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- 검색키워드
- 저자 : Won-Jun Choe (검색결과 323 건)
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( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche
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S-148 HBV reactivation in a HBV/HCV-coinfected patient after daclatasvir and asunaprevir treatment
( Jun-hyun Kim ),( Won Hyeok Choe ) 대한내과학회 2016 대한내과학회 추계학술발표논문집 Vol.2016 No.1
Hepatitis B virus (HBV) could reactivate after the treatment of hepatitis C virus (HCV) in patients who were coinfected with HBV and HCV. This case demonstrates reactivation of HBV after treatment of HCV with direct-acting antivirals (DAAs) in a HBV-HCV co-infected patient. 41-year-old female patient was diagnosed with HBV-HCV coinfection. HCV-RNA levels were 1,140,000 IU/mL and the HCV genotype was 1b. HBV-DNA levels were 2,700 IU/mL and HBeAg was negative. Aspartate transaminase (AST) and alanine transaminase (ALT) were 28 and 24 IU/L, respectively. Triphasic dynamic computed tomography showed signs of underlying early liver cirrhosis, and her Child-Pugh score was five. Initially, HCV were treated with pegylated-interferon and ribavirin for 48 weeks, but HCV were relapsed at 24 weeks after HCV treatment. Instead, HBV-DNA titers decreased to undetectable levels and sustained for three years. Three years later, HCV were retreated with daclatasvir and asunaprevir for 24 weeks. 12 weeks after HCV retreatment, HCV-RNA reached undetectable level. However, HBV-DNA levels increased up to 7,300 IU/L, and entecavir was initiated for HBV management. In conclusion, in cases of treating HCV with DAA on a paitent with HBV-HCV coinfections, possibility of HBV reactivation must be considered and periodic HBV-DNA titer monitoring should be required.
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A Genetic Risk Score for Atrial Fibrillation Predicts the Response to Catheter Ablation
Won-Seok Choe,Jun Hyuk Kang,Eue-Keun Choi,Seung Yong Shin,Steven A. Lubitz,Patrick T. Ellinor,Seil Oh,Hong Euy Lim 대한심장학회 2019 Korean Circulation Journal Vol.49 No.4
Background and Objectives: The association of susceptibility loci for atrial fibrillation (AF) with AF recurrence after ablation has been reported, although with controversial results. In this prospective cohort analysis, we aimed to investigate whether a genetic risk score (GRS) can predict the rhythm outcomes after catheter ablation of AF. Methods: We determined the association between 20 AF-susceptible single nucleotide polymorphisms (SNPs) and AF recurrence after catheter ablation in 746 patients (74% males; age, 59±11 years; 56% paroxysmal AF). A GRS was calculated by summing the unweighted numbers of risk alleles of selected SNPs. A Cox proportional hazard model was used to identify the association between the GRS and risk of AF recurrence after catheter ablation. Results: AF recurrences after catheter ablation occurred in 168 (22.5%) subjects with a median follow-up of 23 months. The GRS was calculated using 5 SNPs (rs1448818, rs2200733, rs6843082, rs6838973 at chromosome 4q25 [PITX2] and rs2106261 at chromosome 16q22 [ZFHX3]), which showed modest associations with AF recurrence. The GRS was significantly associated with AF recurrence (hazard ratio [HR] per each score, 1.13; 95% confidence interval [CI], 1.03–1.24). Patients with intermediate (GRS 4–6) and high risks (GRS 7–10) showed HRs of 2.00 (95% CI, 0.99–4.04) and 2.66 (95% CI, 1.32–5.37), respectively, compared to patients with low risk (GRS 0–3). Conclusions: Our novel GRS using 5 AF-susceptible SNPs was strongly associated with AF recurrence after catheter ablation in Korean population, beyond clinical risk factors. Further efforts are warranted to construct a generalizable, robust genetic prediction model which can guide the optimal treatment strategies.
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Choe, Eugenie,Lee, Tae Young,Kim, Minah,Hur, Ji-Won,Yoon, Youngwoo Bryan,Cho, Kang-Ik K.,Kwon, Jun Soo Elsevier 2018 Schizophrenia Research Vol.199 No.-
<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>It has been suggested that the mentalizing network and the mirror neuron system network support important social cognitive processes that are impaired in schizophrenia. However, the integrity and interaction of these two networks have not been sufficiently studied, and their effects on social cognition in schizophrenia remain unclear.</P> <P><B>Methods</B></P> <P>Our study included 26 first-episode psychosis (FEP) patients and 26 healthy controls. We utilized resting-state functional connectivity to examine the a priori-defined mirror neuron system network and the mentalizing network and to assess the within- and between-network connectivities of the networks in FEP patients. We also assessed the correlation between resting-state functional connectivity measures and theory of mind performance.</P> <P><B>Results</B></P> <P>FEP patients showed altered within-network connectivity of the mirror neuron system network, and aberrant between-network connectivity between the mirror neuron system network and the mentalizing network. The within-network connectivity of the mirror neuron system network was noticeably correlated with theory of mind task performance in FEP patients.</P> <P><B>Conclusion</B></P> <P>The integrity and interaction of the mirror neuron system network and the mentalizing network may be altered during the early stages of psychosis. Additionally, this study suggests that alterations in the integrity of the mirror neuron system network are highly related to deficient theory of mind in schizophrenia, and this problem would be present from the early stage of psychosis.</P>
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( Jun Jae Kim ),( Jeong Han Kim ),( Ja Kyung Koo ),( Yun Jung Choi ),( Soon Young Ko ),( Won Hyeok Choe ),( So Young Kwon ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.1
Background/Aims: The modification of the Model for End-Stage Liver Disease (MELD) scoring system (Refit MELD) and the modification of MELD-Na (Refit MELDNa), which optimized the MELD coefficients, were published in 2011. We aimed to validate the superiority of the Refit MELDNa over the Refit MELD for the prediction of 3-month mortality in Korean patients with cirrhosis and ascites. Methods: We reviewed the medical records of patients admitted with hepatic cirrhosis and ascites to the Konkuk University Hospital between January 2006 and December 2011. The Refit MELD and Refit MELDNa were compared using the predictive value of the 3-month mortality, as assessed by the Child-Pugh score. Results: In total, 530 patients were enrolled, 87 of whom died within 3 months. Alcohol was the most common etiology of their cirrhosis (n=271, 51.1%), and the most common cause of death was variceal bleeding (n=20, 23%). The areas under the receiver operating curve (AUROCs) for the Child-Pugh, Refit MELD, and Refit MELDNa scores were 0.754, 0.791, and 0.764 respectively; the corresponding values when the analysis was performed only in patients with persistent ascites (n=115) were 0.725, 0.804, and 0.796, respectively. The significant difference found among the Child-Pugh, Refit MELD, and Refit MELDNa scores was between the Child-Pugh score and Refit MELD in patients with persistent ascites (P=0.039). Conclusions: Refit MELD and Refit MELDNa exhibited good predictability for 3-month mortality in patients with cirrhosis and ascites. However, Refit MELDNa was not found to be a better predictor than Refit MELD, despite the known relationship between hyponatremia and mortality in cirrhotic patients with ascites. (Clin Mol Hepatol 2014;20:47-55)
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( Jun Jae Kim ),( Jeong Han Kim ),( Yong Hoon Choi ),( Hong Seok Choi ),( Yong Hwang ),( Young Baek Kim ),( Yong Hoon Choi ),( Ja Kyung Koo ),( Yun Jung Choi ),( Soon Young Ko ),( Won Hyeok Choe ),( S 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: The Model for end-stage liver disease (MELD) has been widely used for predicting short term mortality in cirrhotic patients and employed for deceased donor liver allocation in the U.S. In year 2011, modification of MELD (Refit MELD) and MELDNa (Refit MELD-Na) was published (Gastroenterology 2011;140:1952-1960). We aimed to validate this for Korean patients with cirrhosis and ascites Methods: We retrospectively reviewed medical records of cirrhotic patients who admitted at konkuk university hospital from 2006 to 2010. Predictive value for 3 month mortality was compared between serum sodium (Na), Refit MELD, Refit MELD-Na, Child-Pugh score. Comparison was done by calculating area under receiver operating curve (AUROC). Results: Total 469 patients were enrolled and there were 60 deaths and 19 patients were performed liver transplantation (LT) within 3 month. Male patients were 358 patients (76.3%) and alcohol was the most common cause of cirrhosis (n=223, 47.5%). The most common cause of death was variceal bleeding (n=29, 48.3%) and hepatic failure was the next (n=27, 45.0%). After exclude patients who performed LT, 450 patients were analysed. AUROCs of Na, Refit MELD, Refit MELD-Na and Child-Pugh score were 0.636, 0.813, 0.776 and 0.771 respectively. There were significant differences between scores except between Refit MELD and Child-Pugh score (P=0.092), between Refit MELd-Na and Child-Pugh score (P=0.811). If analysis was performed in only patients with refractory ascites (n=109), AUROCs were 0.681, 0.801, 0.783 and 0.708 respectively. There were no significant differences between scores except between Refit MELD and Chld-Pugh score (P=0.032). Conclusions: Refit MELD and Refit MELD-Na showed good predictability for 3 month mortality in patients with cirrhosis and ascites. However, Refit MELD-Na is not a better predictor than Refit MELD although hyponatremia is related with mortality in cirrhotic patients with ascites.
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Alteration of Gene Expression Pattern in the Mouse Heart with Infarction
Jun-Kyoung Choe,Eun-Kyung Kim,Deug-Young Ryu,Young-Suk Won,Ok-Seong Moon,Cheol-Goo Hur,Hyoung-Chin Kim,Byeongwoo Ahn,Ki-Hoan Nam 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.3
Myocardial infarction (MI) is one of the leading causes of death in advanced nations. The therapeutic option is limited for chronic heart failure which is the result of MI. Recently, it has been reported that adult cardomyocytes can proliferate although the proliferating ability is quite low. To find clues for efficient induction of myocardial proliferation in heart with MI, we analyzed gene expression pattern in the heart with MI using microarray assay in mice. We found 17 and 8 genes of which the expression level increased and decreased in mouse heart with MI compared with those in normal ones, respectively. These alterations in the gene expressions reflect the heart under healing from MI. Therefore, further analysis for these genetic changes may helpful in future cell-based therapeutic application and induction of myocardial cell proliferation in patients with MI.
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Clinicopathologic Characteristics of Barrett`s Cancer in Korea
( Jun Won Chung ),( Gin Hyug Lee ),( Hwoon Yong Jung ),( Kee Don Choi ),( Ho June Song ),( Kwi Sook Choi ),( Hyung Chul Oh ),( Kee Wook Jung ),( Jae Won Choe ),( Jeong Won Kim ),( Eun Sil Yu ),( Jin H 대한소화기학회 2008 Gut and Liver Vol.2 No.3
Background/Aims: The incidence of Barrett`s cancer is increasing in Western countries, but there have been only a few case reports of this condition in Korea. The aim of this study was to elucidate the endoscopic and pathologic characteristics of Barrett`s cancer in a single center in Korea. Methods: We retrospectively reviewed the demographic, endoscopic, and pathologic characteristics of six patients with Barrett`s cancer, defined as a tumor centered above the esophagogastric junction and surrounded by Barrett`s esophagus. Results: All six patients were male, and three (50%) were symptomatic. Barrett`s cancer had developed from short-segment Barrett`s esophagus in all patients. All tumors were located on the right side of the lower esophagus and showed hyperemic mucosal changes. Three patients were treated surgically and three by endoscopic resection. All cases had pathologic evidence of Barrett`s cancer. Conclusions: Early detection of Barrett`s cancer requires meticulous endoscopic observations of subtle mucosal color and morphological changes around the esophagogastric junction. (Gut and Liver 2008;2:193-198)
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Jun Hyun Kim,Ji Yeon Kim,Wonil Kim,Kyung Woo Kim,Sang-il Lee,Kyung-Tae Kim,Jang Su Park,Won Joo Choe,Jung Won Kim 대한중환자의학회 2015 Acute and Critical Care Vol.30 No.1
Background: Simplified acute physiology score 3 (SAPS3) was developed in 2005 to evaluate intensive care unit (ICU) performance and to predict patient mortality or disease severity. The score is usually calculated by doctors, but it requires substantial human resources. And many nurse-lead studies use this scoring system. In the present study, we examined the inter-rater reliability of SAPS3 among nurses in an ICU. Methods: Five ICU nurses who worked in an ICU for a mean length of 7.8 years were educated for 2 hours about SAPS3 score and its components. Each nurse scored 26 patients, and the intraclass correlation coefficient (ICC) of the total scores and each subset were evaluated. Results: The ICC (95% confidence interval) of SAPS3 score was 0.89 (0.82-0.95), that of subset I was 0.90 (0.82-0.95), subset II was 0.54 (0.35-0.73), and subset III was 0.95 (0.91-0.97). The ICC of predicted mortality was 0.91 (0.85-0.96). Conclusions: The ICC of SAPS3 score and predicted mortality among ICU nurses were reliable. According to these ICC values, SAPS3 score is a reliable scale to be used by nurses. The ICC of subset II was lower than those of the other subsets, suggesting that education of SAPS3 should focus on the definition of each subset II component.
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