http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jun-Sub Jung,A Ra Kho,Song Hee Lee,Bo Young Choi,Shin-Hae Kang,Jae-Young Koh,Sang Won Suh,Dong-Keun Song 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.2
Ischemic and traumatic brain injuries are the major acute central nervous system disorders that need to be adequately diagnosed and treated. To find biomarkers for these acute brain injuries, plasma levels of some specialized pro-resolving mediators (SPMs, i.e., lipoxin A4 [LXA4], resolvin [Rv] E1, RvE2, RvD1 and RvD2), CD59 and interleukin (IL)-6 were measured at 0, 6, 24, 72, and 168 h after global cerebral ischemic (GCI) and traumatic brain injuries (TBI) in rats. Plasma LXA4 levels tended to increase at 24 and 72 h after GCI. Plasma RvE1, RvE2, RvD1, and RvD2 levels showed a biphasic response to GCI; a significant decrease at 6 h with a return to the levels of the sham group at 24 h, and again a decrease at 72 h. Plasma CD59 levels increased at 6 and 24 h post-GCI, and returned to basal levels at 72 h post-GCI. For TBI, plasma LXA4 levels tended to decrease, while RvE1, RvE2, RvD1, and RvD2 showed barely significant changes. Plasma IL-6 levels were significantly increased after GCI and TBI, but with different time courses. These results show that plasma LXA4, RvE1, RvE2, RvD1, RvD2, and CD59 levels display differential responses to GCI and TBI, and need to be evaluated for their usefulness as biomarkers.
Role of PET/CT Scan and Brain MRI in Patients with Ground-glass Opacity Lung Nodules
( Jun Whi Song ),( Jae Uk Song ),( Kyung Jong Lee ),( Kyeong Man Jeon ),( Won Jung Koh ),( Gee Young Suh ),( Man Pyo Chung ),( Ho Joong Kim ),( O Jeong Kwon ),( Sang Won Um ) 대한결핵 및 호흡기학회 2011 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.112 No.-
Won-Jun Koh,Jeong-Hyeon Cho,Ji-Hyun Lee,Won-Sik Kang,Min-Kyung Lee,Jun-Hyoung Kim,Deok-kyu Cho 영남대학교 의과대학 2012 Yeungnam University Journal of Medicine Vol.29 No.2
A 70-year-old male came to the emergency room of the authors’ hospital because of sudden cardiac arrest due to inferior wall ST elevation myocardial infarction. His coronary angiography revealed multiple severe coronary spasms in his very long left anterior descending artery. After an injection of intracoronary nitroglycerine, his stenosis improved. The cardiac arrest relapsed, however, accompanied by ST elevation of the inferior leads, while the patient was on diltiazem and nitrate medication to prevent coronary spasm. Recovery was not achieved even with cardiac massage, intravenous injection of epinephrine and atropine, and intravenous infusion of nitroglycerine. The patient eventually recovered through high-dose nicorandil intravenous infusion without ST elevation of his inferior leads. Therefore, intravenous infusion of a high dose of nicorandil must be considered a treatment option for cardiac arrest caused by refractory coronary vasospasm.
Comparative Evaluation of Animal Models for Atopic Dermatitis in NC/Nga Mice
Jun-Won Yun,Hyuk Kim,Hyun-Jin Kang,Jae-Young Koh,Bae-Hwan Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1
Atopic dermatitis is a chronic and relapsing inflammatory skin disease accompanied by severe itching. Recently, animal models of atopic dermatitis, including NC/Nga mouse and hapten-induced mouse model, have received increasing attention. This study was designed to compare four mouse models for atopic dermatitis: 2,4-dinitrochlorobenzene (DNCB) short-term model, DNCB long-term model, dermatophagoides farina (Df) model, and dermatophagoides pteronyssinus (Dp) model. Repeated application of DNCB, Df, and Dp induced chronic skin inflammation, including thickening of the epidermis with marked hyperkeratosis and parakeratosis, and elevated the serum IgE levels compared than normal mice. Therefore, we suggested that 4 models induce not only AD-like skin lesions but also Th2-dominated immune responses in NC/Nga mice maintained under SPF conditions. Application of DNCB also evoked the increase in number of hindlimb scratching in short-term and long-term model. However, in both Df model and Dp model, there was no significant difference in number of hindlimb scratching between Dp- or Df-treated mice and control mice. The scratching frequency and serum immunoglobulin E (IgE) level in DNCB long-term model are higher than those of DNCB short-term model. Moreover, in DNCB long-term model, an increase in degranulating cutaneous mast cells, together with an increase in serum histamine level, was observed in DNCB-treated mice. And, interleukin-4 (IL-4) in the splenic T cell culture supernatants significantly increased in DNCB-treated mice. Consequently, considering all results, NC/Nga mice model developed through repeated long-term treatment of DNCB may be a good model for studying atopic dermatitis.