximum 17.5 g/s of liquid helium for 18 current leads, provided from the HRS which has a 4.5 K equivalent cooling power of 9 kW. The helium distribution system consists of a helium distribution box (DB), 5 helium transfer lines, a PLC based helium control system (HCS), etc. The helium control system is connected to the KSTAR supervisory control & interlock system. The detailed status regarding the construction, commissioning during first cool-down, and the instrumentation & control (I&C) system are included in this paper.</P>

태양광·풍력 복합 발전을 적용한 축산 폐기물 처리 시스템의 응용

김영훈,노인배,박지호,우성훈,박승조,우정인 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

In this paper, we applied the Utility Interactive Photovoltaic-Wind Hybrid Generation System for stock raising waste disposal system. For the power consumption reduction of proposed system, we used the electromotive control system. And structure of sewage disposal tank is half-underground and slope a roop to raise thermal efficiency. Therefore, A period of procrss is able to reduce. So as to verify the propriety of proposed system, we made a Pilot Plant and examined the system.